Deep learning has undeniably sharpened our ability to forecast risk in neuropsychiatry[1].Yet the very success of prediction has exposed a deeper limitation:we are still remarkably uncertain about which levers to pull...Deep learning has undeniably sharpened our ability to forecast risk in neuropsychiatry[1].Yet the very success of prediction has exposed a deeper limitation:we are still remarkably uncertain about which levers to pull to change patient trajectories[2].Accurate risk scores that cannot be translated into credible actions leave clinicians where they began,testing symptomatic fixes and hoping for the best.If we want to move beyond this impasse,the next step is not simply to train larger models,but to rethink what we ask of them.展开更多
This article chronicles a failed research project.We designed and carried out a psychological intervention aimed at increasing esogastric and lung cancer patients’emotional competencies after treatments.We present th...This article chronicles a failed research project.We designed and carried out a psychological intervention aimed at increasing esogastric and lung cancer patients’emotional competencies after treatments.We present the final protocol of the study,a randomized controlled trial in a public hospital,and describe the difficulties encountered and our subsequent reflections,to provide researchers and clinicians with advice for the implementation of such interventions.Firstly,the role of psychology,emotions,and emotional competencies,is still underacknowledged in cancer care.Pedagogical efforts must be made to convince both physicians and patients of the importance of those elements.Secondly and consequently,even distressed patients sure to benefit from such an intervention,do not take it up.In particular,male patients often declined the intervention due to gender stereotypes,and as such creativity is needed to present such interventions in a motivating way for patients.Finally,and most importantly,even if there is a good rationale for a psychological intervention and all favorable conditions are present,it is essential to first conduct a feasibility/pilot study.Indeed,even the most thorough preparation is no guarantee of anticipating all issues due to important gaps between theory and practice.展开更多
What is the psychological mechanism of the radical behavior towards the public affairs?Carl Jung’s analytical psychology can be an approach to this problem.We tested 268 people on their cognitive,emotional and behavi...What is the psychological mechanism of the radical behavior towards the public affairs?Carl Jung’s analytical psychology can be an approach to this problem.We tested 268 people on their cognitive,emotional and behavioral reflex on suicide components expression and terrorism ideology acceptance.The results shows that,based on psychoanalytical dipole model,“mine/alien’s”archetype’s polarization factors impacts the shahidism behavior.展开更多
Nevertheless parents often fall into depression,anxiety,and stress because of their children’s school refusal which hinders their children’s school reentry on the contrary,they still play primary and critical roles ...Nevertheless parents often fall into depression,anxiety,and stress because of their children’s school refusal which hinders their children’s school reentry on the contrary,they still play primary and critical roles in the school reentry process of school-refusing adolescents.This study aimed to provide targeted psychological support to 274 parents of school-refusing adolescents through an action research through four action cycles.Based on parental needs and cutting-edge research,we underwent four cycles from top-down expert support to peer support for parents of school-refusing adolescents,from intervening in the families of school-refusing adolescents to intervening in the social-ecological system in which these families live,from a single discipline to interdisciplinary exploration,and emphasizing the postmodern psychological philosophy that emphasizes local knowledge.The results are:(1)a warm and peer-support internet we-chat group was established,(2)multi-disciplinary and multi-perspective psychological support and systems with different programs for these parents are figuring out,(3)a more comprehensive social atmosphere without stigmatization are for the phenomenon of school attendance problem are come into being,step by step.展开更多
Addiction literacy equips older adults with the knowledge to navigate substance use risks amid unique challenges like polypharmacy and social isolation.With rising trends in cannabis use among this group,targeted educ...Addiction literacy equips older adults with the knowledge to navigate substance use risks amid unique challenges like polypharmacy and social isolation.With rising trends in cannabis use among this group,targeted education can promote safe practices and reduce preventable harms.By fostering open conversations and integrating addiction literacy into healthcare,providers can support informed decision-making.展开更多
The purpose of this study is to explore the mental health status of college students in Beijing and develop a scientific assessment scale.First,a systematic review of domestic and international literature related to c...The purpose of this study is to explore the mental health status of college students in Beijing and develop a scientific assessment scale.First,a systematic review of domestic and international literature related to college students’mental health was conducted,and a three-dimensional model covering adaptation,distress,and resilience was proposed.Then,open-ended questionnaire surveys were carried out based on the literature review to collect data,and a preliminary scale was developed through factor analysis.This study further tested and optimized the preliminary scale to ensure its reliability and validity,so as to form a formal scale.As a result,a formal scale is devised after three testing processes that consist of 134 items.The scale primarily consists of three subscales:adaptation,distress,and resilience.The adaptation subscale covers six points:interpersonal relationships,learning,career choice,emotions,self-adaptation,and satisfaction.The distress subscale includes seven aspects:depression,anxiety,somatization,compulsion,Internet addiction,withdrawal and aggression.The resilience subscale consists of four features:self-confidence,positive cognition,problem-solving,and social support.The results show that all three subscales have good reliability and validity.This scale enables mental health assessment from three distinct levels:adaptation,distress,and resilience,thus objectively reporting the developmental characteristics of college students’mental health.The division of these three levels not only remedies the deficiencies of previous mental health measurements but also meets the practical needs of developmental psychological counseling in universities,clarifying the tasks of mental health education.展开更多
BACKGROUND Alexithymia is defined as difficulties in identifying,expressing,and understanding emotions.An unapproving environment during childhood is defined as the child not receiving emotional approval from their pa...BACKGROUND Alexithymia is defined as difficulties in identifying,expressing,and understanding emotions.An unapproving environment during childhood is defined as the child not receiving emotional approval from their parents,being punished,or having their emotions devalued.The formation of self-esteem is shaped by the influence of parental behavior during childhood.The commu-nication that the child establishes with their parents contributes to their increased self-esteem and sense of importance.The absence of this may play a role in developmental psychopathology.AIM To examine the mediating role of self-esteem in the relationship between a disapproving environment in childhood and alexithymia.METHODS The research in the relational screening model was conducted with 404 participants.Demographic Information Form,Disapproving Environment Scale in Childhood,Toronto Alexithymia Scale,and Rosenberg Self-Esteem Scale were used as data collection tools.Hayes’bootstrapping technique was used in the analysis of the data obtained from the research.RESULTS As a result of the analyses,parental disapproval positively predicted the level of alexithymia(rmother=0.51,rfather=0.52,P<0.05)and negatively predicted selfesteem(rmother=-0.75,rfather=-0.67,P<0.05).Additionally,self-esteem negatively predicted alexithymia(r=-0.58,P<0.05).It was observed that self-esteem had a partial mediating effect on the relationship between parental disapproval and alexithymia.Family types were analyzed separately as chaotic,approving,perfect,and typical.Of these,the chaotic family type positively predicted alexithymia(r=0.33,P<0.05)and negatively predicted self-esteem(r=-0.60,P<0.05).The approving family type negatively predicted alexithymia(r=-0.43,P<0.05)and positively predicted self-esteem(r=0.61,P<0.05).The perfect family type negatively predicted alexithymia(r=-0.27,P<0.05)and positively predicted self-esteem(r=-0.45,P<0.05).CONCLUSION The type of family in which the child grows up in and parental disapproval during childhood affected the child’s self-esteem and caused alexithymic personality traits.展开更多
Human functional MRI studies in acute and various chronic pain conditions have revolutionized how we view pain, and have led to a new theory that complex multi-dimensional pain experience （sensory-discriminative, aff...Human functional MRI studies in acute and various chronic pain conditions have revolutionized how we view pain, and have led to a new theory that complex multi-dimensional pain experience （sensory-discriminative, affective/motivational, and cognitive） is represented by concurrent activity in widely-distributed brain regions （termed a network or pain matrix）. Despite these break- through discoveries, the specific functions proposed for these regions remain elusive, because detailed electrophys- iological characterizations of these regions in the primate brain are lacking. To fill in this knowledge gap, we have studied the cortical areas around the central and lateral sulci of the non-human primate brain with combined submillimeter resolution functional imaging （optical imaging and fMRI） and intracranial electrophysiological recording. In this mini-review, I summarize and present data showing that the cortical circuitry engaged in nociceptive processing is much more complex than previously recognized. Electrophysiological evidence supports the engage- ment of a distinct nociceptive-processing network within SI （i.e., areas 3a, 3b, 1 and 2）, SII, and other areas along the lateral sulcus. Deafferentation caused by spinal cord injury profoundly alters the relationships between fMRI and electrophysiological signals. This finding has significant implications for using fMRI to study chronic pain conditions involving deafferentation in humans.展开更多
A number of studies have indicated that disor- ders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. Howe...A number of studies have indicated that disor- ders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections （ECs） between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls. Prediction of the patients＇ outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level.展开更多
AIM To define regional grey-matter abnormalities in schizophrenia patients with poor insight(Insight-),relative to patients with preserved clinical insight(Insight+),and healthy controls.METHODS Forty stable schizophr...AIM To define regional grey-matter abnormalities in schizophrenia patients with poor insight(Insight-),relative to patients with preserved clinical insight(Insight+),and healthy controls.METHODS Forty stable schizophrenia outpatients(20 Insight-and 20 Insight+) and 20 healthy controls underwent whole brain magnetic resonance imaging(MRI).Insight in all patients was assessed using the Birchwood Insight Scale(BIS;a self-report measure).The two patient groups were preselected to match on most clinical and demographic parameters but,by design,they had markedly distinct BIS scores.Voxel-based morphometry employed in SPM8 was used to examine group differences in grey matter volumes across the whole brain.RESULTS The three participant groups were comparable in age [F(2,57) = 0.34,P = 0.71] and the patient groups did not differ in age at illness onset [t(38) = 0.87,P = 0.39].Insight-and Insight+ patient groups also did not differ in symptoms on the Positive and Negative Syndromes scale(PANSS):Positive symptoms [t(38) = 0.58,P = 0.57],negative symptoms [t(38) = 0.61,P = 0.55],general psychopathology [t(38) = 1.30,P = 0.20] and total PANSS scores [t(38) = 0.21,P = 0.84].The two patient groups,as expected,varied significantly in the level of BIS-assessed insight [t(38) = 12.11,P < 0.001].MRI results revealed lower fronto-temporal,parahippocampal,occipital and cerebellar grey matter volumes in Insightpatients,relative to Insight+ patients and healthy controls(for all clusters,family-wise error corrected P < 0.05).Insight+ patient and healthy controls did not differ significantly(P > 0.20) from each other.CONCLUSION Our findings demonstrate a clear association between poor clinical insight and smaller fronto-temporal,occipital and cerebellar grey matter volumes in stable long-term schizophrenia patients.展开更多
Voxel-based morphometry-diffeomorphic anatomical registration using exponentiated lie algebra analysis was used to investigate the structural characteristics of white matter in young males with antisocial personality ...Voxel-based morphometry-diffeomorphic anatomical registration using exponentiated lie algebra analysis was used to investigate the structural characteristics of white matter in young males with antisocial personality disorder （APD） and healthy controls without APD. The results revealed that APD subjects, relative to healthy subjects, exhibited increased white matter volume in the bilateral prefrontal lobe, right insula, precentral gyrus, bilateral superior temporal gyrus, right postcentral gyrus, right inferior parietal Iobule, right precuneus, right middle occipital lobe, right parahippocampal gyrus and bilateral cingulate, and decreased volume in the middle temporal cortex and right cerebellum. The white matter volume in the medial frontal gyrus was significantly correlated with antisocial type scores on the Personality Diagnostic Questionnaire in APD subjects. These experimental findings indicate that white matter abnormalities in several brain areas may contribute to antisocial behaviors in APD subjects.展开更多
Dear Editor,Neuromodulation,a rapidly expanding field attracting wide attention over recent decades,facilitates human cognition,behavior,and pathology by modifying the activity of specific neural targets.Human brain f...Dear Editor,Neuromodulation,a rapidly expanding field attracting wide attention over recent decades,facilitates human cognition,behavior,and pathology by modifying the activity of specific neural targets.Human brain functions can be modified by exogenous brain neuromodulation techniques that deliver physical energy(e.g.,electrical current or magnetic pulses)into the brain[1],such as deep brain stimulation,transcranial magnetic stimulation,and tran-scranial direct current stimulation.展开更多
The aim of this study was to investigate the temporal cortical activation patterns underlying different stages of humor comprehension (e.g., detection of incongruity stage, resolution of incongruity stage, and affecti...The aim of this study was to investigate the temporal cortical activation patterns underlying different stages of humor comprehension (e.g., detection of incongruity stage, resolution of incongruity stage, and affective stage). Event-related potentials (ERPs) were measured when 16 subjects were apprehending cartoon pictures including humorous, non-humorous and unrelated items. Results showed that both humorous and unrelated items elicited a more negative ERP deflection (N500-800) than non-humorous ones between 500 - 800 ms, which might reflect detection to incongruent element during humor apprehension. Then, both humorous and non-humorous items elicited a more positive ERP deflection (P800-1000) than unrelated ones between 800 - 1000 ms, which might reflect a classification process preliminarily evaluating whether there were attainable cues in the pictures used to form possible association between context and picture (we named it “association evaluation” stage). Furthermore, humorous items elicited a more positive slow wave than non-humorous items which also elicited a more positive wave than unrelated items between 1000 - 1600 ms, during which this component might be involved in the forming of novel associations (resolution of incongruity). Lastly, between 1600 - 2000 ms, humorous items elicited a more positive ERP deflection (P1600-2000) than both non-humorous and unrelated items, which might be related to emotion processing during humor apprehension. Based on these results, we deeply subdivided the second stage (resolution of incongruity) into two stages: association evaluation and incongruity resolution.展开更多
Irreproducibility of research causes a major concern in academia.This concern affects all study designs regardless of scientific fields.Without testing the reproducibility and replicability it is almost impossible to ...Irreproducibility of research causes a major concern in academia.This concern affects all study designs regardless of scientific fields.Without testing the reproducibility and replicability it is almost impossible to repeat the research and to gain the same or similar results.In addition,irreproducibility limits the translation of research findings into practice where the same results are expected.To find the solutions,the Interacademy Partnership for Health gathered academics from established networks of science,medicine and engineering around a table to introduce seven strategies that can enhance the reproducibility:pre-registration,open methods,open data,collaboration,automation,reporting guidelines,and post-publication reviews.The current editorial discusses the generalisability and practicality of these strategies to systematic reviews and claims that systematic reviews have even a greater potential than other research designs to lead the movement toward the reproducibility of research.Moreover,I discuss the potential of reproducibility,on the other hand,to upgrade the systematic review from review to research.Furthermore,there are references to the successful and ongoing practices from collaborative efforts around the world to encourage the systematic reviewers,the journal editors and publishers,the organizations linked to evidence synthesis,and the funders and policy makers to facilitate this movement and to gain the public trust in research.展开更多
Purpose: Socially anxious people are typically thought of as being behaviorally inhibited;however, an atypical subgroup, which is impulsive rather than inhibited, has recently been identified [1]. Theoretically, inhib...Purpose: Socially anxious people are typically thought of as being behaviorally inhibited;however, an atypical subgroup, which is impulsive rather than inhibited, has recently been identified [1]. Theoretically, inhibition and impulsivity could be viewed as different strategies for coping with anxiety that have the same goal—escape from negative emotions—but they seem to have different implications. Previous studies have found that the socially anxious-impulsive subgroup was higher on risk-prone behavior, as for example drug use, compared with a socially anxious-inhibited subgroup [1]. In this study, we aimed to identify these subgroups in a general population, and asked whether they also experience various levels of depressive symptoms and life satisfaction, as well as moderating effects of gender. Methods: Cluster analysis was used to identify subgroups of young adults (20 - 24 years old;N = 772) characterized by different profiles of social anxiety and impulsivity. These subgroups were compared on levels of internal adjustment, and the moderating effects of gender were also tested. Results: We identified five clusters, including an Anxious-Inhibited and an Anxious-Impulsive cluster. In the interaction between gender and cluster membership, gender showed evidence of moderation regarding both depressive symptoms and life satisfaction, with the young women in the Anxious-Inhibited and the Anxious-Impulsive clusters faring worst. Conclusions: We replicated previous findings demonstrating the existence of a socially anxious-impulsive subgroup, thus solidifying current knowledge that may be important when it comes to diagnostics and treatment. This may prove particularly important for young women regarding internalizing symptoms.展开更多
Background： The influence of self-presentation concerns on the adolescent sport experience has received scant empirical attention. The purpose of this investigation was to prospectively examine the relationship among...Background： The influence of self-presentation concerns on the adolescent sport experience has received scant empirical attention. The purpose of this investigation was to prospectively examine the relationship among self-presentational concerns and pre-game affective states among middle and high school aged football players. Methods： American football players （n = 112; mean age = 15.57 years） completed a measure of self-presentational concerns （SPSQ, McGowan, et al., 2008） a week prior to the measurement of selected pre-game affective states （i.e., attentiveness, self-assurance, serenity, and fear）. Results： Regression analyses revealed that concerns about appearing athletically untalented negatively contributed to the significant prediction （p 〈 0.001） of pre-game attentiveness, /3 = -0.43, Radj ^2 19.5% （p 〈 0.001）, and self-assurance, /3 = -0.38, R^dj = 11.9% （p 〈 0.01）. Conclusion： These findings highlight the importance of reducing self-presentational concerns in promoting positive pre-game mental states that likely impact the quality of athletes＇ competitive play and experience. Copyright @ 2012, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved.展开更多
The concept of Multidisciplinary approach is not new to Medical Science. It is an evolving concept that is widely appreciated and adopted in most of the disciplines of medicine. It’s rational and applicable in the ma...The concept of Multidisciplinary approach is not new to Medical Science. It is an evolving concept that is widely appreciated and adopted in most of the disciplines of medicine. It’s rational and applicable in the management of Child and Adolescent Depression,which needs to be revisited focusing on the interplay of various contextual factors that are entwined and tend to affect the course of the illness. The limitations of any one mental health professional in envisioning all possible dimensions of Child and Adolescent Depression make this approach all the more important wherein Psychiatrists, Clinical Psychologists, Psychiatric Social Workers collaborate with each other and other allied professionals in the treatment and management of the disorder. India, being a heavily populated country, where multidisciplinary management approach is in a phase of expansion and is practiced in many leading institutes to meet the quality needs of patients. This article focuses on the Indian scene of multidisciplinary management approach in child and adolescent depression.展开更多
文摘Deep learning has undeniably sharpened our ability to forecast risk in neuropsychiatry[1].Yet the very success of prediction has exposed a deeper limitation:we are still remarkably uncertain about which levers to pull to change patient trajectories[2].Accurate risk scores that cannot be translated into credible actions leave clinicians where they began,testing symptomatic fixes and hoping for the best.If we want to move beyond this impasse,the next step is not simply to train larger models,but to rethink what we ask of them.
文摘This article chronicles a failed research project.We designed and carried out a psychological intervention aimed at increasing esogastric and lung cancer patients’emotional competencies after treatments.We present the final protocol of the study,a randomized controlled trial in a public hospital,and describe the difficulties encountered and our subsequent reflections,to provide researchers and clinicians with advice for the implementation of such interventions.Firstly,the role of psychology,emotions,and emotional competencies,is still underacknowledged in cancer care.Pedagogical efforts must be made to convince both physicians and patients of the importance of those elements.Secondly and consequently,even distressed patients sure to benefit from such an intervention,do not take it up.In particular,male patients often declined the intervention due to gender stereotypes,and as such creativity is needed to present such interventions in a motivating way for patients.Finally,and most importantly,even if there is a good rationale for a psychological intervention and all favorable conditions are present,it is essential to first conduct a feasibility/pilot study.Indeed,even the most thorough preparation is no guarantee of anticipating all issues due to important gaps between theory and practice.
文摘What is the psychological mechanism of the radical behavior towards the public affairs?Carl Jung’s analytical psychology can be an approach to this problem.We tested 268 people on their cognitive,emotional and behavioral reflex on suicide components expression and terrorism ideology acceptance.The results shows that,based on psychoanalytical dipole model,“mine/alien’s”archetype’s polarization factors impacts the shahidism behavior.
基金funded by Outstanding Young Talents Project of the 2022 Beijing Municipal University Teacher Team Construction Support Plan“Interdisciplinary Ecological Intervention on School Attendance of young people”,grant number BPHR202203224Beijing Union University High Level Incubation Project“exploration on the path of’accompanying intervention’for adolescents with school attendance difficulties”,grant number SK20202303+1 种基金Beijing Union University High-quality Development for the Capital Project“School-Family-Community Collaborative Education Mechanism Research in Beijing”,grant number SK30202303China Preschool Education Research Association Project“an Action Research of Children’s Social Emotional Ability Curriculum Development and Implementation”,grant number K20210195.This research was funded by them.
文摘Nevertheless parents often fall into depression,anxiety,and stress because of their children’s school refusal which hinders their children’s school reentry on the contrary,they still play primary and critical roles in the school reentry process of school-refusing adolescents.This study aimed to provide targeted psychological support to 274 parents of school-refusing adolescents through an action research through four action cycles.Based on parental needs and cutting-edge research,we underwent four cycles from top-down expert support to peer support for parents of school-refusing adolescents,from intervening in the families of school-refusing adolescents to intervening in the social-ecological system in which these families live,from a single discipline to interdisciplinary exploration,and emphasizing the postmodern psychological philosophy that emphasizes local knowledge.The results are:(1)a warm and peer-support internet we-chat group was established,(2)multi-disciplinary and multi-perspective psychological support and systems with different programs for these parents are figuring out,(3)a more comprehensive social atmosphere without stigmatization are for the phenomenon of school attendance problem are come into being,step by step.
基金Supported by FAPESP and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico,No.2024/13209-0.
文摘Addiction literacy equips older adults with the knowledge to navigate substance use risks amid unique challenges like polypharmacy and social isolation.With rising trends in cannabis use among this group,targeted education can promote safe practices and reduce preventable harms.By fostering open conversations and integrating addiction literacy into healthcare,providers can support informed decision-making.
基金This work was supported by the Education Science Research Project of Beijing Union University grant number[JK202506]“Optimization and Application Exploration of Immersive Virtual Reality Practice Teaching Platform for Future Psychological Teachers,”and by the R&D Program of Beijing Municipal Education Commission grant number[KM202311417008].
文摘The purpose of this study is to explore the mental health status of college students in Beijing and develop a scientific assessment scale.First,a systematic review of domestic and international literature related to college students’mental health was conducted,and a three-dimensional model covering adaptation,distress,and resilience was proposed.Then,open-ended questionnaire surveys were carried out based on the literature review to collect data,and a preliminary scale was developed through factor analysis.This study further tested and optimized the preliminary scale to ensure its reliability and validity,so as to form a formal scale.As a result,a formal scale is devised after three testing processes that consist of 134 items.The scale primarily consists of three subscales:adaptation,distress,and resilience.The adaptation subscale covers six points:interpersonal relationships,learning,career choice,emotions,self-adaptation,and satisfaction.The distress subscale includes seven aspects:depression,anxiety,somatization,compulsion,Internet addiction,withdrawal and aggression.The resilience subscale consists of four features:self-confidence,positive cognition,problem-solving,and social support.The results show that all three subscales have good reliability and validity.This scale enables mental health assessment from three distinct levels:adaptation,distress,and resilience,thus objectively reporting the developmental characteristics of college students’mental health.The division of these three levels not only remedies the deficiencies of previous mental health measurements but also meets the practical needs of developmental psychological counseling in universities,clarifying the tasks of mental health education.
文摘BACKGROUND Alexithymia is defined as difficulties in identifying,expressing,and understanding emotions.An unapproving environment during childhood is defined as the child not receiving emotional approval from their parents,being punished,or having their emotions devalued.The formation of self-esteem is shaped by the influence of parental behavior during childhood.The commu-nication that the child establishes with their parents contributes to their increased self-esteem and sense of importance.The absence of this may play a role in developmental psychopathology.AIM To examine the mediating role of self-esteem in the relationship between a disapproving environment in childhood and alexithymia.METHODS The research in the relational screening model was conducted with 404 participants.Demographic Information Form,Disapproving Environment Scale in Childhood,Toronto Alexithymia Scale,and Rosenberg Self-Esteem Scale were used as data collection tools.Hayes’bootstrapping technique was used in the analysis of the data obtained from the research.RESULTS As a result of the analyses,parental disapproval positively predicted the level of alexithymia(rmother=0.51,rfather=0.52,P<0.05)and negatively predicted selfesteem(rmother=-0.75,rfather=-0.67,P<0.05).Additionally,self-esteem negatively predicted alexithymia(r=-0.58,P<0.05).It was observed that self-esteem had a partial mediating effect on the relationship between parental disapproval and alexithymia.Family types were analyzed separately as chaotic,approving,perfect,and typical.Of these,the chaotic family type positively predicted alexithymia(r=0.33,P<0.05)and negatively predicted self-esteem(r=-0.60,P<0.05).The approving family type negatively predicted alexithymia(r=-0.43,P<0.05)and positively predicted self-esteem(r=0.61,P<0.05).The perfect family type negatively predicted alexithymia(r=-0.27,P<0.05)and positively predicted self-esteem(r=-0.45,P<0.05).CONCLUSION The type of family in which the child grows up in and parental disapproval during childhood affected the child’s self-esteem and caused alexithymic personality traits.
基金supported by NIH Grant R01 NS069909an imaging track Grant from the Dana Foundation
文摘Human functional MRI studies in acute and various chronic pain conditions have revolutionized how we view pain, and have led to a new theory that complex multi-dimensional pain experience （sensory-discriminative, affective/motivational, and cognitive） is represented by concurrent activity in widely-distributed brain regions （termed a network or pain matrix）. Despite these break- through discoveries, the specific functions proposed for these regions remain elusive, because detailed electrophys- iological characterizations of these regions in the primate brain are lacking. To fill in this knowledge gap, we have studied the cortical areas around the central and lateral sulci of the non-human primate brain with combined submillimeter resolution functional imaging （optical imaging and fMRI） and intracranial electrophysiological recording. In this mini-review, I summarize and present data showing that the cortical circuitry engaged in nociceptive processing is much more complex than previously recognized. Electrophysiological evidence supports the engage- ment of a distinct nociceptive-processing network within SI （i.e., areas 3a, 3b, 1 and 2）, SII, and other areas along the lateral sulcus. Deafferentation caused by spinal cord injury profoundly alters the relationships between fMRI and electrophysiological signals. This finding has significant implications for using fMRI to study chronic pain conditions involving deafferentation in humans.
基金supported by National Natural Science Foundation of China (81471654, 81428013, 81371535, and 81271548)the Natural Science Foundation of Guangdong Province, China (2015A030313609)+1 种基金Planned Science and Technology Project of Guangzhou Municipality, China (20160402007 and 201604020184)the Innovation Project of The Graduate School of South China Normal University
文摘A number of studies have indicated that disor- ders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections （ECs） between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls. Prediction of the patients＇ outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level.
基金Supported by The Wellcome Trust,United Kingdom and was carried out as part of the first author’s PhD research under Professor Veena Kumari and Dr Dominic ffytche’s supervision,Nos.067427 and 072298Professor Kumari is part funded by the Biomedical Research Centre for Mental Health at the Institute of Psychiatry,Psychology and Neuroscience King’s College London,and the South London and Maudsley NHS Foundation Trust,United Kingdom(to Kumari V)
文摘AIM To define regional grey-matter abnormalities in schizophrenia patients with poor insight(Insight-),relative to patients with preserved clinical insight(Insight+),and healthy controls.METHODS Forty stable schizophrenia outpatients(20 Insight-and 20 Insight+) and 20 healthy controls underwent whole brain magnetic resonance imaging(MRI).Insight in all patients was assessed using the Birchwood Insight Scale(BIS;a self-report measure).The two patient groups were preselected to match on most clinical and demographic parameters but,by design,they had markedly distinct BIS scores.Voxel-based morphometry employed in SPM8 was used to examine group differences in grey matter volumes across the whole brain.RESULTS The three participant groups were comparable in age [F(2,57) = 0.34,P = 0.71] and the patient groups did not differ in age at illness onset [t(38) = 0.87,P = 0.39].Insight-and Insight+ patient groups also did not differ in symptoms on the Positive and Negative Syndromes scale(PANSS):Positive symptoms [t(38) = 0.58,P = 0.57],negative symptoms [t(38) = 0.61,P = 0.55],general psychopathology [t(38) = 1.30,P = 0.20] and total PANSS scores [t(38) = 0.21,P = 0.84].The two patient groups,as expected,varied significantly in the level of BIS-assessed insight [t(38) = 12.11,P < 0.001].MRI results revealed lower fronto-temporal,parahippocampal,occipital and cerebellar grey matter volumes in Insightpatients,relative to Insight+ patients and healthy controls(for all clusters,family-wise error corrected P < 0.05).Insight+ patient and healthy controls did not differ significantly(P > 0.20) from each other.CONCLUSION Our findings demonstrate a clear association between poor clinical insight and smaller fronto-temporal,occipital and cerebellar grey matter volumes in stable long-term schizophrenia patients.
基金the National Natural Science Foundation of China, No. 30570609
文摘Voxel-based morphometry-diffeomorphic anatomical registration using exponentiated lie algebra analysis was used to investigate the structural characteristics of white matter in young males with antisocial personality disorder （APD） and healthy controls without APD. The results revealed that APD subjects, relative to healthy subjects, exhibited increased white matter volume in the bilateral prefrontal lobe, right insula, precentral gyrus, bilateral superior temporal gyrus, right postcentral gyrus, right inferior parietal Iobule, right precuneus, right middle occipital lobe, right parahippocampal gyrus and bilateral cingulate, and decreased volume in the middle temporal cortex and right cerebellum. The white matter volume in the medial frontal gyrus was significantly correlated with antisocial type scores on the Personality Diagnostic Questionnaire in APD subjects. These experimental findings indicate that white matter abnormalities in several brain areas may contribute to antisocial behaviors in APD subjects.
基金the National Natural Science Foundation of China(82071999,61431002,31521063,and 61273287)the National 973 Program(2014CB846100).
文摘Dear Editor,Neuromodulation,a rapidly expanding field attracting wide attention over recent decades,facilitates human cognition,behavior,and pathology by modifying the activity of specific neural targets.Human brain functions can be modified by exogenous brain neuromodulation techniques that deliver physical energy(e.g.,electrical current or magnetic pulses)into the brain[1],such as deep brain stimulation,transcranial magnetic stimulation,and tran-scranial direct current stimulation.
文摘The aim of this study was to investigate the temporal cortical activation patterns underlying different stages of humor comprehension (e.g., detection of incongruity stage, resolution of incongruity stage, and affective stage). Event-related potentials (ERPs) were measured when 16 subjects were apprehending cartoon pictures including humorous, non-humorous and unrelated items. Results showed that both humorous and unrelated items elicited a more negative ERP deflection (N500-800) than non-humorous ones between 500 - 800 ms, which might reflect detection to incongruent element during humor apprehension. Then, both humorous and non-humorous items elicited a more positive ERP deflection (P800-1000) than unrelated ones between 800 - 1000 ms, which might reflect a classification process preliminarily evaluating whether there were attainable cues in the pictures used to form possible association between context and picture (we named it “association evaluation” stage). Furthermore, humorous items elicited a more positive slow wave than non-humorous items which also elicited a more positive wave than unrelated items between 1000 - 1600 ms, during which this component might be involved in the forming of novel associations (resolution of incongruity). Lastly, between 1600 - 2000 ms, humorous items elicited a more positive ERP deflection (P1600-2000) than both non-humorous and unrelated items, which might be related to emotion processing during humor apprehension. Based on these results, we deeply subdivided the second stage (resolution of incongruity) into two stages: association evaluation and incongruity resolution.
文摘Irreproducibility of research causes a major concern in academia.This concern affects all study designs regardless of scientific fields.Without testing the reproducibility and replicability it is almost impossible to repeat the research and to gain the same or similar results.In addition,irreproducibility limits the translation of research findings into practice where the same results are expected.To find the solutions,the Interacademy Partnership for Health gathered academics from established networks of science,medicine and engineering around a table to introduce seven strategies that can enhance the reproducibility:pre-registration,open methods,open data,collaboration,automation,reporting guidelines,and post-publication reviews.The current editorial discusses the generalisability and practicality of these strategies to systematic reviews and claims that systematic reviews have even a greater potential than other research designs to lead the movement toward the reproducibility of research.Moreover,I discuss the potential of reproducibility,on the other hand,to upgrade the systematic review from review to research.Furthermore,there are references to the successful and ongoing practices from collaborative efforts around the world to encourage the systematic reviewers,the journal editors and publishers,the organizations linked to evidence synthesis,and the funders and policy makers to facilitate this movement and to gain the public trust in research.
文摘Purpose: Socially anxious people are typically thought of as being behaviorally inhibited;however, an atypical subgroup, which is impulsive rather than inhibited, has recently been identified [1]. Theoretically, inhibition and impulsivity could be viewed as different strategies for coping with anxiety that have the same goal—escape from negative emotions—but they seem to have different implications. Previous studies have found that the socially anxious-impulsive subgroup was higher on risk-prone behavior, as for example drug use, compared with a socially anxious-inhibited subgroup [1]. In this study, we aimed to identify these subgroups in a general population, and asked whether they also experience various levels of depressive symptoms and life satisfaction, as well as moderating effects of gender. Methods: Cluster analysis was used to identify subgroups of young adults (20 - 24 years old;N = 772) characterized by different profiles of social anxiety and impulsivity. These subgroups were compared on levels of internal adjustment, and the moderating effects of gender were also tested. Results: We identified five clusters, including an Anxious-Inhibited and an Anxious-Impulsive cluster. In the interaction between gender and cluster membership, gender showed evidence of moderation regarding both depressive symptoms and life satisfaction, with the young women in the Anxious-Inhibited and the Anxious-Impulsive clusters faring worst. Conclusions: We replicated previous findings demonstrating the existence of a socially anxious-impulsive subgroup, thus solidifying current knowledge that may be important when it comes to diagnostics and treatment. This may prove particularly important for young women regarding internalizing symptoms.
文摘Background： The influence of self-presentation concerns on the adolescent sport experience has received scant empirical attention. The purpose of this investigation was to prospectively examine the relationship among self-presentational concerns and pre-game affective states among middle and high school aged football players. Methods： American football players （n = 112; mean age = 15.57 years） completed a measure of self-presentational concerns （SPSQ, McGowan, et al., 2008） a week prior to the measurement of selected pre-game affective states （i.e., attentiveness, self-assurance, serenity, and fear）. Results： Regression analyses revealed that concerns about appearing athletically untalented negatively contributed to the significant prediction （p 〈 0.001） of pre-game attentiveness, /3 = -0.43, Radj ^2 19.5% （p 〈 0.001）, and self-assurance, /3 = -0.38, R^dj = 11.9% （p 〈 0.01）. Conclusion： These findings highlight the importance of reducing self-presentational concerns in promoting positive pre-game mental states that likely impact the quality of athletes＇ competitive play and experience. Copyright @ 2012, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved.
文摘The concept of Multidisciplinary approach is not new to Medical Science. It is an evolving concept that is widely appreciated and adopted in most of the disciplines of medicine. It’s rational and applicable in the management of Child and Adolescent Depression,which needs to be revisited focusing on the interplay of various contextual factors that are entwined and tend to affect the course of the illness. The limitations of any one mental health professional in envisioning all possible dimensions of Child and Adolescent Depression make this approach all the more important wherein Psychiatrists, Clinical Psychologists, Psychiatric Social Workers collaborate with each other and other allied professionals in the treatment and management of the disorder. India, being a heavily populated country, where multidisciplinary management approach is in a phase of expansion and is practiced in many leading institutes to meet the quality needs of patients. This article focuses on the Indian scene of multidisciplinary management approach in child and adolescent depression.
