Numerous studies have identified many specific structural alterations in the brains of patients with schizophrenia and depression. Schizophrenia is associated with gray matter volume (GMV) impairment in certain key br...Numerous studies have identified many specific structural alterations in the brains of patients with schizophrenia and depression. Schizophrenia is associated with gray matter volume (GMV) impairment in certain key brain regions, which progresses in the first 2-3 years after the first episode of schizophrenic symptoms,m Schizophrenia has also been shown to be associated with concurrent white matter (WM) alterations. The fasciculus uncinatus and arcuate fasciculus have been proposed to be a part of the quality index for schizophrenia.12j Similar to schizophrenia, major depressive disorder (MDD) is associated with a GMV reduction and aberrant WM. GMV reductions in the bilateral middle temporal gyrus left ventral medial prefrontal gyrus, left lingual gyms, and dorsal medial prefrontal gyrus have been correlated with the severity of the depressive symptoms. Schizophrenic and depressive symptoms usually coexist in schizophrenia and MDD. In this pilot study, we compared the GMV and WM differences in the brains of chronic schizophrenia patients with depressive symptoms with those of chronic depression patients with psychotic symptoms.展开更多
Previous studies have reported that auditory verbal hallucinations （AVHs） may be caused by resting-state neuronal hyperactivity in the default mode network （DMN）. Abnormally increased functional connectivity （FC...Previous studies have reported that auditory verbal hallucinations （AVHs） may be caused by resting-state neuronal hyperactivity in the default mode network （DMN）. Abnormally increased functional connectivity （FC） between the DMN and other cortical regions may cause disturbances in neuronal network architecture and interactions. Subsequently, disturbed neuronal network architecture and interactions may induce increased activation in auditory and speech perception areas in the absence of external auditory stimuli as well as reduced activation in the same areas in the presence of external auditory stimuli.展开更多
文摘Numerous studies have identified many specific structural alterations in the brains of patients with schizophrenia and depression. Schizophrenia is associated with gray matter volume (GMV) impairment in certain key brain regions, which progresses in the first 2-3 years after the first episode of schizophrenic symptoms,m Schizophrenia has also been shown to be associated with concurrent white matter (WM) alterations. The fasciculus uncinatus and arcuate fasciculus have been proposed to be a part of the quality index for schizophrenia.12j Similar to schizophrenia, major depressive disorder (MDD) is associated with a GMV reduction and aberrant WM. GMV reductions in the bilateral middle temporal gyrus left ventral medial prefrontal gyrus, left lingual gyms, and dorsal medial prefrontal gyrus have been correlated with the severity of the depressive symptoms. Schizophrenic and depressive symptoms usually coexist in schizophrenia and MDD. In this pilot study, we compared the GMV and WM differences in the brains of chronic schizophrenia patients with depressive symptoms with those of chronic depression patients with psychotic symptoms.
基金This work was＇supported by grants from the Tianjin Health Bureau Foundation （No. 2014KR02） and Key Projects of the Natural Science Foundation of Tianjin, China （No. 17JCZDJC35700）.
文摘Previous studies have reported that auditory verbal hallucinations （AVHs） may be caused by resting-state neuronal hyperactivity in the default mode network （DMN）. Abnormally increased functional connectivity （FC） between the DMN and other cortical regions may cause disturbances in neuronal network architecture and interactions. Subsequently, disturbed neuronal network architecture and interactions may induce increased activation in auditory and speech perception areas in the absence of external auditory stimuli as well as reduced activation in the same areas in the presence of external auditory stimuli.
