Dear Editor,Pyruvate dehydrogenase complex(PDHc) is a large multienzyme assembly(Mr = 4–10 million Daltons) consisting of three essential components: pyruvate dehydrogenase(E1p), dihydrolipoyl transacetylase(E2p), an...Dear Editor,Pyruvate dehydrogenase complex(PDHc) is a large multienzyme assembly(Mr = 4–10 million Daltons) consisting of three essential components: pyruvate dehydrogenase(E1p), dihydrolipoyl transacetylase(E2p), and dihydrolipoyl dehydrogenase(E3). These three enzymes perform distinct functions sequentially to catalyze the oxidative decarboxylation of pyruvate with formation of nicotinamide adenine dinucleotide(NADH) and acetyl-coenzyme A(Patel and Roche, 1990).展开更多
基金supported by the National Key R&D Program of China(2022YFA1302701)the National Natural Science Foundation of China(32030056 to M.Y.+4 种基金32241031 and 32171195 to S.L.)the scientific project of Beijing Life Science Academy(2023300CA0090)Tsinghua University Initiative Scientific Research Program(2023Z11DSZ001)the King Abdullah University of Science and Technology(KAUST)Office of Sponsored Research(OSR)under Award(OSR-2020-CRG9-4352)Office of Research Administration(ORA)under Award No.URF/1/4352-01-01,FCC/1/1976-44-01,FCC/1/1976-45-01,REI/1/5234-01-01,and REI/1/5414-01-01.
文摘Dear Editor,Pyruvate dehydrogenase complex(PDHc) is a large multienzyme assembly(Mr = 4–10 million Daltons) consisting of three essential components: pyruvate dehydrogenase(E1p), dihydrolipoyl transacetylase(E2p), and dihydrolipoyl dehydrogenase(E3). These three enzymes perform distinct functions sequentially to catalyze the oxidative decarboxylation of pyruvate with formation of nicotinamide adenine dinucleotide(NADH) and acetyl-coenzyme A(Patel and Roche, 1990).
