Cancer is the second leading cause of death globally.Its treatment remains a major challenge due to the disease's complexity,heterogeneity,and adaptive nature.Among the array of available treatments,targeted thera...Cancer is the second leading cause of death globally.Its treatment remains a major challenge due to the disease's complexity,heterogeneity,and adaptive nature.Among the array of available treatments,targeted therapy emerges as a paramount approach to address this substantial unmet clinical need,owing to its precise tumor targeting capabilities and potential for mitigating tumor progression risks.Drug conjugates are in high demand for targeted therapy due to their unique ligand specificity and potent cytotoxicity,thereby significantly enhancing therapeutic efficacy and reducing the incidence of adverse effects.Therefore,as a burgeoning field in biomedical research,it is timely to outline the latest advances in drug conjugates-driven cancer treatment.Herein,we aim to present the emerging breakthroughs in this exciting field at the intersection of target ligands,linkers,payloads,and cancer treatments.This review focuses on several drug conjugates-related strategies,including antibody-drug conjugates(ADCs),peptide-drug conjugates(PDCs),small molecule-drug conjugates(SMDCs),aptamer-drug conjugates(ApDCs)and radionuclide-drug conjugates(RDCs).Finally,we discuss the fundamentals behind drug conjugate-based anticancer therapeutics,along with their inherent advantages and associated challenges,as well as recent research advances.展开更多
Biodegradable electronic fibers offer high flexibility,large surface area,and spatial deformability,enabling conformal tissue contact,efficient signal acquisition,and minimal invasiveness—ideal for sustainable and tr...Biodegradable electronic fibers offer high flexibility,large surface area,and spatial deformability,enabling conformal tissue contact,efficient signal acquisition,and minimal invasiveness—ideal for sustainable and transient electronics.However,previously developed biodegradable conductivefibers often suffered from incomplete degradability,limited flexibility,and scalability.Here,we introduce a biodegradable,flexible,and mass-producible fiber electrode,consisting of tungsten microparticles,a polybutylene adipate-co-terephthalate matrix and a poly butanedithiol 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione pentenoic anhydride coating.The dry-jet wet-spinning process ensures uniform filler dispersion and continuous fiber formation,yielding high conductivity(~2500 S m^(-1))over lengths exceeding 10 m.The coating provides flexibility(~38%strain)and durability against repeated deformation and laundering.We demonstrate wearable textile electronics by integrating fiber-based temperature sensors,electromyography electrodes,and a wireless coil into an arm sleeve.Finally,enzymatic and soil biodegradation tests highlight their potential as sustainable and eco-friendly disposable electronics.展开更多
Starting with the self-organized evolution of the trader group’s structure, a parsimonious percolation model for stock market is established, which can be considered as a kind of betterment of the Cont-Bouchaud model...Starting with the self-organized evolution of the trader group’s structure, a parsimonious percolation model for stock market is established, which can be considered as a kind of betterment of the Cont-Bouchaud model. The return distribution of the present model obeys Lévy form in the center and displays fat-tail property, in accord with the styl-ized facts observed in real-life financial time series. Fur-thermore, this model reveals the power-law relationship be-tween the peak value of the probability distribution and the time scales, in agreement with the empirical studies on the Hang Seng Index.展开更多
基金the Project of China-Japan Joint International Laboratory of Advanced Drug Delivery System Research and Translation of Liaoning Province(No.2024JH2/102100007)the open fund of National Key Laboratory of Advanced DrugFormulations for Overcoming Delivery Barriers(No.2024-KFB-003)+1 种基金the National Natural Science Foundation of China(No.82104109)Scientific Research Project of Liaoning Department of Education(No.LJ212410163045).
文摘Cancer is the second leading cause of death globally.Its treatment remains a major challenge due to the disease's complexity,heterogeneity,and adaptive nature.Among the array of available treatments,targeted therapy emerges as a paramount approach to address this substantial unmet clinical need,owing to its precise tumor targeting capabilities and potential for mitigating tumor progression risks.Drug conjugates are in high demand for targeted therapy due to their unique ligand specificity and potent cytotoxicity,thereby significantly enhancing therapeutic efficacy and reducing the incidence of adverse effects.Therefore,as a burgeoning field in biomedical research,it is timely to outline the latest advances in drug conjugates-driven cancer treatment.Herein,we aim to present the emerging breakthroughs in this exciting field at the intersection of target ligands,linkers,payloads,and cancer treatments.This review focuses on several drug conjugates-related strategies,including antibody-drug conjugates(ADCs),peptide-drug conjugates(PDCs),small molecule-drug conjugates(SMDCs),aptamer-drug conjugates(ApDCs)and radionuclide-drug conjugates(RDCs).Finally,we discuss the fundamentals behind drug conjugate-based anticancer therapeutics,along with their inherent advantages and associated challenges,as well as recent research advances.
基金supported by the National R&D Program through the National Research Foundation of Korea funded by the Ministry of Science and ICT(Grant No.2022M3H4A1A04096393 and Grant No.RS-2025-02305569).
文摘Biodegradable electronic fibers offer high flexibility,large surface area,and spatial deformability,enabling conformal tissue contact,efficient signal acquisition,and minimal invasiveness—ideal for sustainable and transient electronics.However,previously developed biodegradable conductivefibers often suffered from incomplete degradability,limited flexibility,and scalability.Here,we introduce a biodegradable,flexible,and mass-producible fiber electrode,consisting of tungsten microparticles,a polybutylene adipate-co-terephthalate matrix and a poly butanedithiol 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione pentenoic anhydride coating.The dry-jet wet-spinning process ensures uniform filler dispersion and continuous fiber formation,yielding high conductivity(~2500 S m^(-1))over lengths exceeding 10 m.The coating provides flexibility(~38%strain)and durability against repeated deformation and laundering.We demonstrate wearable textile electronics by integrating fiber-based temperature sensors,electromyography electrodes,and a wireless coil into an arm sleeve.Finally,enzymatic and soil biodegradation tests highlight their potential as sustainable and eco-friendly disposable electronics.
基金Th is work was supported by the National Natural Science Foundation of China (Grant Nos． 70171053． 70271070，70471033& 10472ll61)the Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP No．20020358009) the Foundation for Graduate Students of University of Science and Tech—nology of China(Grant No．KD 200408)．
文摘Starting with the self-organized evolution of the trader group’s structure, a parsimonious percolation model for stock market is established, which can be considered as a kind of betterment of the Cont-Bouchaud model. The return distribution of the present model obeys Lévy form in the center and displays fat-tail property, in accord with the styl-ized facts observed in real-life financial time series. Fur-thermore, this model reveals the power-law relationship be-tween the peak value of the probability distribution and the time scales, in agreement with the empirical studies on the Hang Seng Index.
