Special Purpose Rice (SPR) is a technology that consists of different rice varieties that were developed by Central Luzon State University. The unique varietal characteristics of SPR are pigmented, glutinous, good-yie...Special Purpose Rice (SPR) is a technology that consists of different rice varieties that were developed by Central Luzon State University. The unique varietal characteristics of SPR are pigmented, glutinous, good-yielding varieties planted in lowland areas. This study was conducted to increase farmers’ income through employing different promotion and extension activities and enterprise development. Data were analyzed using descriptive statistics. Cost and return and benefit-cost analysis were used to determine the financial benefits of using the SPR in different production systems. Results revealed that incorporating the following parameters is critical in the sustainable adoption of the SPR. Amongst them are: ensuring that recommended production technologies are strictly followed by the farmers, ensuring the quality of seeds for planting, the presence of a market for the produce, engaging the farmers in value-adding activities like processing, capability development in entrepreneurship, and adopting clustering approach of the farmers to address economies of scale in marketing and processing. The use of SPR produced an average yield of 6.11 MT/ha and 5.04 MT/ha during the dry and wet seasons from 2021-2023, respectively, higher than the usual varieties of inbred rice. The net benefit from producing a CLS-2 variety of SPR is higher than regular rice, having an average difference of Php 22,355.53 per hectare from 2021-2023.展开更多
The principle and technique were reported here to produce lignin-based sand stabilizing material （LSSM） using extracted lignin from black liquor of straw paper mills. Field tests using LSSM to stabilize and green sa...The principle and technique were reported here to produce lignin-based sand stabilizing material （LSSM） using extracted lignin from black liquor of straw paper mills. Field tests using LSSM to stabilize and green sand dunes were started in 2002. The field experiment was carded out in August 2005 when the newly formed plant community was 3 years old. The results from the comprehensive field experiment demonstrated that unlike polyvinyl acetate or foamed asphalt commonly used for dune stabilization, LSSM was plant- friendly material and could be used in combination with seeding and planting of desert species. With the help of LSSM, the desert species （i.e., Agriophyllum squarrosum （L.） Moq. and Artemisia desertorum Spreng. etc.） could be used to form community in 2-3 yeas and to stabilize sand dune effectively. The newly formed community was sustainable under an extremely dry climate condition. The organic matter and total nitrogen in the soil increased significantly as the community were formed, while the change in P and K contents in the soil was negligible.展开更多
Riverine carbon flux is an important component of the global carbon cycle. The spatial and temporal variations of organic and inorganic carbon were examined during both dry and wet seasons in the Yellow River estuary....Riverine carbon flux is an important component of the global carbon cycle. The spatial and temporal variations of organic and inorganic carbon were examined during both dry and wet seasons in the Yellow River estuary. Concentrations of dissolved organic carbon （DOC） and dissolved inorganic carbon （DIC） in the Yellow River during dry seasons were higher than those during wet seasons. The effective concentrations of DOC （CDOC＊） were higher than the observed DOC at zero salinity. This input of DOC in the Yellow River estuary was due to sediment desorption processes in low salinity regions. In contrast to DOC, the effective concen- trations of DIC were 10% lower than the DIC measured at freshwater end, and the loss of DIC was caused by CaCO3 precipitation in low salinity region, Particulate organic carbon （POC） and particulate inorganic carbon （PIC） contents of the particles stabilized to constant values （0.5%：t：0.05% and 1.8%--0.2%, respectively） within the turbidity maximum zone （TMZ） and showed no noticeable seasonal variations. A rapid drop of PIC and rise of POC occurred simultaneously outside the TMZ due to an intense dilution of riv- erine inorganic-rich particles being transported into a pool of aquatic organic-poor particles outside the TMZ. Annually, the Yellow River transported 6.95× 10^5 t of DIC, 0.64× 10^5 t of DOC, 78.58× 10^5 t of PIC and 2.29× 10^5 t of POC to the sea.展开更多
This works presents the first fully validated and predictive capability to model the V_0-V_(100) probabilistic penetration response of a woven fabric using a yarn-level fabric finite element model. The V_0-V_(100) cur...This works presents the first fully validated and predictive capability to model the V_0-V_(100) probabilistic penetration response of a woven fabric using a yarn-level fabric finite element model. The V_0-V_(100) curve describes the probability of complete fabric penetration as a function of projectile impact velocity. The exemplar case considered in this paper comprises of a single-layer, fully-clamped, plain-weave Kevlar fabric impacted at the center by a 17-gr, 0.22 cal FSP or fragment-simulating projectile. Each warp and fill yarn in the fabric is individually modeled using 3 D finite elements and the virtual fabric microstructure is validated in detail against the experimental fabric microstructure. Material and testing sources of statistical variability including yarn strength and modulus, inter-yarn friction, precise projectile impact location, and projectile rotation are mapped into the finite element model. A series of impact simulations at varying projectile impact velocities is executed using LS-DYNA on the fabric models, with each model comprising unique mappings. The impact velocities together with the outcomes(penetration, nonpenetration) are used to generate the numerical V_0-V_(100) curve which is then validated against the experimental V_0-V_(100) curve. The numerical Vi-Vrdata(impact, residual velocities) is also validated against the experimental Vi-Vrdata. For completeness, this paper also reports the experimental characterization data and its statistical analysis used for model input, viz. the Kevlar yarn tensile strengths, moduli, and inter-yarn friction, and the experimental ballistic test data used for model validation.展开更多
The 0.4 nm molecular sieve supported Cu-Ni bimetal catalysts for direct synthesis of dimethyl carbonate (DMC) from CO 2 and CH 3 OH were prepared and investigated. The synthesized catalysts were fully characterized by...The 0.4 nm molecular sieve supported Cu-Ni bimetal catalysts for direct synthesis of dimethyl carbonate (DMC) from CO 2 and CH 3 OH were prepared and investigated. The synthesized catalysts were fully characterized by BET, XRD (X-ray diffraction), TPR (temperature programmed reduction), IR (infra-red adsorption), NH 3-TPD (temperature programmed desorption) and CO 2-TPD (temperature programmed desorption) techniques. The results showed that the surface area of catalysts decreased with increasing metal content, and the metals as well as Cu-Ni alloy co-existed on the reduced catalyst surface. There existed interaction between metal and carrier, and moreover, metal particles affected obviously the acidity and basicity of carrier. The large amount of basic sites facilitated the activation of methanol to methoxyl species and their subsequent reaction with activated carbon dioxide. The catalysts were evaluated in a continuous tubular fixed-bed micro-gaseous reactor and the catalyst with bimetal loading of 20% (by mass) had best catalytic activities. Under the conditions of 393 K, 1.1 MPa, 5 h and gas space velocity of 510 h 1 , the selectivity and yield of DMC were higher than 86.0 % and 5.0 %, respectively.展开更多
Alcaligenes faecalis C16 was found to have the ability to heterotrophically nitrify and aerobically denitrify. In order to further understand its nitrogen removal ability and mechanism, the growth and ammonium removal...Alcaligenes faecalis C16 was found to have the ability to heterotrophically nitrify and aerobically denitrify. In order to further understand its nitrogen removal ability and mechanism, the growth and ammonium removal response were investigated at different C/N ratios and ammonium concentrations in the medium with citrate and acetate as carbon source separately. Furthermore, experiments of nitrogen sources, production of nitrogen gas and enzyme assay were conducted. Results show that the bacterium converts NH+4-N and produces NH2 OH during the growing phase and nitrite accumulation is its distinct metabolic feature. A. faecalis C16 is able to tolerate not only high ammonium concentration but also high C/N ratio, and the ammonium tolerance is associated with carbon source and C/N ratio. The nitrogen balance under different conditions shows that approximately28%–45% of the initial ammonium is assimilated into the cells, 44%–60% is denitrified and several percent is converted to nitrification products. A. faecalis C16 cannot utilize hydroxylamine, nitrite or nitrate as the sole nitrogen source for growth. However, nitrate can be used when ammonium is simultaneously present in the medium. A possible pathway for nitrogen removal by C16 is suggested. The preliminary enzyme assay provides more evidence for this nitrogen removal pathway.展开更多
Food consumption is one of the key exposure routes of humans to contaminants. This article evaluated the residue levels of 51 pesticides and 16 polychlorinated biphenyls （PCBs） in selected fish and food items which ...Food consumption is one of the key exposure routes of humans to contaminants. This article evaluated the residue levels of 51 pesticides and 16 polychlorinated biphenyls （PCBs） in selected fish and food items which were commonly consumed in the Nantong area of Jiangsu Province, Southeast China. The 51 pesticides and 16 PCBs were analyzed by highly sensitive gas chromatography- tandem mass spectrometry （GC-MS/MS）. The results showed that organochlorine pesticides such as dichlorodiphenyltrichloroethanes （DDTs）, hexachlorocyclohexanes （I-ICHs）, hexachlorobenzene （HCB） and mirex and other pesticides including chlorpyrifos, pyrethroid pesticides, metolachlor, pyridaben and trifluralin were frequently detected in the samples, which was consistent with the accumulation level and characteristics of these toxic chemicals in human adipose tissue of people living in Nantong. Meanwhile, correlation of the residue level of toxic chemicals with their physical chemical properties and historic use pattern in Nantong area was observed. Combined with dietary survey results at the same sampling locations, human health risk assessment of ingestion through the dietary route was performed. The results suggested that the non-cancer risks of the chemicals investigated can be considered negligible in the Nantong area, however, the cancer risks from lifetime dietary exposure to DDTs and HCB have exceeded the acceptable levels.展开更多
The Mo-promoted Cu-Fe bimetal catalysts were prepared and used for the formation of dimethyl carbonate （DMC） from CO2 and methanol. The catalysts were characterized by X-ray diffraction （XRD）, temperature programm...The Mo-promoted Cu-Fe bimetal catalysts were prepared and used for the formation of dimethyl carbonate （DMC） from CO2 and methanol. The catalysts were characterized by X-ray diffraction （XRD）, temperature programmed reduction （TPR）, laser Raman spectra （LRS）, energy dispersive spectroscopy （EDS） and temperature programmed desorption （TPD） techniques. The experimental results demonstrated that the Mo promoters can decrease the reducibility and increase the dispersion of Cu-Fe clusters, The concentration balance of base-acid sites can be readily adjusted by changing the Mo content. The moderate concentration balance of acid and base sites was in favor of the DMC formation, Under optimal experimental conditions, the highest methanol conversion of 6,99% with a DMC selectivity of 87.7% can be obtained when 2.5 wt% of Mo was loaded.展开更多
Long noncoding RNA(lncRNA)HOTAIR and MALAT1 are implicated in the development of multiple cancers.Genetic variants within HOTAIR and MALAT1 may affect the gene expression,thereby modifying genetic susceptibility to ce...Long noncoding RNA(lncRNA)HOTAIR and MALAT1 are implicated in the development of multiple cancers.Genetic variants within HOTAIR and MALAT1 may affect the gene expression,thereby modifying genetic susceptibility to cervical cancer.A case-control study was designed,including 1486 cervical cancer patients and 1536 healthy controls.Based on RegulomeDB database,11 SNPs were selected and genotyped by using Sequenom’s Mass ARRAY.Univariate and multivariate logistic regression models were used to calculate the odds ratio(OR)and 95%confidence interval(CI).We found that the A allele of rs35643724 in HOTAIR was associated with increased risk of cervical cancer,while the C allele of rs1787666 in MALAT1 was associated with decreased risk.Compared to individuals with 0–1 unfavorable allele,those with 3–4 unfavorable alleles showed18%increased odds of having cervical cancer.Our findings suggest that HOTAIR rs35643724 and MALAT1 rs1787666 might represent potential biomarkers for cervical cancer susceptibility.展开更多
Real-world study is valuable for traditional Chinese medicine.However,there are no gold standards of statistical approaches for analyzing data from real-world study of traditional Chinese medicine.With the development...Real-world study is valuable for traditional Chinese medicine.However,there are no gold standards of statistical approaches for analyzing data from real-world study of traditional Chinese medicine.With the development of computer technology,researchers have increasingly paid attention to Bayesian statistics in the biomedical field.In present study,real-world study and Bayesian statistics were introduced.It was discussed that why and when to use Bayesian analysis and the challenge in the real-world study of traditional Chinese medicine.展开更多
In September 1994 the University of Twente, the Netherlands, and Zhejiang University, China, decided to cooperate in the field of science, education and management. After several visits of delegations from both sides ...In September 1994 the University of Twente, the Netherlands, and Zhejiang University, China, decided to cooperate in the field of science, education and management. After several visits of delegations from both sides it was considered worthwhile to explore further opportunities for mutual cooperation. The directors of international cooperation on each side jointly commissioned a project to investigate the potential in a systematic way and to establish further contacts where appropriate. This paper reports on the results of the research cum matching project. To reveal promising matches between multiple departments of both academic institutions a matching model for uni-versities was designed. The study was carried out along two parallel lines. In the research line the theoretical framework was developed into a model for international university co-operation. Moreover, an analysis was carried out on internal, external and cultural aspects resulting in a set of thirty four influencing factors. In the matching line a total of seventy interviews were held in order to identify promising matches between units at both universities. This line resulted in eleven promising matches for further co-operation. The novel model appeared useful in analyzing the variety of factors and in developing matches between both univer-sities. In the further implementation of the model the issues of 搇evel of co-operation?and 搕op-down versus bottom-up?need to be addressed in more detail.展开更多
Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC...Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective.展开更多
Few records of the impressed tortoise （Manouria impressa） are available from Myanmar and most are based on historic accounts, old museum specimens, and shells obtained from villagers and wildlife traffickers. We her...Few records of the impressed tortoise （Manouria impressa） are available from Myanmar and most are based on historic accounts, old museum specimens, and shells obtained from villagers and wildlife traffickers. We herein report the observation of a living M. impressa in the Hukaung Valley Wildlife Sanctuary of northern Myanmar. Our observation extends the known distribution of M. impressa in Myanmar approximately 850 km northwards from previously reported populations in the Rakhine Hills of Magway Region.展开更多
Background: Esophageal cancer is associated with substantial disease burden in China, and data on the economic burden are fundamental for setting priorities in cancer interventions. The medical expenditure for the dia...Background: Esophageal cancer is associated with substantial disease burden in China, and data on the economic burden are fundamental for setting priorities in cancer interventions. The medical expenditure for the diagnosis and treatment of esophageal cancer in China has not been fully quantified. This study aimed to examine the medical expenditure of Chinese patients with esophageal cancer and the associated trends.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 37 hospitals in 13 provinces/municipalities across China as a part of the Cancer Screening Program of Urban China. For each esophageal cancer patient diagnosed between 2002 and 2011, clinical information and expense data were extracted by using structured questionnaires. All expense data were reported in Chinese Yuan(CNY; 1 CNY = 0.155 USD) based on the2011 value and inflated using the year-specific health care consumer price index for China.Results: A total of 14,967 esophageal cancer patients were included in the analysis. It was estimated that the overall average expenditure per patient was 38,666 CNY, and an average annual increase of 6.27% was observed from 2002(25,111 CNY) to 2011(46,124 CNY). The average expenditures were 34,460 CNY for stage Ⅰ,39,302 CNY for stage Ⅱ,40,353 CNY for stage Ⅲ, and 37,432 CNY for stage IV diseases(P < 0.01). The expenditure also differed by the therapy type, which was 38,492 CNY for surgery, 27,933 CNY for radiotherapy, and 27,805 CNY for chemotherapy(P < 0.05).Drugs contributed to 45.02% of the overall expenditure.Conclusions: These conservative estimates suggested that medical expenditures for esophageal cancer in China substantially increased in the last 10 years, treatment for early-stage esophageal cancer costs less than that for advanced cases, and spending on drugs continued to account for a considerable proportion of the overall expenditure.展开更多
In a Conference convened at Princeton University in January 2010, international relations experts were asked to consider, among other things, great power leadership and explore what would enable these powers
The Municipality of Carranglan is a rural community where agriculture is the main source of livelihood. The Kalanguya Ancestral Domain (KAD) is also located in the area, and it provides a home for the Kalanguya indige...The Municipality of Carranglan is a rural community where agriculture is the main source of livelihood. The Kalanguya Ancestral Domain (KAD) is also located in the area, and it provides a home for the Kalanguya indigenous cultural community. They have fled to the area for a variety of reasons. Despite its rural setting, Carranglan is regarded as a first-class municipality and the largest municipality in Nueva Ecija. This study described and documented the socio-economic profile, and existing issues and problems the Kalanguya Indigenous Peoples (IPs) experienced in their milieu, especially in terms of environmental protection. Recognizing and valuing their perspectives is vital for inclusive development. This study also situated the current status and conditions of the IPs, who generally live below the poverty line and face a range of plights and challenges. As part of safeguarding indigenous rights and interests, this study was undertaken after series of consultations with community elders and leaders. Key informant interviews, household surveys, semi-structured interviews, focused-group discussion (FGD), and direct observations were used to elicit information. Many of the respondents are elementary undergraduates which show that the community had lacked access to education. The following are the primary socioeconomic issues confronting IPs: insufficient access to potable water, suboptimal agricultural productivity, meager monthly income, and a dearth of supplementary and alternative livelihood opportunities. Forest fires, landslides, encroachment of illegal loggers, and concerns about wildlife resources are some of the current environmental issues they have encountered. The local population was supportive of plans and actions targeted at improving the environment. This reveals that the IPs possess unique indigenous forest expertise that enables them to properly manage natural resources.展开更多
文摘Special Purpose Rice (SPR) is a technology that consists of different rice varieties that were developed by Central Luzon State University. The unique varietal characteristics of SPR are pigmented, glutinous, good-yielding varieties planted in lowland areas. This study was conducted to increase farmers’ income through employing different promotion and extension activities and enterprise development. Data were analyzed using descriptive statistics. Cost and return and benefit-cost analysis were used to determine the financial benefits of using the SPR in different production systems. Results revealed that incorporating the following parameters is critical in the sustainable adoption of the SPR. Amongst them are: ensuring that recommended production technologies are strictly followed by the farmers, ensuring the quality of seeds for planting, the presence of a market for the produce, engaging the farmers in value-adding activities like processing, capability development in entrepreneurship, and adopting clustering approach of the farmers to address economies of scale in marketing and processing. The use of SPR produced an average yield of 6.11 MT/ha and 5.04 MT/ha during the dry and wet seasons from 2021-2023, respectively, higher than the usual varieties of inbred rice. The net benefit from producing a CLS-2 variety of SPR is higher than regular rice, having an average difference of Php 22,355.53 per hectare from 2021-2023.
基金supported by the National Natural Science Foundation of China (No. 40675040, 30771687, and90302015)the National Basic Research Program of China (No. 2006CB400505)
文摘The principle and technique were reported here to produce lignin-based sand stabilizing material （LSSM） using extracted lignin from black liquor of straw paper mills. Field tests using LSSM to stabilize and green sand dunes were started in 2002. The field experiment was carded out in August 2005 when the newly formed plant community was 3 years old. The results from the comprehensive field experiment demonstrated that unlike polyvinyl acetate or foamed asphalt commonly used for dune stabilization, LSSM was plant- friendly material and could be used in combination with seeding and planting of desert species. With the help of LSSM, the desert species （i.e., Agriophyllum squarrosum （L.） Moq. and Artemisia desertorum Spreng. etc.） could be used to form community in 2-3 yeas and to stabilize sand dune effectively. The newly formed community was sustainable under an extremely dry climate condition. The organic matter and total nitrogen in the soil increased significantly as the community were formed, while the change in P and K contents in the soil was negligible.
基金supported by the National Basic Research Program of China (No. 2002CB412504)
文摘Riverine carbon flux is an important component of the global carbon cycle. The spatial and temporal variations of organic and inorganic carbon were examined during both dry and wet seasons in the Yellow River estuary. Concentrations of dissolved organic carbon （DOC） and dissolved inorganic carbon （DIC） in the Yellow River during dry seasons were higher than those during wet seasons. The effective concentrations of DOC （CDOC＊） were higher than the observed DOC at zero salinity. This input of DOC in the Yellow River estuary was due to sediment desorption processes in low salinity regions. In contrast to DOC, the effective concen- trations of DIC were 10% lower than the DIC measured at freshwater end, and the loss of DIC was caused by CaCO3 precipitation in low salinity region, Particulate organic carbon （POC） and particulate inorganic carbon （PIC） contents of the particles stabilized to constant values （0.5%：t：0.05% and 1.8%--0.2%, respectively） within the turbidity maximum zone （TMZ） and showed no noticeable seasonal variations. A rapid drop of PIC and rise of POC occurred simultaneously outside the TMZ due to an intense dilution of riv- erine inorganic-rich particles being transported into a pool of aquatic organic-poor particles outside the TMZ. Annually, the Yellow River transported 6.95× 10^5 t of DIC, 0.64× 10^5 t of DOC, 78.58× 10^5 t of PIC and 2.29× 10^5 t of POC to the sea.
基金supported by Teledyne Scientific&Imaging(TS&I),Internal Research and Development(IR&D)and approved for public release under TSI-PP-17-08
文摘This works presents the first fully validated and predictive capability to model the V_0-V_(100) probabilistic penetration response of a woven fabric using a yarn-level fabric finite element model. The V_0-V_(100) curve describes the probability of complete fabric penetration as a function of projectile impact velocity. The exemplar case considered in this paper comprises of a single-layer, fully-clamped, plain-weave Kevlar fabric impacted at the center by a 17-gr, 0.22 cal FSP or fragment-simulating projectile. Each warp and fill yarn in the fabric is individually modeled using 3 D finite elements and the virtual fabric microstructure is validated in detail against the experimental fabric microstructure. Material and testing sources of statistical variability including yarn strength and modulus, inter-yarn friction, precise projectile impact location, and projectile rotation are mapped into the finite element model. A series of impact simulations at varying projectile impact velocities is executed using LS-DYNA on the fabric models, with each model comprising unique mappings. The impact velocities together with the outcomes(penetration, nonpenetration) are used to generate the numerical V_0-V_(100) curve which is then validated against the experimental V_0-V_(100) curve. The numerical Vi-Vrdata(impact, residual velocities) is also validated against the experimental Vi-Vrdata. For completeness, this paper also reports the experimental characterization data and its statistical analysis used for model input, viz. the Kevlar yarn tensile strengths, moduli, and inter-yarn friction, and the experimental ballistic test data used for model validation.
基金Supported by the National High Technology Research and Development Program of China (2008AA03Z3472294,2009AA302410)the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2010)+1 种基金the Guangdong Province Sci & Tech Bureau (2006B12401006, 2008A080800024)the Chinese Universities Basic Research Founding
文摘The 0.4 nm molecular sieve supported Cu-Ni bimetal catalysts for direct synthesis of dimethyl carbonate (DMC) from CO 2 and CH 3 OH were prepared and investigated. The synthesized catalysts were fully characterized by BET, XRD (X-ray diffraction), TPR (temperature programmed reduction), IR (infra-red adsorption), NH 3-TPD (temperature programmed desorption) and CO 2-TPD (temperature programmed desorption) techniques. The results showed that the surface area of catalysts decreased with increasing metal content, and the metals as well as Cu-Ni alloy co-existed on the reduced catalyst surface. There existed interaction between metal and carrier, and moreover, metal particles affected obviously the acidity and basicity of carrier. The large amount of basic sites facilitated the activation of methanol to methoxyl species and their subsequent reaction with activated carbon dioxide. The catalysts were evaluated in a continuous tubular fixed-bed micro-gaseous reactor and the catalyst with bimetal loading of 20% (by mass) had best catalytic activities. Under the conditions of 393 K, 1.1 MPa, 5 h and gas space velocity of 510 h 1 , the selectivity and yield of DMC were higher than 86.0 % and 5.0 %, respectively.
基金the China High-Tech Development 863 Program,Guangdong Province Sci & Tech Bureau(No.2006B12401006)Guangzhou Sci & Tech Bureau(No.2005U13D2031,2007Z2-D2031)financial support of this work National University of Singapore for financial support.
文摘Novel Cu-Ni/C has been prepared and utilized as an efficient catalyst system in direct synthesis of DMC from CH3OH and CO2.
基金National Natural Science Foundation of China(51078252)the Science and Technology Program of Taiyuan(120233)the Natural Science Foundation of Shanxi Province(2010011016–1)
文摘Alcaligenes faecalis C16 was found to have the ability to heterotrophically nitrify and aerobically denitrify. In order to further understand its nitrogen removal ability and mechanism, the growth and ammonium removal response were investigated at different C/N ratios and ammonium concentrations in the medium with citrate and acetate as carbon source separately. Furthermore, experiments of nitrogen sources, production of nitrogen gas and enzyme assay were conducted. Results show that the bacterium converts NH+4-N and produces NH2 OH during the growing phase and nitrite accumulation is its distinct metabolic feature. A. faecalis C16 is able to tolerate not only high ammonium concentration but also high C/N ratio, and the ammonium tolerance is associated with carbon source and C/N ratio. The nitrogen balance under different conditions shows that approximately28%–45% of the initial ammonium is assimilated into the cells, 44%–60% is denitrified and several percent is converted to nitrification products. A. faecalis C16 cannot utilize hydroxylamine, nitrite or nitrate as the sole nitrogen source for growth. However, nitrate can be used when ammonium is simultaneously present in the medium. A possible pathway for nitrogen removal by C16 is suggested. The preliminary enzyme assay provides more evidence for this nitrogen removal pathway.
基金supported by the 2008 Commonwealand Environmental protection Project of the Ministry of Environmental Protection of the People’s Republic of China (MEP) (No. 200809102)"333 High-level Talent Cultivation Project" research funding of Jiangsu Province-"Research on human health risk assessment of pesticides"
文摘Food consumption is one of the key exposure routes of humans to contaminants. This article evaluated the residue levels of 51 pesticides and 16 polychlorinated biphenyls （PCBs） in selected fish and food items which were commonly consumed in the Nantong area of Jiangsu Province, Southeast China. The 51 pesticides and 16 PCBs were analyzed by highly sensitive gas chromatography- tandem mass spectrometry （GC-MS/MS）. The results showed that organochlorine pesticides such as dichlorodiphenyltrichloroethanes （DDTs）, hexachlorocyclohexanes （I-ICHs）, hexachlorobenzene （HCB） and mirex and other pesticides including chlorpyrifos, pyrethroid pesticides, metolachlor, pyridaben and trifluralin were frequently detected in the samples, which was consistent with the accumulation level and characteristics of these toxic chemicals in human adipose tissue of people living in Nantong. Meanwhile, correlation of the residue level of toxic chemicals with their physical chemical properties and historic use pattern in Nantong area was observed. Combined with dietary survey results at the same sampling locations, human health risk assessment of ingestion through the dietary route was performed. The results suggested that the non-cancer risks of the chemicals investigated can be considered negligible in the Nantong area, however, the cancer risks from lifetime dietary exposure to DDTs and HCB have exceeded the acceptable levels.
基金the China High-Tech Development 863 Program(N0.2009AA03Z2340)Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2010)+2 种基金Guangdong Province Sci & Tech Bureau(Key Strategic Project Nos. 2008A080800024 and 10151027501000096)Chinese Universities Basic Research Founding for financial support of the work.National University of Singapore for financial support
文摘The Mo-promoted Cu-Fe bimetal catalysts were prepared and used for the formation of dimethyl carbonate （DMC） from CO2 and methanol. The catalysts were characterized by X-ray diffraction （XRD）, temperature programmed reduction （TPR）, laser Raman spectra （LRS）, energy dispersive spectroscopy （EDS） and temperature programmed desorption （TPD） techniques. The experimental results demonstrated that the Mo promoters can decrease the reducibility and increase the dispersion of Cu-Fe clusters, The concentration balance of base-acid sites can be readily adjusted by changing the Mo content. The moderate concentration balance of acid and base sites was in favor of the DMC formation, Under optimal experimental conditions, the highest methanol conversion of 6,99% with a DMC selectivity of 87.7% can be obtained when 2.5 wt% of Mo was loaded.
基金supported by National Natural Science Foundation of China(81502873)the Natural Science Foundation of Jiangsu Province(BK20150997)+3 种基金Priority Academic Program for the Development of Jiangsu Higher Education Institutions(Public Health and Preventive Medicine)Innovation Fund of State key Laboratory of Reproductive Medicine(SKLRMGC201802)Clinical Medicine Research Fund of the Chinese Medical Association(17020420711)Top-notch Academic Programs Project of Jiangsu Higher Education Institutions(PPZY2015A067)
文摘Long noncoding RNA(lncRNA)HOTAIR and MALAT1 are implicated in the development of multiple cancers.Genetic variants within HOTAIR and MALAT1 may affect the gene expression,thereby modifying genetic susceptibility to cervical cancer.A case-control study was designed,including 1486 cervical cancer patients and 1536 healthy controls.Based on RegulomeDB database,11 SNPs were selected and genotyped by using Sequenom’s Mass ARRAY.Univariate and multivariate logistic regression models were used to calculate the odds ratio(OR)and 95%confidence interval(CI).We found that the A allele of rs35643724 in HOTAIR was associated with increased risk of cervical cancer,while the C allele of rs1787666 in MALAT1 was associated with decreased risk.Compared to individuals with 0–1 unfavorable allele,those with 3–4 unfavorable alleles showed18%increased odds of having cervical cancer.Our findings suggest that HOTAIR rs35643724 and MALAT1 rs1787666 might represent potential biomarkers for cervical cancer susceptibility.
基金the project of National Natural Science Foundation of China(grant numbers 81273935,81303093,81602930).
文摘Real-world study is valuable for traditional Chinese medicine.However,there are no gold standards of statistical approaches for analyzing data from real-world study of traditional Chinese medicine.With the development of computer technology,researchers have increasingly paid attention to Bayesian statistics in the biomedical field.In present study,real-world study and Bayesian statistics were introduced.It was discussed that why and when to use Bayesian analysis and the challenge in the real-world study of traditional Chinese medicine.
文摘In September 1994 the University of Twente, the Netherlands, and Zhejiang University, China, decided to cooperate in the field of science, education and management. After several visits of delegations from both sides it was considered worthwhile to explore further opportunities for mutual cooperation. The directors of international cooperation on each side jointly commissioned a project to investigate the potential in a systematic way and to establish further contacts where appropriate. This paper reports on the results of the research cum matching project. To reveal promising matches between multiple departments of both academic institutions a matching model for uni-versities was designed. The study was carried out along two parallel lines. In the research line the theoretical framework was developed into a model for international university co-operation. Moreover, an analysis was carried out on internal, external and cultural aspects resulting in a set of thirty four influencing factors. In the matching line a total of seventy interviews were held in order to identify promising matches between units at both universities. This line resulted in eleven promising matches for further co-operation. The novel model appeared useful in analyzing the variety of factors and in developing matches between both univer-sities. In the further implementation of the model the issues of 搇evel of co-operation?and 搕op-down versus bottom-up?need to be addressed in more detail.
基金supported by the grants from the Beijing Hope Run Special Fund(#LC2012YF44)National Natural Science Foundation of China(No.81402740)+1 种基金Specialized Research Fund for the Doctoral Program of Higher Education(No.20131106120014)The National Health and Family Planning Committee of P.R.China
文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective.
文摘Few records of the impressed tortoise （Manouria impressa） are available from Myanmar and most are based on historic accounts, old museum specimens, and shells obtained from villagers and wildlife traffickers. We herein report the observation of a living M. impressa in the Hukaung Valley Wildlife Sanctuary of northern Myanmar. Our observation extends the known distribution of M. impressa in Myanmar approximately 850 km northwards from previously reported populations in the Rakhine Hills of Magway Region.
基金supported by the National Health and Family Plan Commission of P. R. China
文摘Background: Esophageal cancer is associated with substantial disease burden in China, and data on the economic burden are fundamental for setting priorities in cancer interventions. The medical expenditure for the diagnosis and treatment of esophageal cancer in China has not been fully quantified. This study aimed to examine the medical expenditure of Chinese patients with esophageal cancer and the associated trends.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 37 hospitals in 13 provinces/municipalities across China as a part of the Cancer Screening Program of Urban China. For each esophageal cancer patient diagnosed between 2002 and 2011, clinical information and expense data were extracted by using structured questionnaires. All expense data were reported in Chinese Yuan(CNY; 1 CNY = 0.155 USD) based on the2011 value and inflated using the year-specific health care consumer price index for China.Results: A total of 14,967 esophageal cancer patients were included in the analysis. It was estimated that the overall average expenditure per patient was 38,666 CNY, and an average annual increase of 6.27% was observed from 2002(25,111 CNY) to 2011(46,124 CNY). The average expenditures were 34,460 CNY for stage Ⅰ,39,302 CNY for stage Ⅱ,40,353 CNY for stage Ⅲ, and 37,432 CNY for stage IV diseases(P < 0.01). The expenditure also differed by the therapy type, which was 38,492 CNY for surgery, 27,933 CNY for radiotherapy, and 27,805 CNY for chemotherapy(P < 0.05).Drugs contributed to 45.02% of the overall expenditure.Conclusions: These conservative estimates suggested that medical expenditures for esophageal cancer in China substantially increased in the last 10 years, treatment for early-stage esophageal cancer costs less than that for advanced cases, and spending on drugs continued to account for a considerable proportion of the overall expenditure.
文摘In a Conference convened at Princeton University in January 2010, international relations experts were asked to consider, among other things, great power leadership and explore what would enable these powers
文摘The Municipality of Carranglan is a rural community where agriculture is the main source of livelihood. The Kalanguya Ancestral Domain (KAD) is also located in the area, and it provides a home for the Kalanguya indigenous cultural community. They have fled to the area for a variety of reasons. Despite its rural setting, Carranglan is regarded as a first-class municipality and the largest municipality in Nueva Ecija. This study described and documented the socio-economic profile, and existing issues and problems the Kalanguya Indigenous Peoples (IPs) experienced in their milieu, especially in terms of environmental protection. Recognizing and valuing their perspectives is vital for inclusive development. This study also situated the current status and conditions of the IPs, who generally live below the poverty line and face a range of plights and challenges. As part of safeguarding indigenous rights and interests, this study was undertaken after series of consultations with community elders and leaders. Key informant interviews, household surveys, semi-structured interviews, focused-group discussion (FGD), and direct observations were used to elicit information. Many of the respondents are elementary undergraduates which show that the community had lacked access to education. The following are the primary socioeconomic issues confronting IPs: insufficient access to potable water, suboptimal agricultural productivity, meager monthly income, and a dearth of supplementary and alternative livelihood opportunities. Forest fires, landslides, encroachment of illegal loggers, and concerns about wildlife resources are some of the current environmental issues they have encountered. The local population was supportive of plans and actions targeted at improving the environment. This reveals that the IPs possess unique indigenous forest expertise that enables them to properly manage natural resources.
