A growing body of evidence from multiple areas proposes that periodontal disease,accompanied by oral inflammation and pathological changes in the microbiome,induces gut dysbiosis and is involved in the pathogenesis of...A growing body of evidence from multiple areas proposes that periodontal disease,accompanied by oral inflammation and pathological changes in the microbiome,induces gut dysbiosis and is involved in the pathogenesis of nonalcoholic fatty liver disease(NAFLD).A subgroup of NAFLD patients have a severely progressive form,namely nonalcoholic steatohepatitis(NASH),which is characterized by histological findings that include inflammatory cell infiltration and fibrosis.NASH has a high risk of further progression to cirrhosis and hepatocellular carcinoma.The oral microbiota may serve as an endogenous reservoir for gut microbiota,and transport of oral bacteria through the gastro-intestinal tract can set up a gut microbiome dysbiosis.Gut dysbiosis increases the production of potential hepatotoxins,including lipopolysaccharide,ethanol,and other volatile organic compounds such as acetone,phenol and cyclopentane.Moreover,gut dysbiosis increases intestinal permeability by disrupting tight junctions in the intestinal wall,leading to enhanced translocation of these hepatotoxins and enteric bacteria into the liver through the portal circulation.In particular,many animal studies support that oral administration of Porphyromonas gingivalis,a typical periodontopathic bacterium,induces disturbances in glycolipid metabolism and inflammation in the liver with gut dysbiosis.NAFLD,also known as the hepatic phenotype of metabolic syndrome,is strongly associated with metabolic complications,such as obesity and diabetes.Periodontal disease also has a bidirectional relationship with metabolic syndrome,and both diseases may induce oral and gut microbiome dysbiosis with insulin resistance and systemic chronic inflammation cooperatively.In this review,we will describe the link between periodontal disease and NAFLD with a focus on basic,epidemiological,and clinical studies,and discuss potential mechanisms linking the two diseases and possible therapeutic approaches focused on the microbiome.In conclusion,it is presumed that the pathogenesis of NAFLD involves a complex crosstalk between periodontal disease,gut microbiota,and metabolic syndrome.Thus,the conventional periodontal treatment and novel microbiome-targeted therapies that include probiotics,prebiotics and bacteriocins would hold great promise for preventing the onset and progression of NAFLD and subsequent complications in patients with periodontal disease.展开更多
Mergers and acquisitions of Chinese enterprises by foreign investors have moved onto the public radar in recent years.To date,the M&A frenzy has drawn widespread attention,with a mixed reaction from proponents and...Mergers and acquisitions of Chinese enterprises by foreign investors have moved onto the public radar in recent years.To date,the M&A frenzy has drawn widespread attention,with a mixed reaction from proponents and opponents.Proponents consider such mergers and acquisitions conducive to realizing strategic readjustment of the national economic structure,optimizing resource allocation and improving the corporate governance structure.Opponents,however,are concerned that foreign mergers and acquisitions may jeopardize China’s industrial security and erode the executive power of the central government in undertaking industrial development planning.Are the benefits of M&A outweighed by the costs,or vice versa? The focus column of this edition features two articles which debate this issue from opposing viewpoints.In the article"Positive and Negative Impacts of Cross-border M&A",the authors consider foreign M(?)A to be a new way of boosting the level of foreign investment utilization,and advocate China taking full advantage of this approach.The authors of the article"Self-Improvement Or Self-Mutilation",meanwhile,hold foreign M&A to blame for state-owned asset erosion,and insist that China should oppose mergers and acquisitions of key state- owned enterprises by foreign investors at fire-sale prices.展开更多
In 2015,the U.S National Institute of Standards and Technology(NIST)funded the Center of Excellence for Risk-Based Community Resilience Planning(CoE),a fourteen university-based consortium of almost 100 col-laborators...In 2015,the U.S National Institute of Standards and Technology(NIST)funded the Center of Excellence for Risk-Based Community Resilience Planning(CoE),a fourteen university-based consortium of almost 100 col-laborators,including faculty,students,post-doctoral scholars,and NIST researchers.This paper highlights the scientific theory behind the state-of-the-art cloud platform being developed by the CoE-the Interdisciplinary Networked Community Resilience Modeling Environment(IN-CORE).IN-CORE enables communities,consul-tants,and researchers to set up complex interdependent models of an entire community consisting of people,businesses,social institutions,buildings,transportation networks,water networks,and electric power networks and to predict their performance and recovery to hazard scenario events,including uncertainty propagation through the chained models.The modeling environment includes a detailed building inventory,hazard scenario models,building and infrastructure damage(fragility)and recovery functions,social science data-driven house-hold and business models,and computable general equilibrium(CGE)models of local economies.An important aspect of IN-CORE is the characterization of uncertainty and its propagation throughout the chained models of the platform.Three illustrative examples of community testbeds are presented that look at hazard impacts and recovery on population,economics,physical services,and social services.An overview of the IN-CORE technology and scientific implementation is described with a focus on four key community stability areas(CSA)that encompass an array of community resilience metrics(CRM)and support community resilience informed decision-making.Each testbed within IN-CORE has been developed by a team of engineers,social scientists,urban planners,and economists.Community models,begin with a community description,i.e.,people,businesses,buildings,infras-tructure,and progresses to the damage and loss of functions caused by a hazard scenario,i.e.,a flood,tornado,hurricane,or earthquake.This process is accomplished through chaining of modular algorithms,as described.The baseline community characteristics and the hazard-induced damage sets are the initial conditions for the recovery models,which have been the least studied area of community resilience but arguably one of the most important.Communities can then test the effect of mitigation and/or policies and compare the effects of“what if”scenarios on physical,social,and economic metrics with the only requirement being that the change much be able to be numerically modeled in IN-CORE.展开更多
文摘A growing body of evidence from multiple areas proposes that periodontal disease,accompanied by oral inflammation and pathological changes in the microbiome,induces gut dysbiosis and is involved in the pathogenesis of nonalcoholic fatty liver disease(NAFLD).A subgroup of NAFLD patients have a severely progressive form,namely nonalcoholic steatohepatitis(NASH),which is characterized by histological findings that include inflammatory cell infiltration and fibrosis.NASH has a high risk of further progression to cirrhosis and hepatocellular carcinoma.The oral microbiota may serve as an endogenous reservoir for gut microbiota,and transport of oral bacteria through the gastro-intestinal tract can set up a gut microbiome dysbiosis.Gut dysbiosis increases the production of potential hepatotoxins,including lipopolysaccharide,ethanol,and other volatile organic compounds such as acetone,phenol and cyclopentane.Moreover,gut dysbiosis increases intestinal permeability by disrupting tight junctions in the intestinal wall,leading to enhanced translocation of these hepatotoxins and enteric bacteria into the liver through the portal circulation.In particular,many animal studies support that oral administration of Porphyromonas gingivalis,a typical periodontopathic bacterium,induces disturbances in glycolipid metabolism and inflammation in the liver with gut dysbiosis.NAFLD,also known as the hepatic phenotype of metabolic syndrome,is strongly associated with metabolic complications,such as obesity and diabetes.Periodontal disease also has a bidirectional relationship with metabolic syndrome,and both diseases may induce oral and gut microbiome dysbiosis with insulin resistance and systemic chronic inflammation cooperatively.In this review,we will describe the link between periodontal disease and NAFLD with a focus on basic,epidemiological,and clinical studies,and discuss potential mechanisms linking the two diseases and possible therapeutic approaches focused on the microbiome.In conclusion,it is presumed that the pathogenesis of NAFLD involves a complex crosstalk between periodontal disease,gut microbiota,and metabolic syndrome.Thus,the conventional periodontal treatment and novel microbiome-targeted therapies that include probiotics,prebiotics and bacteriocins would hold great promise for preventing the onset and progression of NAFLD and subsequent complications in patients with periodontal disease.
文摘Mergers and acquisitions of Chinese enterprises by foreign investors have moved onto the public radar in recent years.To date,the M&A frenzy has drawn widespread attention,with a mixed reaction from proponents and opponents.Proponents consider such mergers and acquisitions conducive to realizing strategic readjustment of the national economic structure,optimizing resource allocation and improving the corporate governance structure.Opponents,however,are concerned that foreign mergers and acquisitions may jeopardize China’s industrial security and erode the executive power of the central government in undertaking industrial development planning.Are the benefits of M&A outweighed by the costs,or vice versa? The focus column of this edition features two articles which debate this issue from opposing viewpoints.In the article"Positive and Negative Impacts of Cross-border M&A",the authors consider foreign M(?)A to be a new way of boosting the level of foreign investment utilization,and advocate China taking full advantage of this approach.The authors of the article"Self-Improvement Or Self-Mutilation",meanwhile,hold foreign M&A to blame for state-owned asset erosion,and insist that China should oppose mergers and acquisitions of key state- owned enterprises by foreign investors at fire-sale prices.
基金The Center for Risk-Based Community Resilience Planning is a NIST-funded Center of Excellencethe Center is funded through a cooperative agreement between the U.S.National Institute of Standards and Tech-nology and Colorado State University(NIST Financial Assistance Award Numbers:70NANB15H044 and 70NANB20H008)。
文摘In 2015,the U.S National Institute of Standards and Technology(NIST)funded the Center of Excellence for Risk-Based Community Resilience Planning(CoE),a fourteen university-based consortium of almost 100 col-laborators,including faculty,students,post-doctoral scholars,and NIST researchers.This paper highlights the scientific theory behind the state-of-the-art cloud platform being developed by the CoE-the Interdisciplinary Networked Community Resilience Modeling Environment(IN-CORE).IN-CORE enables communities,consul-tants,and researchers to set up complex interdependent models of an entire community consisting of people,businesses,social institutions,buildings,transportation networks,water networks,and electric power networks and to predict their performance and recovery to hazard scenario events,including uncertainty propagation through the chained models.The modeling environment includes a detailed building inventory,hazard scenario models,building and infrastructure damage(fragility)and recovery functions,social science data-driven house-hold and business models,and computable general equilibrium(CGE)models of local economies.An important aspect of IN-CORE is the characterization of uncertainty and its propagation throughout the chained models of the platform.Three illustrative examples of community testbeds are presented that look at hazard impacts and recovery on population,economics,physical services,and social services.An overview of the IN-CORE technology and scientific implementation is described with a focus on four key community stability areas(CSA)that encompass an array of community resilience metrics(CRM)and support community resilience informed decision-making.Each testbed within IN-CORE has been developed by a team of engineers,social scientists,urban planners,and economists.Community models,begin with a community description,i.e.,people,businesses,buildings,infras-tructure,and progresses to the damage and loss of functions caused by a hazard scenario,i.e.,a flood,tornado,hurricane,or earthquake.This process is accomplished through chaining of modular algorithms,as described.The baseline community characteristics and the hazard-induced damage sets are the initial conditions for the recovery models,which have been the least studied area of community resilience but arguably one of the most important.Communities can then test the effect of mitigation and/or policies and compare the effects of“what if”scenarios on physical,social,and economic metrics with the only requirement being that the change much be able to be numerically modeled in IN-CORE.
