I applaud Adekeye AP and the journal for publishing‘Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention’.It is important to draw attention to newly recognised us...I applaud Adekeye AP and the journal for publishing‘Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention’.It is important to draw attention to newly recognised uses of substances which might alter perception,mood,and/or behaviour.展开更多
The introduction of the digital renminbi(eCNY)by the People’s Bank of China serves as a means for the central bank to effectively comprehend macroeconomic dynamics and enhance payment infrastructure within the domest...The introduction of the digital renminbi(eCNY)by the People’s Bank of China serves as a means for the central bank to effectively comprehend macroeconomic dynamics and enhance payment infrastructure within the domestic market.Among the pioneering digital currencies,the eCNY is at the forefront of technological research and development,pilot implementation,and the establishment of a robust system.Thus,employing the unified theory of acceptance and use of technology,this study aims to explore the factors shaping the adoption of the eCNY and to determine the mediating effects of intention toward the eCNY and the moderating role of age and gender among various relationships.A cross-sectional survey methodology was deployed to collect data from pilot communities situated within the Yangtze River Delta,Pearl River Delta,and Beijing–Tianjin–Hebei regions.The empirical analysis comprised 809 valid online questionnaires,and the examination was conducted through structural equation modeling employing the partial least squares technique,ultimately subjecting the conceptual model to a comprehensive assessment.The results for intention to use the eCNY indicate that performance expectancy,effort expectancy,social influence,and perceived government policy have significant effects.Facilitating conditions and intentions toward the eCNY positively influenced its actual use.According to the findings of this study,age and sex did not moderate the effect of each hypothesis on the intention to use in the research model.This study breaks new ground by investigating the adoption of the eCNY,a novel form of currency,highlighting its multifaceted nature and providing empirical evidence for a comprehensive model encompassing psychological,social,and contextual factors.This study employs social surveys to identify obstacles in the process of promoting the widespread adoption of the eCNY and offers suggestions to the central bank and government to increase user enthusiasm and decrease user perceptions of risk,thereby promoting its widespread adoption.展开更多
Objective:This study aims to determine the effectiveness of giving a combination of Fe tablets and beetroot juice in increasing hemoglobin(Hb)levels of pregnant women with anemia in the Mataram City area.Methods:This ...Objective:This study aims to determine the effectiveness of giving a combination of Fe tablets and beetroot juice in increasing hemoglobin(Hb)levels of pregnant women with anemia in the Mataram City area.Methods:This study was designed with quasi-experimental design with pre-test and post-test with control design.The location of this study was conducted in the city of Mataram on pregnant women with anemia.The sample of this study was pregnant women with mild anemia based on inclusion and exclusion criteria,divided into 2 groups:a control group and a treatment group of 15 respondents each,bringing the total respondents to 30 people.Analysis of Hb level measurement results was carried out using the independent sample t-test.Results:The results obtained in the treatment group(combination of beet juice and Fe tablets)were the mean pre-test of 9.93 mg/dL and post-test of 11.90 mg/dL(P-value=0.000),which means there is effectiveness in increasing hemoglobin levels while in the control group.Comparison of increased Hb levels of the control group and significantly different treatments marked by a P value of 0.001.Conclusions:the combination of Fe tablets and beetroot juice is effective in increasing Hb levels of pregnant women with anemia in the Mataram City area.展开更多
Cancer is a formidable andmultifaceted disease driven by genetic aberrations and metabolic disruptions.Around 19% of cancer-related deaths worldwide are attributable to lung and colon cancer,which is also the top caus...Cancer is a formidable andmultifaceted disease driven by genetic aberrations and metabolic disruptions.Around 19% of cancer-related deaths worldwide are attributable to lung and colon cancer,which is also the top cause of death worldwide.The malignancy has a terrible 5-year survival rate of 19%.Early diagnosis is critical for improving treatment outcomes and survival rates.The study aims to create a computer-aided diagnosis(CAD)that accurately diagnoses lung disease by classifying histopathological images.It uses a publicly accessible dataset that includes 15,000 images of benign,malignant,and squamous cell carcinomas in the lung.In addition,this research employs multiscale processing to extract relevant image features and conducts a comprehensive comparative analysis using four Convolutional Neural Network(CNN)based on pre-trained models such as AlexNet,VGG(Visual Geometry Group)16,ResNet-50,and VGG19,after hyper-tuning these models by optimizing factors such as batch size,learning rate,and epochs.The proposed(CNN+VGG19)model achieves the highest accuracy of 99.04%.This outstanding performance demonstrates the potential of the CAD system in accurately classifying lung cancer histopathological images.This study contributes significantly to the creation of a more precise CNN-based model for lung cancer identification,giving researchers and medical professionals in this vital sector a useful tool using advanced deep learning techniques and publicly available datasets.展开更多
Ornithine transcarbamylase （OTC） deficiency is an X-linked trait that accounts for nearly half of all inherited disorders of the urea cycle. OTC is one of the enzymes common to both the urea cycle and the bacterial ...Ornithine transcarbamylase （OTC） deficiency is an X-linked trait that accounts for nearly half of all inherited disorders of the urea cycle. OTC is one of the enzymes common to both the urea cycle and the bacterial arginine biosynthesis pathway; however, the role of OTC has changed over evolution. For animals with a urea cycle, defects in OTC can trigger hyperammonemic episodes that can lead to brain damage and death. This is the fifth mutation update for human OTC with previous updates reported in 1993, 1995, 2002, and 2006. In the 2006 update, 341 mutations were reported. This current update contains 417 disease-causing mutations, and also is the first report of this series to incorporate information about natural variation of the OTC gene in the general population through examination of publicly available genomic data and examination of phenotype/genotype correlations from patients participating in the Urea Cycle Disorders Consortium Longitudinal Study and the first to evaluate the suitability of systematic computational approaches to predict severity of disease associated with different types of OTC mutations.展开更多
Chronic infection with the hepatitis B virus(HBV) is the leading risk factor for the development of hepatocellular carcinoma(HCC). With nearly 750000 deaths yearly, hepatocellular carcinoma is the second highest cause...Chronic infection with the hepatitis B virus(HBV) is the leading risk factor for the development of hepatocellular carcinoma(HCC). With nearly 750000 deaths yearly, hepatocellular carcinoma is the second highest cause of cancer-related death in the world. Unfortunately, the molecular mechanisms that contribute to the development of HBV-associated HCC remain incompletely understood. Recently, micro RNAs(mi RNAs), a family of small non-coding RNAs that play a role primarily in post-transcriptional gene regulation, have been recognized as important regulators of cellular homeostasis, and altered regulation of mi RNA expression has been suggested to play a significant role in virus-associated diseases and the development of many cancers. With this in mind, many groups have begun to investigate the relationship between mi RNAs and HBV replication and HBV-associated disease. Multiple findings suggest that some mi RNAs, such as mi R-122, and mi R-125 and mi R-199 family members, are playing a role in HBV replication and HBV-associated disease, including the development of HBV-associated HCC. In this review, we discuss the current state of our understanding of the relationship between HBV and mi RNAs, including how HBV affects cellular mi RNAs, how these mi RNAs impact HBV replication, and the relationship between HBV-mediated mi RNA regulation and HCC development. We also address the impact of challenges in studying HBV, such as the lack of an effective model system for infectivity and a reliance on transformed cell lines, on our understanding of the relationship between HBV and mi RNAs, and proposepotential applications of mi RNA-related techniques that could enhance our understanding of the role mi RNAs play in HBV replication and HBV-associated disease, ultimately leading to new therapeutic options and improved patient outcomes.展开更多
In the healthcare system,the Internet of Things(IoT)based distributed systems play a vital role in transferring the medical-related documents and information among the organizations to reduce the replication in medica...In the healthcare system,the Internet of Things(IoT)based distributed systems play a vital role in transferring the medical-related documents and information among the organizations to reduce the replication in medical tests.This datum is sensitive,and hence security is a must in transforming the sensational contents.In this paper,an Evolutionary Algorithm,namely the Memetic Algorithm is used for encrypting the text messages.The encrypted information is then inserted into the medical images using Discrete Wavelet Transform 1 level and 2 levels.The reverse method of the Memetic Algorithm is implemented when extracting a hidden message from the encoded letter.To show its precision,equivalent to five RGB images and five Grayscale images are used to test the proposed algorithm.The results of the proposed algorithm were analyzed using statistical methods,and the proposed algorithm showed the importance of data transfer in healthcare systems in a stable environment.In the future,to embed the privacy-preserving of medical data,it can be extended with blockchain technology.展开更多
In medical imaging,computer vision researchers are faced with a variety of features for verifying the authenticity of classifiers for an accurate diagnosis.In response to the coronavirus 2019(COVID-19)pandemic,new tes...In medical imaging,computer vision researchers are faced with a variety of features for verifying the authenticity of classifiers for an accurate diagnosis.In response to the coronavirus 2019(COVID-19)pandemic,new testing procedures,medical treatments,and vaccines are being developed rapidly.One potential diagnostic tool is a reverse-transcription polymerase chain reaction(RT-PCR).RT-PCR,typically a time-consuming process,was less sensitive to COVID-19 recognition in the disease’s early stages.Here we introduce an optimized deep learning(DL)scheme to distinguish COVID-19-infected patients from normal patients according to computed tomography(CT)scans.In the proposed method,contrast enhancement is used to improve the quality of the original images.A pretrained DenseNet-201 DL model is then trained using transfer learning.Two fully connected layers and an average pool are used for feature extraction.The extracted deep features are then optimized with a Firefly algorithm to select the most optimal learning features.Fusing the selected features is important to improving the accuracy of the approach;however,it directly affects the computational cost of the technique.In the proposed method,a new parallel high index technique is used to fuse two optimal vectors;the outcome is then passed on to an extreme learning machine for final classification.Experiments were conducted on a collected database of patients using a 70:30 training:Testing ratio.Our results indicated an average classification accuracy of 94.76%with the proposed approach.A comparison of the outcomes to several other DL models demonstrated the effectiveness of our DL method for classifying COVID-19 based on CT scans.展开更多
Wireless Capsule Endoscopy(WCE)is an imaging technology,widely used in medical imaging for stomach infection recognition.However,a one patient procedure takes almost seven to eight minutes and approximately 57,000 fra...Wireless Capsule Endoscopy(WCE)is an imaging technology,widely used in medical imaging for stomach infection recognition.However,a one patient procedure takes almost seven to eight minutes and approximately 57,000 frames are captured.The privacy of patients is very important and manual inspection is time consuming and costly.Therefore,an automated system for recognition of stomach infections from WCE frames is always needed.An existing block chain-based approach is employed in a convolutional neural network model to secure the network for accurate recognition of stomach infections such as ulcer and bleeding.Initially,images are normalized in fixed dimension and passed in pre-trained deep models.These architectures are modified at each layer,to make them safer and more secure.Each layer contains an extra block,which stores certain information to avoid possible tempering,modification attacks and layer deletions.Information is stored in multiple blocks,i.e.,block attached to each layer,a ledger block attached with the network,and a cloud ledger block stored in the cloud storage.After that,features are extracted and fused using a Mode value-based approach and optimized using a Genetic Algorithm along with an entropy function.The Softmax classifier is applied at the end for final classification.Experiments are performed on a private collected dataset and achieve an accuracy of 96.8%.The statistical analysis and individual model comparison show the proposed method’s authenticity.展开更多
In this paper,we provide a new approach to data encryption using generalized inverses.Encryption is based on the implementation of weighted Moore–Penrose inverse A y MNenxmT over the nx8 constant matrix.The square He...In this paper,we provide a new approach to data encryption using generalized inverses.Encryption is based on the implementation of weighted Moore–Penrose inverse A y MNenxmT over the nx8 constant matrix.The square Hermitian positive definite matrix N8x8 p is the key.The proposed solution represents a very strong key since the number of different variants of positive definite matrices of order 8 is huge.We have provided NIST(National Institute of Standards and Technology)quality assurance tests for a random generated Hermitian matrix(a total of 10 different tests and additional analysis with approximate entropy and random digression).In the additional testing of the quality of the random matrix generated,we can conclude that the results of our analysis satisfy the defined strict requirements.This proposed MP encryption method can be applied effectively in the encryption and decryption of images in multi-party communications.In the experimental part of this paper,we give a comparison of encryption methods between machine learning methods.Machine learning algorithms could be compared by achieved results of classification concentrating on classes.In a comparative analysis,we give results of classifying of advanced encryption standard(AES)algorithm and proposed encryption method based on Moore–Penrose inverse.展开更多
Planning and production optimization within multiple mines or several work sites （entities） mining systems by using fuzzy linear programming （LP） was studied. LP is the most commonly used operations research metho...Planning and production optimization within multiple mines or several work sites （entities） mining systems by using fuzzy linear programming （LP） was studied. LP is the most commonly used operations research methods in mining engineering. After the introductory review of properties and limitations of applying LP, short reviews of the general settings of deterministic and fuzzy LP models are presented. With the purpose of comparative analysis, the application of both LP models is presented using the example of the Bauxite Basin Niksic with five mines. After the assessment, LP is an efficient mathematical modeling tool in production planning and solving many other single-criteria optimization problems of mining engineering. After the comparison of advantages and deficiencies of both deterministic and fuzzy LP models, the conclusion presents benefits of the fuzzy LP model but is also stating that seeking the optimal plan of production means to accomplish the overall analysis that will encompass the LP model approaches.展开更多
Current research focussed on the assessment of metal machining process parameters and on the development of adaptive control, shows that machine performance, work-piece and tool material selections, tool life, quality...Current research focussed on the assessment of metal machining process parameters and on the development of adaptive control, shows that machine performance, work-piece and tool material selections, tool life, quality of machined surfaces, the geometry of cutting tool edges, and cutting conditions are closely related to the cutting forces. This information is of great interest to cutting tool manufactures and users alike. Over the years there have been significant developments and improvements in the equipment used to monitor such forces. In 1930 mechanical gauges were replaced by resistance strain gauges, and some 30 years later compact air gauge dynamometers were invented. Since this time intensive research has continued being directed to- wards developing new approaches to cutting force measurement. The Kistler Company, well-known manufacturer of acceleration and piezoelectrical dynamometers, has worked in this field for more than three decades, and developed very sensitive devices. While leading manufacturing research laboratories are often equipped with this technology, classical electrical strain gauges and other dynamometers of individual designs are still commonly used in industry. The present paper presents data obtained using different techniques of force measurement in metal machining processes. In particular, areas of uncertainties, illustrated through results concerning the turning process, are analysed, leading to an appraisal of the current status of these measurements and their significance.展开更多
Background: The department of defense's field manual(FM) 3-11 is among the military's field manuals for preparing for, reacting to and recovering from chemical, biological, radiological and nuclear attacks. Si...Background: The department of defense's field manual(FM) 3-11 is among the military's field manuals for preparing for, reacting to and recovering from chemical, biological, radiological and nuclear attacks. Since post 9-11, U.S. military service members have been deployed in the global war on terrorism. This study attempted to determine the effectiveness of the FM 3-11 in detecting, deterring or preventing a human-borne with bioagent(HBBA) terrorist breach at an entry control point(ECP).Methods: This time-specific, cross-sectional study disseminated a validated survey tool with Cronbach's α>0.82 to respondents who have had antiterrorism training and combat ECP experience. The return rate was greater than 75.0%; however, many of the respondents failed to meet the inclusion criteria. Consequently, only 26 questionnaires were included in the sample.Results: The results revealed that while over 60.0% of the respondents either strongly agreed or agreed that biointelligence, the deployment of biodetectors and the use of biowarning systems could be effective in preventing an ECP breach by a terrorist with a bioagent, the use of protective equipment and immunization to decontaminate service members or other tactics, techniques and procedures(TTPs) would never prevent a breach. A large percentage of respondents claimed that soldiers at the ECP lacked the devices or the knowledge to detect an HBBA at an ECP, and 72.0% suggested modifying current ECP TTPs to include education, training and equipment for security personnel at military base ECPs.Conclusion: If obtained from appropriate sources and communicated to the personnel at the ECP in an effective or timely manner, the possible effectiveness of certain TTPs in the FM 3-11, specifically FM 3-11.86(intelligence), might increase.展开更多
The surface quality of solid wood is very important for its effective response in manufacturing processes. The effects of feed rate, cutting depth and rake angle on surface roughness and power consumption were investi...The surface quality of solid wood is very important for its effective response in manufacturing processes. The effects of feed rate, cutting depth and rake angle on surface roughness and power consumption were investigated and modeled. Neuro-fuzzy methodology was applied and shown that it could be useful, reliable and an effective tool for modeling the surface roughness of wood.Thus, the results of the present research can be successfully applied in the wood industry to reduce time, energy and high experimental costs.展开更多
Collecting silver artefacts has traditionally been a very popular hobby.Silver is addictive,therefore the number of potential collectors and investors appears to grow each year.Unfortunately,increases in the interest ...Collecting silver artefacts has traditionally been a very popular hobby.Silver is addictive,therefore the number of potential collectors and investors appears to grow each year.Unfortunately,increases in the interest and buying potentials resulted in a number of forgeries manufactured and introduced to the open antique market.The items such as early silver candlesticks dictate a very high price,for many high quality fakes show very good appearances and matching similarities with originals.Such copies are traditionally manufactured by casting using the original items as patterns.Small details and variances in design features,position and shape of hallmarks,including the final surface quality are usual features to distinguish the fakes from the originals.This paper presents results of a study conducted on several silver candlesticks,including two artefacts bearing features of those produced in the mid 18th century,one original Italian candelabrum from Fascist era,and small candlesticks made in the early 20th century.Also,the paper presents some interesting contemporary coins-replicas of many those produced in different countries.The coins were offered for sale by unscrupulous dealers via auctions and e-bays.Finally the main results and findings from this study are discussed from a manufacturing point of view,such as fabrication technology,surface quality and hallmarks,which will help the collectors,dealers and investors to detect and avoid forgeries.展开更多
Background:The global war on terrorism has prompted an increase in the deployment of security personnel from multi-national forces on foreign lands,especially in places where known terrorist groups are based.The aim o...Background:The global war on terrorism has prompted an increase in the deployment of security personnel from multi-national forces on foreign lands,especially in places where known terrorist groups are based.The aim of this study was to obtain U.S.military and security personnel's perceptions of the possibility of encountering a humanborne with bioagent(HBBA) terrorist at an entry control point(ECP).Methods:This study was a mixed-method,cross-sectional,survey-based,time-limited study.A validated,five-option Likert scale questionnaire with Cronbach's alphas of 0.82 and 0.894 for Constructs 1 and 2 was distributed to over 113 respondents with combat experience.Results:The results indicated that 92.3% of the respondents thought it was possible for a terrorist to employ a biological agent to cause terror; 61.5% claimed it was either possible or very possible,and 26.9% claimed it was somewhat possible for a terrorist carrying a biological agent to successfully breach a combat Forward Operating Bases(FOB) ECP undetected.26.9% of the respondents agreed that "ECP soldiers are knowledgeable about bioagents(BA)",only 15.4% responded that ECP soldiers have effective devices for detecting a BA on a terrorist at an ECP.Conclusion:Despite some limitations,this pre-study tends to indicate that while many U.S.military or security personnel acknowledge the possibility of an HBBA terrorist breach and the vulnerability of U.S.combat post ECPs to a BA breach,the soldiers at the ECPs lack adequate knowledge or devices to effectively detect a BA on a terrorist at an ECP.展开更多
AIM: To develop an eye health knowledge, attitude and practice(EH-KAP) field-based assessment tool for use in implementing effective eye health care services.METHODS: An instrument development and validation study. A ...AIM: To develop an eye health knowledge, attitude and practice(EH-KAP) field-based assessment tool for use in implementing effective eye health care services.METHODS: An instrument development and validation study. A Vietnam EH-KAP dataset were used to identify and eliminate redundant questions to develop a standardized tool. Face validity was assessed by the KAP survey team. Internal validity(congruency/criterion) was assessed by comparing descriptive analysis of two datasets(n=531;n=38) collected from the same sampling frame at different time points. Weighted scores were calculated for each construct. Kappa values for test-retest and inter-observer agreement were calculated to check the reliability of responses. The modified version was assessed by analysing the raw and ungrouped data. Responses were weighted and agreement was tested by comparing construct scores.RESULTS: Totally 38 respondents were included in this validation process(mean age 58.5 y). Mean scores for knowledge were 9.15(old questionnaire n=531) and 5.05(modified version). For attitude, the scores were 2.23 and 2.42, and for practice the scores were 3.33 and 2.21. Testretest agreement was between 62% to 93%(Kappa 0.24 to 0.86) for the ungrouped raw data, and 55% to 72%(Kappa 0.42 to 0.65) for KAP domain. Inter-observer Kappa value for ungrouped data was 0.37 and 0.45 for the weighted scores.CONCLUSION: This standardized tool applied at critical time points can assess trends in KAP within the same population and for comparison across groups. If used alongside a Rapid Assessment of Avoidable Blindness(RAAB), this tool provides a comprehensive perspective on eye-health of a population.展开更多
Increasing numbers of overweight and obese children resulting from sedentary and abundant lifestyles are a health concern in Hong Kong and other affluent communities around the globe. The importance of physical activi...Increasing numbers of overweight and obese children resulting from sedentary and abundant lifestyles are a health concern in Hong Kong and other affluent communities around the globe. The importance of physical activity is well documented for health and wellbeing, with sedentary behavior emerging as an independent risk factor for chronic diseases and mortality. In this study, Pender’s Health-Promotion Model informed the development of an intervention program aimed to engage junior high school students in increased physical activity, specifically brisk-walking. The model set out to motivate participants to engage in behaviors to enhance their health across the life span, including developing self-efficacy with regard to brisk walking. The intervention featured four stages. First, participants were provided with information about the benefits and in stage two were trained in the technique of brisk walking. Next they engaged in the brisk walking program and in stage four were encouraged to serve as health ambassadors by introducing brisk walking and its associated benefits to others, thereby exercising peer influence to diffuse the practice of brisk walking more widely among members of the community. Motivational strategies were used as incentives in the program, including the involvement of a popular singing band to award certificates at the completion of the program. This 7-week intervention program including a 4-week brisk walking component was conducted in a high school context with 71 participants. Data were collected to enable paired-sample t-tests to be conducted to statistically analyze the data at pre- and post-intervention. Findings indicate significant differences among the mean Body Mass Index (BMI), Waist-to-Hip Ratio (WHR), knowledge and attitudes of the participants at pre- and post-intervention. These findings suggest that the intervention was effective as a strategy to reduce sedentary behavior with the concomitant effect of positive shifts in measurable indicators and attitudes.展开更多
The study examined the determinant of mobile banking adoption among bank customers in Ghana, with specific emphasis on Access Bank. In line with literature, the study applies theoretical frameworks which have been dev...The study examined the determinant of mobile banking adoption among bank customers in Ghana, with specific emphasis on Access Bank. In line with literature, the study applies theoretical frameworks which have been developed from existing literatures on innovation and adoption to collect responses from one hundred and fifty (150) sampled customers of Access Bank in order to investigate the determinants of mobile banking adoption in the Ghanaian banking industry. The results from the study revealed that, each factor measured had some level of significant effect on consumer intention to adopt and use mobile banking services provided by Access Bank. Additionally, the study unveiled that, perceived credibility and perceived financial cost were the major setback with regards to customers adoption of mobile banking services provided by Access Bank, and as a result of this, Ghanaians have formed a negative behavioural pattern towards mobile banking. In addition, the findings showed that, perceived credibility and perceived financial cost have a stronger effect on consumer intention to adopt and use mobile banking service than perceived usefulness and perceived ease of use. It was, therefore, recommended that banks in Ghana should create more awareness through personal interaction with customers, develop quality initiatives in order to build customer’s confidence. Equally, banks should also review the cost of their mobile banking service.展开更多
文摘I applaud Adekeye AP and the journal for publishing‘Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention’.It is important to draw attention to newly recognised uses of substances which might alter perception,mood,and/or behaviour.
基金funded by Jiangsu Education Department(Ref.No.2022SJYB0750).
文摘The introduction of the digital renminbi(eCNY)by the People’s Bank of China serves as a means for the central bank to effectively comprehend macroeconomic dynamics and enhance payment infrastructure within the domestic market.Among the pioneering digital currencies,the eCNY is at the forefront of technological research and development,pilot implementation,and the establishment of a robust system.Thus,employing the unified theory of acceptance and use of technology,this study aims to explore the factors shaping the adoption of the eCNY and to determine the mediating effects of intention toward the eCNY and the moderating role of age and gender among various relationships.A cross-sectional survey methodology was deployed to collect data from pilot communities situated within the Yangtze River Delta,Pearl River Delta,and Beijing–Tianjin–Hebei regions.The empirical analysis comprised 809 valid online questionnaires,and the examination was conducted through structural equation modeling employing the partial least squares technique,ultimately subjecting the conceptual model to a comprehensive assessment.The results for intention to use the eCNY indicate that performance expectancy,effort expectancy,social influence,and perceived government policy have significant effects.Facilitating conditions and intentions toward the eCNY positively influenced its actual use.According to the findings of this study,age and sex did not moderate the effect of each hypothesis on the intention to use in the research model.This study breaks new ground by investigating the adoption of the eCNY,a novel form of currency,highlighting its multifaceted nature and providing empirical evidence for a comprehensive model encompassing psychological,social,and contextual factors.This study employs social surveys to identify obstacles in the process of promoting the widespread adoption of the eCNY and offers suggestions to the central bank and government to increase user enthusiasm and decrease user perceptions of risk,thereby promoting its widespread adoption.
基金supported by Muhammadiyah Research Grant (RisetMu) Batch Ⅵ (No. 1687.186/PD/I.3/D/2022)
文摘Objective:This study aims to determine the effectiveness of giving a combination of Fe tablets and beetroot juice in increasing hemoglobin(Hb)levels of pregnant women with anemia in the Mataram City area.Methods:This study was designed with quasi-experimental design with pre-test and post-test with control design.The location of this study was conducted in the city of Mataram on pregnant women with anemia.The sample of this study was pregnant women with mild anemia based on inclusion and exclusion criteria,divided into 2 groups:a control group and a treatment group of 15 respondents each,bringing the total respondents to 30 people.Analysis of Hb level measurement results was carried out using the independent sample t-test.Results:The results obtained in the treatment group(combination of beet juice and Fe tablets)were the mean pre-test of 9.93 mg/dL and post-test of 11.90 mg/dL(P-value=0.000),which means there is effectiveness in increasing hemoglobin levels while in the control group.Comparison of increased Hb levels of the control group and significantly different treatments marked by a P value of 0.001.Conclusions:the combination of Fe tablets and beetroot juice is effective in increasing Hb levels of pregnant women with anemia in the Mataram City area.
文摘Cancer is a formidable andmultifaceted disease driven by genetic aberrations and metabolic disruptions.Around 19% of cancer-related deaths worldwide are attributable to lung and colon cancer,which is also the top cause of death worldwide.The malignancy has a terrible 5-year survival rate of 19%.Early diagnosis is critical for improving treatment outcomes and survival rates.The study aims to create a computer-aided diagnosis(CAD)that accurately diagnoses lung disease by classifying histopathological images.It uses a publicly accessible dataset that includes 15,000 images of benign,malignant,and squamous cell carcinomas in the lung.In addition,this research employs multiscale processing to extract relevant image features and conducts a comprehensive comparative analysis using four Convolutional Neural Network(CNN)based on pre-trained models such as AlexNet,VGG(Visual Geometry Group)16,ResNet-50,and VGG19,after hyper-tuning these models by optimizing factors such as batch size,learning rate,and epochs.The proposed(CNN+VGG19)model achieves the highest accuracy of 99.04%.This outstanding performance demonstrates the potential of the CAD system in accurately classifying lung cancer histopathological images.This study contributes significantly to the creation of a more precise CNN-based model for lung cancer identification,giving researchers and medical professionals in this vital sector a useful tool using advanced deep learning techniques and publicly available datasets.
基金the support of the Kettering Family FoundationThe Urea Cycle Disorders Consortium (U54HD061221) is a part of the National Institutes of Health (NIH) Rare Disease Clinical Research Network (RDCRN)+3 种基金supported through collaboration between the Office of Rare Diseases Research (ORDR)the National Center for Advancing Translational Science (NCATS)the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)The Urea Cycle Disorders Consortium is also supported by the O’Malley Foundation, the Rotenberg Family Fund, the Dietmar-Hopp Foundation, and the Kettering Fund
文摘Ornithine transcarbamylase （OTC） deficiency is an X-linked trait that accounts for nearly half of all inherited disorders of the urea cycle. OTC is one of the enzymes common to both the urea cycle and the bacterial arginine biosynthesis pathway; however, the role of OTC has changed over evolution. For animals with a urea cycle, defects in OTC can trigger hyperammonemic episodes that can lead to brain damage and death. This is the fifth mutation update for human OTC with previous updates reported in 1993, 1995, 2002, and 2006. In the 2006 update, 341 mutations were reported. This current update contains 417 disease-causing mutations, and also is the first report of this series to incorporate information about natural variation of the OTC gene in the general population through examination of publicly available genomic data and examination of phenotype/genotype correlations from patients participating in the Urea Cycle Disorders Consortium Longitudinal Study and the first to evaluate the suitability of systematic computational approaches to predict severity of disease associated with different types of OTC mutations.
基金Supported by Pennsylvania state CURE grant,No.4100057658,[to Steel LF and Bouchard MJ(partially)]a Ruth L Kirschstein(F31)Predoctoral Fellowship,No.5F31CA171712-03,[to Lamontagne J(partially)]
文摘Chronic infection with the hepatitis B virus(HBV) is the leading risk factor for the development of hepatocellular carcinoma(HCC). With nearly 750000 deaths yearly, hepatocellular carcinoma is the second highest cause of cancer-related death in the world. Unfortunately, the molecular mechanisms that contribute to the development of HBV-associated HCC remain incompletely understood. Recently, micro RNAs(mi RNAs), a family of small non-coding RNAs that play a role primarily in post-transcriptional gene regulation, have been recognized as important regulators of cellular homeostasis, and altered regulation of mi RNA expression has been suggested to play a significant role in virus-associated diseases and the development of many cancers. With this in mind, many groups have begun to investigate the relationship between mi RNAs and HBV replication and HBV-associated disease. Multiple findings suggest that some mi RNAs, such as mi R-122, and mi R-125 and mi R-199 family members, are playing a role in HBV replication and HBV-associated disease, including the development of HBV-associated HCC. In this review, we discuss the current state of our understanding of the relationship between HBV and mi RNAs, including how HBV affects cellular mi RNAs, how these mi RNAs impact HBV replication, and the relationship between HBV-mediated mi RNA regulation and HCC development. We also address the impact of challenges in studying HBV, such as the lack of an effective model system for infectivity and a reliance on transformed cell lines, on our understanding of the relationship between HBV and mi RNAs, and proposepotential applications of mi RNA-related techniques that could enhance our understanding of the role mi RNAs play in HBV replication and HBV-associated disease, ultimately leading to new therapeutic options and improved patient outcomes.
文摘In the healthcare system,the Internet of Things(IoT)based distributed systems play a vital role in transferring the medical-related documents and information among the organizations to reduce the replication in medical tests.This datum is sensitive,and hence security is a must in transforming the sensational contents.In this paper,an Evolutionary Algorithm,namely the Memetic Algorithm is used for encrypting the text messages.The encrypted information is then inserted into the medical images using Discrete Wavelet Transform 1 level and 2 levels.The reverse method of the Memetic Algorithm is implemented when extracting a hidden message from the encoded letter.To show its precision,equivalent to five RGB images and five Grayscale images are used to test the proposed algorithm.The results of the proposed algorithm were analyzed using statistical methods,and the proposed algorithm showed the importance of data transfer in healthcare systems in a stable environment.In the future,to embed the privacy-preserving of medical data,it can be extended with blockchain technology.
基金Korea Institute for Advancement of Technology(KIAT)grant funded by the Korea Government(MOTIE)(P0012724,The Competency Development Program for Industry Specialist)and the Soonchunhyang University Research Fund.
文摘In medical imaging,computer vision researchers are faced with a variety of features for verifying the authenticity of classifiers for an accurate diagnosis.In response to the coronavirus 2019(COVID-19)pandemic,new testing procedures,medical treatments,and vaccines are being developed rapidly.One potential diagnostic tool is a reverse-transcription polymerase chain reaction(RT-PCR).RT-PCR,typically a time-consuming process,was less sensitive to COVID-19 recognition in the disease’s early stages.Here we introduce an optimized deep learning(DL)scheme to distinguish COVID-19-infected patients from normal patients according to computed tomography(CT)scans.In the proposed method,contrast enhancement is used to improve the quality of the original images.A pretrained DenseNet-201 DL model is then trained using transfer learning.Two fully connected layers and an average pool are used for feature extraction.The extracted deep features are then optimized with a Firefly algorithm to select the most optimal learning features.Fusing the selected features is important to improving the accuracy of the approach;however,it directly affects the computational cost of the technique.In the proposed method,a new parallel high index technique is used to fuse two optimal vectors;the outcome is then passed on to an extreme learning machine for final classification.Experiments were conducted on a collected database of patients using a 70:30 training:Testing ratio.Our results indicated an average classification accuracy of 94.76%with the proposed approach.A comparison of the outcomes to several other DL models demonstrated the effectiveness of our DL method for classifying COVID-19 based on CT scans.
基金supported by Korea Institute for Advancement of Technology(KIAT)grant funded by the Korea Government(MOTIE)(P0012724The Competency Development Program for Industry Specialist)and the Soonchunhyang University Research Fund.
文摘Wireless Capsule Endoscopy(WCE)is an imaging technology,widely used in medical imaging for stomach infection recognition.However,a one patient procedure takes almost seven to eight minutes and approximately 57,000 frames are captured.The privacy of patients is very important and manual inspection is time consuming and costly.Therefore,an automated system for recognition of stomach infections from WCE frames is always needed.An existing block chain-based approach is employed in a convolutional neural network model to secure the network for accurate recognition of stomach infections such as ulcer and bleeding.Initially,images are normalized in fixed dimension and passed in pre-trained deep models.These architectures are modified at each layer,to make them safer and more secure.Each layer contains an extra block,which stores certain information to avoid possible tempering,modification attacks and layer deletions.Information is stored in multiple blocks,i.e.,block attached to each layer,a ledger block attached with the network,and a cloud ledger block stored in the cloud storage.After that,features are extracted and fused using a Mode value-based approach and optimized using a Genetic Algorithm along with an entropy function.The Softmax classifier is applied at the end for final classification.Experiments are performed on a private collected dataset and achieve an accuracy of 96.8%.The statistical analysis and individual model comparison show the proposed method’s authenticity.
基金the support of Network Communication Technology(NCT)Research Groups,FTSM,UKM in providing facilities for this research.This paper is supported under the Dana Impak Perdana UKM DIP-2018-040 and Fundamental Research Grant Scheme FRGS/1/2018/TK04/UKM/02/7.
文摘In this paper,we provide a new approach to data encryption using generalized inverses.Encryption is based on the implementation of weighted Moore–Penrose inverse A y MNenxmT over the nx8 constant matrix.The square Hermitian positive definite matrix N8x8 p is the key.The proposed solution represents a very strong key since the number of different variants of positive definite matrices of order 8 is huge.We have provided NIST(National Institute of Standards and Technology)quality assurance tests for a random generated Hermitian matrix(a total of 10 different tests and additional analysis with approximate entropy and random digression).In the additional testing of the quality of the random matrix generated,we can conclude that the results of our analysis satisfy the defined strict requirements.This proposed MP encryption method can be applied effectively in the encryption and decryption of images in multi-party communications.In the experimental part of this paper,we give a comparison of encryption methods between machine learning methods.Machine learning algorithms could be compared by achieved results of classification concentrating on classes.In a comparative analysis,we give results of classifying of advanced encryption standard(AES)algorithm and proposed encryption method based on Moore–Penrose inverse.
文摘Planning and production optimization within multiple mines or several work sites （entities） mining systems by using fuzzy linear programming （LP） was studied. LP is the most commonly used operations research methods in mining engineering. After the introductory review of properties and limitations of applying LP, short reviews of the general settings of deterministic and fuzzy LP models are presented. With the purpose of comparative analysis, the application of both LP models is presented using the example of the Bauxite Basin Niksic with five mines. After the assessment, LP is an efficient mathematical modeling tool in production planning and solving many other single-criteria optimization problems of mining engineering. After the comparison of advantages and deficiencies of both deterministic and fuzzy LP models, the conclusion presents benefits of the fuzzy LP model but is also stating that seeking the optimal plan of production means to accomplish the overall analysis that will encompass the LP model approaches.
基金Project supported by the Postgraduate Award of University of SouthAustralia, Australia
文摘Current research focussed on the assessment of metal machining process parameters and on the development of adaptive control, shows that machine performance, work-piece and tool material selections, tool life, quality of machined surfaces, the geometry of cutting tool edges, and cutting conditions are closely related to the cutting forces. This information is of great interest to cutting tool manufactures and users alike. Over the years there have been significant developments and improvements in the equipment used to monitor such forces. In 1930 mechanical gauges were replaced by resistance strain gauges, and some 30 years later compact air gauge dynamometers were invented. Since this time intensive research has continued being directed to- wards developing new approaches to cutting force measurement. The Kistler Company, well-known manufacturer of acceleration and piezoelectrical dynamometers, has worked in this field for more than three decades, and developed very sensitive devices. While leading manufacturing research laboratories are often equipped with this technology, classical electrical strain gauges and other dynamometers of individual designs are still commonly used in industry. The present paper presents data obtained using different techniques of force measurement in metal machining processes. In particular, areas of uncertainties, illustrated through results concerning the turning process, are analysed, leading to an appraisal of the current status of these measurements and their significance.
文摘Background: The department of defense's field manual(FM) 3-11 is among the military's field manuals for preparing for, reacting to and recovering from chemical, biological, radiological and nuclear attacks. Since post 9-11, U.S. military service members have been deployed in the global war on terrorism. This study attempted to determine the effectiveness of the FM 3-11 in detecting, deterring or preventing a human-borne with bioagent(HBBA) terrorist breach at an entry control point(ECP).Methods: This time-specific, cross-sectional study disseminated a validated survey tool with Cronbach's α>0.82 to respondents who have had antiterrorism training and combat ECP experience. The return rate was greater than 75.0%; however, many of the respondents failed to meet the inclusion criteria. Consequently, only 26 questionnaires were included in the sample.Results: The results revealed that while over 60.0% of the respondents either strongly agreed or agreed that biointelligence, the deployment of biodetectors and the use of biowarning systems could be effective in preventing an ECP breach by a terrorist with a bioagent, the use of protective equipment and immunization to decontaminate service members or other tactics, techniques and procedures(TTPs) would never prevent a breach. A large percentage of respondents claimed that soldiers at the ECP lacked the devices or the knowledge to detect an HBBA at an ECP, and 72.0% suggested modifying current ECP TTPs to include education, training and equipment for security personnel at military base ECPs.Conclusion: If obtained from appropriate sources and communicated to the personnel at the ECP in an effective or timely manner, the possible effectiveness of certain TTPs in the FM 3-11, specifically FM 3-11.86(intelligence), might increase.
文摘The surface quality of solid wood is very important for its effective response in manufacturing processes. The effects of feed rate, cutting depth and rake angle on surface roughness and power consumption were investigated and modeled. Neuro-fuzzy methodology was applied and shown that it could be useful, reliable and an effective tool for modeling the surface roughness of wood.Thus, the results of the present research can be successfully applied in the wood industry to reduce time, energy and high experimental costs.
文摘Collecting silver artefacts has traditionally been a very popular hobby.Silver is addictive,therefore the number of potential collectors and investors appears to grow each year.Unfortunately,increases in the interest and buying potentials resulted in a number of forgeries manufactured and introduced to the open antique market.The items such as early silver candlesticks dictate a very high price,for many high quality fakes show very good appearances and matching similarities with originals.Such copies are traditionally manufactured by casting using the original items as patterns.Small details and variances in design features,position and shape of hallmarks,including the final surface quality are usual features to distinguish the fakes from the originals.This paper presents results of a study conducted on several silver candlesticks,including two artefacts bearing features of those produced in the mid 18th century,one original Italian candelabrum from Fascist era,and small candlesticks made in the early 20th century.Also,the paper presents some interesting contemporary coins-replicas of many those produced in different countries.The coins were offered for sale by unscrupulous dealers via auctions and e-bays.Finally the main results and findings from this study are discussed from a manufacturing point of view,such as fabrication technology,surface quality and hallmarks,which will help the collectors,dealers and investors to detect and avoid forgeries.
文摘Background:The global war on terrorism has prompted an increase in the deployment of security personnel from multi-national forces on foreign lands,especially in places where known terrorist groups are based.The aim of this study was to obtain U.S.military and security personnel's perceptions of the possibility of encountering a humanborne with bioagent(HBBA) terrorist at an entry control point(ECP).Methods:This study was a mixed-method,cross-sectional,survey-based,time-limited study.A validated,five-option Likert scale questionnaire with Cronbach's alphas of 0.82 and 0.894 for Constructs 1 and 2 was distributed to over 113 respondents with combat experience.Results:The results indicated that 92.3% of the respondents thought it was possible for a terrorist to employ a biological agent to cause terror; 61.5% claimed it was either possible or very possible,and 26.9% claimed it was somewhat possible for a terrorist carrying a biological agent to successfully breach a combat Forward Operating Bases(FOB) ECP undetected.26.9% of the respondents agreed that "ECP soldiers are knowledgeable about bioagents(BA)",only 15.4% responded that ECP soldiers have effective devices for detecting a BA on a terrorist at an ECP.Conclusion:Despite some limitations,this pre-study tends to indicate that while many U.S.military or security personnel acknowledge the possibility of an HBBA terrorist breach and the vulnerability of U.S.combat post ECPs to a BA breach,the soldiers at the ECPs lack adequate knowledge or devices to effectively detect a BA on a terrorist at an ECP.
基金Supported by the Australian Government Avoidable Blindness Initiative granted through CBM Australia
文摘AIM: To develop an eye health knowledge, attitude and practice(EH-KAP) field-based assessment tool for use in implementing effective eye health care services.METHODS: An instrument development and validation study. A Vietnam EH-KAP dataset were used to identify and eliminate redundant questions to develop a standardized tool. Face validity was assessed by the KAP survey team. Internal validity(congruency/criterion) was assessed by comparing descriptive analysis of two datasets(n=531;n=38) collected from the same sampling frame at different time points. Weighted scores were calculated for each construct. Kappa values for test-retest and inter-observer agreement were calculated to check the reliability of responses. The modified version was assessed by analysing the raw and ungrouped data. Responses were weighted and agreement was tested by comparing construct scores.RESULTS: Totally 38 respondents were included in this validation process(mean age 58.5 y). Mean scores for knowledge were 9.15(old questionnaire n=531) and 5.05(modified version). For attitude, the scores were 2.23 and 2.42, and for practice the scores were 3.33 and 2.21. Testretest agreement was between 62% to 93%(Kappa 0.24 to 0.86) for the ungrouped raw data, and 55% to 72%(Kappa 0.42 to 0.65) for KAP domain. Inter-observer Kappa value for ungrouped data was 0.37 and 0.45 for the weighted scores.CONCLUSION: This standardized tool applied at critical time points can assess trends in KAP within the same population and for comparison across groups. If used alongside a Rapid Assessment of Avoidable Blindness(RAAB), this tool provides a comprehensive perspective on eye-health of a population.
文摘Increasing numbers of overweight and obese children resulting from sedentary and abundant lifestyles are a health concern in Hong Kong and other affluent communities around the globe. The importance of physical activity is well documented for health and wellbeing, with sedentary behavior emerging as an independent risk factor for chronic diseases and mortality. In this study, Pender’s Health-Promotion Model informed the development of an intervention program aimed to engage junior high school students in increased physical activity, specifically brisk-walking. The model set out to motivate participants to engage in behaviors to enhance their health across the life span, including developing self-efficacy with regard to brisk walking. The intervention featured four stages. First, participants were provided with information about the benefits and in stage two were trained in the technique of brisk walking. Next they engaged in the brisk walking program and in stage four were encouraged to serve as health ambassadors by introducing brisk walking and its associated benefits to others, thereby exercising peer influence to diffuse the practice of brisk walking more widely among members of the community. Motivational strategies were used as incentives in the program, including the involvement of a popular singing band to award certificates at the completion of the program. This 7-week intervention program including a 4-week brisk walking component was conducted in a high school context with 71 participants. Data were collected to enable paired-sample t-tests to be conducted to statistically analyze the data at pre- and post-intervention. Findings indicate significant differences among the mean Body Mass Index (BMI), Waist-to-Hip Ratio (WHR), knowledge and attitudes of the participants at pre- and post-intervention. These findings suggest that the intervention was effective as a strategy to reduce sedentary behavior with the concomitant effect of positive shifts in measurable indicators and attitudes.
文摘The study examined the determinant of mobile banking adoption among bank customers in Ghana, with specific emphasis on Access Bank. In line with literature, the study applies theoretical frameworks which have been developed from existing literatures on innovation and adoption to collect responses from one hundred and fifty (150) sampled customers of Access Bank in order to investigate the determinants of mobile banking adoption in the Ghanaian banking industry. The results from the study revealed that, each factor measured had some level of significant effect on consumer intention to adopt and use mobile banking services provided by Access Bank. Additionally, the study unveiled that, perceived credibility and perceived financial cost were the major setback with regards to customers adoption of mobile banking services provided by Access Bank, and as a result of this, Ghanaians have formed a negative behavioural pattern towards mobile banking. In addition, the findings showed that, perceived credibility and perceived financial cost have a stronger effect on consumer intention to adopt and use mobile banking service than perceived usefulness and perceived ease of use. It was, therefore, recommended that banks in Ghana should create more awareness through personal interaction with customers, develop quality initiatives in order to build customer’s confidence. Equally, banks should also review the cost of their mobile banking service.
