The purpose of this paper is to explore the effectiveness of the Qinglan Project in promoting the professional growth of young secondary vocational teachers.Through the empirical analysis of the implementation process...The purpose of this paper is to explore the effectiveness of the Qinglan Project in promoting the professional growth of young secondary vocational teachers.Through the empirical analysis of the implementation process and effect,this paper finds that the Qinglan Project has a positive impact on the professional development of secondary vocational teachers,with a view to providing a guideline for the development of secondary vocational education.展开更多
According to several researches and survey findings, violence and the threat of violence are increasingly present at workplaces in the field of healthcare. In 2011, the Finnish Union of Health and Social Care Professi...According to several researches and survey findings, violence and the threat of violence are increasingly present at workplaces in the field of healthcare. In 2011, the Finnish Union of Health and Social Care Professionals--Tehy implemented a poster campaign targeted at the users of healthcare services, as well as healthcare staff. Representatives of local trade unions, as well as safety representatives, reported that the campaign was relevant. Most employers had a favorable attitude toward distributing campaign posters at the workplace. Raising this issue, which increases the mental burden of work and risks occupational safety at the workplace, helps to achieve improvements. Following the poster campaign, Tehy conducted an electronic survey in early 2012 about the impacts of the campaign among representatives of local trade unions （N= 279） and safety representatives （N = 278）. The campaign resulted in some working environment improvements, as well as an increase in reporting situations involving violence. On a more worrying note, the provision of workplace-level training on managing violent situations did not increase.展开更多
Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extra...Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extracellular matrix proteins,mainly collagen in the cardiac interstitium.Many experimental studies have demonstrated that fibrotic injury in the heart is reversible;therefore,it is vital to understand differ-ent molecular mechanisms that are involved in the initiation,progression,and resolu-tion of cardiac fibrosis to enable the development of antifibrotic agents.Of the many experimental models,one of the recent models that has gained renewed interest is isoproterenol(ISP)-induced cardiac fibrosis.ISP is a synthetic catecholamine,sympa-thomimetic,and nonselectiveβ-adrenergic receptor agonist.The overstimulated and sustained activation ofβ-adrenergic receptors has been reported to induce biochemi-cal and physiological alterations and ultimately result in cardiac remodeling.ISP has been used for decades to induce acute myocardial infarction.However,the use of low doses and chronic administration of ISP have been shown to induce cardiac fibrosis;this practice has increased in recent years.Intraperitoneal or subcutaneous ISP has been widely used in preclinical studies to induce cardiac remodeling manifested by fibrosis and hypertrophy.The induced oxidative stress with subsequent perturbations in cellular signaling cascades through triggering the release of free radicals is consid-ered the initiating mechanism of myocardial fibrosis.ISP is consistently used to induce fibrosis in laboratory animals and in cardiomyocytes isolated from animals.In recent years,numerous phytochemicals and synthetic molecules have been evaluated in ISP-induced cardiac fibrosis.The present review exclusively provides a comprehensive summary of the pathological biochemical,histological,and molecular mechanisms of ISP in inducing cardiac fibrosis and hypertrophy.It also summarizes the application of this experimental model in the therapeutic evaluation of natural as well as syn-thetic compounds to demonstrate their potential in mitigating myocardial fibrosis and hypertrophy.展开更多
I applaud Adekeye AP and the journal for publishing‘Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention’.It is important to draw attention to newly recognised us...I applaud Adekeye AP and the journal for publishing‘Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention’.It is important to draw attention to newly recognised uses of substances which might alter perception,mood,and/or behaviour.展开更多
Metabolic syndrome(MetS)is a cluster of risk factors that significantly increase the chances of developing heart disease,type 2 diabetes mellitus,stroke,and other cardiovascular complications.Since current anti-MetS m...Metabolic syndrome(MetS)is a cluster of risk factors that significantly increase the chances of developing heart disease,type 2 diabetes mellitus,stroke,and other cardiovascular complications.Since current anti-MetS medications like statins,angiotensin-converting enzyme inhibitors,β-blockers,insulin sensitizers and diuretics have been reported to cause unwanted side effects,researchers are exploring promising alternatives.One such alternative relies on the potential of spices and condiments,which have a long history of use in traditional medicine.Among them,Cinnamomum zeylanicum Blume stands out as a popular spice worldwide for its unique taste,aroma,and delicate sweetness compared to other cinnamon varieties.This narrative review aims to summarize the in vivo and clinical evidence concerning the efficacy of C.zeylanicum against MetS indices.Relevant articles from PubMed,Scopus and Google scholar databases were reviewed.In vivo results suggested that C.zeylanicum preparations(extracts,essential oil,crude powder,bioactive compounds,and biosynthesized nanoparticles)were remarkably efficient in ameliorating MetS indices,while the clinical data were less and with several methodological limitations.Further robust clinical studies are warranted to definitively establish C.zeylanicum as a promising functional food for mitigating MetS,potentially leading to its dietary integration as a natural approach to improve metabolic health.展开更多
Background Diet plays a crucial role in insulin resistance and diabetes,with high-fat and high-carbohydrate diets being major contributors.However,the type of fat consumed is critical,as different fatty acids impact i...Background Diet plays a crucial role in insulin resistance and diabetes,with high-fat and high-carbohydrate diets being major contributors.However,the type of fat consumed is critical,as different fatty acids impact insulin sensitivity differently.Objective This review examines the potential benefits of avocado oil,which is rich in monounsaturated fatty acids(MUFAs),in improving glycaemic control and lipid metabolism.It also explores variations in avocado oil composition across different avocado cultivars.Methods Experimental and clinical studies were analysed to assess the metabolic effects of avocado oil.The impact of MUFAs on insulin sensitivity,lipid profiles,and metabolic health was reviewed,alongside the influence of fruit quality,maturity,and cultivar differences.Results Avocado oil may enhance glycaemic control and lipid metabolism,benefiting individuals with diabetes and hyper-cholesterolemia.However,its composition varies significantly across avocado variants such as Hass,Reed,Ettinger,and Fuerte,influencing its therapeutic properties.Conclusion Avocado oil's high MUFA content offers promising metabolic benefits.Further research is needed to standardize its therapeutic application,considering cultivar-dependent variations in composition.展开更多
To address the global issue of climate change and create focused mitigation plans,accurate CO_(2)emissions forecasting is essential.Using CO_(2)emissions data from 1990 to 2023,this study assesses the predicting perfo...To address the global issue of climate change and create focused mitigation plans,accurate CO_(2)emissions forecasting is essential.Using CO_(2)emissions data from 1990 to 2023,this study assesses the predicting performance of five sophisticated models:Random Forest(RF),XGBoost,Support Vector Regression(SVR),Long Short-Term Memory networks(LSTM),and ARIMA To give a thorough evaluation of the models’performance,measures including Mean Absolute Error(MAE),Root Mean Square Error(RMSE),and Mean Absolute Percentage Error(MAPE)are used.To guarantee dependable model implementation,preprocessing procedures are carried out,such as feature engineering and stationarity tests.Machine learning models outperform ARIMA in identifying complex patterns and long-term associations,but ARIMA does better with data that exhibits strong linear trends.These results provide important information about how well the model fits various forecasting scenarios,which helps develop data-driven carbon reduction programs.Predictive modeling should be incorporated into sustainable climate policy to encourage the adoption of low-carbon technologies and proactive decisionmaking.Achieving long-term environmental sustainability requires strengthening carbon trading systems,encouraging clean energy investments,and enacting stronger emission laws.In line with international climate goals,suggestions for lowering CO_(2)emissions include switching to renewable energy,increasing energy efficiency,and putting afforestation initiatives into action.展开更多
Plants are under constant exposure to varied biotic and abiotic stresses,which significantly affect their growth,productivity,and survival.Biotic stress,caused by pathogens,and abiotic stress,including drought,salinit...Plants are under constant exposure to varied biotic and abiotic stresses,which significantly affect their growth,productivity,and survival.Biotic stress,caused by pathogens,and abiotic stress,including drought,salinity,extreme temperatures,and heavy metals,activate overlapping yet distinct immune pathways.These are comprised of morphological barriers,hormonal signaling,and the induction of stress-responsive genes through complex pathways mediated by reactive oxygen species(ROS),phytohormones,and secondary metabolites.Abiotic stress triggers organelle-mediated retrograde signaling from organelles like chloroplasts and mitochondria,which causes unfolded protein responses and the regulation of cellular homeostasis.Simultaneously,biotic stress activates both PAMP-triggered immunity(PTI)and effector-triggered immunity(ETI),mediated by salicylic acid(SA),jasmonic acid(JA),and ethylene(ET).This review aims to provide an integrated overview of plant immune responses tomultiple stressors,with emphasis on molecular crosstalk and recent technological interventions.A systematic literature search was conducted using the Scopus database,covering studies published between 2010 and 2025.Advances in CRISPR-Cas genome editing,RNA interference,omics technologies,nanotechnology,and artificial intelligence have improved our knowledge of plant stress physiology and facilitated the design of resilient crop varieties.Despite these advances,the integration of immune signals under simultaneous biotic and abiotic stress remains poorly understood,particularly at tissue-specific and cellular levels.Additionally,practical challenges persist in delivery methods,regulatory hurdles,and long-term field validation.With the escalation of climate change,understanding the complex crosstalk between stress signalling pathways is essential formaintaining sustainable agriculture and global food security.Future directions point toward real-time monitoring tools,such as single-cell omics and spatial transcriptomics,to fine-tune immune responses and support precision crop improvement.展开更多
This research examines the dynamics of a cosh-Gaussian laser pulse travelling through a vacuum and its impact on electron acceleration. We examine the impact of several critical factors, such as laser electric field a...This research examines the dynamics of a cosh-Gaussian laser pulse travelling through a vacuum and its impact on electron acceleration. We examine the impact of several critical factors, such as laser electric field amplitude, decentered parameter, beam waist, and laser chirp parameter, on the energy gain of electrons using coupled momentum equations. Our results indicate that the energy acquisition of electrons escalates with the amplitude of the laser electric field, decentered parameter, and chirp parameter. An appropriate beam waist is essential for attaining energyefficient electron acceleration in a vacuum. Through the optimization of these parameters, we get a maximum electron energy gain of 2.80 Ge V. This study highlights the significance of customized laser pulse attributes in improving electron acceleration and aids in the progression of high-energy particle physics.展开更多
The fabrication of bifunctional electrocatalysts for hydrogen and oxygen evolution in aqueous environment has far-reaching significance.Especially,reasonable interface process regulation toward heterogeneous composite...The fabrication of bifunctional electrocatalysts for hydrogen and oxygen evolution in aqueous environment has far-reaching significance.Especially,reasonable interface process regulation toward heterogeneous composites can make full use of the active sites and improve the electrocatalytic activity.In this study,we designed and synthesized NiS_(2)-MoS_(2)-based heterogeneous composites as efficient and stable electrocatalysts for hydrogen and oxygen evolution in alkaline electrolyte.The heterostructure was obtained by one-step hydrothermal ulfurization operation towards polymolybdate-based metal-organic complex.The composition and nanostructures can be tailored by modulating experiment parameter,realizing the phase-controlled synthesis and interface regulation:(1)High-percentage of 1T-MoS_(2)can be achieved via selecting appropriate vulcanization time and thiourea concentration,benifiting for the higher electroconductivity and more active sites;(2)Regular and orderly vulcanization time promotes the gradual growth and aggregation of nanosheets;(3)The existence of nickel hydroxide improves the electrocatalytic stability for oxygen production performance.The optimized heterogeneous interfaces provide sufficient active sites and accelerate electron transfer.Consequently,the optimal heterogeneous nanosheets present low overpotentials of 33 and 122 m V at the catalytic current densities of 10 m A/cm2for HER and OER,respectively.展开更多
BACKGROUND Giant coronary artery aneurysms(CAA),entailing thrombosis,myocardial infarction,and sudden death,are the most severe and life-threatening complications of Kawasaki disease(KD).Giant aneurysms rarely regress...BACKGROUND Giant coronary artery aneurysms(CAA),entailing thrombosis,myocardial infarction,and sudden death,are the most severe and life-threatening complications of Kawasaki disease(KD).Giant aneurysms rarely regress and can later transform into stenoses.Data on dynamic follow-up are scarce in the literature.AIM To evaluate clinical features and long-term outcomes of giant CAA in children with KD.METHODS A single-center retrospective study included data from patients with KD and giant CAA in the Irkutsk region(2012-2023).CAA criteria according to the American Heart Association guidelines of 2017 were used:(1)Dilated coronary artery with diameter Z-score>2 standard deviations(SD)but<2.5 SD;(2)Small CAA with Z-score>2.5 SD but<5 SD;(3)Medium CAA with Z-score>5 SD but<10 SD;and(4)Giant CAA with Z-score>10 SD or≥8 mm.RESULTS The mean age of children with coronary dilatation/aneurysms was 2.5 years,and the male-to-female ratio was 3:1.Patients with giant/medium CAA had symptoms of cerebral dysfunction more often compared with children with moderate(Z-score<5 SD but>2.0 SD)coronary dilatation(62.0%vs 21.0%,P=0.019).Major cardiovascular events(myocardial infarction,coronary artery bypass grafting,acute coronary syndrome,ischemic cardiomyopathy,left ventricular aneurysm,and giant extracardiac aneurysm)occurred in 55.5%of patients who had giant CAA.At follow-up the complete regression of giant/medium CAA was observed in 58.0%and partial regression in 42.0%after a mean of 2.3 and 5.5 years,respectively.All thrombi detected by echocardiography,CT,and angiography in giant/medium CAA disappeared between 1 year and 5 years(mean:15 months).All patients survived.CONCLUSION Risk factors for giant CAA were male sex,early age,and cerebral dysfunction.Complete regression of giant coronary aneurysms occurred in 58.0%of patients after follow-up of 2.3 years.展开更多
Wheat fungal infections pose a danger to the grain quality and crop productivity.Thus,prompt and precise diagnosis is essential for efficient crop management.This study used the WFD2020 image dataset,which is availabl...Wheat fungal infections pose a danger to the grain quality and crop productivity.Thus,prompt and precise diagnosis is essential for efficient crop management.This study used the WFD2020 image dataset,which is available to everyone,to look into howdeep learningmodels could be used to find powdery mildew,leaf rust,and yellow rust,which are three common fungal diseases in Punjab,India.We changed a few hyperparameters to test TensorFlowbased models,such as SSD and Faster R-CNN with ResNet50,ResNet101,and ResNet152 as backbones.Faster R-CNN with ResNet50 achieved amean average precision(mAP)of 0.68 among these models.We then used the PyTorch-based YOLOv8 model,which significantly outperformed the previous methods with an impressive mAP of 0.99.YOLOv8 proved to be a beneficial approach for the early-stage diagnosis of fungal diseases,especially when it comes to precisely identifying diseased areas and various object sizes in images.Problems,such as class imbalance and possible model overfitting,persisted despite these developments.The results show that YOLOv8 is a good automated disease diagnosis tool that helps farmers quickly find and treat fungal infections using image-based systems.展开更多
Purpose: This study aimed to investigate the immediate effects of optokinetic stimulation (OKS) using virtual reality (VR) on visual dependency and sensory reweighting in postural control during static standing. Speci...Purpose: This study aimed to investigate the immediate effects of optokinetic stimulation (OKS) using virtual reality (VR) on visual dependency and sensory reweighting in postural control during static standing. Specifically, it examined whether VR-based OKS could reduce visual dependency more effectively than visual deprivation through eye closure. Methods: Ten healthy adults participated in this study. A balance function meter was used to measure postural stability, including Romberg ratios before and after two conditions: VR-based OKS (VR + OKS) and eye closure (EC). Participants performed a two-minute standing task under each condition in random order, with adequate rest between tasks. In the VR + OKS condition, a smartphone-based VR headset presented a rotational OKS, while in the EC condition, participants stood with their eyes closed. Statistical analyses were conducted using paired t-tests to compare pre- and post-task Romberg ratios. Results: No significant differences were observed in the pre-task Romberg ratios between conditions. After the VR + OKS condition, significant reductions in Romberg A and Romberg V were observed. In contrast, no significant changes were noted in Romberg ratios after the EC condition. Conclusion: VR-based OKS significantly reduced visual dependency, as indicated by decreased Romberg ratios, suggesting its potential to facilitate sensory reweighting during postural control. These findings highlight the utility of low-cost VR devices in balance rehabilitation for conditions involving high visual dependency. Future studies should expand on this preliminary research by including larger sample sizes and diverse populations to confirm its clinical applicability.展开更多
A recent study in World Journal of Hepatology examined the use of intravascular ultrasound(IVUS)for transjugular intrahepatic portosystemic shunt(TIPS)creation.The study concluded that IVUS significantly reduces proce...A recent study in World Journal of Hepatology examined the use of intravascular ultrasound(IVUS)for transjugular intrahepatic portosystemic shunt(TIPS)creation.The study concluded that IVUS significantly reduces procedure time,radiation exposure,and the number of needle passes compared to conventional fluoroscopic guidance.IVUS offers real-time visualization of the portal vein,but challenges remain in terms of equipment costs and the operator learning curve.TIPS creation techniques vary widely in clinical practice,where methods,such as conventional fluoroscopy,three-dimensional image fusion,electromagnetic navigation,and IVUS,are commonly employed.In this editorial,we provide a comparative analysis of these methods based on clinical experience and the literature.By evaluating the strengths and limitations of each technique,we aim to inform clinical decision-making and enhance procedural outcomes.Future developments in TIPS creation are likely to focus on hybrid techniques that combine the strengths of IVUS,electromagnetic navigation,and real-time image fusion,potentially leading to more precise,cost-effective,and accessible methods.展开更多
The whole concept and relative value of nuclear energy is being reassessed against the juxtaposed background of climate change induced by global warming versus the imperatives of international energy security.This res...The whole concept and relative value of nuclear energy is being reassessed against the juxtaposed background of climate change induced by global warming versus the imperatives of international energy security.This research focuses on the new trends and developments of nuclear energy against the guidelines being set for attaining carbon neutrality and the demands for energy security.展开更多
AIM:To measure the contrast sensitivity(CS)using computer-based Chart2020 software pre-and post-white light exposure with and without blue-blocking lenses(BBLs).METHODS:The study included participants aged 18 to 25y(n...AIM:To measure the contrast sensitivity(CS)using computer-based Chart2020 software pre-and post-white light exposure with and without blue-blocking lenses(BBLs).METHODS:The study included participants aged 18 to 25y(n=30 eyes),where baseline CS was measured before the experiment.Following this,the participants were exposed to two white light-emitting diodes(LEDs;450 lx each),placed at a 45-degree angle from the participant’s eye and 80 cm from the light source.All participants were randomly divided into three groups(BBL1-Placebo lens,BBL2-Crizal Prevencia,BBL3-Duravision)by sequential randomisation,which was double-blinded.Post-light exposure,the CS was measured monocularly with a calibrated computer-based CS Chart-2020 software at different log units.RESULTS:CS measured using Chart-2020 software at 0.8,1.5,6,12,and 18 cpd pre-and post-white LED exposure with and without BBLs showed a significant difference(P<0.05)in contrast threshold and log contrast at 6 cpd and 18 cpd(P<0.05)and showed no significant differences in 0.8,1.5,12 cpd(P>0.05).CONCLUSION:This study shows that exposure to white LEDs can diminish CS,while BBLs may ameliorate these negative effects.展开更多
In integrated circuit packaging,thermal interface materials(TIMs)must exhibit high thermal conductivity and electrical resistivity to prevent short circuits,enhance reliability,and ensure safety in high-voltage applic...In integrated circuit packaging,thermal interface materials(TIMs)must exhibit high thermal conductivity and electrical resistivity to prevent short circuits,enhance reliability,and ensure safety in high-voltage applications.We proposed the thermal-percolation electrical-resistive TIM incorporating binary fillers of both insulating and metallic nanowires with an orientation in the insulating polymer matrix.High thermal conductivity can be achieved through thermal percolation,while electrical non-conductivity is preserved by carefully controlling the electrical percolation threshold through metallic nanowire orientation.The electrical conductivity of the composite can be further regulated by adjusting the orientation and aspect ratio of the metallic fillers.A thermal conductivity of 10 W·m^(-1)·K^(-1)is achieved,with electrical non-conductive behavior preserved.This approach offers a pathway to realizing“thermal-percolation electrical-resistive”in hybrid TIMs,providing a strategic framework for designing high-performance TIMs.展开更多
Livestock transportation is a key factor that contributes to the spatial spread of brucellosis.To analyze the impact of sheep transportation on brucellosis transmission,we develop a human–sheep coupled brucellosis mo...Livestock transportation is a key factor that contributes to the spatial spread of brucellosis.To analyze the impact of sheep transportation on brucellosis transmission,we develop a human–sheep coupled brucellosis model within a metapopulation network framework.Theoretically,we examine the positively invariant set,the basic reproduction number,the existence,uniqueness,and stability of disease-free equilibrium and the existence of the endemic equilibrium of the model.For practical application,using Heilongjiang province as a case study,we simulate brucellosis transmission across 12 cities based on data using three network types:the BA network,the ER network,and homogeneous mixing network.The simulation results indicate that the network's average degree plays a role in the spread of brucellosis.For BA and ER networks,the basic reproduction number and cumulative incidence of brucellosis stabilize when the network's average degree reaches 4 or 5.In contrast,sheep transport in a homogeneous mixing network accelerates the cross-regional spread of brucellosis,whereas transportation in a BA network helps to control it effectively.Furthermore,the findings suggest that the movement of sheep is not always detrimental to controlling the spread of brucellosis.For cities with smaller sheep populations,such as Shuangyashan and Qitaihe,increasing the transport of sheep outward amplifies the spatial spread of the disease.In contrast,in cities with larger sheep populations,such as Qiqihar,Daqing,and Suihua,moderate sheep outflow can help reduce the spread.In addition,cities with large livestock populations play a dominant role in the overall transmission dynamics,underscoring the need for stricter supervision in these areas.展开更多
Next-generation 6G networks seek to provide ultra-reliable and low-latency communications,necessitating network designs that are intelligent and adaptable.Network slicing has developed as an effective option for resou...Next-generation 6G networks seek to provide ultra-reliable and low-latency communications,necessitating network designs that are intelligent and adaptable.Network slicing has developed as an effective option for resource separation and service-level differentiation inside virtualized infrastructures.Nonetheless,sustaining elevated Quality of Service(QoS)in dynamic,resource-limited systems poses significant hurdles.This study introduces an innovative packet-based proactive end-to-end(ETE)resource management system that facilitates network slicing with improved resilience and proactivity.To get around the drawbacks of conventional reactive systems,we develop a cost-efficient slice provisioning architecture that takes into account limits on radio,processing,and transmission resources.The optimization issue is non-convex,NP-hard,and requires online resolution in a dynamic setting.We offer a hybrid solution that integrates an advanced Deep Reinforcement Learning(DRL)methodology with an Improved Manta-Ray Foraging Optimization(ImpMRFO)algorithm.The ImpMRFO utilizes Chebyshev chaotic mapping for the formation of a varied starting population and incorporates Lévy flight-based stochastic movement to avert premature convergence,hence facilitating improved exploration-exploitation trade-offs.The DRL model perpetually acquires optimum provisioning strategies via agent-environment interactions,whereas the ImpMRFO enhances policy performance for effective slice provisioning.The solution,developed in Python,is evaluated across several 6G slicing scenarios that include varied QoS profiles and traffic requirements.The DRL model perpetually acquires optimum provisioning methods via agent-environment interactions,while the ImpMRFO enhances policy performance for effective slice provisioning.The solution,developed in Python,is evaluated across several 6G slicing scenarios that include varied QoS profiles and traffic requirements.Experimental findings reveal that the proactive ETE system outperforms DRL models and non-resilient provisioning techniques.Our technique increases PSSRr,decreases average latency,and optimizes resource use.These results demonstrate that the hybrid architecture for robust,real-time,and scalable slice management in future 6G networks is feasible.展开更多
文摘The purpose of this paper is to explore the effectiveness of the Qinglan Project in promoting the professional growth of young secondary vocational teachers.Through the empirical analysis of the implementation process and effect,this paper finds that the Qinglan Project has a positive impact on the professional development of secondary vocational teachers,with a view to providing a guideline for the development of secondary vocational education.
文摘According to several researches and survey findings, violence and the threat of violence are increasingly present at workplaces in the field of healthcare. In 2011, the Finnish Union of Health and Social Care Professionals--Tehy implemented a poster campaign targeted at the users of healthcare services, as well as healthcare staff. Representatives of local trade unions, as well as safety representatives, reported that the campaign was relevant. Most employers had a favorable attitude toward distributing campaign posters at the workplace. Raising this issue, which increases the mental burden of work and risks occupational safety at the workplace, helps to achieve improvements. Following the poster campaign, Tehy conducted an electronic survey in early 2012 about the impacts of the campaign among representatives of local trade unions （N= 279） and safety representatives （N = 278）. The campaign resulted in some working environment improvements, as well as an increase in reporting situations involving violence. On a more worrying note, the provision of workplace-level training on managing violent situations did not increase.
基金United Arab Emirates University,Grant/Award Number:12R104 and 12R121。
文摘Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extracellular matrix proteins,mainly collagen in the cardiac interstitium.Many experimental studies have demonstrated that fibrotic injury in the heart is reversible;therefore,it is vital to understand differ-ent molecular mechanisms that are involved in the initiation,progression,and resolu-tion of cardiac fibrosis to enable the development of antifibrotic agents.Of the many experimental models,one of the recent models that has gained renewed interest is isoproterenol(ISP)-induced cardiac fibrosis.ISP is a synthetic catecholamine,sympa-thomimetic,and nonselectiveβ-adrenergic receptor agonist.The overstimulated and sustained activation ofβ-adrenergic receptors has been reported to induce biochemi-cal and physiological alterations and ultimately result in cardiac remodeling.ISP has been used for decades to induce acute myocardial infarction.However,the use of low doses and chronic administration of ISP have been shown to induce cardiac fibrosis;this practice has increased in recent years.Intraperitoneal or subcutaneous ISP has been widely used in preclinical studies to induce cardiac remodeling manifested by fibrosis and hypertrophy.The induced oxidative stress with subsequent perturbations in cellular signaling cascades through triggering the release of free radicals is consid-ered the initiating mechanism of myocardial fibrosis.ISP is consistently used to induce fibrosis in laboratory animals and in cardiomyocytes isolated from animals.In recent years,numerous phytochemicals and synthetic molecules have been evaluated in ISP-induced cardiac fibrosis.The present review exclusively provides a comprehensive summary of the pathological biochemical,histological,and molecular mechanisms of ISP in inducing cardiac fibrosis and hypertrophy.It also summarizes the application of this experimental model in the therapeutic evaluation of natural as well as syn-thetic compounds to demonstrate their potential in mitigating myocardial fibrosis and hypertrophy.
文摘I applaud Adekeye AP and the journal for publishing‘Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention’.It is important to draw attention to newly recognised uses of substances which might alter perception,mood,and/or behaviour.
文摘Metabolic syndrome(MetS)is a cluster of risk factors that significantly increase the chances of developing heart disease,type 2 diabetes mellitus,stroke,and other cardiovascular complications.Since current anti-MetS medications like statins,angiotensin-converting enzyme inhibitors,β-blockers,insulin sensitizers and diuretics have been reported to cause unwanted side effects,researchers are exploring promising alternatives.One such alternative relies on the potential of spices and condiments,which have a long history of use in traditional medicine.Among them,Cinnamomum zeylanicum Blume stands out as a popular spice worldwide for its unique taste,aroma,and delicate sweetness compared to other cinnamon varieties.This narrative review aims to summarize the in vivo and clinical evidence concerning the efficacy of C.zeylanicum against MetS indices.Relevant articles from PubMed,Scopus and Google scholar databases were reviewed.In vivo results suggested that C.zeylanicum preparations(extracts,essential oil,crude powder,bioactive compounds,and biosynthesized nanoparticles)were remarkably efficient in ameliorating MetS indices,while the clinical data were less and with several methodological limitations.Further robust clinical studies are warranted to definitively establish C.zeylanicum as a promising functional food for mitigating MetS,potentially leading to its dietary integration as a natural approach to improve metabolic health.
文摘Background Diet plays a crucial role in insulin resistance and diabetes,with high-fat and high-carbohydrate diets being major contributors.However,the type of fat consumed is critical,as different fatty acids impact insulin sensitivity differently.Objective This review examines the potential benefits of avocado oil,which is rich in monounsaturated fatty acids(MUFAs),in improving glycaemic control and lipid metabolism.It also explores variations in avocado oil composition across different avocado cultivars.Methods Experimental and clinical studies were analysed to assess the metabolic effects of avocado oil.The impact of MUFAs on insulin sensitivity,lipid profiles,and metabolic health was reviewed,alongside the influence of fruit quality,maturity,and cultivar differences.Results Avocado oil may enhance glycaemic control and lipid metabolism,benefiting individuals with diabetes and hyper-cholesterolemia.However,its composition varies significantly across avocado variants such as Hass,Reed,Ettinger,and Fuerte,influencing its therapeutic properties.Conclusion Avocado oil's high MUFA content offers promising metabolic benefits.Further research is needed to standardize its therapeutic application,considering cultivar-dependent variations in composition.
文摘To address the global issue of climate change and create focused mitigation plans,accurate CO_(2)emissions forecasting is essential.Using CO_(2)emissions data from 1990 to 2023,this study assesses the predicting performance of five sophisticated models:Random Forest(RF),XGBoost,Support Vector Regression(SVR),Long Short-Term Memory networks(LSTM),and ARIMA To give a thorough evaluation of the models’performance,measures including Mean Absolute Error(MAE),Root Mean Square Error(RMSE),and Mean Absolute Percentage Error(MAPE)are used.To guarantee dependable model implementation,preprocessing procedures are carried out,such as feature engineering and stationarity tests.Machine learning models outperform ARIMA in identifying complex patterns and long-term associations,but ARIMA does better with data that exhibits strong linear trends.These results provide important information about how well the model fits various forecasting scenarios,which helps develop data-driven carbon reduction programs.Predictive modeling should be incorporated into sustainable climate policy to encourage the adoption of low-carbon technologies and proactive decisionmaking.Achieving long-term environmental sustainability requires strengthening carbon trading systems,encouraging clean energy investments,and enacting stronger emission laws.In line with international climate goals,suggestions for lowering CO_(2)emissions include switching to renewable energy,increasing energy efficiency,and putting afforestation initiatives into action.
文摘Plants are under constant exposure to varied biotic and abiotic stresses,which significantly affect their growth,productivity,and survival.Biotic stress,caused by pathogens,and abiotic stress,including drought,salinity,extreme temperatures,and heavy metals,activate overlapping yet distinct immune pathways.These are comprised of morphological barriers,hormonal signaling,and the induction of stress-responsive genes through complex pathways mediated by reactive oxygen species(ROS),phytohormones,and secondary metabolites.Abiotic stress triggers organelle-mediated retrograde signaling from organelles like chloroplasts and mitochondria,which causes unfolded protein responses and the regulation of cellular homeostasis.Simultaneously,biotic stress activates both PAMP-triggered immunity(PTI)and effector-triggered immunity(ETI),mediated by salicylic acid(SA),jasmonic acid(JA),and ethylene(ET).This review aims to provide an integrated overview of plant immune responses tomultiple stressors,with emphasis on molecular crosstalk and recent technological interventions.A systematic literature search was conducted using the Scopus database,covering studies published between 2010 and 2025.Advances in CRISPR-Cas genome editing,RNA interference,omics technologies,nanotechnology,and artificial intelligence have improved our knowledge of plant stress physiology and facilitated the design of resilient crop varieties.Despite these advances,the integration of immune signals under simultaneous biotic and abiotic stress remains poorly understood,particularly at tissue-specific and cellular levels.Additionally,practical challenges persist in delivery methods,regulatory hurdles,and long-term field validation.With the escalation of climate change,understanding the complex crosstalk between stress signalling pathways is essential formaintaining sustainable agriculture and global food security.Future directions point toward real-time monitoring tools,such as single-cell omics and spatial transcriptomics,to fine-tune immune responses and support precision crop improvement.
文摘This research examines the dynamics of a cosh-Gaussian laser pulse travelling through a vacuum and its impact on electron acceleration. We examine the impact of several critical factors, such as laser electric field amplitude, decentered parameter, beam waist, and laser chirp parameter, on the energy gain of electrons using coupled momentum equations. Our results indicate that the energy acquisition of electrons escalates with the amplitude of the laser electric field, decentered parameter, and chirp parameter. An appropriate beam waist is essential for attaining energyefficient electron acceleration in a vacuum. Through the optimization of these parameters, we get a maximum electron energy gain of 2.80 Ge V. This study highlights the significance of customized laser pulse attributes in improving electron acceleration and aids in the progression of high-energy particle physics.
基金financially supported by the National Natural Science Foundation of China(Nos.22271021,21971024)Liao Ning Revitalization Talents Program(No.XLYC1902011)Research Foundation of Education Bureau of Liaoning Province(No.LJKQZ20222290)。
文摘The fabrication of bifunctional electrocatalysts for hydrogen and oxygen evolution in aqueous environment has far-reaching significance.Especially,reasonable interface process regulation toward heterogeneous composites can make full use of the active sites and improve the electrocatalytic activity.In this study,we designed and synthesized NiS_(2)-MoS_(2)-based heterogeneous composites as efficient and stable electrocatalysts for hydrogen and oxygen evolution in alkaline electrolyte.The heterostructure was obtained by one-step hydrothermal ulfurization operation towards polymolybdate-based metal-organic complex.The composition and nanostructures can be tailored by modulating experiment parameter,realizing the phase-controlled synthesis and interface regulation:(1)High-percentage of 1T-MoS_(2)can be achieved via selecting appropriate vulcanization time and thiourea concentration,benifiting for the higher electroconductivity and more active sites;(2)Regular and orderly vulcanization time promotes the gradual growth and aggregation of nanosheets;(3)The existence of nickel hydroxide improves the electrocatalytic stability for oxygen production performance.The optimized heterogeneous interfaces provide sufficient active sites and accelerate electron transfer.Consequently,the optimal heterogeneous nanosheets present low overpotentials of 33 and 122 m V at the catalytic current densities of 10 m A/cm2for HER and OER,respectively.
文摘BACKGROUND Giant coronary artery aneurysms(CAA),entailing thrombosis,myocardial infarction,and sudden death,are the most severe and life-threatening complications of Kawasaki disease(KD).Giant aneurysms rarely regress and can later transform into stenoses.Data on dynamic follow-up are scarce in the literature.AIM To evaluate clinical features and long-term outcomes of giant CAA in children with KD.METHODS A single-center retrospective study included data from patients with KD and giant CAA in the Irkutsk region(2012-2023).CAA criteria according to the American Heart Association guidelines of 2017 were used:(1)Dilated coronary artery with diameter Z-score>2 standard deviations(SD)but<2.5 SD;(2)Small CAA with Z-score>2.5 SD but<5 SD;(3)Medium CAA with Z-score>5 SD but<10 SD;and(4)Giant CAA with Z-score>10 SD or≥8 mm.RESULTS The mean age of children with coronary dilatation/aneurysms was 2.5 years,and the male-to-female ratio was 3:1.Patients with giant/medium CAA had symptoms of cerebral dysfunction more often compared with children with moderate(Z-score<5 SD but>2.0 SD)coronary dilatation(62.0%vs 21.0%,P=0.019).Major cardiovascular events(myocardial infarction,coronary artery bypass grafting,acute coronary syndrome,ischemic cardiomyopathy,left ventricular aneurysm,and giant extracardiac aneurysm)occurred in 55.5%of patients who had giant CAA.At follow-up the complete regression of giant/medium CAA was observed in 58.0%and partial regression in 42.0%after a mean of 2.3 and 5.5 years,respectively.All thrombi detected by echocardiography,CT,and angiography in giant/medium CAA disappeared between 1 year and 5 years(mean:15 months).All patients survived.CONCLUSION Risk factors for giant CAA were male sex,early age,and cerebral dysfunction.Complete regression of giant coronary aneurysms occurred in 58.0%of patients after follow-up of 2.3 years.
基金supported by Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2025R432),Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
文摘Wheat fungal infections pose a danger to the grain quality and crop productivity.Thus,prompt and precise diagnosis is essential for efficient crop management.This study used the WFD2020 image dataset,which is available to everyone,to look into howdeep learningmodels could be used to find powdery mildew,leaf rust,and yellow rust,which are three common fungal diseases in Punjab,India.We changed a few hyperparameters to test TensorFlowbased models,such as SSD and Faster R-CNN with ResNet50,ResNet101,and ResNet152 as backbones.Faster R-CNN with ResNet50 achieved amean average precision(mAP)of 0.68 among these models.We then used the PyTorch-based YOLOv8 model,which significantly outperformed the previous methods with an impressive mAP of 0.99.YOLOv8 proved to be a beneficial approach for the early-stage diagnosis of fungal diseases,especially when it comes to precisely identifying diseased areas and various object sizes in images.Problems,such as class imbalance and possible model overfitting,persisted despite these developments.The results show that YOLOv8 is a good automated disease diagnosis tool that helps farmers quickly find and treat fungal infections using image-based systems.
文摘Purpose: This study aimed to investigate the immediate effects of optokinetic stimulation (OKS) using virtual reality (VR) on visual dependency and sensory reweighting in postural control during static standing. Specifically, it examined whether VR-based OKS could reduce visual dependency more effectively than visual deprivation through eye closure. Methods: Ten healthy adults participated in this study. A balance function meter was used to measure postural stability, including Romberg ratios before and after two conditions: VR-based OKS (VR + OKS) and eye closure (EC). Participants performed a two-minute standing task under each condition in random order, with adequate rest between tasks. In the VR + OKS condition, a smartphone-based VR headset presented a rotational OKS, while in the EC condition, participants stood with their eyes closed. Statistical analyses were conducted using paired t-tests to compare pre- and post-task Romberg ratios. Results: No significant differences were observed in the pre-task Romberg ratios between conditions. After the VR + OKS condition, significant reductions in Romberg A and Romberg V were observed. In contrast, no significant changes were noted in Romberg ratios after the EC condition. Conclusion: VR-based OKS significantly reduced visual dependency, as indicated by decreased Romberg ratios, suggesting its potential to facilitate sensory reweighting during postural control. These findings highlight the utility of low-cost VR devices in balance rehabilitation for conditions involving high visual dependency. Future studies should expand on this preliminary research by including larger sample sizes and diverse populations to confirm its clinical applicability.
基金Supported by National Natural Science Foundation of China,No.82330061The PUMC Graduate Curriculum Informatization Development Special Fund Project,No.2024YXX004The CAMS Initiative for Innovative Medicine,No.2021-I2M-1-015.
文摘A recent study in World Journal of Hepatology examined the use of intravascular ultrasound(IVUS)for transjugular intrahepatic portosystemic shunt(TIPS)creation.The study concluded that IVUS significantly reduces procedure time,radiation exposure,and the number of needle passes compared to conventional fluoroscopic guidance.IVUS offers real-time visualization of the portal vein,but challenges remain in terms of equipment costs and the operator learning curve.TIPS creation techniques vary widely in clinical practice,where methods,such as conventional fluoroscopy,three-dimensional image fusion,electromagnetic navigation,and IVUS,are commonly employed.In this editorial,we provide a comparative analysis of these methods based on clinical experience and the literature.By evaluating the strengths and limitations of each technique,we aim to inform clinical decision-making and enhance procedural outcomes.Future developments in TIPS creation are likely to focus on hybrid techniques that combine the strengths of IVUS,electromagnetic navigation,and real-time image fusion,potentially leading to more precise,cost-effective,and accessible methods.
文摘The whole concept and relative value of nuclear energy is being reassessed against the juxtaposed background of climate change induced by global warming versus the imperatives of international energy security.This research focuses on the new trends and developments of nuclear energy against the guidelines being set for attaining carbon neutrality and the demands for energy security.
文摘AIM:To measure the contrast sensitivity(CS)using computer-based Chart2020 software pre-and post-white light exposure with and without blue-blocking lenses(BBLs).METHODS:The study included participants aged 18 to 25y(n=30 eyes),where baseline CS was measured before the experiment.Following this,the participants were exposed to two white light-emitting diodes(LEDs;450 lx each),placed at a 45-degree angle from the participant’s eye and 80 cm from the light source.All participants were randomly divided into three groups(BBL1-Placebo lens,BBL2-Crizal Prevencia,BBL3-Duravision)by sequential randomisation,which was double-blinded.Post-light exposure,the CS was measured monocularly with a calibrated computer-based CS Chart-2020 software at different log units.RESULTS:CS measured using Chart-2020 software at 0.8,1.5,6,12,and 18 cpd pre-and post-white LED exposure with and without BBLs showed a significant difference(P<0.05)in contrast threshold and log contrast at 6 cpd and 18 cpd(P<0.05)and showed no significant differences in 0.8,1.5,12 cpd(P>0.05).CONCLUSION:This study shows that exposure to white LEDs can diminish CS,while BBLs may ameliorate these negative effects.
基金supported by the National Key R&D Program(Grant No.2022YFA1203-100)sponsorship by Shanghai Sailing Program(Grant No.24YF2713800)+2 种基金financial support from the Local College Capacity Building Project of Shanghai Municipal Science and Technology Commission(Grant No.20010500700)the Natural Science Foundation of Shanghai(Grant No.23ZR1424300)Shanghai Shuguang Program(Grant No.22SG56)。
文摘In integrated circuit packaging,thermal interface materials(TIMs)must exhibit high thermal conductivity and electrical resistivity to prevent short circuits,enhance reliability,and ensure safety in high-voltage applications.We proposed the thermal-percolation electrical-resistive TIM incorporating binary fillers of both insulating and metallic nanowires with an orientation in the insulating polymer matrix.High thermal conductivity can be achieved through thermal percolation,while electrical non-conductivity is preserved by carefully controlling the electrical percolation threshold through metallic nanowire orientation.The electrical conductivity of the composite can be further regulated by adjusting the orientation and aspect ratio of the metallic fillers.A thermal conductivity of 10 W·m^(-1)·K^(-1)is achieved,with electrical non-conductive behavior preserved.This approach offers a pathway to realizing“thermal-percolation electrical-resistive”in hybrid TIMs,providing a strategic framework for designing high-performance TIMs.
基金Project supported by the National Natural Science Foundation of China(Grant No.12101443,12371493)the Natural Science Foundation of Shanxi Province(Grant Nos.20210302124260 and 202303021221024)。
文摘Livestock transportation is a key factor that contributes to the spatial spread of brucellosis.To analyze the impact of sheep transportation on brucellosis transmission,we develop a human–sheep coupled brucellosis model within a metapopulation network framework.Theoretically,we examine the positively invariant set,the basic reproduction number,the existence,uniqueness,and stability of disease-free equilibrium and the existence of the endemic equilibrium of the model.For practical application,using Heilongjiang province as a case study,we simulate brucellosis transmission across 12 cities based on data using three network types:the BA network,the ER network,and homogeneous mixing network.The simulation results indicate that the network's average degree plays a role in the spread of brucellosis.For BA and ER networks,the basic reproduction number and cumulative incidence of brucellosis stabilize when the network's average degree reaches 4 or 5.In contrast,sheep transport in a homogeneous mixing network accelerates the cross-regional spread of brucellosis,whereas transportation in a BA network helps to control it effectively.Furthermore,the findings suggest that the movement of sheep is not always detrimental to controlling the spread of brucellosis.For cities with smaller sheep populations,such as Shuangyashan and Qitaihe,increasing the transport of sheep outward amplifies the spatial spread of the disease.In contrast,in cities with larger sheep populations,such as Qiqihar,Daqing,and Suihua,moderate sheep outflow can help reduce the spread.In addition,cities with large livestock populations play a dominant role in the overall transmission dynamics,underscoring the need for stricter supervision in these areas.
文摘Next-generation 6G networks seek to provide ultra-reliable and low-latency communications,necessitating network designs that are intelligent and adaptable.Network slicing has developed as an effective option for resource separation and service-level differentiation inside virtualized infrastructures.Nonetheless,sustaining elevated Quality of Service(QoS)in dynamic,resource-limited systems poses significant hurdles.This study introduces an innovative packet-based proactive end-to-end(ETE)resource management system that facilitates network slicing with improved resilience and proactivity.To get around the drawbacks of conventional reactive systems,we develop a cost-efficient slice provisioning architecture that takes into account limits on radio,processing,and transmission resources.The optimization issue is non-convex,NP-hard,and requires online resolution in a dynamic setting.We offer a hybrid solution that integrates an advanced Deep Reinforcement Learning(DRL)methodology with an Improved Manta-Ray Foraging Optimization(ImpMRFO)algorithm.The ImpMRFO utilizes Chebyshev chaotic mapping for the formation of a varied starting population and incorporates Lévy flight-based stochastic movement to avert premature convergence,hence facilitating improved exploration-exploitation trade-offs.The DRL model perpetually acquires optimum provisioning strategies via agent-environment interactions,whereas the ImpMRFO enhances policy performance for effective slice provisioning.The solution,developed in Python,is evaluated across several 6G slicing scenarios that include varied QoS profiles and traffic requirements.The DRL model perpetually acquires optimum provisioning methods via agent-environment interactions,while the ImpMRFO enhances policy performance for effective slice provisioning.The solution,developed in Python,is evaluated across several 6G slicing scenarios that include varied QoS profiles and traffic requirements.Experimental findings reveal that the proactive ETE system outperforms DRL models and non-resilient provisioning techniques.Our technique increases PSSRr,decreases average latency,and optimizes resource use.These results demonstrate that the hybrid architecture for robust,real-time,and scalable slice management in future 6G networks is feasible.
