Saccharide production is critical to the development of biotechnology in the field of food and biofuel.The extraction of saccharide from biomass-based hydrolysate mixtures has become a trend due to low cost and abunda...Saccharide production is critical to the development of biotechnology in the field of food and biofuel.The extraction of saccharide from biomass-based hydrolysate mixtures has become a trend due to low cost and abundant biomass reserves.Compared to conventional methods of fractionation and recovery of saccharides,nanofiltration(NF)has received considerable attention in recent decades because of its high selectivity and low energy consumption and environmental impact.In this review the advantages and challenges of NF based technology in the separation of saccharides are critically evaluated.Hybrid membrane processes,i.e.,combining NF with ultrafiltration,can complement each other to provide an efficient approach for removal of unwanted solutes to obtain higher purity saccharides.However,use of NF membrane separation technology is limited due to irreversible membrane fouling that results in high capital and operating costs.Future development of NF membrane technology should therefore focus on improving material stability,antifouling ability and saccharide targeting selectivity,as well as on engineering aspects such as process optimisation and membrane module design.展开更多
The domain of industrial biomanufacturing is enthusiastically embracing the concept of Digital Twin,owing to its promises of increased process efficiency and resource utilisation.However,Digital Twin in biomanufacturi...The domain of industrial biomanufacturing is enthusiastically embracing the concept of Digital Twin,owing to its promises of increased process efficiency and resource utilisation.However,Digital Twin in biomanufacturing is not yet clearly defined and this sector of the industry is falling behind the others in terms of its implementation.On the other hand,some of the benefits of Digital Twin seem to overlap with the more established practices of process control and optimization,and the term is vaguely used in different scenarios.In an attempt to clarify this issue,we investigate this overlap for the specific case of fermentation operation,a central step in many biomanufacturing processes.Based on this investigation,a framework built upon a five-step pathway starting from a basic steady-state process model is proposed to develop a fully-fledged Digital Twin.For demonstration purposes,the framework is applied to a bench-scale second-generation ethanol fermentation process as a case study.It is proposed that the success or failure of a fully-fledged Digital Twin implementation is determined by key factors that comprise the role of modelling,human operator actions,and other propositions of economic value.展开更多
基金Dr.X.Li thanks the European Union's Horizon 2020 Research and Innovation Program for funding under Marie Sklodowska-Curie Grant Agreement No.713683(COFUNDfellowsDTU).
文摘Saccharide production is critical to the development of biotechnology in the field of food and biofuel.The extraction of saccharide from biomass-based hydrolysate mixtures has become a trend due to low cost and abundant biomass reserves.Compared to conventional methods of fractionation and recovery of saccharides,nanofiltration(NF)has received considerable attention in recent decades because of its high selectivity and low energy consumption and environmental impact.In this review the advantages and challenges of NF based technology in the separation of saccharides are critically evaluated.Hybrid membrane processes,i.e.,combining NF with ultrafiltration,can complement each other to provide an efficient approach for removal of unwanted solutes to obtain higher purity saccharides.However,use of NF membrane separation technology is limited due to irreversible membrane fouling that results in high capital and operating costs.Future development of NF membrane technology should therefore focus on improving material stability,antifouling ability and saccharide targeting selectivity,as well as on engineering aspects such as process optimisation and membrane module design.
基金The work is funded by the Novo Nordisk Foundation in the frame of the‘Accelerated Innovation in Manufacturing Biologics’(AIMBio)project(Grant number NNF19SA0035474).
文摘The domain of industrial biomanufacturing is enthusiastically embracing the concept of Digital Twin,owing to its promises of increased process efficiency and resource utilisation.However,Digital Twin in biomanufacturing is not yet clearly defined and this sector of the industry is falling behind the others in terms of its implementation.On the other hand,some of the benefits of Digital Twin seem to overlap with the more established practices of process control and optimization,and the term is vaguely used in different scenarios.In an attempt to clarify this issue,we investigate this overlap for the specific case of fermentation operation,a central step in many biomanufacturing processes.Based on this investigation,a framework built upon a five-step pathway starting from a basic steady-state process model is proposed to develop a fully-fledged Digital Twin.For demonstration purposes,the framework is applied to a bench-scale second-generation ethanol fermentation process as a case study.It is proposed that the success or failure of a fully-fledged Digital Twin implementation is determined by key factors that comprise the role of modelling,human operator actions,and other propositions of economic value.
