In recent years, there has been a growing concern about potential impacts on public health and wellbeing due to exposure to environmental odour. Separation distances between odour-emitting sources and residential area...In recent years, there has been a growing concern about potential impacts on public health and wellbeing due to exposure to environmental odour. Separation distances between odour-emitting sources and residential areas can be calculated using dispersion models, as a means of protecting the neighbourhood from odour annoyance. This study investigates the suitability of using one single year of meteorological input data to calculate reliable direction-dependent separation distances. Accordingly, we assessed and quantified the inter-annual variability of separation distances at two sites with different meteorological conditions, one in Brazil and the other in Austria. A 5-year dataset of hourly meteorological observations was used for each site. Two odour impact criteria set in current regulations were selected to explore their effect on the separation distances. The coefficient of variation was used as a statistical measure to characterise the amount of annual variation. Overall,for all scenarios, the separation distances had a low degree of inter-annual variability(mean coefficient of variation values from 8% to 21%). Reasonable agreements from year to year were therefore observed at the two sites under investigation, showing that one year of meteorological data is a good compromise to achieve reliable accuracy. This finding can provide a more cost-effective solution to calculate separation distances in the vicinity of odour sources.展开更多
Technological development has led to the emergence of new substances with many different purposes generating a new profile of pollutants in waterways. Among these, endocrine disruptors, such as 17EE （17ct-ethinylestr...Technological development has led to the emergence of new substances with many different purposes generating a new profile of pollutants in waterways. Among these, endocrine disruptors, such as 17EE （17ct-ethinylestradiol）, are of great importance due to their wide application and harmful consequences to the environment, human health and animals. The inefficiency of most water treatment processes in withdrawing such substances poses a global concern for the development of effective and environmentally clean methods. The electrochemical remediation processes appear as a powerful and ＂green＂ alternative for waste removal of organic or inorganic pollutants from complex environments, such as geosphere and hydrosphere. The research focus in this field is mostly related to the optimization of electronic devices with higher （photo） catalytic efficiency, whereas the starting material remains based on metal and carbon conventional electrodes. In the present study, the anodic removal process of 17ct-ethinylestradiol at carbon cardboards was investigated in stationary and hydrodynamic conditions. The influence of pH and applied potential were evaluated, always taking into account the transposition of scale and environmental aspects. Thus, the principle of hormone removal showed to be strictly related to such parameters. It was observed that mild alkaline medium favors the anodic oxidation, whereas neutral and mild acid ones lead to higher adsorption at carbon surface. Also, when the applied potential was higher than 1.25 V, the electrochemical oxidation rate increased, and the adsorption was decreased. Furthermore, the removal efficiency of ! 7EE showed to be lower, the flow rate was higher.展开更多
The valorization of winery pomace,traditionally considered waste,offers a sustainable approach to harnessing its bioactive compounds.In this study,we investigated the antiproliferative potential of winery pomace extra...The valorization of winery pomace,traditionally considered waste,offers a sustainable approach to harnessing its bioactive compounds.In this study,we investigated the antiproliferative potential of winery pomace extract against thyroid cancer cells.An ultrasound-assisted extraction technique was employed to extract the bioactive compounds.The optimal conditions for this process were determined through a Rotational Central Composite Design(50℃,4 g/L solid-to-liquid ratio,40%ethanol concentration,and 79 W ultrasound power).The resulting extract demonstrated robust antioxidant activity,reflected in the elevated total phenolic content(TPC)and free radical scavenging ability.Furthermore,the effect of the extract on peripheral blood mononuclear cells(PBMCs)and TPC-1 cancer cells was assessed.PBMCs exposed to the extract at 10 mg/mL concentration exhibited enhanced viability,whereas cancer cells displayed concentration-dependent cytotoxic responses,indicating a selective anticancer effect.These findings underscore the potential of winery pomace extract as a natural antioxidant with promising anticancer properties,warranting further investigation for potential applications in cancer therapy.Moreover,to the best of the authors’knowledge,this work represents one of the first publications to demonstrate the potential of wine pomace extract to inhibit thyroid cancer cells.展开更多
基金supported by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior(CAPES,Ministry of Education,Brazil)within the Programa Geral de Cooperacao Internacional(PGCI)(No.88881.117633/2016-01)
文摘In recent years, there has been a growing concern about potential impacts on public health and wellbeing due to exposure to environmental odour. Separation distances between odour-emitting sources and residential areas can be calculated using dispersion models, as a means of protecting the neighbourhood from odour annoyance. This study investigates the suitability of using one single year of meteorological input data to calculate reliable direction-dependent separation distances. Accordingly, we assessed and quantified the inter-annual variability of separation distances at two sites with different meteorological conditions, one in Brazil and the other in Austria. A 5-year dataset of hourly meteorological observations was used for each site. Two odour impact criteria set in current regulations were selected to explore their effect on the separation distances. The coefficient of variation was used as a statistical measure to characterise the amount of annual variation. Overall,for all scenarios, the separation distances had a low degree of inter-annual variability(mean coefficient of variation values from 8% to 21%). Reasonable agreements from year to year were therefore observed at the two sites under investigation, showing that one year of meteorological data is a good compromise to achieve reliable accuracy. This finding can provide a more cost-effective solution to calculate separation distances in the vicinity of odour sources.
文摘Technological development has led to the emergence of new substances with many different purposes generating a new profile of pollutants in waterways. Among these, endocrine disruptors, such as 17EE （17ct-ethinylestradiol）, are of great importance due to their wide application and harmful consequences to the environment, human health and animals. The inefficiency of most water treatment processes in withdrawing such substances poses a global concern for the development of effective and environmentally clean methods. The electrochemical remediation processes appear as a powerful and ＂green＂ alternative for waste removal of organic or inorganic pollutants from complex environments, such as geosphere and hydrosphere. The research focus in this field is mostly related to the optimization of electronic devices with higher （photo） catalytic efficiency, whereas the starting material remains based on metal and carbon conventional electrodes. In the present study, the anodic removal process of 17ct-ethinylestradiol at carbon cardboards was investigated in stationary and hydrodynamic conditions. The influence of pH and applied potential were evaluated, always taking into account the transposition of scale and environmental aspects. Thus, the principle of hormone removal showed to be strictly related to such parameters. It was observed that mild alkaline medium favors the anodic oxidation, whereas neutral and mild acid ones lead to higher adsorption at carbon surface. Also, when the applied potential was higher than 1.25 V, the electrochemical oxidation rate increased, and the adsorption was decreased. Furthermore, the removal efficiency of ! 7EE showed to be lower, the flow rate was higher.
文摘The valorization of winery pomace,traditionally considered waste,offers a sustainable approach to harnessing its bioactive compounds.In this study,we investigated the antiproliferative potential of winery pomace extract against thyroid cancer cells.An ultrasound-assisted extraction technique was employed to extract the bioactive compounds.The optimal conditions for this process were determined through a Rotational Central Composite Design(50℃,4 g/L solid-to-liquid ratio,40%ethanol concentration,and 79 W ultrasound power).The resulting extract demonstrated robust antioxidant activity,reflected in the elevated total phenolic content(TPC)and free radical scavenging ability.Furthermore,the effect of the extract on peripheral blood mononuclear cells(PBMCs)and TPC-1 cancer cells was assessed.PBMCs exposed to the extract at 10 mg/mL concentration exhibited enhanced viability,whereas cancer cells displayed concentration-dependent cytotoxic responses,indicating a selective anticancer effect.These findings underscore the potential of winery pomace extract as a natural antioxidant with promising anticancer properties,warranting further investigation for potential applications in cancer therapy.Moreover,to the best of the authors’knowledge,this work represents one of the first publications to demonstrate the potential of wine pomace extract to inhibit thyroid cancer cells.
