Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily...Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily involving abnormal development and damage of the dopaminergic system,pose significant public health challenges.Microglia,as the primary immune cells in the brain,are crucial in regulating neuronal circuit development and survival.From the embryonic stage to adulthood,microglia exhibit stage-specific gene expression profiles,transcriptome characteristics,and functional phenotypes,enhancing the susceptibility to early life stress.However,the role of microglia in mediating dopaminergic system disorders under early life stress conditions remains poorly understood.This review presents an up-to-date overview of preclinical studies elucidating the impact of early life stress on microglia,leading to dopaminergic system disorders,along with the underlying mechanisms and therapeutic potential for neurodegenerative and neurodevelopmental conditions.Impaired microglial activity damages dopaminergic neurons by diminishing neurotrophic support(e.g.,insulin-like growth factor-1)and hinders dopaminergic axon growth through defective phagocytosis and synaptic pruning.Furthermore,blunted microglial immunoreactivity suppresses striatal dopaminergic circuit development and reduces neuronal transmission.Furthermore,inflammation and oxidative stress induced by activated microglia can directly damage dopaminergic neurons,inhibiting dopamine synthesis,reuptake,and receptor activity.Enhanced microglial phagocytosis inhibits dopamine axon extension.These long-lasting effects of microglial perturbations may be driven by early life stress–induced epigenetic reprogramming of microglia.Indirectly,early life stress may influence microglial function through various pathways,such as astrocytic activation,the hypothalamic–pituitary–adrenal axis,the gut–brain axis,and maternal immune signaling.Finally,various therapeutic strategies and molecular mechanisms for targeting microglia to restore the dopaminergic system were summarized and discussed.These strategies include classical antidepressants and antipsychotics,antibiotics and anti-inflammatory agents,and herbal-derived medicine.Further investigations combining pharmacological interventions and genetic strategies are essential to elucidate the causal role of microglial phenotypic and functional perturbations in the dopaminergic system disrupted by early life stress.展开更多
4-Nitrophenol(4-NP),a toxic and persistent pollutant in chemical wastewater,presents significant challenges in degradation and mineralization.Conventional ozone oxidation catalysts are hindered by low efficiency,mass ...4-Nitrophenol(4-NP),a toxic and persistent pollutant in chemical wastewater,presents significant challenges in degradation and mineralization.Conventional ozone oxidation catalysts are hindered by low efficiency,mass transfer constraints and metal leaching,necessitating the development of stable and efficient catalysts.Herein,BCn-H/MS,the derivative of Bi(Ce)-MOF,was prepared by in situ incorporation,thermal decomposition and acid etching.The resulting materials were characterized and employed in catalytic ozonation for the reduction of 4-NP.Under the specific experimental conditions of the O_(3)+BC0.3-H/MS system,the total organic carbon(TOC)and chemical oxygen demand(COD)removal rates of 4-NP were observed to reach 94.6%and 91.8%within 30 min,respectively.These two parameters were improved by raising the initial pH,reducing the pollutant concentration and increasing the catalyst dosage.The abundant oxygen vacancies(OVs)were regarded as the pivotal catalytic site of BC0.3-H/MS,which was conducive to the adsorption of O_(3) and the acceleration of the formation of reactive oxygen species(ROS).The regular hollow square structure effectively boosted the specific surface area,increased OVs exposure and accelerated the adsorption and mass transfer process.The electron paramagnetic resonance(EPR)results demonstrated that the primary ROS engaged in the degradation reaction were⋅OH and⋅O_(2)−.BC0.3-H/MS demonstrated excellent stability and reusability in cyclic experiments.Toxicity analysis revealed that the O_(3)+BC0.3-H/MS system exhibited an effective detoxification effect.Ultimately,the primary degradation pathway of 4-NP was proposed through liquid chromatography-mass spectroscopy(LC-MS)and in-situ diffuse reflectance infrared fourier-transform spectroscopy(DRIFTS)analyses at varying reaction times.展开更多
The traceability system can effectively reduce the food safety risks, however, it is confronted with various problems during its implementation. In this context, the paper carries out a case study of consumers in Weif...The traceability system can effectively reduce the food safety risks, however, it is confronted with various problems during its implementation. In this context, the paper carries out a case study of consumers in Weifang, Shandong Province, and studies their willingness to pay the traceable pork with different quality information. The results indicate that, the consumers show high expectations towards the introduction of traceability system, and they tend to buy the traceable pork only with breeding and slaughter information; their behaviors of purchase are greatly influenced by the following factors: the consumers education, age, income, attention on food safety and whether there are pregnant family members, etc..展开更多
Long-term kinematic research of slow- moving debris slide is rare despite of the widespread global distribution of this kind. This paper presents a study of the kinematics and mechanism of the Jinpingzi debris slide l...Long-term kinematic research of slow- moving debris slide is rare despite of the widespread global distribution of this kind. This paper presents a study of the kinematics and mechanism of the Jinpingzi debris slide located on the Jinsha river bank in southwest China. This debris slide is known to have a volume of 27×106 ms in active state for at least one century. Field survey and geotechnical investigation were carried out to define the structure of the landslide. The physical and mechanical properties of the landslide materials were obtained by in-situ and laboratory tests. Additionally, surface and subsurface displacements, as well as groundwater level fluctuations, were monitored since 2005. Movement features, especially the response of the landslide movement to rainfall, were analysed. Relationships between resisting forces and driving forces were analysed by using the limit equilibrium method assuming rigid-plastic frictional slip. The results confirmed a viscous comoonent in the long-term continuous movement resulting in the quasioverconsolidated state of the slip zone with higher strength parameters than some other types of slowmoving landslides. Both surface and subsurface displacements showed an advancing pattern by the straight outwardly inclined （rather than gently or reversely inclined） slip zone, which resulted in low resistance to the entire sliding mass. The average surface displacement rate from 2005 to 2016 was estimated to be 0.19-0.87 mm/d. Basal sliding on the silty clay seam accounted for most of the deformation with different degrees of internal deformation in different parts. Rainfall was the predominant factor affecting the kinematics of Jinpingzi landslide while the role of groundwater level, though positive, was not significant. The response of the groundwater level to rainfall infiltration was not apparent. Unlike some shallow slow-moving earth flows or mudslides, whose behaviors are directly related to the phreatic groundwater level, the mechanism for Jinpingzi landslide kinematics is more likely related to the changing weight of the sliding mass and the downslope seepage pressure in the shallow soil mass resulting from rainfall events.展开更多
The loading on U-steel yieldable support cannot be organically combined withthe law of strata behaviors from the surrounding rocks of roadway. In order to effectivelysolve the problem, U-steel yieldable support with b...The loading on U-steel yieldable support cannot be organically combined withthe law of strata behaviors from the surrounding rocks of roadway. In order to effectivelysolve the problem, U-steel yieldable support with backfill material and the performancerequirements of backfill material were analyzed on the basis of structural mechanics. Themechanical properties of backfill material selected were tested in the laboratory, and thetest results show that the ratio of the backfill material complies with the requirements ofbackfill technology; it can effectively optimize the relationship between the support and thesurrounding rock, and the filling layer can avoid the partial stress concentration and fullyimprove the support performance. Compared with U-steel yieldable support with ganguefilling, the filed application shows that the supporting result of U-steel yieldable supportwith backfill technology is satisfactory, the stress on U-steel yieldable support with backfilltechnology decreases greatly and distributes uniformly, convergence of the surroundingrock of roadway is decreased by more than 50%, and the surrounding rocks of roadwayare controlled effectively.展开更多
As the agricultural heritage,Hani terrace is not only culturally authentic and non- renew able,but has its ow n characteristics. Firstly,it is a kind of economic and social mode of production. Secondly,it reflects the...As the agricultural heritage,Hani terrace is not only culturally authentic and non- renew able,but has its ow n characteristics. Firstly,it is a kind of economic and social mode of production. Secondly,it reflects the idea of harmonious and sustainable development betw een human beings and nature. T hirdly,the participation of human beings — or farmers is important. As a result,to exploit and protect the agricultural heritage,it is crucial to balance systematic protection and sustainable development in order to realize dynamic protection. In addition,the agricultural heritage shall be treated as the driving agent to coordinate the social and economic development. T hrough analyzing the characteristics of the agricultural heritage and the concept of protecting the agricultural heritage,this paper proposes to promote the protection of agricultural authenticity by alternative tourism development in order to balance the development and realize the sustainability of the agricultural dynamic system.展开更多
The circulatory system is indispensable for an animal’s normal physiology.In addition to well-characterized hematopoietic cells,several types of circulating non-hematopoietic cells have been identified in adult mice(...The circulatory system is indispensable for an animal’s normal physiology.In addition to well-characterized hematopoietic cells,several types of circulating non-hematopoietic cells have been identified in adult mice(Zhang and Huang,2012;Schreier and Triampo,2020).展开更多
The beam-to-column semirigid connection in a steel frame structure is represented by a zero-length rotational spring at the end of the beam element. The beam-to-column semirigid connection behavior is represented by i...The beam-to-column semirigid connection in a steel frame structure is represented by a zero-length rotational spring at the end of the beam element. The beam-to-column semirigid connection behavior is represented by its moment-rotation relationship. Several traditional mathematical models have been proposed to fit the moment-rotation curves from the experimental database,but they may be more reliable within certain ranges. In this paper, the intellectualized analytical model is proposed in the semirigid connections for top and seat angles with double web angles using the feed-forward back-propagation artificial neural network （BP-ANN） technique. the intellectualized analytical model from experimental results based on BP-ANN is more reliable and it is a better choice to the moment-rotation curves for beam-to-column semirigid connection. The results are found to provide effectiveness to the experimental response that is satisfactory for use in steel structural engineering design.展开更多
innovation driven development strategy,as a national strategy of our country,has attracted wide attention in the academic field,and it is very rich in theory and practice of innovation driven development.But innovatio...innovation driven development strategy,as a national strategy of our country,has attracted wide attention in the academic field,and it is very rich in theory and practice of innovation driven development.But innovation driven development,as a national strategy,is a long-term,not only from institutional and policy perspective,but also need to build a theoretical framework of relatively rich,can practice on the guiding role of theory.展开更多
Objective:Using network pharmacology to explore the target and mechanism of Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma in the treatment of vascular dementia(VaD),so as to provide a reference for treating VaD thr...Objective:Using network pharmacology to explore the target and mechanism of Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma in the treatment of vascular dementia(VaD),so as to provide a reference for treating VaD through them.Methods:Traditional Chinese medicine systems pharmacology database and analysis platform were used to screen the main active ingredients and targets of Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma.By means of Gene Cards and Online Mendelian Inheritance in Man(OMIM),targets of VaD were collected.The intersecting targets were obtained by using the Venn map.The String online database was used to build a protein-protein interactions Network and the Metascape database was used to perform GO function enrichment analysis and KEGG pathway enrichment analysis.A“drug-ingredient-target-pathway”network was constructed by Cytoscape software.Autodock vina software was used to conduct molecular docking between targets.Results:A total of 7 active ingredients in Chuanxiong Rhizoma and 4 active ingredients in Acori Tatarinowii Rhizoma were screened.There were 42 active targets of Chuanxiong Rhizoma and 70 active targets of Acori Tatarinowii Rhizoma and 1152 disease targets.After deleting the repeat value,51 drugs targets were obtained.After the intersection,with a total of 25 targets.According to GO and KEGG enrichment analysis,the main biological processes involved include cellular response to lipid,negative regulation of apoptotic signaling pathway,blood circulation,response to a steroid hormone,etc.The main pathways include pathways in cancer,PI3K-Akt signaling pathway,and AGE-RAGE signaling pathway in diabetic complications,etc.Molecular docking showed that the most active docking combinations were AKT1 and Perlolyrine,RELA and FA,MAPK14 and FA,respectively.Conclusion:Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma play an important role in the treatment of VaD mainly by anti-inflammatory and anti-apoptosis.展开更多
A new species of the Macrophya malaisei group in the genus Macrophya Dahlbom,1835 from Zhejiang in China is described:M.alboclypea Li,Liu&Wei sp.nov.A revised key to the Chinese and Japanese species of the M.malai...A new species of the Macrophya malaisei group in the genus Macrophya Dahlbom,1835 from Zhejiang in China is described:M.alboclypea Li,Liu&Wei sp.nov.A revised key to the Chinese and Japanese species of the M.malaisei group is provided.展开更多
Two new species of the Aglaostigma laticinctum subgroup belonging to A.tertium group,are described and illustrated in this study:A.leucogaster Liu,Li&Wei sp.nov.and A.rufitegula Liu,Li&Wei sp.nov.The Aglaostig...Two new species of the Aglaostigma laticinctum subgroup belonging to A.tertium group,are described and illustrated in this study:A.leucogaster Liu,Li&Wei sp.nov.and A.rufitegula Liu,Li&Wei sp.nov.The Aglaostigma laticinctum subgroup is proposed here for the first time,with a brief discussion of its diagnostic features.Additionally,a key to all known species of the A.laticinctum subgroup from China is provided.展开更多
Vegetation change is the most intuitive and sensitive bioindicator reflecting seasonal and interannual variations in the external environment,and it can directly reflect the rapid response of terrestrial ecosystems to...Vegetation change is the most intuitive and sensitive bioindicator reflecting seasonal and interannual variations in the external environment,and it can directly reflect the rapid response of terrestrial ecosystems to climate change.Using remote sensing and meteorological data,this study revealed the spatiotemporal characteristics of leaf area index(LAI)in the north of China during 1982–2022,clarified the response of LAI change to different meteorological factors,quantified the impacts of climate change and human activities on LAI change,and predicted the future trends in LAI change.From 1982 to 2022,the vegetation in the north of China generally showed a greening trend with a change rate of 0.0071 m2/(m2•a).Temperature was strongly positively correlated with LAI and was the main climate factor driving LAI change.Residual analysis revealed that vegetation improvement occurred in across 74.53%of the study area,and vegetation improvement in about 96.83%of the improved zone was attributed to a combination of climate change and human activities.The regions where anthropogenic contribution exceeded 60.00%covered 36.83%of human-affected areas,while the regions where climatic contribution exceeded 60.00%covered 19.77%of climate-affected areas,demonstrating that human activities influenced the intensity of LAI change more deeply despite the broad spatial impact of climate change.Human activities such as afforestation and the Three-North Protective Forest Program played the dominant role in vegetation greening compared to climate change.Hurst index analysis indicated that 80.30%of vegetation in the north of China is expected to experience a non-sustained improvement in the future.These findings will provide a scientific basis for optimizing the protection strategies of the national ecological barrier areas and evaluating the effectiveness of major ecological projects.展开更多
Glaucoma filtration surgery(GFS)stands as the most effective intervention for reducing intraocular pressure,a critical component in glaucoma management.Despite its pivotal role,the scarring of the filtration bleb rema...Glaucoma filtration surgery(GFS)stands as the most effective intervention for reducing intraocular pressure,a critical component in glaucoma management.Despite its pivotal role,the scarring of the filtration bleb remains the primary impediment to successful GFS outcomes.Perioperative utilization of antimitotics,while frontline in combating fibrosis and modulating the wound healing process,carries the risk of vision-threatening complications.Given the complexity of the wound healing cascade and the potential insufficiency of targeting a single molecule,there is an imperative to expand therapeutic modalities through combination therapies.This review offers a comprehensive elucidation of the fibrogenesis post-GFS,a synthesis unprecedented in the available literature,and aims to inform the broadening of therapeutic strategies for GFS.展开更多
To improve the traffic scheduling capability in operator data center networks,an analysis prediction and online scheduling mechanism(APOS)is designed,considering both the network structure and the network traffic in t...To improve the traffic scheduling capability in operator data center networks,an analysis prediction and online scheduling mechanism(APOS)is designed,considering both the network structure and the network traffic in the operator data center.Fibonacci tree optimization algorithm(FTO)is embedded into the analysis prediction and the online scheduling stages,the FTO traffic scheduling strategy is proposed.By taking the global optimal and the multi-modal optimization advantage of FTO,the traffic scheduling optimal solution and many suboptimal solutions can be obtained.The experiment results show that the FTO traffic scheduling strategy can schedule traffic in data center networks reasonably,and improve the load balancing in the operator data center network effectively.展开更多
Hybrid teaching has become an essential direction of the teaching reform and innovation of higher education,and puts forward new requirements for the evaluation system of teaching quality.The background of hybrid teac...Hybrid teaching has become an essential direction of the teaching reform and innovation of higher education,and puts forward new requirements for the evaluation system of teaching quality.The background of hybrid teaching,the CIPP model,and teaching quality evaluation system,and the necessity of constructing a hybrid teaching quality evaluation system are further discussed.This paper also discusses the evaluation focus of the CIPP model and its applicability in the hybrid teaching quality evaluation and believes that the CIPP model can reflect the concept innovation,target diversity,process advancement,and subject participation;the evaluation indicator system of hybrid teaching quality is designed based on the CIPP model,which provides a reference for the hybrid teaching quality evaluation and teaching reform.展开更多
Full waveform inversion is a precise method for parameter inversion,harnessing the complete wavefield information of seismic waves.It holds the potential to intricately characterize the detailed features of the model ...Full waveform inversion is a precise method for parameter inversion,harnessing the complete wavefield information of seismic waves.It holds the potential to intricately characterize the detailed features of the model with high accuracy.However,due to inaccurate initial models,the absence of low-frequency data,and incomplete observational data,full waveform inversion(FWI)exhibits pronounced nonlinear characteristics.When the strata are buried deep,the inversion capability of this method is constrained.To enhance the accuracy and precision of FWI,this paper introduces a novel approach to address the aforementioned challenges—namely,a fractional-order anisotropic total p-variation regularization for full waveform inversion(FATpV-FWI).This method incorporates fractional-order total variation(TV)regularization to construct the inversion objective function,building upon TV regularization,and subsequently employs the alternating direction multiplier method for solving.This approach mitigates the step effect stemming from total variation in seismic inversion,thereby facilitating the reconstruction of sharp interfaces of geophysical parameters while smoothing background variations.Simultaneously,replacing integer-order differences with fractional-order differences bolsters the correlation among seismic data and diminishes the scattering effect caused by integer-order differences in seismic inversion.The outcomes of model tests validate the efficacy of this method,highlighting its ability to enhance the overall accuracy of the inversion process.展开更多
BACKGROUND In recent years,the number of pediatric patients with unexplained liver disease has been increasing.Whole-exome sequencing(WES)technology has played a significant role in the diagnosis;however,related studi...BACKGROUND In recent years,the number of pediatric patients with unexplained liver disease has been increasing.Whole-exome sequencing(WES)technology has played a significant role in the diagnosis;however,related studies remain limited.AIM To investigate the clinical characteristics and genetic causes of unexplained pediatric liver disease to improve the diagnosis and treatment of this disease.METHODS Eighty children with unexplained liver disease were divided into two groups:The liver enzyme elevation group(Group A)and the cholestasis group(Group B).Children with both elevated liver enzymes and cholestasis were assigned to Group B.The clinical characteristics of the patients were retrospectively summarized,and WES was performed in the patients and their parents.RESULTS Genetic results were obtained in 46 patients(46/80,57.5%),including 38 in Group A(38/65,58.5%)and 8 in Group B(8/15,53.3%).A total of 53 pathogenic or likely pathogenic variants were identified in 42 patients(42/80,52.5%),including 40 previously reported variants and 13 novel variants.Seven variants of uncertain significance were identified in 7 patients(7/80,8.8%),of which 4 were novel variants.A total of 19 gene mutations were identified:2 cases of AGL,15 cases of ATP7B,1 case of CAPN3,4 cases of DMD,1 case of FLG,1 case of G6PC,5 cases of JAG1,2 cases of PHKA2,2 cases of PYGL,1 case of SMARCAL1,1 case of SMPD1,1 case of TNFAIP3,1 case of GLB1,and 1 case of MAT1A in Group A;and 1 case of SLC25A13,3 cases of JAG1,1 case of ATP8B1,1 case of ABCC2,1 case of ABCD3,and 1 case of 45X in Group B.CONCLUSION WES significantly improved the etiological diagnosis of unexplained pediatric liver disease,helping guide individualized treatment and improve prognosis.展开更多
Hydrated ions play essential roles in diverse chemical and biological processes,yet accurately characterizing their hydration structures remains challenging due to the delicate interplay of ion–water and water–water...Hydrated ions play essential roles in diverse chemical and biological processes,yet accurately characterizing their hydration structures remains challenging due to the delicate interplay of ion–water and water–water interactions.Here,we use ab initio molecular dynamics(AIMD)simulations based on the strongly constrained and appropriately normed(SCAN)exchange–correlation functional to systematically investigate the hydration structures of eight representative ions(Mg^(2+),Ca^(2+),Li^(+),Na^(+),K^(+),F^(-),Cl^(-),Br^(-))in aqueous solution.Compared to the widely used Perdew–Burke–Ernzerhof(PBE)functional,SCAN substantially improves the description of solvent water by weakening the hydrogen-bond network and enhancing structural disorder,yielding results in closer agreement with experiments.SCAN modifies ionic hydration shells in an ion-specific manner,governed by ionic size and charge,and reproduces experimental hydration geometries especially well for intermediate-size monovalent ions(Na^(+),Cl^(-)).Moreover,SCAN consistently reduces the overpolarization of water molecules near ions.These improvements lead to more accurate and physically consistent hydration structures,highlighting SCAN's utility for modeling complex aqueous systems and offering guidance for future studies of ionic solvation.展开更多
Two new species in the genus Aglaostigma Kirby(Hymenoptera:Tenthredinidae)are described and illustrated from Mts.Nanling,China:A.luoyoulaii Li,Liu&Wei sp.nov.and A.mengmeng Li&Wei sp.nov.
基金supported by the National Natural Science Foundation of China,Nos.82304990(to NY),81973748(to JC),82174278(to JC)the National Key R&D Program of China,No.2023YFE0209500(to JC)+4 种基金China Postdoctoral Science Foundation,No.2023M732380(to NY)Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine,No.202102010014(to JC)Huang Zhendong Research Fund for Traditional Chinese Medicine of Jinan University,No.201911(to JC)National Innovation and Entrepreneurship Training Program for Undergraduates in China,No.202310559128(to NY and QM)Innovation and Entrepreneurship Training Program for Undergraduates at Jinan University,Nos.CX24380,CX24381(both to NY and QM)。
文摘Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily involving abnormal development and damage of the dopaminergic system,pose significant public health challenges.Microglia,as the primary immune cells in the brain,are crucial in regulating neuronal circuit development and survival.From the embryonic stage to adulthood,microglia exhibit stage-specific gene expression profiles,transcriptome characteristics,and functional phenotypes,enhancing the susceptibility to early life stress.However,the role of microglia in mediating dopaminergic system disorders under early life stress conditions remains poorly understood.This review presents an up-to-date overview of preclinical studies elucidating the impact of early life stress on microglia,leading to dopaminergic system disorders,along with the underlying mechanisms and therapeutic potential for neurodegenerative and neurodevelopmental conditions.Impaired microglial activity damages dopaminergic neurons by diminishing neurotrophic support(e.g.,insulin-like growth factor-1)and hinders dopaminergic axon growth through defective phagocytosis and synaptic pruning.Furthermore,blunted microglial immunoreactivity suppresses striatal dopaminergic circuit development and reduces neuronal transmission.Furthermore,inflammation and oxidative stress induced by activated microglia can directly damage dopaminergic neurons,inhibiting dopamine synthesis,reuptake,and receptor activity.Enhanced microglial phagocytosis inhibits dopamine axon extension.These long-lasting effects of microglial perturbations may be driven by early life stress–induced epigenetic reprogramming of microglia.Indirectly,early life stress may influence microglial function through various pathways,such as astrocytic activation,the hypothalamic–pituitary–adrenal axis,the gut–brain axis,and maternal immune signaling.Finally,various therapeutic strategies and molecular mechanisms for targeting microglia to restore the dopaminergic system were summarized and discussed.These strategies include classical antidepressants and antipsychotics,antibiotics and anti-inflammatory agents,and herbal-derived medicine.Further investigations combining pharmacological interventions and genetic strategies are essential to elucidate the causal role of microglial phenotypic and functional perturbations in the dopaminergic system disrupted by early life stress.
基金supported by the National Natural Science Foundation of China(Regional Fund)(No.51868054)the Natural Science Foundation of Inner Mongolia of China(General Program)(No.2022MS05052).
文摘4-Nitrophenol(4-NP),a toxic and persistent pollutant in chemical wastewater,presents significant challenges in degradation and mineralization.Conventional ozone oxidation catalysts are hindered by low efficiency,mass transfer constraints and metal leaching,necessitating the development of stable and efficient catalysts.Herein,BCn-H/MS,the derivative of Bi(Ce)-MOF,was prepared by in situ incorporation,thermal decomposition and acid etching.The resulting materials were characterized and employed in catalytic ozonation for the reduction of 4-NP.Under the specific experimental conditions of the O_(3)+BC0.3-H/MS system,the total organic carbon(TOC)and chemical oxygen demand(COD)removal rates of 4-NP were observed to reach 94.6%and 91.8%within 30 min,respectively.These two parameters were improved by raising the initial pH,reducing the pollutant concentration and increasing the catalyst dosage.The abundant oxygen vacancies(OVs)were regarded as the pivotal catalytic site of BC0.3-H/MS,which was conducive to the adsorption of O_(3) and the acceleration of the formation of reactive oxygen species(ROS).The regular hollow square structure effectively boosted the specific surface area,increased OVs exposure and accelerated the adsorption and mass transfer process.The electron paramagnetic resonance(EPR)results demonstrated that the primary ROS engaged in the degradation reaction were⋅OH and⋅O_(2)−.BC0.3-H/MS demonstrated excellent stability and reusability in cyclic experiments.Toxicity analysis revealed that the O_(3)+BC0.3-H/MS system exhibited an effective detoxification effect.Ultimately,the primary degradation pathway of 4-NP was proposed through liquid chromatography-mass spectroscopy(LC-MS)and in-situ diffuse reflectance infrared fourier-transform spectroscopy(DRIFTS)analyses at varying reaction times.
基金Supported by the Youth Project for Humanities and Social Sciences of Ministry of Education in 2012(12YJC630326 and 12XJJC790003)
文摘The traceability system can effectively reduce the food safety risks, however, it is confronted with various problems during its implementation. In this context, the paper carries out a case study of consumers in Weifang, Shandong Province, and studies their willingness to pay the traceable pork with different quality information. The results indicate that, the consumers show high expectations towards the introduction of traceability system, and they tend to buy the traceable pork only with breeding and slaughter information; their behaviors of purchase are greatly influenced by the following factors: the consumers education, age, income, attention on food safety and whether there are pregnant family members, etc..
文摘Long-term kinematic research of slow- moving debris slide is rare despite of the widespread global distribution of this kind. This paper presents a study of the kinematics and mechanism of the Jinpingzi debris slide located on the Jinsha river bank in southwest China. This debris slide is known to have a volume of 27×106 ms in active state for at least one century. Field survey and geotechnical investigation were carried out to define the structure of the landslide. The physical and mechanical properties of the landslide materials were obtained by in-situ and laboratory tests. Additionally, surface and subsurface displacements, as well as groundwater level fluctuations, were monitored since 2005. Movement features, especially the response of the landslide movement to rainfall, were analysed. Relationships between resisting forces and driving forces were analysed by using the limit equilibrium method assuming rigid-plastic frictional slip. The results confirmed a viscous comoonent in the long-term continuous movement resulting in the quasioverconsolidated state of the slip zone with higher strength parameters than some other types of slowmoving landslides. Both surface and subsurface displacements showed an advancing pattern by the straight outwardly inclined （rather than gently or reversely inclined） slip zone, which resulted in low resistance to the entire sliding mass. The average surface displacement rate from 2005 to 2016 was estimated to be 0.19-0.87 mm/d. Basal sliding on the silty clay seam accounted for most of the deformation with different degrees of internal deformation in different parts. Rainfall was the predominant factor affecting the kinematics of Jinpingzi landslide while the role of groundwater level, though positive, was not significant. The response of the groundwater level to rainfall infiltration was not apparent. Unlike some shallow slow-moving earth flows or mudslides, whose behaviors are directly related to the phreatic groundwater level, the mechanism for Jinpingzi landslide kinematics is more likely related to the changing weight of the sliding mass and the downslope seepage pressure in the shallow soil mass resulting from rainfall events.
文摘The loading on U-steel yieldable support cannot be organically combined withthe law of strata behaviors from the surrounding rocks of roadway. In order to effectivelysolve the problem, U-steel yieldable support with backfill material and the performancerequirements of backfill material were analyzed on the basis of structural mechanics. Themechanical properties of backfill material selected were tested in the laboratory, and thetest results show that the ratio of the backfill material complies with the requirements ofbackfill technology; it can effectively optimize the relationship between the support and thesurrounding rock, and the filling layer can avoid the partial stress concentration and fullyimprove the support performance. Compared with U-steel yieldable support with ganguefilling, the filed application shows that the supporting result of U-steel yieldable supportwith backfill technology is satisfactory, the stress on U-steel yieldable support with backfilltechnology decreases greatly and distributes uniformly, convergence of the surroundingrock of roadway is decreased by more than 50%, and the surrounding rocks of roadwayare controlled effectively.
基金This paper is the phased achievement of the key program of the social science fund of the Education Department of Yunnan Province-R esearch on the Bridgehead Strategy of the Yunnan Frontier culture(N o.:2012Z059)
文摘As the agricultural heritage,Hani terrace is not only culturally authentic and non- renew able,but has its ow n characteristics. Firstly,it is a kind of economic and social mode of production. Secondly,it reflects the idea of harmonious and sustainable development betw een human beings and nature. T hirdly,the participation of human beings — or farmers is important. As a result,to exploit and protect the agricultural heritage,it is crucial to balance systematic protection and sustainable development in order to realize dynamic protection. In addition,the agricultural heritage shall be treated as the driving agent to coordinate the social and economic development. T hrough analyzing the characteristics of the agricultural heritage and the concept of protecting the agricultural heritage,this paper proposes to promote the protection of agricultural authenticity by alternative tourism development in order to balance the development and realize the sustainability of the agricultural dynamic system.
基金supported by the National Key Research and Development Program of China(2020YFA0112400,2016YFA0100601,2017YFA0103400,2017YFA0102702)the National Natural Science Foundation of China(81890991,31871173,31930054,31625018,81900103,81900115)+1 种基金the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2017ZT07S347)the Key Research and Development Program of Guangdong Province(2019B020234002)。
文摘The circulatory system is indispensable for an animal’s normal physiology.In addition to well-characterized hematopoietic cells,several types of circulating non-hematopoietic cells have been identified in adult mice(Zhang and Huang,2012;Schreier and Triampo,2020).
文摘The beam-to-column semirigid connection in a steel frame structure is represented by a zero-length rotational spring at the end of the beam element. The beam-to-column semirigid connection behavior is represented by its moment-rotation relationship. Several traditional mathematical models have been proposed to fit the moment-rotation curves from the experimental database,but they may be more reliable within certain ranges. In this paper, the intellectualized analytical model is proposed in the semirigid connections for top and seat angles with double web angles using the feed-forward back-propagation artificial neural network （BP-ANN） technique. the intellectualized analytical model from experimental results based on BP-ANN is more reliable and it is a better choice to the moment-rotation curves for beam-to-column semirigid connection. The results are found to provide effectiveness to the experimental response that is satisfactory for use in steel structural engineering design.
文摘innovation driven development strategy,as a national strategy of our country,has attracted wide attention in the academic field,and it is very rich in theory and practice of innovation driven development.But innovation driven development,as a national strategy,is a long-term,not only from institutional and policy perspective,but also need to build a theoretical framework of relatively rich,can practice on the guiding role of theory.
基金supported by National Key R&D Program of(China2019YFC1708502).
文摘Objective:Using network pharmacology to explore the target and mechanism of Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma in the treatment of vascular dementia(VaD),so as to provide a reference for treating VaD through them.Methods:Traditional Chinese medicine systems pharmacology database and analysis platform were used to screen the main active ingredients and targets of Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma.By means of Gene Cards and Online Mendelian Inheritance in Man(OMIM),targets of VaD were collected.The intersecting targets were obtained by using the Venn map.The String online database was used to build a protein-protein interactions Network and the Metascape database was used to perform GO function enrichment analysis and KEGG pathway enrichment analysis.A“drug-ingredient-target-pathway”network was constructed by Cytoscape software.Autodock vina software was used to conduct molecular docking between targets.Results:A total of 7 active ingredients in Chuanxiong Rhizoma and 4 active ingredients in Acori Tatarinowii Rhizoma were screened.There were 42 active targets of Chuanxiong Rhizoma and 70 active targets of Acori Tatarinowii Rhizoma and 1152 disease targets.After deleting the repeat value,51 drugs targets were obtained.After the intersection,with a total of 25 targets.According to GO and KEGG enrichment analysis,the main biological processes involved include cellular response to lipid,negative regulation of apoptotic signaling pathway,blood circulation,response to a steroid hormone,etc.The main pathways include pathways in cancer,PI3K-Akt signaling pathway,and AGE-RAGE signaling pathway in diabetic complications,etc.Molecular docking showed that the most active docking combinations were AKT1 and Perlolyrine,RELA and FA,MAPK14 and FA,respectively.Conclusion:Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma play an important role in the treatment of VaD mainly by anti-inflammatory and anti-apoptosis.
基金supported by the Scientific Research Project of Baishanzu National Park(2023JBGS07)the National Natural Science Foundation of China(31970447,32370500)the Special Funds for Scientific Research of Postdoctoral Work Station Assessment in Zhejiang Province,China(2023).
文摘A new species of the Macrophya malaisei group in the genus Macrophya Dahlbom,1835 from Zhejiang in China is described:M.alboclypea Li,Liu&Wei sp.nov.A revised key to the Chinese and Japanese species of the M.malaisei group is provided.
基金supported by the National Natural Science Foundation of China(31970447)starting fund for doctoral research of Lishui University(6004LMM01Z)the Special Funds for Scientific Research of Postdoctoral Work Station Assessment in Zhejiang Province,China(2023).
文摘Two new species of the Aglaostigma laticinctum subgroup belonging to A.tertium group,are described and illustrated in this study:A.leucogaster Liu,Li&Wei sp.nov.and A.rufitegula Liu,Li&Wei sp.nov.The Aglaostigma laticinctum subgroup is proposed here for the first time,with a brief discussion of its diagnostic features.Additionally,a key to all known species of the A.laticinctum subgroup from China is provided.
基金supported by the National Natural Science Foundation of China(42301127)the Natural Science Foundation of Xinjiang Uygur Autonomous Region(2023D01C185).
文摘Vegetation change is the most intuitive and sensitive bioindicator reflecting seasonal and interannual variations in the external environment,and it can directly reflect the rapid response of terrestrial ecosystems to climate change.Using remote sensing and meteorological data,this study revealed the spatiotemporal characteristics of leaf area index(LAI)in the north of China during 1982–2022,clarified the response of LAI change to different meteorological factors,quantified the impacts of climate change and human activities on LAI change,and predicted the future trends in LAI change.From 1982 to 2022,the vegetation in the north of China generally showed a greening trend with a change rate of 0.0071 m2/(m2•a).Temperature was strongly positively correlated with LAI and was the main climate factor driving LAI change.Residual analysis revealed that vegetation improvement occurred in across 74.53%of the study area,and vegetation improvement in about 96.83%of the improved zone was attributed to a combination of climate change and human activities.The regions where anthropogenic contribution exceeded 60.00%covered 36.83%of human-affected areas,while the regions where climatic contribution exceeded 60.00%covered 19.77%of climate-affected areas,demonstrating that human activities influenced the intensity of LAI change more deeply despite the broad spatial impact of climate change.Human activities such as afforestation and the Three-North Protective Forest Program played the dominant role in vegetation greening compared to climate change.Hurst index analysis indicated that 80.30%of vegetation in the north of China is expected to experience a non-sustained improvement in the future.These findings will provide a scientific basis for optimizing the protection strategies of the national ecological barrier areas and evaluating the effectiveness of major ecological projects.
基金Supported by Hospital Level Project of the Eye Hospital of China Academy of Chinese Medical Sciences(No.GSP5-40)Internal Project of the Eye Hospital of China Academy of Chinese Medical Sciences(No.1011632).
文摘Glaucoma filtration surgery(GFS)stands as the most effective intervention for reducing intraocular pressure,a critical component in glaucoma management.Despite its pivotal role,the scarring of the filtration bleb remains the primary impediment to successful GFS outcomes.Perioperative utilization of antimitotics,while frontline in combating fibrosis and modulating the wound healing process,carries the risk of vision-threatening complications.Given the complexity of the wound healing cascade and the potential insufficiency of targeting a single molecule,there is an imperative to expand therapeutic modalities through combination therapies.This review offers a comprehensive elucidation of the fibrogenesis post-GFS,a synthesis unprecedented in the available literature,and aims to inform the broadening of therapeutic strategies for GFS.
基金supported by National Natural Science Foundation of China(No.62163036).
文摘To improve the traffic scheduling capability in operator data center networks,an analysis prediction and online scheduling mechanism(APOS)is designed,considering both the network structure and the network traffic in the operator data center.Fibonacci tree optimization algorithm(FTO)is embedded into the analysis prediction and the online scheduling stages,the FTO traffic scheduling strategy is proposed.By taking the global optimal and the multi-modal optimization advantage of FTO,the traffic scheduling optimal solution and many suboptimal solutions can be obtained.The experiment results show that the FTO traffic scheduling strategy can schedule traffic in data center networks reasonably,and improve the load balancing in the operator data center network effectively.
基金The 2025 Beijing Postdoctoral Research Activity Funding Project“Exploring Hybrid Teaching Quality Evaluation System Based on the CIPP Model Construction in Higher Education”(2025114)。
文摘Hybrid teaching has become an essential direction of the teaching reform and innovation of higher education,and puts forward new requirements for the evaluation system of teaching quality.The background of hybrid teaching,the CIPP model,and teaching quality evaluation system,and the necessity of constructing a hybrid teaching quality evaluation system are further discussed.This paper also discusses the evaluation focus of the CIPP model and its applicability in the hybrid teaching quality evaluation and believes that the CIPP model can reflect the concept innovation,target diversity,process advancement,and subject participation;the evaluation indicator system of hybrid teaching quality is designed based on the CIPP model,which provides a reference for the hybrid teaching quality evaluation and teaching reform.
基金supported by the China Postdoctoral Science Foundation(Grant No.2024MF750281)the Postdoctoral Fellowship Program of CPSF(Grant No.GZC20230326)+1 种基金the Natural Science Foundation Project of Sichuan Province(Grant No.2025ZNSFSC1170)Sichuan Science and Technology Program(Grant No.2023ZYD0158).
文摘Full waveform inversion is a precise method for parameter inversion,harnessing the complete wavefield information of seismic waves.It holds the potential to intricately characterize the detailed features of the model with high accuracy.However,due to inaccurate initial models,the absence of low-frequency data,and incomplete observational data,full waveform inversion(FWI)exhibits pronounced nonlinear characteristics.When the strata are buried deep,the inversion capability of this method is constrained.To enhance the accuracy and precision of FWI,this paper introduces a novel approach to address the aforementioned challenges—namely,a fractional-order anisotropic total p-variation regularization for full waveform inversion(FATpV-FWI).This method incorporates fractional-order total variation(TV)regularization to construct the inversion objective function,building upon TV regularization,and subsequently employs the alternating direction multiplier method for solving.This approach mitigates the step effect stemming from total variation in seismic inversion,thereby facilitating the reconstruction of sharp interfaces of geophysical parameters while smoothing background variations.Simultaneously,replacing integer-order differences with fractional-order differences bolsters the correlation among seismic data and diminishes the scattering effect caused by integer-order differences in seismic inversion.The outcomes of model tests validate the efficacy of this method,highlighting its ability to enhance the overall accuracy of the inversion process.
基金Supported by National Natural Science Foundation of China,No.82400641Natural Science Foundation of Shandong Province,No.ZR2022QH076 and ZR2021MH381。
文摘BACKGROUND In recent years,the number of pediatric patients with unexplained liver disease has been increasing.Whole-exome sequencing(WES)technology has played a significant role in the diagnosis;however,related studies remain limited.AIM To investigate the clinical characteristics and genetic causes of unexplained pediatric liver disease to improve the diagnosis and treatment of this disease.METHODS Eighty children with unexplained liver disease were divided into two groups:The liver enzyme elevation group(Group A)and the cholestasis group(Group B).Children with both elevated liver enzymes and cholestasis were assigned to Group B.The clinical characteristics of the patients were retrospectively summarized,and WES was performed in the patients and their parents.RESULTS Genetic results were obtained in 46 patients(46/80,57.5%),including 38 in Group A(38/65,58.5%)and 8 in Group B(8/15,53.3%).A total of 53 pathogenic or likely pathogenic variants were identified in 42 patients(42/80,52.5%),including 40 previously reported variants and 13 novel variants.Seven variants of uncertain significance were identified in 7 patients(7/80,8.8%),of which 4 were novel variants.A total of 19 gene mutations were identified:2 cases of AGL,15 cases of ATP7B,1 case of CAPN3,4 cases of DMD,1 case of FLG,1 case of G6PC,5 cases of JAG1,2 cases of PHKA2,2 cases of PYGL,1 case of SMARCAL1,1 case of SMPD1,1 case of TNFAIP3,1 case of GLB1,and 1 case of MAT1A in Group A;and 1 case of SLC25A13,3 cases of JAG1,1 case of ATP8B1,1 case of ABCC2,1 case of ABCD3,and 1 case of 45X in Group B.CONCLUSION WES significantly improved the etiological diagnosis of unexplained pediatric liver disease,helping guide individualized treatment and improve prognosis.
基金supported by the National Natural Science Foundation of China(Grant Nos.12535001,11935002,and 11525520)the National Key Research and Development Program of China(Grant No.2021YFA1400500)。
文摘Hydrated ions play essential roles in diverse chemical and biological processes,yet accurately characterizing their hydration structures remains challenging due to the delicate interplay of ion–water and water–water interactions.Here,we use ab initio molecular dynamics(AIMD)simulations based on the strongly constrained and appropriately normed(SCAN)exchange–correlation functional to systematically investigate the hydration structures of eight representative ions(Mg^(2+),Ca^(2+),Li^(+),Na^(+),K^(+),F^(-),Cl^(-),Br^(-))in aqueous solution.Compared to the widely used Perdew–Burke–Ernzerhof(PBE)functional,SCAN substantially improves the description of solvent water by weakening the hydrogen-bond network and enhancing structural disorder,yielding results in closer agreement with experiments.SCAN modifies ionic hydration shells in an ion-specific manner,governed by ionic size and charge,and reproduces experimental hydration geometries especially well for intermediate-size monovalent ions(Na^(+),Cl^(-)).Moreover,SCAN consistently reduces the overpolarization of water molecules near ions.These improvements lead to more accurate and physically consistent hydration structures,highlighting SCAN's utility for modeling complex aqueous systems and offering guidance for future studies of ionic solvation.
基金supported by the scientific research project of Baishanzu National Park(2023JBGS07)the National Natural Science Foundation of China(31970447,32370500)the Special Funds for Scientific Research of Postdoctoral Work Station Assessment in Zhejiang Province,China(2023).
文摘Two new species in the genus Aglaostigma Kirby(Hymenoptera:Tenthredinidae)are described and illustrated from Mts.Nanling,China:A.luoyoulaii Li,Liu&Wei sp.nov.and A.mengmeng Li&Wei sp.nov.
