Background:Hemodialysis(HD) per se is a risk factor for thrombosis.Considering the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the...Background:Hemodialysis(HD) per se is a risk factor for thrombosis.Considering the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training model.The aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this molecule.Methods:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of <15 mL/min/1.73 m2).The RE+BFR session consisted of 50% arterial occlusion pressure during 50 min sessions of HD(intradialytic exercise).RE repetitions included concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning specialist.Results:Several variables were associated with elevated levels of D-dimer,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflammatory status,catheter as vascular access,older patients(>70 years old),and HD vintage.Furthermore,RE+BFR significantly increases D-dimer after 4 h.Patients with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.展开更多
Dear editor:We sincerely thank Matthew J.Clarkson for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application...Dear editor:We sincerely thank Matthew J.Clarkson for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.展开更多
This study aimed to investigate the trends of finishers in the Sao Silvestre race in Brazil,taking into account sex,age,and performance levels.A total of 31775 runners(women,n=13847;men,n=17928),aged(45.2±16.8)ye...This study aimed to investigate the trends of finishers in the Sao Silvestre race in Brazil,taking into account sex,age,and performance levels.A total of 31775 runners(women,n=13847;men,n=17928),aged(45.2±16.8)years,finishers in the Sao Silvestre race between 2007 and 2021,were considered in the present analysis.Data(event year,date of birth,sex,and race times)were downloaded from the official race website.The man-Whitney U test,Spearman correlation,and robust regression model were computed.Participation increased over time for both sexes.Regarding age groups,“31-40 years”(women)and“>60 years”(men)were those with the highest number of finishers.We found a decrease in performance across the years(β=2.45;p<0.005),as well as significant differences in race times for both sexes(U=42.844;p<0.001),with men presenting better performances than women.Over time,it was observed an increase in the performance gap between the sexes,but in general,the performance decreased(β=1.76;p<0.001).Stakeholders should consider improving the strategies to improve women and young people's participation in running events.展开更多
基金supported by a grant provided by the Coordenacao de Aperfeicoamento de Pessoal de Nível Superior-Brazil-Finance Code 001 and National Council for Scientific and Technological Developmentfinanced in part by the Conselho Nacional de Desenvolvimento Científico e Tecnológico and Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil--Finance Code 001funded by the Fundacao de Apoio à Pesquisa do Distrito Federal with grants from demanda espontanea-Edital 09/2022
文摘Background:Hemodialysis(HD) per se is a risk factor for thrombosis.Considering the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training model.The aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this molecule.Methods:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of <15 mL/min/1.73 m2).The RE+BFR session consisted of 50% arterial occlusion pressure during 50 min sessions of HD(intradialytic exercise).RE repetitions included concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning specialist.Results:Several variables were associated with elevated levels of D-dimer,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflammatory status,catheter as vascular access,older patients(>70 years old),and HD vintage.Furthermore,RE+BFR significantly increases D-dimer after 4 h.Patients with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.
文摘Dear editor:We sincerely thank Matthew J.Clarkson for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.
基金the Institutional Review Board of Kanton St.Gallen,Switzerland,with a waiver of the requirement for informed consent of the participants as the study involved the analysis of publicly available data(EKSG 01-06-2010).
文摘This study aimed to investigate the trends of finishers in the Sao Silvestre race in Brazil,taking into account sex,age,and performance levels.A total of 31775 runners(women,n=13847;men,n=17928),aged(45.2±16.8)years,finishers in the Sao Silvestre race between 2007 and 2021,were considered in the present analysis.Data(event year,date of birth,sex,and race times)were downloaded from the official race website.The man-Whitney U test,Spearman correlation,and robust regression model were computed.Participation increased over time for both sexes.Regarding age groups,“31-40 years”(women)and“>60 years”(men)were those with the highest number of finishers.We found a decrease in performance across the years(β=2.45;p<0.005),as well as significant differences in race times for both sexes(U=42.844;p<0.001),with men presenting better performances than women.Over time,it was observed an increase in the performance gap between the sexes,but in general,the performance decreased(β=1.76;p<0.001).Stakeholders should consider improving the strategies to improve women and young people's participation in running events.
