Actinic cheilitis can progress to squamous cell carcinoma in 20% of cases. The purpose of this study was to identify the clinical characteristics of 75 patients with actinic cheilitis and to summarise the current lite...Actinic cheilitis can progress to squamous cell carcinoma in 20% of cases. The purpose of this study was to identify the clinical characteristics of 75 patients with actinic cheilitis and to summarise the current literature concerning actinic cheilitis. A total of 75 patients were evaluated over a 3-year period. The medical history, physical examination results and images were collected from each patient. Demographic data were collected and analysed. To review the literature, the relevant data were collected from scientific journals in the last 30 years. The mean age of the patients was 56 years old;42 patients (56%) were female, and 66 patients (88%) were white. Nineteen (25.3%) patients reported at least one symptom, including pain, burning and itching. Sixty-five (86.7%) patients presented actinic cheilitis only in the lower lip. All of the patients reported sun exposure, and 44 (58.6%) patients were exposed for more than 10 years. The main clinical aspects investigated and analysed included dryness (100%), flaking (72%) and white lesions (57.3%). Lip assessment is extremely important in medical and dental care. From the 15 lesions assessed in the presence of actinic cheilitis, the most common clinical characteristics observed were dryness, flaking and white lesions. It is imperative to know the clinical aspects that may be encountered in actinic cheilitis in order to achieve early diagnosis, thus avoiding lip squamous cell carcinoma transformation.展开更多
Parkinson’s disease(PD)is a complex genetic neurodegenerative disorder.Epidemiology genetic discoveries have increased our understanding of the molecular contributors to Parkinson’s pathophysiology,especially when a...Parkinson’s disease(PD)is a complex genetic neurodegenerative disorder.Epidemiology genetic discoveries have increased our understanding of the molecular contributors to Parkinson’s pathophysiology,especially when associated with the advent of genome-wide association studies(GWAS)technologies in the discovery of the risk linked to common germline genetic variants.The biggest limitation of those studies on genetic susceptibility to PD is the lack of information describing the impact of individuals’ancestry on risk associations,especially in non-European populations.Current genetic data are mainly based on individuals of European origin,particularly those included in the UK biobank project.The effects of these ethical discrepancies can directly impact the discovery of risk variants associated with PD susceptibility and clinical management of PD patients in admixture populations,for example.Thus,we performed a PROSPERO-registered systematic review to elucidate the current state of the art about the role of common genetic variants based on GWAS studies in advancing precision medicine for PD susceptibility and pathobiology in multiethnic and non-European populations.Also,we discuss whether there are similarities or discrepancies of these data in relation to genomic data obtained in studies with PD patients of European origin.展开更多
基金CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnologico—National Counsil for Technological and Scientific Developement).
文摘Actinic cheilitis can progress to squamous cell carcinoma in 20% of cases. The purpose of this study was to identify the clinical characteristics of 75 patients with actinic cheilitis and to summarise the current literature concerning actinic cheilitis. A total of 75 patients were evaluated over a 3-year period. The medical history, physical examination results and images were collected from each patient. Demographic data were collected and analysed. To review the literature, the relevant data were collected from scientific journals in the last 30 years. The mean age of the patients was 56 years old;42 patients (56%) were female, and 66 patients (88%) were white. Nineteen (25.3%) patients reported at least one symptom, including pain, burning and itching. Sixty-five (86.7%) patients presented actinic cheilitis only in the lower lip. All of the patients reported sun exposure, and 44 (58.6%) patients were exposed for more than 10 years. The main clinical aspects investigated and analysed included dryness (100%), flaking (72%) and white lesions (57.3%). Lip assessment is extremely important in medical and dental care. From the 15 lesions assessed in the presence of actinic cheilitis, the most common clinical characteristics observed were dryness, flaking and white lesions. It is imperative to know the clinical aspects that may be encountered in actinic cheilitis in order to achieve early diagnosis, thus avoiding lip squamous cell carcinoma transformation.
基金Howard Lopes Ribeiro Junior is recipient of a CNPq Research Productivity Scholarship-Level 2(Project:Chamada CNPq N°09/2023-Bolsas de Produtividade em Pesquisa-PQ#305659/2023-5)funded by the Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnol ógico(FUNCAP)(UNI-0210-00007.01.00/23)entitled:“Estabelecimento de um Escore de Risco Poligênico(PRS)para a Neoplasia Mielodispl ásica no idoso:uma coorte Brasileira.
文摘Parkinson’s disease(PD)is a complex genetic neurodegenerative disorder.Epidemiology genetic discoveries have increased our understanding of the molecular contributors to Parkinson’s pathophysiology,especially when associated with the advent of genome-wide association studies(GWAS)technologies in the discovery of the risk linked to common germline genetic variants.The biggest limitation of those studies on genetic susceptibility to PD is the lack of information describing the impact of individuals’ancestry on risk associations,especially in non-European populations.Current genetic data are mainly based on individuals of European origin,particularly those included in the UK biobank project.The effects of these ethical discrepancies can directly impact the discovery of risk variants associated with PD susceptibility and clinical management of PD patients in admixture populations,for example.Thus,we performed a PROSPERO-registered systematic review to elucidate the current state of the art about the role of common genetic variants based on GWAS studies in advancing precision medicine for PD susceptibility and pathobiology in multiethnic and non-European populations.Also,we discuss whether there are similarities or discrepancies of these data in relation to genomic data obtained in studies with PD patients of European origin.
