The sexual maturation in all mammals is the period in which the quiescent gonads are activated by gonadotropins from anterior pituitary, increasing the secretion of sexual hormones. Sexual maturation it is also relate...The sexual maturation in all mammals is the period in which the quiescent gonads are activated by gonadotropins from anterior pituitary, increasing the secretion of sexual hormones. Sexual maturation it is also related with the development of several other body features such as body mass and maturation of the circulatory, skeletal and hematopoietic systems. The aim of the present study was to evaluate the function of neutrophils submitted to in vivo lower and higher concentration of testosterone (sexually immature: 60 days and sexually mature: 90 days). Using different approaches we evaluated cell viability and function and gene expression in rat neutrophils from 60 and 90 days-old animals. Neutrophils from 90 days-old rats showed a decrease in phagocytic and fungicidal capacity, without change in cellular viability. Additionally, we verified that sexual maturation induced increase in production of reactive oxygen and nitrogen species (RONS) and also in TNF-α, IL-6 and IL-10 cytokines. In conclusion, our data suggest that increase in testosterone levels induced significant alteration in neutrophil function, impairing phagocytic capacity.展开更多
This study aimed to describe yoga practice and verify its association with depression,anxiety,and stress during the COVID-19 pandemic among Brazilian practitioners.A cross-sectional anonymous online survey was conduct...This study aimed to describe yoga practice and verify its association with depression,anxiety,and stress during the COVID-19 pandemic among Brazilian practitioners.A cross-sectional anonymous online survey was conducted in all regions of Brazil using a snowball sampling strategy among yoga practitioners.A total of 860 participants(87%female,aged:19–82 years)completed the survey.Sociodemographic data,lifestyle factors,yoga practice during the pandemic,and the Depression Anxiety and Stress Scale(DASS-21)scores were collected between July 9 and July 15,2021.Overall,9.5%,9.3%,and 5.6%of participants exhibited some traits(mild to severe)of depression,anxiety,and stress,respectively.Hatha yoga(48%)was the most commonly practiced yoga style.In the adjusted analysis,a higher yoga experience(>5 years)was associated with better anxiety(odds ratio;bootstrap 95%confidence interval:2.42;1.32,4.49)and stress status(1.80;1.06,3.00)than beginners(<1 year).Practitioners who reported higher time and days of yoga practice during the study period were more likely to show normal levels of depression(odds ratio:2.56–6.49;p<0.05),anxiety(odds ratio:3.68–8.84;p<0.05),and stress(odds ratio:2.15–5.21;p<0.05).Moreover,the maintenance of practice frequency during the pandemic was associated with higher odds of normal levels of depression(2.27;1.39–3.79),anxiety(1.97;1.25–3.10),and stress(1.97;1.32–2.96).In conclusion,our findings indicated that a higher level of yoga practice was associated with better mental health levels during the COVID-19 pandemic.展开更多
The pandemic of the new coronavirus(COVID-19)may be affecting the physical activity(PA)level in much of the population.This study aimed to investigate the prevalence of physical inactivity and sedentary behavior(SB)am...The pandemic of the new coronavirus(COVID-19)may be affecting the physical activity(PA)level in much of the population.This study aimed to investigate the prevalence of physical inactivity and sedentary behavior(SB)among adults with chronic diseases and their associations with sociodemographic factors during the COVID-19 pandemic.This cross-sectional study included 249 participants(age:18-91 years;61.4%female)with chronic conditions and attended the Family Health Strategy program in a small town in Brazil.Data were collected between 2020-07-13 and 2020-07-24 by face-to-face interviews.Self-reported PA,sitting time,chronic diseases,medication use,sociodemographic data,and self-isolation adherence were obtained by questionnaire.During this specific time point of the COVID-19 pandemic,71.5%of participants did not meet the PA recommendations(≥500 METs-min/week),and the prevalence of SB risk(≥4 h sitting)was 62.7%.Adjusted logistic regression indicated that male participants(odds ratio[OR]:1.89[95%CI 1.02-3.53]),living alone(OR:2.92[95%CI 1.03-8.30])or in a two-person household(OR:2.32[95%CI 1.16-4.63]),and those who reported sometimes performing self-isolation(OR:3.07[95%CI 1.47-6.40])were more likely to meet the minimum PA recommendations.Current smokers had a lower odds(OR:0.36[95%CI 0.14-0.95])of meeting the PA recommendations.Older participants(OR:2.18[95%CI 1.06-4.50])and those who had multimorbidity(OR:1.92[95%CI 1.07-3.44])were more likely to have a higher degree of SB.There is an urgent need to mitigate physical inactivity and SB,and public health interventions must take into account sociodemographic status.展开更多
文摘The sexual maturation in all mammals is the period in which the quiescent gonads are activated by gonadotropins from anterior pituitary, increasing the secretion of sexual hormones. Sexual maturation it is also related with the development of several other body features such as body mass and maturation of the circulatory, skeletal and hematopoietic systems. The aim of the present study was to evaluate the function of neutrophils submitted to in vivo lower and higher concentration of testosterone (sexually immature: 60 days and sexually mature: 90 days). Using different approaches we evaluated cell viability and function and gene expression in rat neutrophils from 60 and 90 days-old animals. Neutrophils from 90 days-old rats showed a decrease in phagocytic and fungicidal capacity, without change in cellular viability. Additionally, we verified that sexual maturation induced increase in production of reactive oxygen and nitrogen species (RONS) and also in TNF-α, IL-6 and IL-10 cytokines. In conclusion, our data suggest that increase in testosterone levels induced significant alteration in neutrophil function, impairing phagocytic capacity.
文摘This study aimed to describe yoga practice and verify its association with depression,anxiety,and stress during the COVID-19 pandemic among Brazilian practitioners.A cross-sectional anonymous online survey was conducted in all regions of Brazil using a snowball sampling strategy among yoga practitioners.A total of 860 participants(87%female,aged:19–82 years)completed the survey.Sociodemographic data,lifestyle factors,yoga practice during the pandemic,and the Depression Anxiety and Stress Scale(DASS-21)scores were collected between July 9 and July 15,2021.Overall,9.5%,9.3%,and 5.6%of participants exhibited some traits(mild to severe)of depression,anxiety,and stress,respectively.Hatha yoga(48%)was the most commonly practiced yoga style.In the adjusted analysis,a higher yoga experience(>5 years)was associated with better anxiety(odds ratio;bootstrap 95%confidence interval:2.42;1.32,4.49)and stress status(1.80;1.06,3.00)than beginners(<1 year).Practitioners who reported higher time and days of yoga practice during the study period were more likely to show normal levels of depression(odds ratio:2.56–6.49;p<0.05),anxiety(odds ratio:3.68–8.84;p<0.05),and stress(odds ratio:2.15–5.21;p<0.05).Moreover,the maintenance of practice frequency during the pandemic was associated with higher odds of normal levels of depression(2.27;1.39–3.79),anxiety(1.97;1.25–3.10),and stress(1.97;1.32–2.96).In conclusion,our findings indicated that a higher level of yoga practice was associated with better mental health levels during the COVID-19 pandemic.
基金This research was approved by the local Research Ethics Committee(protocol number 4.152.055),and all participants signed an informed consent form prior to participation.
文摘The pandemic of the new coronavirus(COVID-19)may be affecting the physical activity(PA)level in much of the population.This study aimed to investigate the prevalence of physical inactivity and sedentary behavior(SB)among adults with chronic diseases and their associations with sociodemographic factors during the COVID-19 pandemic.This cross-sectional study included 249 participants(age:18-91 years;61.4%female)with chronic conditions and attended the Family Health Strategy program in a small town in Brazil.Data were collected between 2020-07-13 and 2020-07-24 by face-to-face interviews.Self-reported PA,sitting time,chronic diseases,medication use,sociodemographic data,and self-isolation adherence were obtained by questionnaire.During this specific time point of the COVID-19 pandemic,71.5%of participants did not meet the PA recommendations(≥500 METs-min/week),and the prevalence of SB risk(≥4 h sitting)was 62.7%.Adjusted logistic regression indicated that male participants(odds ratio[OR]:1.89[95%CI 1.02-3.53]),living alone(OR:2.92[95%CI 1.03-8.30])or in a two-person household(OR:2.32[95%CI 1.16-4.63]),and those who reported sometimes performing self-isolation(OR:3.07[95%CI 1.47-6.40])were more likely to meet the minimum PA recommendations.Current smokers had a lower odds(OR:0.36[95%CI 0.14-0.95])of meeting the PA recommendations.Older participants(OR:2.18[95%CI 1.06-4.50])and those who had multimorbidity(OR:1.92[95%CI 1.07-3.44])were more likely to have a higher degree of SB.There is an urgent need to mitigate physical inactivity and SB,and public health interventions must take into account sociodemographic status.
