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Investigation and Research on Students'Learning Ability in Vocational Undergraduate Education:A Case Study of the Integrated Circuits Major at Shenzhen Polytechnic University
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作者 CHENG Bowen 《Philosophy Study》 2025年第5期269-276,共8页
Vocational undergraduate education has entered a new stage of high-quality development,making the cultivation of students'learning ability a core issue in enhancing talent cultivation quality.This study conducted ... Vocational undergraduate education has entered a new stage of high-quality development,making the cultivation of students'learning ability a core issue in enhancing talent cultivation quality.This study conducted a questionnaire survey with 177 students majoring in integrated circuits at Shenzhen Polytechnic University(SZPU),focusing on six dimensions:self-learning proficiency,academic competence,goal planning,self-discipline,learning initiative,and learning environment.The results indicate that while students possess a solid learning foundation and clear career planning,significant deficiencies exist in the execution of academic plans,self-discipline,and learning initiative.In response to these issues,this study proposes four systematic improvement pathways from the institutional perspective:establishing a closed-loop academic navigation system incorporating“goal-process-feedback”,creating an immersive“virtual-physical integrated”learning environment,implementing a multi-dimensional“cognitive-affective-practical”initiative activation plan,and building a synergistic cultivation mechanism for“self-discipline and core competencies”.The findings aim to provide references for talent cultivation and teaching reform in vocational undergraduate integrated circuit programs. 展开更多
关键词 vocational undergraduate education students'learning ability integrated circuit major
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Build an International Teaching Resource Construction System and Practice International Talent Training in the Context of “Double First-class” ——Take the School of Software of Northwestern Polytechnical University Case as an Example
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作者 Liming Lin Jiangbin Zheng +1 位作者 Chunyan Ma Qianru Wei 《计算机教育》 2022年第12期163-170,共8页
From the perspective of the development of world-class universities,internationalization is an essential strategic choice and external feature,and also an inevitable choice to improve the discourse power and competiti... From the perspective of the development of world-class universities,internationalization is an essential strategic choice and external feature,and also an inevitable choice to improve the discourse power and competitiveness of international higher education.In line with the national“double first-class”international development strategy of higher education,based on the cultivation of students’overall quality,the improvement of teachers’professional ability,and the development of school’s improvement of quality and efficiency,we School of Software,Northwestern Polytechnical University,explore new ideas and new measures for the cultivation of international software engineering talents,build a set of international teaching resources construction system,to form a reference standard and scheme for the cultivation of international software engineering talents.At present,we have achieved excellent results. 展开更多
关键词 “Double first-class” International teaching resources construction system INTERNATIONALIZATION Talents’training
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Analysis on the University-enterprise Collaborative Training Path for Engineering Doctor from the Perspective of Deep Integration—Innovative Synergies in Talent and Technology Development 被引量:1
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作者 Peirong Guo Mingjian Song +1 位作者 Chunwei Tian Qi Zhu 《计算机教育》 2025年第3期138-144,共7页
With the rapid development of China’s economy,the demand for high-end talents in the field of engineering technology is becoming increasingly prominent.Engineering doctors,as an important force in this field,have a d... With the rapid development of China’s economy,the demand for high-end talents in the field of engineering technology is becoming increasingly prominent.Engineering doctors,as an important force in this field,have a direct impact on the progress of national technological innovation and the upgrading of industrial structure.Currently,there are still some issues in the university-enterprise collaboration for engineering doctor training in China,such as unclear cooperation mechanisms and responsibility divisions,insufficient corporate participation and enthusiasm,and imperfect evaluation and feedback mechanisms.This paper aims to explore the university-enterprise collaborative training path of engineering doctors from the perspective of deep integration,analyzing multiple dimensions including training objectives,curriculum design,practical sessions,mentor teams,and evaluation systems,in order to provide reference for the reform and practice of engineering doctor training in China. 展开更多
关键词 Engineering doctor Deep integration University-enterprise collaborative training
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Appropriation and Actualization of a Formative Assessment Initiative at a Chinese Local University:The Power-Process Nexus
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作者 Qiuxian Chen Jingwei Song 《Chinese Journal of Applied Linguistics》 2025年第2期285-301,322,共18页
The past two decades have seen formative assessment claim legitimacy in policy discourse and engender immense tensions within the testing-dominated assessment regimes of multiple educational settings.These tensions,al... The past two decades have seen formative assessment claim legitimacy in policy discourse and engender immense tensions within the testing-dominated assessment regimes of multiple educational settings.These tensions,along with the top-down approach of the policy process,have made the inroads of formative assessment in local contexts very complex.This study seeks to unveil the localized appropriation and actualization of a formative assessment initiative in the College English area at a Chinese local university.The focus is on how the key actors at the institutional and classroom levels appropriate and negotiate the policy meaning within their local community of practice.Analysis of an individual interview with the dean and a focus-group interview with six 1 teachers has revealed a“two-hand”approach to the national policy and a nested mediation from local constraints,“cultural tools for thinking”and,more importantly,power in the policymaking process at the institutional level.The classroom level,on the other hand,witnesses capable teachers exercising their agency within a limited space.As a result,we would caution that power and agency could be solid mediators in the policy process and need to be exercised with care to ensure a more coherent implementation of assessment innovations. 展开更多
关键词 formative assessment College English China power-process nexus testing-dominated contexts two-hand approach
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Enhancing the Effectiveness of Overseas Study Programs for University Teachers:Strategies and Influencing Factors
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作者 ZHOU Yuntao 《International Journal of Plant Engineering and Management》 2025年第2期65-79,共15页
Overseas study for university teachers is a crucial path for their professional development and an effective means to enhance the level of education internationalization.However,the effectiveness of these studies is i... Overseas study for university teachers is a crucial path for their professional development and an effective means to enhance the level of education internationalization.However,the effectiveness of these studies is influenced by the various factors,including pre⁃study selection and preparation,management and support in the study period,application and assessment of study outcomes afterward,as well as personal factors such as age,family background,and education experience.This paper aims to explore the impact of these factors on the effectiveness of teachers′international education studies and propose the corresponding improvement suggestions,in order to provide a reference for improving the quality and effectiveness of teachers′studies. 展开更多
关键词 university teachers overseas study and research influencing factors internationalization of education
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KCUBE:A Knowledge Graph University Curriculum Framework for Student Advising and Career Planning
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作者 Qing Li 《计算机教育》 2025年第12期32-35,共4页
In recent years,various efforts have been devoted to advancing university education through artificial intelligence(AI).To this end,this paper introduces KCUBE,a novel framework centered on knowledge graphs(KGs)design... In recent years,various efforts have been devoted to advancing university education through artificial intelligence(AI).To this end,this paper introduces KCUBE,a novel framework centered on knowledge graphs(KGs)designed to enhance student advising and career planning in university courses.Owing to KCUBE,we can improve university education in the AI era by leveraging the expressiveness,operability,and interpretability of KGs.We detail a bottom-up approach for KG construction,empowering professors to develop subject-specific KGs,augmented by tools like ChatGPT,which has demonstrated promising accuracy and coverage.Based on KGs,KCUBE supports KG reasoning for applications such as automated teaching plan generation with dynamic editing capabilities.Furthermore,KCUBE offers advanced KG manipulation through 2D and 3D visualization platforms,such as virtual reality(VR)for immersive exploration of academic subjects and potential career paths.A comparative study on collaborative learning highlights the benefits of VR and KG-enhanced environments in promoting student engagement,participation,and collaborative decision-making. 展开更多
关键词 KCUBE Knowledge graph Virtual reality Artificial intelligence
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Domestic brain circulation in China:Impact on publication,citation,collaboration and university prestige
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作者 Yurui Huang Jialong Guo +3 位作者 Chaolin Tian Shibing Xiang Yongshen He Yifang Ma 《Journal of Data and Information Science》 2025年第4期243-268,共26页
Purpose:This study investigates the impact of domestic mobility on Chinese scientists’academic performance and explores the predictors influencing their chances of moving to more prestigious institutions.Design/metho... Purpose:This study investigates the impact of domestic mobility on Chinese scientists’academic performance and explores the predictors influencing their chances of moving to more prestigious institutions.Design/methodology/approach:Using publication and affiliation data from OpenAlex,we identified 2,896 scientists who relocated between cities in China from 2014 to 2017.We applied propensity score matching(PSM)to compare their academic outcomes post-mobility with a matched group of non-mobile peers.Multiple performance metrics were examined,including publication count,citation impact,number of collaborators,and university prestige.Ordered logistic regression was used to analyze factors influencing moves to higher-level institutions.Findings:Mobility enhances collaboration by increasing the number of coauthors but is associated with a short-term decline in citation impact.Scientists were more likely to move to lower-prestige universities.However,prior collaboration breadth and citation count positively predicted transitions to more prestigious institutions,while the number of publications did not.Research limitations:This study focuses on intra-national mobility within China from 2014 to 2017 and relies on quantitative data,lacking personal or qualitative variables such as gender,discipline-specific norms,or institutional culture.Data coverage for Chinese-language publications may also be limited.Practical implications:This research provides insights into academic hiring patterns and the trade-offs involved in scientist mobility.It offers valuable guidance for institutions aiming to enhance faculty recruitment and retention,as well as for researchers considering career transitions.Originality/value:This is a quantitative analysis of domestic scientist mobility in China using matched comparison and multi-dimensional academic indicators.The integration of university prestige metrics(Double First-Class and citation-based rankings)offers a nuanced view of career dynamics within the Chinese higher education system. 展开更多
关键词 Scientific mobility in China Scientific performance Propensity Score Matching Career development Computational Social Science
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Metabolic adaptations of Qingke:A review of stress resilience and nutritional functions 被引量:2
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作者 Congping Xu Yulin Wang +19 位作者 Naoxue Fei Yuzhen Basang Haizhen Yang Jiabu Dunzhu Hongjun Yuan Mu Wang Sang Zha Wa Da Taba Xiongnu Puci Basang Chunbao Yang Qijun Xu Zexiu Wei Yawen Gan Yawei Tang Alisdair R.Fernie Zhaoyan Chen Jie Luo Ganggang Guo Xingquan Zeng 《The Crop Journal》 2026年第1期61-73,共13页
Qingke,a staple crop grown on the high-altitude Tibetan Plateau,has evolved a metabolomic profile providing both environmental stress resilience and human nutrition.We review the hypothesis that the metabolites that c... Qingke,a staple crop grown on the high-altitude Tibetan Plateau,has evolved a metabolomic profile providing both environmental stress resilience and human nutrition.We review the hypothesis that the metabolites that confer cold and UV resistance on the crop also facilitate human adaptation to high-altitude stresses.Specifically,β-glucans regulate blood glucose primarily via short-chain fatty acids(SCFAs)produced through gut microbiota fermentation,which directly mediate glucose homeostasis.Phenolamides accumulate via the phenylpropanoid pathway,with chalcone isomerase(CHI)serving as a key enzyme in flavonoid biosynthesis and enhancing UV-B resistance.Under low temperatures,β-glucans improve frost tolerance by modulating osmotic balance and inhibiting ice-nucleating proteins,while lipids maintain membrane fluidity to sustain cellular function during cold stress.Importantly,we explore the hypothesis that these same metabolites,upon consumption,may facilitate human adaptation to high-altitude stresses.This hypothesis is supported by preliminary epidemiological associations between Qingke consumption and favorable health outcomes in high-altitude populations,as well as established bioactivities of the implicated metabolites in vitro and in animal models.However,direct causal evidence in humans and a comprehensive understanding of the underlying molecular mechanisms remain key knowledge gaps that warrant future investigation.Qingke as a unique resource at the interface of agricultural resilience and human nutrition.Understanding its metabolic blueprint will inform the development of functional foods and climate-resilient crops. 展开更多
关键词 Qingke Metabolomics Multi-omics integration Plateau adaptation
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Orthogonal Optimization of Solution Treatment and Aging Process for TB18 Titanium Alloy and Toughness Regulation Mechanism
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作者 Gao Huixian Li Ke +7 位作者 Shao Shan Yang Haoxue Li Qinqin Zhao Yanru Luo Wenzhong Feng Yong Lei Qiang Liu Xianghong 《稀有金属材料与工程》 北大核心 2026年第4期841-855,共15页
To investigate the effect of solution treatment and aging process parameters on the microstructure and mechanical properties of TB18 titanium alloy,process optimization research was conducted based on the mixed-level ... To investigate the effect of solution treatment and aging process parameters on the microstructure and mechanical properties of TB18 titanium alloy,process optimization research was conducted based on the mixed-level orthogonal experiment design of factor levels.Results show that through range analysis,the significance order of process parameters is determined as follows:solution cooling method>solution temperature>aging time>aging temperature>solution time.Considering the strength-ductility matching and engineering application requirements,the benchmark parameters are selected as solution time of 1 h,solution cooling method of air cooling(AC),aging temperature of 525℃,and aging time of 4 h.Furthermore,the effects of solution temperature in the range of 790–870℃ on the impact toughness and micro-fracture characteristics of the alloy were studied.The results reveal that the larger the area of shear lip and fibrous zone,and the smaller the area of radiation zone,the better the toughness of the alloy.With the increase in solution temperature,the length of secondary cracks on the fracture surface increases,the number of dimples increases,and the toughness is enhanced.Based on the collaborative optimization of strength and toughness,the optimal heat treatment process for TB18 alloy is determined as 870℃/1 h,AC+525℃/4 h,AC. 展开更多
关键词 TB18 titanium alloy solution and aging orthogonal test TOUGHNESS MICROSTRUCTURE
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Research Progress on High Thermal Conductivity Graphene/Copper-Based Composite Heat Sinks for Electronic Equipment
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作者 Li Hongzhao Jiang Haojie +3 位作者 Pan Jiabao Jia Hongsheng Chen Minghe Chen Yang 《稀有金属材料与工程》 北大核心 2026年第3期636-654,共19页
Graphene/copper-based composite heat sinks demonstrate extensive application potential in military equipment thermal management,high-power electronic packaging,new energy vehicles,and 5G communication systems,due to t... Graphene/copper-based composite heat sinks demonstrate extensive application potential in military equipment thermal management,high-power electronic packaging,new energy vehicles,and 5G communication systems,due to their outstanding properties,including high thermal conductivity,tunable thermal expansion coefficients,excellent mechanical strength,and low density.However,the industrial-scale application of these composites faces critical challenges during the fabrication of components with complex structures,such as inhomogeneous dispersion of graphene within the copper matrix and poor interfacial bonding between the two phases,which substantially undermine the overall performance of graphene/copper-based composites.To address these issues,the preparation methods for graphene/copper-based composite heat sinks were reviewed.For each method,a rigorous analysis was presented to clarify its inherent advantages and unavoidable restrictions.Furthermore,the latest research progress in addressing three core scientific challenges was synthesized,including uniform dispersion of graphene,interfacial optimization mechanisms,and molecular dynamics simulations for elucidating the structure-property relationships.Finally,the future development directions of graphene/copper-based composite heat sinks in engineering applications were prospected. 展开更多
关键词 graphene/copper-based composite heat sinks preparation methods interfacial bonding MECHANISM molecular dynamics
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Syntheses,structures,and catalytic performances of complexes with 4,4'-dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid ligands
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作者 LING Weizhong LIN Jingyi +3 位作者 ZHU Jianglin LIANG Yuyi DAI Shanshan LI Yu 《无机化学学报》 北大核心 2026年第1期152-160,共9页
Three copper(Ⅱ),nickel and cadmium(Ⅱ)complexes,namely[Cu_(2)(μ-H2dbda)2(phen)2]·2H_(2)O(1),[Ni(μ-H2dbda)(μ-bpb)(H_(2)O)2]n(2),and[Cd(μ-H2dbda)(μ-bpa)]n(3),have been constructed hydrothermally using H4dbda(... Three copper(Ⅱ),nickel and cadmium(Ⅱ)complexes,namely[Cu_(2)(μ-H2dbda)2(phen)2]·2H_(2)O(1),[Ni(μ-H2dbda)(μ-bpb)(H_(2)O)2]n(2),and[Cd(μ-H2dbda)(μ-bpa)]n(3),have been constructed hydrothermally using H4dbda(4,4'-dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid),phen(1,10-phenanthroline),bpb(1,4-bis(pyrid-4-yl)benzene),bpa(bis(4-pyridyl)amine),and copper,nickel and cadmium chlorides at 160℃.The products were isolated as stable crystalline solids and were characterized by IR spectra,elemental analyses,thermogravimetric analyses,and singlecrystal X-ray diffraction analyses.Single-crystal X-ray diffraction analyses revealed that three complexes crystallize in the monoclinic P21/n,tetragonal I42d,and orthorhombic P21212 space groups.The complexes exhibit molecular dimers(1)or 2D metal-organic networks(2 and 3).The catalytic performances in the Knoevenagel reaction of these complexes were investigated.Complex 1 exhibits an effective catalytic activity and excellent reusability as a heterogeneous catalyst in the Knoevenagel reaction at room temperature.CCDC:2463800,1;2463801,2;2463802,3. 展开更多
关键词 COMPLEX dicarboxylic acid catalytic properties Knoevenagel reaction
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Effect of Channel Segregation on Microstructure and Mechanical Properties of Ti45Nb Alloy Wire
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作者 Shang Jinjin Yang Hui +6 位作者 Bai Huiwen Wu Yulun Zhao Xiaohua Lei Qiang He Tao Liu Xianghong Zeng Weidong 《稀有金属材料与工程》 北大核心 2026年第4期869-876,共8页
The effects of channel segregation on the macro-and micro-scale chemical composition,microstructure,hardness,and tensile deformation behavior of Ti45Nb wires were investigated.The results show that wires with severe c... The effects of channel segregation on the macro-and micro-scale chemical composition,microstructure,hardness,and tensile deformation behavior of Ti45Nb wires were investigated.The results show that wires with severe channel segregation exhibit a macroscopic chemical composition identical to those without segregation,and 3D X-ray imaging result also reveals no abnormalities.After annealing,both types of wires exhibit an equiaxed single-phase microstructure with comparable grain sizes,suggesting that channel segregation has negligible influence on the macroscopic composition and grain size.Metallographic examination reveals that channel segregation manifests as spot-like features in the transverse section and band-like structures in the longitudinal section.EDS analysis identifies these regions as Ti-enriched segregations,with a Ti content higher than that of the surrounding matrix by approximately 4.42wt%.Compared to segregation-free wires,those containing extensive channel segregation demonstrate a 15.5%increase in ultimate tensile strength and a 12.3%increase in yield strength,but suffer a reduction in elongation and reduction of area by 19.8%and 18.9%,respectively.Furthermore,the mechanical properties of wires with segregation show significant fluctuations.Fractographic analysis reveals a larger fracture surface area in segregated wires.Severe dislocation pile-ups occur at the interfaces of these segregated regions,initiating microcrack nucleation.This promotes rapid crack propagation of the Ti45Nb wire,leading to a significant decrease in plasticity and reduction of area. 展开更多
关键词 Ti45Nb alloy channel segregation mechanical properties
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Research Progress of Ta-Nb-Hf-Zr-Ti High Entropy Alloy Superconductors
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作者 Cao Likun Yang Fang +3 位作者 Hao Qingbin Zhang Shengnan Yan Guo Zhang Pingxiang 《稀有金属材料与工程》 北大核心 2026年第4期926-940,共15页
High-entropy alloys,a novel class of materials characterized by the statistical distribution of multiple principal elements on simple crystalline lattices,have emerged as a research hotspot in materials science and co... High-entropy alloys,a novel class of materials characterized by the statistical distribution of multiple principal elements on simple crystalline lattices,have emerged as a research hotspot in materials science and condensed matter physics due to their exceptional mechanical properties and unique high-entropy characteristic.Since the discovery of the first high-entropy superconductor in 2014,exploring their superconducting performance and advantages has progressively become a frontier in scientific research.The Ta-Nb-Hf-Zr-Ti system,in particular,exhibits remarkable mechanical robustness,outstanding radiation tolerance,and superconducting performance comparable to the binary NbTi alloy,positioning it as a promising candidate for advanced applications,such as high-field superconducting magnets,superconducting electric motors,and next-generation nuclear fusion reactors.This review systematically summarized global research progress on Ta-Nb-Hf-Zr-Ti-based superconductors,aiming to provide a comprehensive reference for advancing this burgeoning field. 展开更多
关键词 high-entropy alloys Ta-Nb-Hf-Zr-Ti SUPERCONDUCTOR
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Achieving serrated grain boundaries within gradient microstructures of nickel-based superalloys for dual-property turbine disks in aeroengines
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作者 Bingchao XIE Yongquan NING +4 位作者 Youwei LUO Zhaotian WANG Bowen SHI Mei ZHAN Mingwang FU 《Chinese Journal of Aeronautics》 2026年第2期641-660,共20页
Gradient microstructures strengthened by serrated Grain Boundaries(GBs)were achieved through a combination of Gradient Strain Deformation(GSD)and Serration Heat Treatment(SHT),with particular focus on microstructural ... Gradient microstructures strengthened by serrated Grain Boundaries(GBs)were achieved through a combination of Gradient Strain Deformation(GSD)and Serration Heat Treatment(SHT),with particular focus on microstructural evolution,underlying mechanisms,and the critical influencing factors.Dynamic recrystallization governed the microstructural evolution in the fine-grained and transition regions during GSD,where multiple nucleation mechanisms were active.Plastic deformation facilitated the dissolution ofγ'phase in fine-grained regions,ultimately resulting in its morphological transformation.During the subsequent SHT,serrated GBs formed within the gradient microstructures produced by prior GSD without disrupting the grain size gradient,thereby enhancing creep resistance.Two distinct mechanisms associated withγ'gbparticles governed the formation of the serrations at GBs.Owing to the stronger dragging effect of grain boundary junctions in fine-grained regions,the amplitude and wavelength of serrations in these regions were smaller than those in coarse-grained regions.Moreover,the formation of serrations exhibited a strong dependence on the inherent properties of the GBs.The random high-angle grain boundaries(HAGBs)with misorientation angles in the range of 30-59°tended to become serrated more easily during SHT due to their high mobility and the accelerated precipitation ofγ'gbparticles at them.Low-ΣHAGBs and low-angle GBs were not prone to form serrations.In particular,serration formation was completely inhibited atΣ3 twin boundaries due to their extremely low mobility and the absence ofγ'gbparticles. 展开更多
关键词 Gradient microstructures Grain boundary migration Grain boundary properties Serrated grain boundaries Serration formation mechanisms SUPERALLOYS
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Mission capability assessment of UAV swarms based on UAF and interval-valued spherical fuzzy ANP
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作者 LI Minghao ZHANG An +2 位作者 BI Wenhao FAN Qiucen YANG Pan 《Journal of Systems Engineering and Electronics》 2026年第1期225-241,共17页
For mission-oriented unmanned aerial vehicle(UAV)swarms,mission capability assessment provides an important reference in the design and development process,and is a precondition for mission success.For this multi-crit... For mission-oriented unmanned aerial vehicle(UAV)swarms,mission capability assessment provides an important reference in the design and development process,and is a precondition for mission success.For this multi-criteria decisionmaking(MCDM)problem,the current literature lacks a way to unambiguously present criteria and the popular fuzzy analytic network process(ANP)approaches neglect the hesitancy of subjective judgments.To fill these research gaps,an MCDM method based on unified architecture framework(UAF)and interval-valued spherical fuzzy ANP(IVSF-ANP)is proposed in this paper.Firstly,selected viewpoints in UAF are extended to construct criteria models with standardized representation.Secondly,interval-valued spherical fuzzy sets are introduced to ANP to weight interdependent criteria,handling fuzziness and hesitancy in pairwise comparisons.A method of adjusting weights of experts based on their decision similarities is also included in this process to reduce ambiguity brought by multiple experts.Next,performance characteristics are non-linearly transformed regarding to expectations to get final results.This proposition is applied to assess the mission capability of UAV swarms to search and strike surface vessels.Comparative analysis shows that the proposed method is valid and reasonable. 展开更多
关键词 unmanned aerial vehicle(UAV)swarm capability assessment multi-criteria decision-making(MCDM) unified architecture framework interval-valued spherical fuzzy set analytical network process(ANP)
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Environmental sustainability assessment of remediation alternatives for highly contaminated marine sediments
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作者 Alessia Amato Alessandro Becci +2 位作者 Giulia Merli Francesca Beolchini Antonio Dell’Anno 《Journal of Environmental Sciences》 2026年第1期731-740,共10页
This study compares the environmental sustainability of five alternatives for the remediation of marine sediments of one of the most polluted coastal sites in Europe(Bagnoli-Coroglio bay,Mediterranean Sea),using the L... This study compares the environmental sustainability of five alternatives for the remediation of marine sediments of one of the most polluted coastal sites in Europe(Bagnoli-Coroglio bay,Mediterranean Sea),using the Life Cycle Assessment(LCA)methodology.The treatments are either in-situ or exsitu,the latter requiring an initial dredging to transport the contaminated sediments to the management site.More in detail,four ex-situ remediation technologies based on landfilling,bioremediation,electrokinetic technique and soil washing were identified.These technologies are compared to an in-situ strategy currently under validation for enhancing bioremediation of the polluted sediments of the Bagnoli-Coroglio site.Our results indicate that the disposal in landfilling site is the worst option in most categories(e.g.,650 kg CO_(2) eq./t of treated sediment,considering the nearest landfilling site),followed by the bioremediation,mainly due to the high energy demand.Electrokinetic remediation,soil washing,and innovative in-situ technology represent the most sustainable options.In particular,the new in-situ technology appears to be the least impacting in all categories(e.g.,54 kg CO_(2) eq./t of treated sediment),although it is expected to require longer treatment time(estimated up to 12 months based on its potential efficiency).It can reduce the impact on climate change more than 12 times compared to the disposal and 7 times compared to bioremediation in addition to the possibility to avoid/reduce the dredging operations and the consequent dispersion of pollutants.The results open relevant perspectives towards more eco-sustainable and costly effective actions for the reclamation of contaminated marine sediments. 展开更多
关键词 Life cycle assessment Marine sediments contamination ELECTROKINETIC BIOREMEDIATION Ex-situ remediation In-situ remediation
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Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?
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作者 Shuangchan Wu Jun Chen 《Neural Regeneration Research》 2026年第2期648-658,共11页
Myelination,the continuous ensheathment of neuronal axons,is a lifelong process in the nervous system that is essential for the precise,temporospatial conduction of action potentials between neurons.Myelin also provid... Myelination,the continuous ensheathment of neuronal axons,is a lifelong process in the nervous system that is essential for the precise,temporospatial conduction of action potentials between neurons.Myelin also provides intercellular metabolic support to axons.Even minor disruptions in the integrity of myelin can impair neural performance and increase susceptibility to neurological diseases.In fact,myelin degeneration is a well-known neuropathological condition that is associated with normal aging and several neurodegenerative diseases,including multiple sclerosis and Alzheimer’s disease.In the central nervous system,compact myelin sheaths are formed by fully mature oligodendrocytes.However,the entire oligodendrocyte lineage is susceptible to changes in the biological microenvironment and other risk factors that arise as the brain ages.In addition to their well-known role in action potential propagation,oligodendrocytes also provide intercellular metabolic support to axons by transferring energy metabolites and delivering exosomes.Therefore,myelin degeneration in the aging central nervous system is a significant contributor to the development of neurodegenerative diseases.Interventions that mitigate age-related myelin degeneration can improve neurological function in aging individuals.In this review,we investigate the changes in myelin that are associated with aging and their underlying mechanisms.We also discuss recent advances in understanding how myelin degeneration in the aging brain contributes to neurodegenerative diseases and explore the factors that can prevent,slow down,or even reverse age-related myelin degeneration.Future research will enhance our understanding of how reducing age-related myelin degeneration can be used as a therapeutic target for delaying or preventing neurodegenerative diseases. 展开更多
关键词 aging Alzheimer’s disease multiple sclerosis MYELIN myelin-axon metabolite crosstalk myelinodegeneration neurodegenerative disease OLIGODENDROCYTE Parkinson’s disease white matter
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Dynamic characterization of pathological and functional deterioration in a mouse model of optic neuritis related to neuromyelitis optica spectrum disorder
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作者 Xiayin Yang Shi-Qi Yao +1 位作者 Henry Ho-Lung Chan Shaoying Tan 《Neural Regeneration Research》 2026年第8期3870-3880,共11页
Neuromyelitis optica spectrum disorder-related optic neuritis involves various cellular responses to inflammation and degeneration.In most patients,the primary mechanism underlying neuromyelitis optica spectrum disord... Neuromyelitis optica spectrum disorder-related optic neuritis involves various cellular responses to inflammation and degeneration.In most patients,the primary mechanism underlying neuromyelitis optica spectrum disorder-related optic neuritis is the interaction of aquaporin-4 antibodies with the aquaporin-4 protein present on astrocytes within posterior optic nerve.This binding subsequently initiates a cascade of events leading to secondary demyelination of the optic nerve,ultimately culminating in optic nerve degeneration.Earlier studies on this disorder primarily used systemic-induced animal models,which often require prior activation of a systemic immune response.This can result in primary demyelination of the optic nerve,complicating the interpretation of experimental results.Such methodologies hinder the ability to isolate immune responses triggered by specific antibodies.Additionally,the lack of a detailed profile of disease progression over time limits our capacity to identify potential intervention windows.Therefore,constructing a targeted optic neuritis animal model induced by specific antibodies and elucidate the disease progression arecrucial for exploring the mechanisms underlying neuromyelitis optica spectrum disorder-related optic neuritis.In this study,specific antibodies against aquaporin-4 were precisely injected into the retrobulbar optic nerve of mice to induce a targeted inflammatory response in the posterior optic nerve,resulting in a more representative mouse model of neuromyelitis optica spectrum disorder-related optic neuritis than current models.The progression of the disease was then dynamically observed from both histological and functional perspectives over the course of 1 month following the induction of inflammation.By the first week,astrocytes were damaged,as evidenced by the loss of aquaporin-4 and glial fibrillary acidic protein,the activation of microglia,and the upregulation of microglia-related cytokines,including tumor necrosis factor,interleukin-6,interleukin-1β,C-X-C motif ligand 10,and brain-derived neurotrophic factor.Starting from the second week,there were signs of optic nerve demyelination and significant damage to axonal fibers and retinal ganglion cell bodies.Visual-evoked potentials and dark adaptation threshold responses in electroretinogram both indicated dysfunction in the visual pathway and retina,while optical coherence tomography revealed thinning of the retinal nerve fiber layer in live mice.In summary,in this study we conducted a dynamic exploration of the occurrence and progression of neuromyelitis optica spectrum disorder-related optic neuritis triggered by specific antibodies.Our results show pathological changes at various stages and correlate histological and molecular alterations with in vivo structural and functional deterioration.The findings from this study lay an important foundation for further research on neuromyelitis optica spectrum disorder-related optic neuritis. 展开更多
关键词 animal model aquaporin-4 immunoglobulin G dynamic profile ELECTRORETINOGRAM functional deterioration in vivo retinal structural scan neuromyelitis optica spectrum disorder-related optic neuritis optic neuritis pathology visual-evoked potential
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