Transarterial radioembolization(TARE) is a form of brachytherapy in which intra-arterially injected yttrium-90-loaded microspheres serve as a source for internal radiation purposes.On the average,it produces disease c...Transarterial radioembolization(TARE) is a form of brachytherapy in which intra-arterially injected yttrium-90-loaded microspheres serve as a source for internal radiation purposes.On the average,it produces disease control rates exceeding 80% and it is a consolidated therapy for hepatocellular carcinoma(HCC);however,current data are all based on retrospective series or non-controlled prospective studies since randomized controlled trials comparing it with the other liver-directed therapies for intermediate and locally advanced stage HCC are still underway.The data available show that TARE provides similar or even better survival rates when compared to transarterial chemoembolization(TACE).First-line TARE is best indicated for both intermediatestage patients(staged according to the barcelona clinic liver cancer staging classification) who have lesions which respond poorly to TACE due to multiple tumors or a large tumor burden,and for locally advanced-stage patients with solitary tumors,and segmental or lobar portal vein tumor thrombosis.In addition,emerging data have suggested the use of TARE in patients who are classified slightly beyond the Milan criteria regarding radical treatment for downstaging purposes.As a secondline treatment,TARE can also be applied in patients progressing to TACE or sorafenib;a large number of phase Ⅱ/Ⅲ trials are ongoing with the purpose of evaluating the best association with systemic therapies.Transarterial radioembolization is very well tolerated and has a low rate of complications which are mainly related to unintended non-target tissue irradiation,including the surrounding liver parenchyma.The complications can be additionally reduced by accurate patient selection and a strict pre-treatment evaluation including dosimetry and assessment of the vascular anatomy.Since a correct treatment algorithm for potential TARE candidates is not clear and standardized,this comprehensive review analyzes the best selection criteria for patients who really benefit from TARE and also the new advances of this therapy,which can be a very important weapon against HCC.展开更多
Objective: We aim to quantify the magnitude of setup errors in intensity-modulated radiotherapy (IMRT) treated Head and Neck cancer patients and recommend appropriate PTV margin. Methods: 60 patients with head and nec...Objective: We aim to quantify the magnitude of setup errors in intensity-modulated radiotherapy (IMRT) treated Head and Neck cancer patients and recommend appropriate PTV margin. Methods: 60 patients with head and neck cancer required bilateral neck irradiation were planned and treated by simultaneous integrated boost IMRT technique either treated radically or postoperative. Patients undergoing image-guided radiotherapy (IGRT) each with once weekly scheduled cone beam computed tomography (CBCT). The 3D displacements, systematic and random errors were calculated. The appropriate PTV expansion was determined using Van Herk’s formula. Results: Mean 3D displacement was 0.16 cm in the vertical direction, 0.14 cm in the horizontal direction and 0.16 cm in the longitudinal direction. Conclusion: Use of weekly CBCT allows the planning target volume (PTV) expansion to be reduced according to our setup. The appropriate clinical target volume (CTV)-PTV margin for our institute is 0.30 cm, 0.38 cm, and 0.33 cm in the horizontal, vertical, and longitudinal directions, respectively.展开更多
In most countries around the globe,adolescent girls are less physically active than boys.However,the majority of studies have been conducted in high-income countries,while there is less evidence from low-and middle-in...In most countries around the globe,adolescent girls are less physically active than boys.However,the majority of studies have been conducted in high-income countries,while there is less evidence from low-and middle-income countries.1 The reasons for this gender difference in physical activity(PA)participation are poorly understood.A recently published article by Ricardo et al.2 on gender inequalities in adolescent PA from 64 global south countries seeks to close this knowledge gap.展开更多
Volatile components in the extracts of basil leaves (Ocimum basilicum L.) were identified by gas chromatography/mass spectrometry (GC/MS) with electron ionization (EI) mode. The major volatile components of basil unde...Volatile components in the extracts of basil leaves (Ocimum basilicum L.) were identified by gas chromatography/mass spectrometry (GC/MS) with electron ionization (EI) mode. The major volatile components of basil under investigation are α-pinene, sabinene, β-pinene, d-limonene, eucalyptol, l-linalool and estragole. Electron ionization mass spectra of these compounds have been obtained and investigated. Furthermore, the semi-empirical MNDO [Modified Neglect of Diatomic Overlap] method was used to calculate the thermochemical data for the structural properties of these compounds.展开更多
It is well known that temperature acts negatively on practically all the parameters of photovoltaic solar cells. Also, the solar cells which are subjected to particularly very high temperatures are the light concentra...It is well known that temperature acts negatively on practically all the parameters of photovoltaic solar cells. Also, the solar cells which are subjected to particularly very high temperatures are the light concentration solar cells and are used in light concentration photovoltaic systems (<i><span style="font-family:Verdana;">CPV</span></i><span style="font-family:Verdana;">). In fact, the significant heating of these solar cells is due to the concentration of the solar flux which arrives on them. Light concentration solar cells appear as solar cells under strong influences of heating and temperature. It is therefore necessary to take into account temperature effect on light concentration solar cells performances in order to obtain realistic results. </span><span style="font-family:""><span style="font-family:Verdana;">This one-dimensional study of a crystalline silicon solar cell under light concentration takes into account electrons concentration gradient electric field in the determination of the continuity equation of minority carriers in the base. To determine excess minority carrier’s density, the effects of temperature on the diffusion and mobility of electrons and holes, on the intrinsic concentration of electrons, on carrier’s generation rate as well as on width of band gap have also been taken into account. The results show that an increase of temperature improves diffusion parameters and leads to an increase of the short-circuit photocurrent density. However, an increase of temperature leads to a significant decrease in open-circuit photovoltage, maximum electric power and conversion efficiency. The results also show that the operating point and the maximum power point (</span><i><span style="font-family:Verdana;">MPP</span></i><span style="font-family:Verdana;">) moves to the open circuit when the cell temperature increases.</span></span>展开更多
Transport of charge carriers in percolating nanocluster devices based on bimetallic PdCu nanoclusters was investigated in this work. The device was fabricated by self-assembly of the nanoclusters between electrical el...Transport of charge carriers in percolating nanocluster devices based on bimetallic PdCu nanoclusters was investigated in this work. The device was fabricated by self-assembly of the nanoclusters between electrical electrodes inside an ultra-high vacuum compatible system. The average size of the produced nanoclusters was 7.3 nm, and the composition was Pdo.77Cuo.23. Systematic in situ current-voltage measurements as a function of temperature were per- formed which provide a conductance-temperature profile. The results are explained in terms of the charge carriers＇ tunneling through small potential barriers at the junctions between nanoclusters. The results predict the size of the nanoclusters as well as the magnitude of the potential difference of the tunneling barriers. This investigation helps understanding the nature of the interface between the nanoclusters and the charge carrier transport within those devices to be utilized for optimizing gas sensing properties of PdCu nanocluster devices.展开更多
This paper is part of a series on the Azimuthally Symmetric Theory of Gravitation （ASTG）. This theory is built on Laplace-Poisson＇s well known equation and it has been shown that the ASTG is capable of explaining, ...This paper is part of a series on the Azimuthally Symmetric Theory of Gravitation （ASTG）. This theory is built on Laplace-Poisson＇s well known equation and it has been shown that the ASTG is capable of explaining, from a purely classical physics standpoint, the precession of the perihelion of solar planets as a consequence of the azimuthal symmetry emerging from the spin of the Sun. This symmetry has and must have an influence on the emergent gravitational field. We show herein that the emergent equations from the ASTG, under some critical conditions determined by the spin, do possess repulsive gravitational fields in the polar regions of the gravitating body in question. This places the ASTG on an interesting pedestal to infer the origins of outflows as a repulsive gravitational phenomenon. Outflows are a ubiquitous phenomenon found in star forming systems and their true origin is a question yet to be settled. Given the current thinking on their origin, the direction that the present paper takes is nothing short of an asymptotic break from conventional wisdom; at the very least, it is a complete paradigm shift because gravitation is not at all associated with this process, but rather it is thought to be an all-attractive force that only tries to squash matter together onto a single point. Additionally, we show that the emergent Azimuthally Symmetric Gravitational Field from the ASTG strongly suggests a solution to the supposed Radiation Problem that is thought to be faced by massive stars in their process of formation. That is, at ,- 8-10M⊙, radiation from the nascent star is expected to halt the accretion of matter. We show that in-falling material will fall onto the equatorial disk and from there, this material will be channeled onto the forming star via the equatorial plane, thus accretion of mass continues well past the value of - 8-10M⊙, albeit via the disk. Along the equatorial plane, the net force （with the radiation force included） on any material there-on right up to the surface of the star is directed toward the forming star, hence accretion of mass by the nascent star is un-hampered.展开更多
Photonic computing has recently become an interesting paradigm for high-speed calculation of computing processes using light-matter interactions.Here,we propose and study an electromagnetic wave-based structure with t...Photonic computing has recently become an interesting paradigm for high-speed calculation of computing processes using light-matter interactions.Here,we propose and study an electromagnetic wave-based structure with the ability to calculate the solution of partial differential equations(PDEs)in the form of the Helmholtz wave equation,∇^(2)(x,y)T+k^(2)(x,y)=0,with k as the wavenumber.To do this,we make use of a network of interconnected waveguides filled with dielectric inserts.In so doing,it is shown how the proposed network can mimic the response of a network of T-circuit elements formed by two series and a parallel impedances,i.e.,the waveguide network effectively behaves as a metatronic network.An in-depth theoretical analysis of the proposed metatronic structure is presented,showing how the governing equation for the currents and impedances of the metatronic network resembles that of the finite difference representation of the Helmholtz wave equation.Different studies are then discussed including the solution of PDEs for Dirichlet and open boundary value problems,demonstrating how the proposed metatronic-based structure has the ability to calculate their solutions.展开更多
Background:Emerging adulthood is a pivotal life stage,presenting significant psychological and social changes,such as decreased sociability,depression,and other mental health problems.Previous studies have associated ...Background:Emerging adulthood is a pivotal life stage,presenting significant psychological and social changes,such as decreased sociability,depression,and other mental health problems.Previous studies have associated these changes with an unhealthy lifestyle.The 24-h movement guidelines for healthy lifestyles have been developed to promote appropriate health behaviors and improve individual wellness.However,the relationship between adherence to the 24-h movement guidelines and different characteristics of Chinese emerging adults is yet to be explored.This cross-sectional study aimed to investigate the association between adherence to the 24-h movement guidelines and four characteristics(self-exploration,instability,possibilities,and responsibility)of Chinese emerging adults.Methods:Overall,1,510 Chinese emerging adults aged 18–29 years were included in this study.Each participant completed a self-administered questionnaire that included questions on adherence to the 24-h movement guidelines(physical activity,sedentary behavior,and sleep)and the inventory of dimensions of emerging adulthood.Multivariable logistic regression analysis was employed to investigate the associations between adherence to the 24-h movement guidelines and each of the four characteristics.Results:The proportion of participants who adhered to the 24-h movement guidelines was 31.72%.Multiple regression analysis revealed a significantly negative relationship between adhering to more guidelines and instability(β=−0.51,p<0.001).A statistically significant association was observed between instability and meeting only sedentary behavior(β=−1.27,95%confidence interval[CI]:[−2.32,−0.24],p=0.02),sedentary behavior+sleep(β=−1.30,95%CI:[−2.24,−0.35],p<0.01),and physical activity+sedentary behavior(β=−1.08,95%CI:[1.94,−0.21],p=0.02)guidelines.Further,positive and significant associations were observed between possibilities and meeting the guidelines for only physical activity(β=0.70,95%CI:[0.14,1.27),p=0.01),only sleep(β=0.61,95%CI:[0.01,1.21],p=0.04),physical activity+sedentary behavior(β=0.56,95%CI:[0.04,1.07),p=0.01),and physical activity+sleep(β=0.76,95%CI:[0.23,1.27],p=0.01).Conclusions:These findings suggest that adherence to the 24-h movement guidelines was associated with instability in Chinese emerging adults.Future studies are warranted to verify our findings to highlight the importance of maintaining a heath lifestyle to promote health in emerging adulthood.展开更多
A massive star is defined as one with mass greater than - 8-10.M⊙. Central to the on-going debate on how these objects [massive stars] come into being is the so-called Radiation Problem. For nearly forty years, it ha...A massive star is defined as one with mass greater than - 8-10.M⊙. Central to the on-going debate on how these objects [massive stars] come into being is the so-called Radiation Problem. For nearly forty years, it has been argued that the radiation field emanating from massive stars is high enough to cause a global re- versal of direct radial in-fall of material onto the nascent star. We argue that only in the case of a non-spinning isolated star does the gravitational field of the nascent star overcome the radiation field. An isolated non-spinning star is a non-spinning star without any circumstellar material around it, and the gravitational field beyond its surface is described exactly by Newton＇s inverse square law. The supposed fact that massive stars have a gravitational field that is much stronger than their radiation field is drawn from the analysis of an isolated massive star. In this case the gravitational field is much stronger than the radiation field. This conclusion has been erroneously extended to the case of massive stars enshrouded in gas and dust. We find that, for the case of a non- spinning gravitating body where we take into consideration the circumstellar material, at ,- 8-10M⊙, the radiation field will not reverse the radial in-fall of matter, but rather a stalemate between the radiation and gravitational field will be achieved, i.e. the infall is halted but not reversed. This picture is very different from the common picture that is projected and accepted in the popular literature where at -8-10 M⊙, all the circumstellar material, from the surface of the star right up to the edge of the molec- ular core, is expected to be swept away by the radiation field. We argue that massive stars should be able to start their normal stellar processes if the molecular core from which they form has some rotation, because a rotating core exhibits an Azimuthally Symmetric Gravitational Field which causes there to be an accretion disk and along this equatorial disk. The radiation field cannot be much stronger than the gravitational field, hence this equatorial accretion disk becomes the channel via which the nascent massive star accretes all of its material.展开更多
<span style="font-family:Verdana;">This manuscript presents a simple method for excess minority carriers’ lifetime measurement</span><span style="font-family:""> </span&g...<span style="font-family:Verdana;">This manuscript presents a simple method for excess minority carriers’ lifetime measurement</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">within the base region of p-n junction polycrystalline solar </span><span style="font-family:Verdana;">cell</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">in transient mode.</span><span style="font-family:""> </span><span style="font-family:Verdana;">This work is an experimental transient</span><span style="font-family:Verdana;"> 3-Dimensionnal study.</span><span style="font-family:""> </span><span style="font-family:Verdana;">The magnitude of the magnetic field B is varied from 0 mT to 0.045 mT. Indeed, the solar cell is illuminated by a stroboscopic flash with air mass 1.5</span><span style="font-family:""> </span><span style="font-family:Verdana;">and under magnetic field in transient state.</span><span style="font-family:""> </span><span style="font-family:Verdana;">The experimental details are assumed in a figure. The procedure is outlined by the Open Circuit Voltage Decay analysis. Effective minority carrier life-time is calculated by fitting the linear zone of the transient voltage decay curve</span><span style="font-family:""> </span><span style="font-family:Verdana;">because linear decay is an ideal decay. The kaleidagraph software permits access to the slope of the curve which is inversely proportional to the</span><span style="font-family:""> </span><span style="font-family:Verdana;">lifetime. The external magnetic effects</span><span style="font-family:""> </span><span style="font-family:Verdana;">on minority carriers’ effective lifetime </span><span style="font-family:Verdana;">is</span><span style="font-family:Verdana;"> then</span><span style="font-family:""> </span><span style="font-family:Verdana;">presented and analyzed.</span><span style="font-family:""> </span><span style="font-family:Verdana;">The analysis show</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> that the charge carrier</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s effective lifetime decrease with the magnetic field increase.</span>展开更多
We present first principles calculations of optical properties of binary semiconductor compounds TlBr and TlCl.Dependences of dielectric function,reflectivity and refractive index on hydrostatic pressure are calculate...We present first principles calculations of optical properties of binary semiconductor compounds TlBr and TlCl.Dependences of dielectric function,reflectivity and refractive index on hydrostatic pressure are calculated using self-consistent scalar relativistic full potential linear augmented plane wave method(FP-LAPW) within a generalized gradient approximation(GGA).They are compared with previous calculations and experimental measurements.Good agreements are found.展开更多
In this paper we have searched for the existence of Lyra’s cosmology in a hybrid universe with minimal interaction between dark energy and normal matter using Bianchi-V space-time. To derive the exact solution, the a...In this paper we have searched for the existence of Lyra’s cosmology in a hybrid universe with minimal interaction between dark energy and normal matter using Bianchi-V space-time. To derive the exact solution, the average scale factor is taken as a =(t~nekt)1/m which describes the hybrid nature of the scale factor and generates a model of the transitioning universe from the early deceleration phase to the present acceleration phase. The quintessence model makes the matter content of the derived universe remarkably able to satisfy the null, dominant and strong energy condition. It has been found that the time varying displacement β(t) co-relates with the nature of cosmological constant Λ(t). We also discuss some physical and geometrical features of the universe.展开更多
We generalize a previously proposed imaging scheme to situations for which the set of hidden objects embedded in the highly scattering medium can take arbitrary shapes.We compare the accuracy of images obtained from o...We generalize a previously proposed imaging scheme to situations for which the set of hidden objects embedded in the highly scattering medium can take arbitrary shapes.We compare the accuracy of images obtained from optical detection fibers with those from a ccd camera.The latter approach is more efficient and can be applied to non-contact geometries,but it requires an a priori linearization of the obtained digitized images.We discuss some details of this calibration for the camera and establish its potential as a new tool for decomposition based imaging.展开更多
To evaluate the efficacy and feasibility of external beam radiotherapy(EBRT)for duodenal adenocarcinoma in an 84-year-old female who underwent EBRT(2.2 Gy/d for a total dose of 46.2 Gy)using helical tomotherapy(HT).To...To evaluate the efficacy and feasibility of external beam radiotherapy(EBRT)for duodenal adenocarcinoma in an 84-year-old female who underwent EBRT(2.2 Gy/d for a total dose of 46.2 Gy)using helical tomotherapy(HT).Toxicity was evaluated on the National Cancer Institute's common toxicity criteria(CTCAE 3.0).The patient completed the treatment without G3-G4 toxicity.After 22-mo follow-up,she is alive and well,in complete remission with no late side effects.HT seems to be feasible and effective for duodenal adenocarcinoma in old to very old patients.展开更多
1.Legacy matters The withdrawal of Australia as hosts for the Commonwealth Games in 2026 demonstrates that large international sporting events are more than just sporting mastery,medals,and memories.Money also matters...1.Legacy matters The withdrawal of Australia as hosts for the Commonwealth Games in 2026 demonstrates that large international sporting events are more than just sporting mastery,medals,and memories.Money also matters.1 The cost of hosting a major international tournament is eye-wateringly high.Host governments need to show that the billions of dollars of investment deliver a return beyond sporting glory to justify the resources that are spent.展开更多
Purpose: To test the use of Intensity Modulated Radiotherapy (IMRT) to spare the bone marrow (BM) in patients treated with cancer cervix through using the bone marrow an organ at risk. Patients and methods: Thirteen p...Purpose: To test the use of Intensity Modulated Radiotherapy (IMRT) to spare the bone marrow (BM) in patients treated with cancer cervix through using the bone marrow an organ at risk. Patients and methods: Thirteen patients with stage (IB2-IIIB) intact cervix cancer were included;C-T simulation was done with contrast and full bladder with slice thickness 2.5 mm. Clinical Target Volume (CTV) included the cervix, uterus, upper half of the vagina, parametrium and regional lymph nodes. The CTV was expanded by 1 cm to form the Planning Target Volume (PTV). The organ at risk (OAR) included the bladder and rectum, the external contour of the pelvic bones to define the Pelvic Bone Marrow (PBM). Four plans were done for every patient with anteroposterior-posteroanterior (AP/PA), three dimensional conformal radiotherapy (3DCRT), IMRT, bone marrow-sparing intensity-modulated pelvic radiotherapy (BMS-IMRT). Results: BMS-IMRT reduced the V20, V30, V40 and V45 of the BM in comparison to 3DCRT and IMRT plans. Reduction in V20 with BMS-IMRT plan compared to 3DCRT (p 0.03). The PBM volume receiving 5, 10 and 20 Gy was lower AP/PA than BMS-IMRT (p < 0.01, p 0.001 and p 0.04 respectively). The volumes of the rectum and bladder receiving dose of 40 and 45 Gy were lower in BMS-IMRT plan compared to AP/PA and 3DCRT plans with p = 0.01 for both of them. PTV cover was better in the BMS-IMRT and IMRT plans. Conclusion: BMS-IMRT decreased the irradiated BM volume compared to other techniques. Thus using BMS-IMRT is recommended to decrease hematological toxicity and avoid treatment interruption.展开更多
Background: In 2010, the International Atomic Energy Agency launched the “3A’s campaign” as an effective tool for primary cancer prevention. In 2011, the American Association of Physicists in Medicine recommended t...Background: In 2010, the International Atomic Energy Agency launched the “3A’s campaign” as an effective tool for primary cancer prevention. In 2011, the American Association of Physicists in Medicine recommended the size specific dose estimate (SSDE). Objectives: To audit doses of Coronary CT Angiography (Coronary CTA) in tertiary care referral center. Methods: We reviewed 998 consecutive Coronary CTA (from 2007 to 2012). Doses (CTDIvol mGy), DLP (mGy*cm), effective dose (DLP*0.014, mSv) were on-line archived. SSDE was estimated retrospectively. Appropriateness score was evaluated for exams performed from the 2010. Results: Overall median dose per Coronary CTA was 49.7 mGy for CTDIvol, 55.5 mGy for SSDE, 994.96 mGy*cm for DLP, 13.9 mSv for effective dose. Median DLP decreased over time (1452.94 in 2007, 1605.56 in 2008, 1113.49 in 2009, 759.99 in 2010, 448.61 in 2011 and 497.88 mGy*cm in 2012, p < 0.0001). SSDE was proportional to the size dependent factor (SDF);in patients with SDF > 1 (88%) CTDIvol underestimated SSDE (48.49 vs 57.19 mGy), whilst in patients with SDF < 1 (12%) CTDIvol overestimated SSDE (56.46 vs 50.3 mGy). Scans were appropriate in 58%, uncertain in 24%, and inappropriate in 18% of cases. Doses were similar in appropriate, uncertain or inappropriate examinations and in excellent-to-good (81%) vs. sufficient-to-poor (19%) image quality exams. Conclusions: Coronary CTA reference doses can be very misleading. SSDE can allow individual technique optimization. The dose is similar in appropriate and inappropriate examinations, and unrelated to image quality. The rate of inappropriate examinations is still too high even after dissemination of guidelines.展开更多
Re-engineering the channel heat exchangers(CHEs)is the goal of many recent studies,due to their great importance in the scope of energy transport in various industrial and environmental fields.Changing the internal ge...Re-engineering the channel heat exchangers(CHEs)is the goal of many recent studies,due to their great importance in the scope of energy transport in various industrial and environmental fields.Changing the internal geometry of the CHEs by using extended surfaces,i.e.,VGs(vortex generators),is the most common technique to enhance the efficiency of heat exchangers.This work aims to develop a newdesign of solar collectors to improve the overall energy efficiency.The study presents a new channel design by introducing VGs.The FVM(finite volume method)was adopted as a numerical technique to solve the problem,with the use of Oil/MWCNT(oil/multi-walled carbon nano-tubes)nanofluid to raise the thermal conductivity of the flow field.The study is achieved for a Re number ranging from12×10^(3) to 27×10^(3),while the concentration(φ)of solid particles in the fluid(Oil)is set to 4%.The computational results showed that the hydrothermal characteristics depend strongly on the flow patterns with the presence of VGs within the CHE.Increasing the Oil/MWCNT rates with the presence of VGs generates negative turbulent velocities with high amounts,which promotes the good agitation of nanofluid particles,resulting in enhanced great transfer rates.展开更多
文摘Transarterial radioembolization(TARE) is a form of brachytherapy in which intra-arterially injected yttrium-90-loaded microspheres serve as a source for internal radiation purposes.On the average,it produces disease control rates exceeding 80% and it is a consolidated therapy for hepatocellular carcinoma(HCC);however,current data are all based on retrospective series or non-controlled prospective studies since randomized controlled trials comparing it with the other liver-directed therapies for intermediate and locally advanced stage HCC are still underway.The data available show that TARE provides similar or even better survival rates when compared to transarterial chemoembolization(TACE).First-line TARE is best indicated for both intermediatestage patients(staged according to the barcelona clinic liver cancer staging classification) who have lesions which respond poorly to TACE due to multiple tumors or a large tumor burden,and for locally advanced-stage patients with solitary tumors,and segmental or lobar portal vein tumor thrombosis.In addition,emerging data have suggested the use of TARE in patients who are classified slightly beyond the Milan criteria regarding radical treatment for downstaging purposes.As a secondline treatment,TARE can also be applied in patients progressing to TACE or sorafenib;a large number of phase Ⅱ/Ⅲ trials are ongoing with the purpose of evaluating the best association with systemic therapies.Transarterial radioembolization is very well tolerated and has a low rate of complications which are mainly related to unintended non-target tissue irradiation,including the surrounding liver parenchyma.The complications can be additionally reduced by accurate patient selection and a strict pre-treatment evaluation including dosimetry and assessment of the vascular anatomy.Since a correct treatment algorithm for potential TARE candidates is not clear and standardized,this comprehensive review analyzes the best selection criteria for patients who really benefit from TARE and also the new advances of this therapy,which can be a very important weapon against HCC.
文摘Objective: We aim to quantify the magnitude of setup errors in intensity-modulated radiotherapy (IMRT) treated Head and Neck cancer patients and recommend appropriate PTV margin. Methods: 60 patients with head and neck cancer required bilateral neck irradiation were planned and treated by simultaneous integrated boost IMRT technique either treated radically or postoperative. Patients undergoing image-guided radiotherapy (IGRT) each with once weekly scheduled cone beam computed tomography (CBCT). The 3D displacements, systematic and random errors were calculated. The appropriate PTV expansion was determined using Van Herk’s formula. Results: Mean 3D displacement was 0.16 cm in the vertical direction, 0.14 cm in the horizontal direction and 0.16 cm in the longitudinal direction. Conclusion: Use of weekly CBCT allows the planning target volume (PTV) expansion to be reduced according to our setup. The appropriate clinical target volume (CTV)-PTV margin for our institute is 0.30 cm, 0.38 cm, and 0.33 cm in the horizontal, vertical, and longitudinal directions, respectively.
文摘In most countries around the globe,adolescent girls are less physically active than boys.However,the majority of studies have been conducted in high-income countries,while there is less evidence from low-and middle-income countries.1 The reasons for this gender difference in physical activity(PA)participation are poorly understood.A recently published article by Ricardo et al.2 on gender inequalities in adolescent PA from 64 global south countries seeks to close this knowledge gap.
文摘Volatile components in the extracts of basil leaves (Ocimum basilicum L.) were identified by gas chromatography/mass spectrometry (GC/MS) with electron ionization (EI) mode. The major volatile components of basil under investigation are α-pinene, sabinene, β-pinene, d-limonene, eucalyptol, l-linalool and estragole. Electron ionization mass spectra of these compounds have been obtained and investigated. Furthermore, the semi-empirical MNDO [Modified Neglect of Diatomic Overlap] method was used to calculate the thermochemical data for the structural properties of these compounds.
文摘It is well known that temperature acts negatively on practically all the parameters of photovoltaic solar cells. Also, the solar cells which are subjected to particularly very high temperatures are the light concentration solar cells and are used in light concentration photovoltaic systems (<i><span style="font-family:Verdana;">CPV</span></i><span style="font-family:Verdana;">). In fact, the significant heating of these solar cells is due to the concentration of the solar flux which arrives on them. Light concentration solar cells appear as solar cells under strong influences of heating and temperature. It is therefore necessary to take into account temperature effect on light concentration solar cells performances in order to obtain realistic results. </span><span style="font-family:""><span style="font-family:Verdana;">This one-dimensional study of a crystalline silicon solar cell under light concentration takes into account electrons concentration gradient electric field in the determination of the continuity equation of minority carriers in the base. To determine excess minority carrier’s density, the effects of temperature on the diffusion and mobility of electrons and holes, on the intrinsic concentration of electrons, on carrier’s generation rate as well as on width of band gap have also been taken into account. The results show that an increase of temperature improves diffusion parameters and leads to an increase of the short-circuit photocurrent density. However, an increase of temperature leads to a significant decrease in open-circuit photovoltage, maximum electric power and conversion efficiency. The results also show that the operating point and the maximum power point (</span><i><span style="font-family:Verdana;">MPP</span></i><span style="font-family:Verdana;">) moves to the open circuit when the cell temperature increases.</span></span>
基金supported by the United Arab Emirates University under a Grant number FOS/IRG-23/11
文摘Transport of charge carriers in percolating nanocluster devices based on bimetallic PdCu nanoclusters was investigated in this work. The device was fabricated by self-assembly of the nanoclusters between electrical electrodes inside an ultra-high vacuum compatible system. The average size of the produced nanoclusters was 7.3 nm, and the composition was Pdo.77Cuo.23. Systematic in situ current-voltage measurements as a function of temperature were per- formed which provide a conductance-temperature profile. The results are explained in terms of the charge carriers＇ tunneling through small potential barriers at the junctions between nanoclusters. The results predict the size of the nanoclusters as well as the magnitude of the potential difference of the tunneling barriers. This investigation helps understanding the nature of the interface between the nanoclusters and the charge carrier transport within those devices to be utilized for optimizing gas sensing properties of PdCu nanocluster devices.
基金supported by the Republic of South Africa's National Research Foundation
文摘This paper is part of a series on the Azimuthally Symmetric Theory of Gravitation （ASTG）. This theory is built on Laplace-Poisson＇s well known equation and it has been shown that the ASTG is capable of explaining, from a purely classical physics standpoint, the precession of the perihelion of solar planets as a consequence of the azimuthal symmetry emerging from the spin of the Sun. This symmetry has and must have an influence on the emergent gravitational field. We show herein that the emergent equations from the ASTG, under some critical conditions determined by the spin, do possess repulsive gravitational fields in the polar regions of the gravitating body in question. This places the ASTG on an interesting pedestal to infer the origins of outflows as a repulsive gravitational phenomenon. Outflows are a ubiquitous phenomenon found in star forming systems and their true origin is a question yet to be settled. Given the current thinking on their origin, the direction that the present paper takes is nothing short of an asymptotic break from conventional wisdom; at the very least, it is a complete paradigm shift because gravitation is not at all associated with this process, but rather it is thought to be an all-attractive force that only tries to squash matter together onto a single point. Additionally, we show that the emergent Azimuthally Symmetric Gravitational Field from the ASTG strongly suggests a solution to the supposed Radiation Problem that is thought to be faced by massive stars in their process of formation. That is, at ,- 8-10M⊙, radiation from the nascent star is expected to halt the accretion of matter. We show that in-falling material will fall onto the equatorial disk and from there, this material will be channeled onto the forming star via the equatorial plane, thus accretion of mass continues well past the value of - 8-10M⊙, albeit via the disk. Along the equatorial plane, the net force （with the radiation force included） on any material there-on right up to the surface of the star is directed toward the forming star, hence accretion of mass by the nascent star is un-hampered.
基金support of the Leverhulme Trust under the Leverhulme Trust Research Project Grant scheme(Grant No.RPG-2020-316)V.P-P.and R.G.M would like to thank the support from the Engineering and Physical Sciences Research Council(EPSRC)under the EPSRC DTP PhD scheme(Grant No.EP/T517914/1).
文摘Photonic computing has recently become an interesting paradigm for high-speed calculation of computing processes using light-matter interactions.Here,we propose and study an electromagnetic wave-based structure with the ability to calculate the solution of partial differential equations(PDEs)in the form of the Helmholtz wave equation,∇^(2)(x,y)T+k^(2)(x,y)=0,with k as the wavenumber.To do this,we make use of a network of interconnected waveguides filled with dielectric inserts.In so doing,it is shown how the proposed network can mimic the response of a network of T-circuit elements formed by two series and a parallel impedances,i.e.,the waveguide network effectively behaves as a metatronic network.An in-depth theoretical analysis of the proposed metatronic structure is presented,showing how the governing equation for the currents and impedances of the metatronic network resembles that of the finite difference representation of the Helmholtz wave equation.Different studies are then discussed including the solution of PDEs for Dirichlet and open boundary value problems,demonstrating how the proposed metatronic-based structure has the ability to calculate their solutions.
基金the Research on Youth Physical Behavior and Mental Health Problems-Department of Science and Technology of Guangdong Province(2022SB0022).
文摘Background:Emerging adulthood is a pivotal life stage,presenting significant psychological and social changes,such as decreased sociability,depression,and other mental health problems.Previous studies have associated these changes with an unhealthy lifestyle.The 24-h movement guidelines for healthy lifestyles have been developed to promote appropriate health behaviors and improve individual wellness.However,the relationship between adherence to the 24-h movement guidelines and different characteristics of Chinese emerging adults is yet to be explored.This cross-sectional study aimed to investigate the association between adherence to the 24-h movement guidelines and four characteristics(self-exploration,instability,possibilities,and responsibility)of Chinese emerging adults.Methods:Overall,1,510 Chinese emerging adults aged 18–29 years were included in this study.Each participant completed a self-administered questionnaire that included questions on adherence to the 24-h movement guidelines(physical activity,sedentary behavior,and sleep)and the inventory of dimensions of emerging adulthood.Multivariable logistic regression analysis was employed to investigate the associations between adherence to the 24-h movement guidelines and each of the four characteristics.Results:The proportion of participants who adhered to the 24-h movement guidelines was 31.72%.Multiple regression analysis revealed a significantly negative relationship between adhering to more guidelines and instability(β=−0.51,p<0.001).A statistically significant association was observed between instability and meeting only sedentary behavior(β=−1.27,95%confidence interval[CI]:[−2.32,−0.24],p=0.02),sedentary behavior+sleep(β=−1.30,95%CI:[−2.24,−0.35],p<0.01),and physical activity+sedentary behavior(β=−1.08,95%CI:[1.94,−0.21],p=0.02)guidelines.Further,positive and significant associations were observed between possibilities and meeting the guidelines for only physical activity(β=0.70,95%CI:[0.14,1.27),p=0.01),only sleep(β=0.61,95%CI:[0.01,1.21],p=0.04),physical activity+sedentary behavior(β=0.56,95%CI:[0.04,1.07),p=0.01),and physical activity+sleep(β=0.76,95%CI:[0.23,1.27],p=0.01).Conclusions:These findings suggest that adherence to the 24-h movement guidelines was associated with instability in Chinese emerging adults.Future studies are warranted to verify our findings to highlight the importance of maintaining a heath lifestyle to promote health in emerging adulthood.
基金supported by the Republic of South Africa's National Research Foundation
文摘A massive star is defined as one with mass greater than - 8-10.M⊙. Central to the on-going debate on how these objects [massive stars] come into being is the so-called Radiation Problem. For nearly forty years, it has been argued that the radiation field emanating from massive stars is high enough to cause a global re- versal of direct radial in-fall of material onto the nascent star. We argue that only in the case of a non-spinning isolated star does the gravitational field of the nascent star overcome the radiation field. An isolated non-spinning star is a non-spinning star without any circumstellar material around it, and the gravitational field beyond its surface is described exactly by Newton＇s inverse square law. The supposed fact that massive stars have a gravitational field that is much stronger than their radiation field is drawn from the analysis of an isolated massive star. In this case the gravitational field is much stronger than the radiation field. This conclusion has been erroneously extended to the case of massive stars enshrouded in gas and dust. We find that, for the case of a non- spinning gravitating body where we take into consideration the circumstellar material, at ,- 8-10M⊙, the radiation field will not reverse the radial in-fall of matter, but rather a stalemate between the radiation and gravitational field will be achieved, i.e. the infall is halted but not reversed. This picture is very different from the common picture that is projected and accepted in the popular literature where at -8-10 M⊙, all the circumstellar material, from the surface of the star right up to the edge of the molec- ular core, is expected to be swept away by the radiation field. We argue that massive stars should be able to start their normal stellar processes if the molecular core from which they form has some rotation, because a rotating core exhibits an Azimuthally Symmetric Gravitational Field which causes there to be an accretion disk and along this equatorial disk. The radiation field cannot be much stronger than the gravitational field, hence this equatorial accretion disk becomes the channel via which the nascent massive star accretes all of its material.
文摘<span style="font-family:Verdana;">This manuscript presents a simple method for excess minority carriers’ lifetime measurement</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">within the base region of p-n junction polycrystalline solar </span><span style="font-family:Verdana;">cell</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">in transient mode.</span><span style="font-family:""> </span><span style="font-family:Verdana;">This work is an experimental transient</span><span style="font-family:Verdana;"> 3-Dimensionnal study.</span><span style="font-family:""> </span><span style="font-family:Verdana;">The magnitude of the magnetic field B is varied from 0 mT to 0.045 mT. Indeed, the solar cell is illuminated by a stroboscopic flash with air mass 1.5</span><span style="font-family:""> </span><span style="font-family:Verdana;">and under magnetic field in transient state.</span><span style="font-family:""> </span><span style="font-family:Verdana;">The experimental details are assumed in a figure. The procedure is outlined by the Open Circuit Voltage Decay analysis. Effective minority carrier life-time is calculated by fitting the linear zone of the transient voltage decay curve</span><span style="font-family:""> </span><span style="font-family:Verdana;">because linear decay is an ideal decay. The kaleidagraph software permits access to the slope of the curve which is inversely proportional to the</span><span style="font-family:""> </span><span style="font-family:Verdana;">lifetime. The external magnetic effects</span><span style="font-family:""> </span><span style="font-family:Verdana;">on minority carriers’ effective lifetime </span><span style="font-family:Verdana;">is</span><span style="font-family:Verdana;"> then</span><span style="font-family:""> </span><span style="font-family:Verdana;">presented and analyzed.</span><span style="font-family:""> </span><span style="font-family:Verdana;">The analysis show</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> that the charge carrier</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s effective lifetime decrease with the magnetic field increase.</span>
文摘We present first principles calculations of optical properties of binary semiconductor compounds TlBr and TlCl.Dependences of dielectric function,reflectivity and refractive index on hydrostatic pressure are calculated using self-consistent scalar relativistic full potential linear augmented plane wave method(FP-LAPW) within a generalized gradient approximation(GGA).They are compared with previous calculations and experimental measurements.Good agreements are found.
文摘In this paper we have searched for the existence of Lyra’s cosmology in a hybrid universe with minimal interaction between dark energy and normal matter using Bianchi-V space-time. To derive the exact solution, the average scale factor is taken as a =(t~nekt)1/m which describes the hybrid nature of the scale factor and generates a model of the transitioning universe from the early deceleration phase to the present acceleration phase. The quintessence model makes the matter content of the derived universe remarkably able to satisfy the null, dominant and strong energy condition. It has been found that the time varying displacement β(t) co-relates with the nature of cosmological constant Λ(t). We also discuss some physical and geometrical features of the universe.
文摘We generalize a previously proposed imaging scheme to situations for which the set of hidden objects embedded in the highly scattering medium can take arbitrary shapes.We compare the accuracy of images obtained from optical detection fibers with those from a ccd camera.The latter approach is more efficient and can be applied to non-contact geometries,but it requires an a priori linearization of the obtained digitized images.We discuss some details of this calibration for the camera and establish its potential as a new tool for decomposition based imaging.
文摘To evaluate the efficacy and feasibility of external beam radiotherapy(EBRT)for duodenal adenocarcinoma in an 84-year-old female who underwent EBRT(2.2 Gy/d for a total dose of 46.2 Gy)using helical tomotherapy(HT).Toxicity was evaluated on the National Cancer Institute's common toxicity criteria(CTCAE 3.0).The patient completed the treatment without G3-G4 toxicity.After 22-mo follow-up,she is alive and well,in complete remission with no late side effects.HT seems to be feasible and effective for duodenal adenocarcinoma in old to very old patients.
文摘1.Legacy matters The withdrawal of Australia as hosts for the Commonwealth Games in 2026 demonstrates that large international sporting events are more than just sporting mastery,medals,and memories.Money also matters.1 The cost of hosting a major international tournament is eye-wateringly high.Host governments need to show that the billions of dollars of investment deliver a return beyond sporting glory to justify the resources that are spent.
文摘Purpose: To test the use of Intensity Modulated Radiotherapy (IMRT) to spare the bone marrow (BM) in patients treated with cancer cervix through using the bone marrow an organ at risk. Patients and methods: Thirteen patients with stage (IB2-IIIB) intact cervix cancer were included;C-T simulation was done with contrast and full bladder with slice thickness 2.5 mm. Clinical Target Volume (CTV) included the cervix, uterus, upper half of the vagina, parametrium and regional lymph nodes. The CTV was expanded by 1 cm to form the Planning Target Volume (PTV). The organ at risk (OAR) included the bladder and rectum, the external contour of the pelvic bones to define the Pelvic Bone Marrow (PBM). Four plans were done for every patient with anteroposterior-posteroanterior (AP/PA), three dimensional conformal radiotherapy (3DCRT), IMRT, bone marrow-sparing intensity-modulated pelvic radiotherapy (BMS-IMRT). Results: BMS-IMRT reduced the V20, V30, V40 and V45 of the BM in comparison to 3DCRT and IMRT plans. Reduction in V20 with BMS-IMRT plan compared to 3DCRT (p 0.03). The PBM volume receiving 5, 10 and 20 Gy was lower AP/PA than BMS-IMRT (p < 0.01, p 0.001 and p 0.04 respectively). The volumes of the rectum and bladder receiving dose of 40 and 45 Gy were lower in BMS-IMRT plan compared to AP/PA and 3DCRT plans with p = 0.01 for both of them. PTV cover was better in the BMS-IMRT and IMRT plans. Conclusion: BMS-IMRT decreased the irradiated BM volume compared to other techniques. Thus using BMS-IMRT is recommended to decrease hematological toxicity and avoid treatment interruption.
文摘Background: In 2010, the International Atomic Energy Agency launched the “3A’s campaign” as an effective tool for primary cancer prevention. In 2011, the American Association of Physicists in Medicine recommended the size specific dose estimate (SSDE). Objectives: To audit doses of Coronary CT Angiography (Coronary CTA) in tertiary care referral center. Methods: We reviewed 998 consecutive Coronary CTA (from 2007 to 2012). Doses (CTDIvol mGy), DLP (mGy*cm), effective dose (DLP*0.014, mSv) were on-line archived. SSDE was estimated retrospectively. Appropriateness score was evaluated for exams performed from the 2010. Results: Overall median dose per Coronary CTA was 49.7 mGy for CTDIvol, 55.5 mGy for SSDE, 994.96 mGy*cm for DLP, 13.9 mSv for effective dose. Median DLP decreased over time (1452.94 in 2007, 1605.56 in 2008, 1113.49 in 2009, 759.99 in 2010, 448.61 in 2011 and 497.88 mGy*cm in 2012, p < 0.0001). SSDE was proportional to the size dependent factor (SDF);in patients with SDF > 1 (88%) CTDIvol underestimated SSDE (48.49 vs 57.19 mGy), whilst in patients with SDF < 1 (12%) CTDIvol overestimated SSDE (56.46 vs 50.3 mGy). Scans were appropriate in 58%, uncertain in 24%, and inappropriate in 18% of cases. Doses were similar in appropriate, uncertain or inappropriate examinations and in excellent-to-good (81%) vs. sufficient-to-poor (19%) image quality exams. Conclusions: Coronary CTA reference doses can be very misleading. SSDE can allow individual technique optimization. The dose is similar in appropriate and inappropriate examinations, and unrelated to image quality. The rate of inappropriate examinations is still too high even after dissemination of guidelines.
基金supported by the Natural Science Foundation of China(Grant Nos.61673169,11301127,11701176,11626101,11601485).
文摘Re-engineering the channel heat exchangers(CHEs)is the goal of many recent studies,due to their great importance in the scope of energy transport in various industrial and environmental fields.Changing the internal geometry of the CHEs by using extended surfaces,i.e.,VGs(vortex generators),is the most common technique to enhance the efficiency of heat exchangers.This work aims to develop a newdesign of solar collectors to improve the overall energy efficiency.The study presents a new channel design by introducing VGs.The FVM(finite volume method)was adopted as a numerical technique to solve the problem,with the use of Oil/MWCNT(oil/multi-walled carbon nano-tubes)nanofluid to raise the thermal conductivity of the flow field.The study is achieved for a Re number ranging from12×10^(3) to 27×10^(3),while the concentration(φ)of solid particles in the fluid(Oil)is set to 4%.The computational results showed that the hydrothermal characteristics depend strongly on the flow patterns with the presence of VGs within the CHE.Increasing the Oil/MWCNT rates with the presence of VGs generates negative turbulent velocities with high amounts,which promotes the good agitation of nanofluid particles,resulting in enhanced great transfer rates.
