1.Background The use of engineering tools,design,research,and thinking to create environments and capabilities whereby individuals who are currently under-employed or unemployed due to a physical disability(e.g.,amput...1.Background The use of engineering tools,design,research,and thinking to create environments and capabilities whereby individuals who are currently under-employed or unemployed due to a physical disability(e.g.,amputation or spinal cord injury)or neurological difference(e.g.,autism)are enabled to become fully productive and employed members of society has been the implicit goal of decades of research at Vanderbilt University and elsewhere.At Vanderbilt University,progress in these areas has been greatly facilitated by the proximity of the School of Engineering to the world-class Vanderbilt University Medical Center and the resulting close collaboration between engineering and medical researchers.展开更多
A new approach to target development for laboratory astrophysics experiments at high-power laser facilities is presented.With the dawn of high-power lasers,laboratory astrophysics has emerged as a field,bringing insig...A new approach to target development for laboratory astrophysics experiments at high-power laser facilities is presented.With the dawn of high-power lasers,laboratory astrophysics has emerged as a field,bringing insight into physical processes in astrophysical objects,such as the formation of stars.An important factor for success in these experiments is targetry.To date,targets have mainly relied on expensive and challenging microfabrication methods.The design presented incorporates replaceable machined parts that assemble into a structure that defines the experimental geometry.This can make targets cheaper and faster to manufacture,while maintaining robustness and reproducibility.The platform is intended for experiments on plasma flows,but it is flexible and may be adapted to the constraints of other experimental setups.Examples of targets used in experimental campaigns are shown,including a design for insertion in a high magnetic field coil.Experimental results are included,demonstrating the performance of the targets.展开更多
The physical basis of meridians and acupoints (acupuncture points) is in a complex system mainly of connective tissue and interwoven with the blood capillaries, nerves, lymph vessels,etc. Elements of Ca, P, K, Fe, Zn,...The physical basis of meridians and acupoints (acupuncture points) is in a complex system mainly of connective tissue and interwoven with the blood capillaries, nerves, lymph vessels,etc. Elements of Ca, P, K, Fe, Zn, Mn, etc are found concentrated in the deep connective tissue structures in locations corresponding to acupoints. On this physical basis, the specific waveband of high efficiency for transmission of infrared rays exists in the collagenous fibre in a liquid crystal state. The development direction and new idea of researching on acupuncture and meridians are discussed.展开更多
Particle Data Group C. Patrignani, K. Agashe, G. Aielli, C. Amsler, M. Antonelli, D.M. Asner H. Baer, Sw. Banerjee, R.M. Barnett, T. Basaglia, C.W. Bauer, J.J. Beatty, V.I. Belousov, J. Beringer, S. Bethke, H. Bichsel...Particle Data Group C. Patrignani, K. Agashe, G. Aielli, C. Amsler, M. Antonelli, D.M. Asner H. Baer, Sw. Banerjee, R.M. Barnett, T. Basaglia, C.W. Bauer, J.J. Beatty, V.I. Belousov, J. Beringer, S. Bethke, H. Bichsel, O. Biebel, E. Blucher, G. Brooijmans, O. Buchmueller, V. Burkert, M.A. Bychkov, R.N. Cahn,展开更多
The rapid advancements of ultrafast intense laser technology have opened new avenues for investigating entanglement in laser-induced systems. However, the application of these advances in quantum technology requires a...The rapid advancements of ultrafast intense laser technology have opened new avenues for investigating entanglement in laser-induced systems. However, the application of these advances in quantum technology requires a reliable and universally applicable method for enhancing and regulating entanglement. Here we demonstrate how a few-cycle intense laser field can significantly enhance the degree of entanglement compared to its multi-cycle counterpart, using the example of electron–electron entanglement of orbital angular momentum(OAM) states in recollision-excitation non-sequential double ionization of Ar atoms. By confining the ionization dynamics to a specific narrow time window, the few-cycle pulse purifies the electron trajectories, thereby ensuring high coherence between entangled OAM channels and enhancing entanglement. Furthermore, the degree of entanglement can be efficiently modulated by varying the carrier envelope phase of the few-cycle laser pulse, which is achieved by altering the population across OAM channels. Optimizing coherence through electron trajectory purification with a designed specific temporal waveform of laser field provides a general pathway for enhancing entanglement in laser-induced systems.展开更多
We propose a novel approach to generate and manipulate topological Floquet bound states in the continuum(BICs)via a class of systems constructed by coupling two identical periodically driven one-dimensional Su-Schrief...We propose a novel approach to generate and manipulate topological Floquet bound states in the continuum(BICs)via a class of systems constructed by coupling two identical periodically driven one-dimensional Su-Schrieffer-Heeger chains.The formation of topological Floquet BICs can be adjusted only by tuning the driving amplitude or frequency,regardless of whether the static system has BICs or not.The interchain bias can only change the localization property of topological Floquet BICs,and a bigger bias can lead to transforming topological Floquet BICs into bound states out of the continuum(BOCs).But it does not change the topological properties of these topological Floquet states.Based on the repulsion effect of edge states,we propose to detect occurrence of topological Floquet BICs and transition point between topological Floquet BICs and BOCs using quantum walk.Our work provided a convenient and realistic approach for the experimental realization and manipulation of BICs in a single-particle quantum system.展开更多
Weak radiative hyperon decays represent a rich interplay between weak interactions and the internal structure of baryons,offering profound insights into Quantum Chromodynamics and weak interactions.Recent experimental...Weak radiative hyperon decays represent a rich interplay between weak interactions and the internal structure of baryons,offering profound insights into Quantum Chromodynamics and weak interactions.Recent experimental observations,particularly from BESIII,have revealed deviations from theoretical predictions.These deviations could signal new physics or the need for refined theoretical models incorporating intermediate resonance effects.This review discusses recent theoretical advancements and key experimental findings,focusing on recent measurements from BESIII and their implications for strong interactions and baryon structure.展开更多
Clarifying how spinel inversion affects the magnetic coupling nature at antiphase boundaries(APBs)is crucial for understanding the intriguing magnetic behaviors of spinel ferrites.Here,MgFe_(2)O_(4) films with an inve...Clarifying how spinel inversion affects the magnetic coupling nature at antiphase boundaries(APBs)is crucial for understanding the intriguing magnetic behaviors of spinel ferrites.Here,MgFe_(2)O_(4) films with an inversion coefficient of 2/3 are grown on MgO substrates using pulsed laser deposition(PLD).In-vestigations by state-of-the-art transmission electron microscopy suggest that two types of APBs are formed on the MgFe_(2)O_(4){110}crystal planes.The typeⅠand typeⅡAPBs have the crystal translation of(1/4)a[110]+(1/6)a[1(1)2]and(1/4)a[110]at the boundary,respectively.First-principles calculations reveal that both typeⅠand typeⅡAPBs tend to form antiferromagnetic coupling when the inversion co-efficient in MgFe_(2)O_(4) is zero.When the inversion coefficient rises to 2/3 due to the occupation of Mg^(2+)cations in octahedral sites,the magnetic coupling at the typeⅠAPBs changes to the ferromagnetic cou-pling,while the typeⅡAPBs still remain the antiferromagnetic one.The magnetic coupling modes of the APBs are closely related to the Fe-O-Fe superexchange interaction across the boundaries.Our findings clarify the atomistic mechanism of how spinel inversion affects the magnetic properties of spinel ferrites,which will promote the applications of magnetoelectricity materials with partial inversion.展开更多
Congenital heart disease(CHD)is the mnost comman birth defect,with 34%of cases attrib utedto genetic variants.NOTCH1,a multi-domain transmembrane protein,regulates heart developmert bycontrolling the differantiation a...Congenital heart disease(CHD)is the mnost comman birth defect,with 34%of cases attrib utedto genetic variants.NOTCH1,a multi-domain transmembrane protein,regulates heart developmert bycontrolling the differantiation and migration of myocardial mesoderm cells,and different variants are presentin differnt types of CHD.In this review,we aim to provide a detailed description of NOTCH1 structuraldomains and their functions,highlighting NOTCH1 variants in CHD and the molecular mechanisms throughwhich they contribute to CHD occurrence,NOTCH1 has two main domains,the NOTCH extracellulardomain(NBCD)and the NOTCH intracellular domain(NICD).NECD facilitates ligand binding and NICDformation,while the NICD functions as a transcrip tion factor,forming complexes with co-factors in thenucleus to initiate gene transcription.Amnong the NOTCH1 variants associated with CHD occurrence,most are loss-of-function variants.Moreover,most of the variants are located in theEGF-like domain.Themolecular mechanism behind the NOTCH1 variant-associated CHD occurrence appears to be either due to aloss-of-function or missense variant.In the loss-of-function mutations,NOTCH1 haploinsufficiency is notedand directly reduces theNICD production,causing CHD ocaurrence.In the less common case of missensevariant,only a mild NOTCH1 malfuncticn is observed,but insufficient to directly lead to CHD occurrence.However,when a missense variant is combined with a risk factor,such as exposure to an environmentaltoxin,the cumulative effect can lead to CHD.Understanding the genetic and molecular mechanisms linkingNOTCH1 variants to CHD is crucial for improving clinical management and patient quality of life.展开更多
A reaction-diffusion model is built to investigate the temporal and spatial patterns of cytoplasmic Ca2＋ dynamics under the effects of Ca2＋-release activated Ca2＋ （CRAC） channels in T cells. Simulation results sh...A reaction-diffusion model is built to investigate the temporal and spatial patterns of cytoplasmic Ca2＋ dynamics under the effects of Ca2＋-release activated Ca2＋ （CRAC） channels in T cells. Simulation results show a strong dependence of the modulation mode of Ca2＋ oscillation and dynamic patterns of Ca2＋ wave on the influx rate through the CRAC channel （ksoc）. When ksoc is small, cytoplasmic Ca2＋ is modulated as a frequency-modulation （FM） signal, whereas it shows an amplitude modulation （AM） mode after ksoc passes through a critical value. The heterogeneity in spatial Ca2＋ distribution is mostly arising from the influx through CRAC channels in both FM and AM modes. During each Ca2＋ spike, a more sustained cytoplasmic Ca2＋ gradient is maintained in the AM mode rather than in the FM mode.展开更多
We review the construction of gravitational solutions holographically dual to N=1 quiver gauge theories with dynamical flavor multiplets.We focus on the D3-D7 construction and consider the finite temperature,finite qu...We review the construction of gravitational solutions holographically dual to N=1 quiver gauge theories with dynamical flavor multiplets.We focus on the D3-D7 construction and consider the finite temperature,finite quark chemical potential case where there is a charged black hole in the dual solution.Discussed physical outputs of the model include its thermodynamics (with susceptibilities) and general hydrodynamic properties.展开更多
Di(4-bromophenyl)ketone and various aromatic diamines as the monomers,a series of novel poly(imino ketone)s (PIKs)have been synthesized via palladium-catalyzed aryl amination,which is Hartwig-Buchwald polycondensation...Di(4-bromophenyl)ketone and various aromatic diamines as the monomers,a series of novel poly(imino ketone)s (PIKs)have been synthesized via palladium-catalyzed aryl amination,which is Hartwig-Buchwald polycondensation reaction.The structures of PIKs are characterized by means of elemental analysis,FT-IR,~1H-NMR and UV-Vis spectroscopy. The results show a good agreement with the proposed structure.The general properties of PIKs are studied by DSC,TG and wide-angle X-ray diffraction,the solubility behavior is...展开更多
BACKGROUND: Fatty liver disease (FLD) is increasingly recognized as one of the most common chronic liver diseases in China. This study aimed to investigate the prevalence and risk factors of FLD in Chengdu, Southwest ...BACKGROUND: Fatty liver disease (FLD) is increasingly recognized as one of the most common chronic liver diseases in China. This study aimed to investigate the prevalence and risk factors of FLD in Chengdu, Southwest China, and to provide a relevant basis for the prevention and intervention of FLD. METHODS: Altogether 9094 subjects (4721 men and 4373 women) of over 18 years old who had received a medical checkup in the West China Hospital of Sichuan University between January and December 2007 were evaluated for FLD. FLD was diagnosed by ultrasonography. Body mass index (BMI), height, body weight, blood pressure, fasting plasma glucose (FPG), triglycerides (TG), total cholesterol (TCh), alanine aminotransferase (ALT), hepatitis B surface antigen (HBsAg), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured using routine laboratory methods. RESULTS: The overall prevalence of FLD was 12.5%, which was more than 3-fold higher in males than in females 2 (18.9% vs. 5.7%, chi(2) =359.624, P<0.001). The prevalence increased with age in females and males of less than 50 years. The prevalence of alcoholic, suspected alcoholic, and non-alcoholic FLD was 2.6%, 3.6%, and 6.3%, respectively. Multiple logistic regression analyses showed that 10 factors (male sex, age, BMI, FPG, hypertension, TG, TCh, HDL-C, LDL-C, and ALT abnormalities) were closely related to FLD. In heavy drinkers, obesity increased the risk of FLD by 23.78-fold (95% CI, 10.22-55.33), but heavy drinking was only associated with a 2-fold (95% CI, 1.50-2.66) increased risk in obese subjects. CONCLUSIONS: The prevalence of FLD among a health-checkup population in Chengdu, Southwest China was lower than the published for other areas of China. FLD in Chengdu adults was found to be closely associated with sex, age, BMI, and other metabolic syndrome features.展开更多
In quorum sensing （QS） process, bacteria regulate gene expression by utilizing small signaling molecules called autoinducers in response to a variety of environmental cues. Autoinducer 2 （AI-2）, a QS signaling mol...In quorum sensing （QS） process, bacteria regulate gene expression by utilizing small signaling molecules called autoinducers in response to a variety of environmental cues. Autoinducer 2 （AI-2）, a QS signaling molecule proposed to be involved in interspecies communication, is produced by many species of gram-negative and gram-positive bacteria. In Escherichia coil and Salmonella typhimurium, the extracellular AI-2 is imported into the cell by a transporter encoded by the lsr operon. Upstream of the lsr operon, there is a divergently transcribed gene encoding LsrR, which was reported previously to repress the transcription of the lsr operon and itself. Here, we have demonstrated for the first time that LsrR represses the transcription of the lsr operon and itself by directly binding to their promoters using gel shift and DNase I footprinting assays. The β-galactosidase reporter assays further suggest that two motifs in both the lsrR and lsrA promoter regions are crucial for the LsrR binding. Furthermore, in agreement with the conclusion that phosphorylated AI-2 can relieve the repression of LsrR in previous studies, our data show that phospho- AI-2 renders LsrR unable to bind to its own promoter in vitro.展开更多
Mg86.33Ni13.67-xYx(x=0, 1, 3, 6, 10) amorphous alloys were obtained by single-roller melt-spinning technique and the effect of Y addition on the glass forming ability(GFA), crystallization and micro-hardness of Mg-Ni ...Mg86.33Ni13.67-xYx(x=0, 1, 3, 6, 10) amorphous alloys were obtained by single-roller melt-spinning technique and the effect of Y addition on the glass forming ability(GFA), crystallization and micro-hardness of Mg-Ni alloys were studied. The results show that the GFA of Mg86.33Ni13.67-xYx(x=0, 1, 3, 6, 10) is improved successfully with the Y addition. The highest GFA appeares at x=6, while the reduced glass transition temperature (Trg) is 0.5225 and the supercooled liquid region(ΔTx) is 42.06 K; the position of the main diffraction halo is different for the alloys, and the maximum of the main diffraction halo of alloys with x=0, 1, 3 corresponds to the main peaks of a metastable fcc-Mg6Ni or fcc-Mg6Ni + Ni-Y intermetallic phases, and for the alloys with x=6, 10, it corresponds to Mg-Y and Ni-Y intermetallic phases; the micro-hardness of the alloys is improved with Y additions, and the highest micro-hardness is obtained at x=6 at.%, which is 960 MPa.展开更多
基金support has been provided by US National Science Foundation(OIA-1936970)a Howard Hughes Medical Institute professorship award.
文摘1.Background The use of engineering tools,design,research,and thinking to create environments and capabilities whereby individuals who are currently under-employed or unemployed due to a physical disability(e.g.,amputation or spinal cord injury)or neurological difference(e.g.,autism)are enabled to become fully productive and employed members of society has been the implicit goal of decades of research at Vanderbilt University and elsewhere.At Vanderbilt University,progress in these areas has been greatly facilitated by the proximity of the School of Engineering to the world-class Vanderbilt University Medical Center and the resulting close collaboration between engineering and medical researchers.
基金Additional funding was provided by the Student Grant Competition of CTU(No.SGS22/180/OHK4/3T/14)the Ministry of Education,Youth&Sports of the Czech Republic(No.LM2018114)+1 种基金the Horizon 2020 project Laserlab-Europe V(No.871124)This work was funded by the Helmholtz Association(No.VHNG-1338).
文摘A new approach to target development for laboratory astrophysics experiments at high-power laser facilities is presented.With the dawn of high-power lasers,laboratory astrophysics has emerged as a field,bringing insight into physical processes in astrophysical objects,such as the formation of stars.An important factor for success in these experiments is targetry.To date,targets have mainly relied on expensive and challenging microfabrication methods.The design presented incorporates replaceable machined parts that assemble into a structure that defines the experimental geometry.This can make targets cheaper and faster to manufacture,while maintaining robustness and reproducibility.The platform is intended for experiments on plasma flows,but it is flexible and may be adapted to the constraints of other experimental setups.Examples of targets used in experimental campaigns are shown,including a design for insertion in a high magnetic field coil.Experimental results are included,demonstrating the performance of the targets.
文摘The physical basis of meridians and acupoints (acupuncture points) is in a complex system mainly of connective tissue and interwoven with the blood capillaries, nerves, lymph vessels,etc. Elements of Ca, P, K, Fe, Zn, Mn, etc are found concentrated in the deep connective tissue structures in locations corresponding to acupoints. On this physical basis, the specific waveband of high efficiency for transmission of infrared rays exists in the collagenous fibre in a liquid crystal state. The development direction and new idea of researching on acupuncture and meridians are discussed.
文摘Particle Data Group C. Patrignani, K. Agashe, G. Aielli, C. Amsler, M. Antonelli, D.M. Asner H. Baer, Sw. Banerjee, R.M. Barnett, T. Basaglia, C.W. Bauer, J.J. Beatty, V.I. Belousov, J. Beringer, S. Bethke, H. Bichsel, O. Biebel, E. Blucher, G. Brooijmans, O. Buchmueller, V. Burkert, M.A. Bychkov, R.N. Cahn,
基金supported by the National Natural Science Foundation of China (Grant Nos.12274273and 12450402)the Innovation Program for Quantum Science and Technology (Grant No.2021ZD0302101)。
文摘The rapid advancements of ultrafast intense laser technology have opened new avenues for investigating entanglement in laser-induced systems. However, the application of these advances in quantum technology requires a reliable and universally applicable method for enhancing and regulating entanglement. Here we demonstrate how a few-cycle intense laser field can significantly enhance the degree of entanglement compared to its multi-cycle counterpart, using the example of electron–electron entanglement of orbital angular momentum(OAM) states in recollision-excitation non-sequential double ionization of Ar atoms. By confining the ionization dynamics to a specific narrow time window, the few-cycle pulse purifies the electron trajectories, thereby ensuring high coherence between entangled OAM channels and enhancing entanglement. Furthermore, the degree of entanglement can be efficiently modulated by varying the carrier envelope phase of the few-cycle laser pulse, which is achieved by altering the population across OAM channels. Optimizing coherence through electron trajectory purification with a designed specific temporal waveform of laser field provides a general pathway for enhancing entanglement in laser-induced systems.
基金supported by the National Natural Science Foundation of China(Grant Nos.12175315 and 12205385)。
文摘We propose a novel approach to generate and manipulate topological Floquet bound states in the continuum(BICs)via a class of systems constructed by coupling two identical periodically driven one-dimensional Su-Schrieffer-Heeger chains.The formation of topological Floquet BICs can be adjusted only by tuning the driving amplitude or frequency,regardless of whether the static system has BICs or not.The interchain bias can only change the localization property of topological Floquet BICs,and a bigger bias can lead to transforming topological Floquet BICs into bound states out of the continuum(BOCs).But it does not change the topological properties of these topological Floquet states.Based on the repulsion effect of edge states,we propose to detect occurrence of topological Floquet BICs and transition point between topological Floquet BICs and BOCs using quantum walk.Our work provided a convenient and realistic approach for the experimental realization and manipulation of BICs in a single-particle quantum system.
基金the supercomputing center of USTC for their strong supportsupported by the National Key R&D Program of China(Grant Nos.2023YFA1609400,2023YFA1606703,2020YFA0406400,and 2020YFA0406300)+3 种基金the International Partnership Program of the Chinese Academy of Sciences(Grant No.211134KYSB20200057)the National Natural Science Foundation of China(Grant Nos.12035013,12061131003,12122509,12105276,11625523,12405091,12235018,and 12435007)the CAS Youth Team Program(Grant No.YSBR-101)the Natural Science Foundation of Guangxi Province,China(Grant No.2025GXNSFBA069314)。
文摘Weak radiative hyperon decays represent a rich interplay between weak interactions and the internal structure of baryons,offering profound insights into Quantum Chromodynamics and weak interactions.Recent experimental observations,particularly from BESIII,have revealed deviations from theoretical predictions.These deviations could signal new physics or the need for refined theoretical models incorporating intermediate resonance effects.This review discusses recent theoretical advancements and key experimental findings,focusing on recent measurements from BESIII and their implications for strong interactions and baryon structure.
基金supported by the National Natural Science Foundation of China(Nos.52125101 and 52271015)Guangdong Major Project of Basic Research,China(No.2021B0301030003)Jihua Laboratory(No.X210141TL210).
文摘Clarifying how spinel inversion affects the magnetic coupling nature at antiphase boundaries(APBs)is crucial for understanding the intriguing magnetic behaviors of spinel ferrites.Here,MgFe_(2)O_(4) films with an inversion coefficient of 2/3 are grown on MgO substrates using pulsed laser deposition(PLD).In-vestigations by state-of-the-art transmission electron microscopy suggest that two types of APBs are formed on the MgFe_(2)O_(4){110}crystal planes.The typeⅠand typeⅡAPBs have the crystal translation of(1/4)a[110]+(1/6)a[1(1)2]and(1/4)a[110]at the boundary,respectively.First-principles calculations reveal that both typeⅠand typeⅡAPBs tend to form antiferromagnetic coupling when the inversion co-efficient in MgFe_(2)O_(4) is zero.When the inversion coefficient rises to 2/3 due to the occupation of Mg^(2+)cations in octahedral sites,the magnetic coupling at the typeⅠAPBs changes to the ferromagnetic cou-pling,while the typeⅡAPBs still remain the antiferromagnetic one.The magnetic coupling modes of the APBs are closely related to the Fe-O-Fe superexchange interaction across the boundaries.Our findings clarify the atomistic mechanism of how spinel inversion affects the magnetic properties of spinel ferrites,which will promote the applications of magnetoelectricity materials with partial inversion.
基金the National Natural Science Foundation of China,GrantNos.82100321 and 82370353.
文摘Congenital heart disease(CHD)is the mnost comman birth defect,with 34%of cases attrib utedto genetic variants.NOTCH1,a multi-domain transmembrane protein,regulates heart developmert bycontrolling the differantiation and migration of myocardial mesoderm cells,and different variants are presentin differnt types of CHD.In this review,we aim to provide a detailed description of NOTCH1 structuraldomains and their functions,highlighting NOTCH1 variants in CHD and the molecular mechanisms throughwhich they contribute to CHD occurrence,NOTCH1 has two main domains,the NOTCH extracellulardomain(NBCD)and the NOTCH intracellular domain(NICD).NECD facilitates ligand binding and NICDformation,while the NICD functions as a transcrip tion factor,forming complexes with co-factors in thenucleus to initiate gene transcription.Amnong the NOTCH1 variants associated with CHD occurrence,most are loss-of-function variants.Moreover,most of the variants are located in theEGF-like domain.Themolecular mechanism behind the NOTCH1 variant-associated CHD occurrence appears to be either due to aloss-of-function or missense variant.In the loss-of-function mutations,NOTCH1 haploinsufficiency is notedand directly reduces theNICD production,causing CHD ocaurrence.In the less common case of missensevariant,only a mild NOTCH1 malfuncticn is observed,but insufficient to directly lead to CHD occurrence.However,when a missense variant is combined with a risk factor,such as exposure to an environmentaltoxin,the cumulative effect can lead to CHD.Understanding the genetic and molecular mechanisms linkingNOTCH1 variants to CHD is crucial for improving clinical management and patient quality of life.
文摘A reaction-diffusion model is built to investigate the temporal and spatial patterns of cytoplasmic Ca2＋ dynamics under the effects of Ca2＋-release activated Ca2＋ （CRAC） channels in T cells. Simulation results show a strong dependence of the modulation mode of Ca2＋ oscillation and dynamic patterns of Ca2＋ wave on the influx rate through the CRAC channel （ksoc）. When ksoc is small, cytoplasmic Ca2＋ is modulated as a frequency-modulation （FM） signal, whereas it shows an amplitude modulation （AM） mode after ksoc passes through a critical value. The heterogeneity in spatial Ca2＋ distribution is mostly arising from the influx through CRAC channels in both FM and AM modes. During each Ca2＋ spike, a more sustained cytoplasmic Ca2＋ gradient is maintained in the AM mode rather than in the FM mode.
基金supported by the European Community Seventh Frame work Programme FP7/2007-2013,under grant agreements n. 253534 and 253937. J.T.supported by the Netherlands Organization for Scientic Research (NWO) under the FOM Foundation research program+3 种基金supported by the MICINN and FEDER (grant FPA2008-01838)the Spanish Consolider-Ingenio 2010 Programme CPAN (CSD2007-00042)the Xunta de Galicia (Conselleria de Educacion and grant INCITE09-206-121-PR)KITPC Beijing for hospitality and financial support (this last under grant KJCX2.YW.W10 of the Chinese Academy of Sciences)
文摘We review the construction of gravitational solutions holographically dual to N=1 quiver gauge theories with dynamical flavor multiplets.We focus on the D3-D7 construction and consider the finite temperature,finite quark chemical potential case where there is a charged black hole in the dual solution.Discussed physical outputs of the model include its thermodynamics (with susceptibilities) and general hydrodynamic properties.
基金This work was financially supported by the National Natural Science Foundation of China(No.15076017).
文摘Di(4-bromophenyl)ketone and various aromatic diamines as the monomers,a series of novel poly(imino ketone)s (PIKs)have been synthesized via palladium-catalyzed aryl amination,which is Hartwig-Buchwald polycondensation reaction.The structures of PIKs are characterized by means of elemental analysis,FT-IR,~1H-NMR and UV-Vis spectroscopy. The results show a good agreement with the proposed structure.The general properties of PIKs are studied by DSC,TG and wide-angle X-ray diffraction,the solubility behavior is...
基金supported by a grant from the National Natural Science Foundation of China(No.30571640)
文摘BACKGROUND: Fatty liver disease (FLD) is increasingly recognized as one of the most common chronic liver diseases in China. This study aimed to investigate the prevalence and risk factors of FLD in Chengdu, Southwest China, and to provide a relevant basis for the prevention and intervention of FLD. METHODS: Altogether 9094 subjects (4721 men and 4373 women) of over 18 years old who had received a medical checkup in the West China Hospital of Sichuan University between January and December 2007 were evaluated for FLD. FLD was diagnosed by ultrasonography. Body mass index (BMI), height, body weight, blood pressure, fasting plasma glucose (FPG), triglycerides (TG), total cholesterol (TCh), alanine aminotransferase (ALT), hepatitis B surface antigen (HBsAg), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured using routine laboratory methods. RESULTS: The overall prevalence of FLD was 12.5%, which was more than 3-fold higher in males than in females 2 (18.9% vs. 5.7%, chi(2) =359.624, P<0.001). The prevalence increased with age in females and males of less than 50 years. The prevalence of alcoholic, suspected alcoholic, and non-alcoholic FLD was 2.6%, 3.6%, and 6.3%, respectively. Multiple logistic regression analyses showed that 10 factors (male sex, age, BMI, FPG, hypertension, TG, TCh, HDL-C, LDL-C, and ALT abnormalities) were closely related to FLD. In heavy drinkers, obesity increased the risk of FLD by 23.78-fold (95% CI, 10.22-55.33), but heavy drinking was only associated with a 2-fold (95% CI, 1.50-2.66) increased risk in obese subjects. CONCLUSIONS: The prevalence of FLD among a health-checkup population in Chengdu, Southwest China was lower than the published for other areas of China. FLD in Chengdu adults was found to be closely associated with sex, age, BMI, and other metabolic syndrome features.
基金We thank our colleagues J Zang and X Liu for their technical assistance in protein purification. This work was supported by the One Hundred Talent Project of the Chinese Academy of Sciences and the National Natural Science Foundation of China （50738006）.
文摘In quorum sensing （QS） process, bacteria regulate gene expression by utilizing small signaling molecules called autoinducers in response to a variety of environmental cues. Autoinducer 2 （AI-2）, a QS signaling molecule proposed to be involved in interspecies communication, is produced by many species of gram-negative and gram-positive bacteria. In Escherichia coil and Salmonella typhimurium, the extracellular AI-2 is imported into the cell by a transporter encoded by the lsr operon. Upstream of the lsr operon, there is a divergently transcribed gene encoding LsrR, which was reported previously to repress the transcription of the lsr operon and itself. Here, we have demonstrated for the first time that LsrR represses the transcription of the lsr operon and itself by directly binding to their promoters using gel shift and DNase I footprinting assays. The β-galactosidase reporter assays further suggest that two motifs in both the lsrR and lsrA promoter regions are crucial for the LsrR binding. Furthermore, in agreement with the conclusion that phosphorylated AI-2 can relieve the repression of LsrR in previous studies, our data show that phospho- AI-2 renders LsrR unable to bind to its own promoter in vitro.
基金supported by the Award Fund for Outstanding Young Scientist in Shandong Province, China (No. BS2011CL004)
文摘Mg86.33Ni13.67-xYx(x=0, 1, 3, 6, 10) amorphous alloys were obtained by single-roller melt-spinning technique and the effect of Y addition on the glass forming ability(GFA), crystallization and micro-hardness of Mg-Ni alloys were studied. The results show that the GFA of Mg86.33Ni13.67-xYx(x=0, 1, 3, 6, 10) is improved successfully with the Y addition. The highest GFA appeares at x=6, while the reduced glass transition temperature (Trg) is 0.5225 and the supercooled liquid region(ΔTx) is 42.06 K; the position of the main diffraction halo is different for the alloys, and the maximum of the main diffraction halo of alloys with x=0, 1, 3 corresponds to the main peaks of a metastable fcc-Mg6Ni or fcc-Mg6Ni + Ni-Y intermetallic phases, and for the alloys with x=6, 10, it corresponds to Mg-Y and Ni-Y intermetallic phases; the micro-hardness of the alloys is improved with Y additions, and the highest micro-hardness is obtained at x=6 at.%, which is 960 MPa.
