Background The alexithymia trait is of high clinical interest.The Perth Alexithymia Questionnaire(PAQ)was recently developed to enable detailed facet-level and valence-specific assessments of alexithymia.Aims In this ...Background The alexithymia trait is of high clinical interest.The Perth Alexithymia Questionnaire(PAQ)was recently developed to enable detailed facet-level and valence-specific assessments of alexithymia.Aims In this paper,we introduce the first Chinese version of the PAQ and examine its psychometric properties and clinical applications.Methods In Study 1,the PAQ was administered to 990 Chinese participants.We examined its factor structure,internal consistency,test-retest reliability,as well as convergent,concurrent and discriminant validity.In Study 2,four groups,including a major depressive disorder(MDD)group(n=50),a matched healthy control group for MDD(n=50),a subclinical depression group(n=50)and a matched healthy control group for subclinical depression(n=50),were recruited.Group comparisons were conducted to assess the clinical relevance of the PAQ.Results In Study 1,the intended five-factor structure of the PAQ was found to fit the data well.The PAQ showed good internal consistency and test-retest reliability,as well as good convergent,concurrent and discriminant validity.In Study 2,the PAQ was able to successfully distinguish the MDD group and the subclinical depression group from their matched healthy controls.Conclusions The Chinese version of the PAQ is a valid and reliable instrument for comprehensively assessing alexithymia in the general population and adults with clinical/subclinical depression.展开更多
Urban agriculture has been increasingly popular as a form of modern agriculture in urban settings. It includes community gardens, fruit orchards, home gardens, veggie patches, public open spaces, reserves, urban fores...Urban agriculture has been increasingly popular as a form of modern agriculture in urban settings. It includes community gardens, fruit orchards, home gardens, veggie patches, public open spaces, reserves, urban forest, and recreational landscaping. However, irrigation using urban water supply has been identified as a major constraints for the development of urban agriculture. This study presents a sustainable water management trial at Butler, a northern sub-urban development in Perth, Western Australia, for urban irrigation. The trial system consists of a number of water saving features including untreated fit-for-purpose groundwater supplied via a third pipe network, drip irrigation, local weather station, soil moisture sensors connected with a local weather station, night time irrigation, soil enhancement with conditioning and mulching, and use of native plants and vegetation. The trial outcome was compared against controlled areas in terms of irrigation efficiency and sustainable water management for urban agriculture. The study demonstrated that a fit-for-purpose irrigation along with water sensitive land management could be a sustainable alternative for urban agriculture that would achieve a significant water saving and irrigation efficiency at urban settings. However, quality of untreated groundwater can be an issue while utilizing it for irrigation, but the research has shown that it can be managed with innovative irrigation techniques. This indicates that the fit-for-purpose irrigation system with water sensitive land management practices would be highly supportive in sustainable development of urban agriculture, vegetation and recreational landscaping.展开更多
Tight gas sands in Whicher Range Field of Perth Basin show large heterogeneity in reservoir characteristics and production behavior related to depositional and diagenetic features. Diagenetic events (compaction and ce...Tight gas sands in Whicher Range Field of Perth Basin show large heterogeneity in reservoir characteristics and production behavior related to depositional and diagenetic features. Diagenetic events (compaction and cementation) have severely affected the pore system. In order to investigate the petrophysical characteristics, reservoir sandstone facies were correlated with core porosity and permeability and their equivalent well log responses to describe hydraulic flow units and electrofacies, respectively. Thus, very tight, tight, and sub-tight sands were differentiated. To reveal the relationship between pore system properties and depositional and diagenetic characteristics in each sand type, reservoir rock types were extracted. The identified reservoir rock types are in fact a reflection of internal reservoir heterogeneity related to pore system properties. All reservoir rock types are characterized by a compacted fabric and cemented framework. But distribution and dominance of diagenetic products in each of them depend on primary depositional composition and texture. The results show that reservoir rock typing based on three aspects of reservoir sandstones (depositional properties, diagenetic features and petrophysical characteristics) is a suitable technique for depiction of reservoir heterogeneity, recognition of reservoir units and identifying factors controlling reservoir quality of tight sandstones. This methodology can be used for the other tight reservoirs.展开更多
模型劫持攻击是一种新型攻击方式,通过植入特定词语,能够隐蔽地控制模型执行与原始任务截然不同的劫持任务,使模型拥有者的训练算力成本增加的同时面临潜在的法律风险。目前,已有研究针对德-英文语言翻译模型探索了这一攻击方式,但在中...模型劫持攻击是一种新型攻击方式,通过植入特定词语,能够隐蔽地控制模型执行与原始任务截然不同的劫持任务,使模型拥有者的训练算力成本增加的同时面临潜在的法律风险。目前,已有研究针对德-英文语言翻译模型探索了这一攻击方式,但在中文自然语言处理(natural language processing,NLP)领域尚属空白。中文语言的独特性使得其面临不同于其他语言环境的安全挑战,因此亟需开发针对中文模型的攻击评估方法。基于上述事实,提出了一种基于中文逻辑词的模型劫持攻击方法Cheater,用于评估中文模型的安全性。Cheater针对中-英文NLP任务,首先使用公共模型对劫持数据进行伪装生成过渡数据,再通过在过渡样本中嵌入中文逻辑词的方式对其进行改造生成毒性数据,最后利用毒性数据完成对目标模型的劫持。实验表明,对于Bart[large]模型,Cheater在0.5%的数据投毒率下攻击成功率可以达到90.2%。展开更多
Polypropylene fibers(PPFs) have been widely used in composite materials due to their sound crack resistance and toughness. In cement-based composites, the incorporation of PPFs can significantly improve their dynamic ...Polypropylene fibers(PPFs) have been widely used in composite materials due to their sound crack resistance and toughness. In cement-based composites, the incorporation of PPFs can significantly improve their dynamic mechanical properties. However, cement-iron ore tailings foam composite(CIFC), a sustainable material utilizing iron ore tailings to partially replace cement, has not been investigated under dynamic loading. This study investigates the dynamic compressive behavior of CIFC with 1%–2.5% PPF content and 3–12 mm PPF lengths under various strain rates. The microstructural characteristics were analyzed prior to dynamic testing. X-ray diffraction(XRD) identified crystalline phases including CaCO_(3)Fe_(2)O_(3), SiO, C-S-H gel, and ettringite. Scanning electron microscopy(SEM) observations demonstrated that appropriate PPF_(2) parameters(e.g., C2L9, a CIFC specimen containing 2% PPF with 9 mm length) enhance fiber-matrix bonding and minimize interconnected pores and microcracks, revealing pronounced fiber bridging effects. Split Hopkinson pressure bar(SHPB) tests were then conducted at strain rates of 120–250 s^(-1), showing that the dynamic properties of CIFC were highly dependent on both strain rates and PPF parameters. Compared to other specimens, C2L9 exhibited a more intact failure pattern with superior compressive strength and energy dissipation capacity, despite showing reduced dynamic increase factor(DIF) and normalized energy dissipation(NED) values. These findings provide practical guidance for applying CIFC with varying PPF parameters in impact-resistant structural designs.展开更多
Stability of base-exposed backfill roof in underhand drift-and-fill mining is crucial for the safety of those working beneath.Given the commonly used primary-and-secondary mining sequence,interfaces are formed between...Stability of base-exposed backfill roof in underhand drift-and-fill mining is crucial for the safety of those working beneath.Given the commonly used primary-and-secondary mining sequence,interfaces are formed between adjacent filled drifts,which can weaken the integrity of the backfill roof.These interfaces also lead to two common drift layouts:aligned drifts and staggered drifts.However,less attention has been paid to the interfaces and the two drift layouts were not adequately distinguished in previous studies.In this paper,the interfaces between filled drifts were firstly considered to investigate the stability of backfill roof.Failure modes and strength requirements of backfill roof in aligned and staggered drifts are comprehensively investigated by FLAC3D,with a focus on considerations of varied shear parameters of the interfaces.Results show that failure modes in aligned drifts transition from block sliding to top caving,bottom caving or sloughing as the interface cohesion increases from zero to at least half of the backfill cohesion.Further increases in interface cohesion allow aligned drifts to behave as if there are no interfaces between them.The critical stability conditions of backfill roof in aligned drifts were mostly determined by the interface strength instead of the backfill strength.However,the stability of backfill roof in staggered drifts is barely affected by the interface strength.The outcomes are expected to provide references for mining engineers to optimize drift layouts and perform cost-effective backfill roof strength design at mines using underhand drift-and-fill mining method.展开更多
Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association betw...Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association between body fat mass(FM)and OCD.Methods Summary statistics from genome-wide association studies of European ancestry were utilized to conduct two-sample Mendelian randomization analysis.Heterogeneity,horizontal pleiotropy,and sensitivity analyses were performed to assess the robustness.Results The inverse variance weighting method demonstrated that a genetically predicted decrease in FM was causally associated with an increased OCD risk[odds ratio(OR)=0.680,95%confidence interval(CI):0.528–0.875,P=0.003].Similar estimates were obtained using the weighted median approach(OR=0.633,95%CI:0.438–0.915,P=0.015).Each standard deviation increases in genetically predicted body fat percentage corresponded to a reduced OCD risk(OR=0.638,95%CI:0.455–0.896,P=0.009).The sensitivity analysis confirmed the robustness of these findings with no outlier instrument variables identified.Conclusion The negative causal association between FM and the risk of OCD suggests that the prevention or treatment of mental disorders should include not only the control of BMI but also fat distribution and body composition.展开更多
Background:Tandem gene repeats naturally occur as important genomic features and determine many traits in living organisms,like human diseases and microbial productivities of target bioproducts.Methods:Here,we develop...Background:Tandem gene repeats naturally occur as important genomic features and determine many traits in living organisms,like human diseases and microbial productivities of target bioproducts.Methods:Here,we developed a bacterial type-II toxin-antitoxin-mediated method to manipulate genomic integration of tandem gene repeats in Saccharomyces cerevisiae and further visualised the evolutionary trajectories of gene repeats.We designed a tri-vector system to introduce toxin-antitoxin-driven gene amplification modules.Results:This system delivered multi-copy gene integration in the form of tandem gene repeats spontaneously and independently from toxin-antitoxin-mediated selection.Inducing the toxin(RelE)expressing via a copper(II)-inducible CUP1 promoter successfully drove the in-situ gene amplification of the antitoxin(RelB)module,resulting in~40 copies of a green fluorescence reporter gene per copy of genome.Copy-number changes,copy-number increase and copy-number decrease,and stable maintenance were visualised using the green fluorescence protein and blue chromoprotein AeBlue as reporters.Copy-number increases happened spontaneously and independent on a selection pressure.Increased copy number was quickly enriched through toxin-antitoxin-mediated selection.Conclusion:In summary,the bacterial toxin-antitoxin systems provide a flexible mechanism to manipulate gene copy number in eukaryotic cells and can be exploited for synthetic biology and metabolic engineering applications.展开更多
基金This work was supported by a grant from the National Natural Science Foundation of China(32200906)STI 2030-Major Projects(2021ZD0201705)+2 种基金Major Project of Philosophy and Social Science Research of the Ministry of Education of China(22JZD044)Research Project of Shanghai Science and Technology Commission(20dz2260300)Fundamental Research Funds for the Central Universities and Starting Research Fund from Hangzhou Normal University.
文摘Background The alexithymia trait is of high clinical interest.The Perth Alexithymia Questionnaire(PAQ)was recently developed to enable detailed facet-level and valence-specific assessments of alexithymia.Aims In this paper,we introduce the first Chinese version of the PAQ and examine its psychometric properties and clinical applications.Methods In Study 1,the PAQ was administered to 990 Chinese participants.We examined its factor structure,internal consistency,test-retest reliability,as well as convergent,concurrent and discriminant validity.In Study 2,four groups,including a major depressive disorder(MDD)group(n=50),a matched healthy control group for MDD(n=50),a subclinical depression group(n=50)and a matched healthy control group for subclinical depression(n=50),were recruited.Group comparisons were conducted to assess the clinical relevance of the PAQ.Results In Study 1,the intended five-factor structure of the PAQ was found to fit the data well.The PAQ showed good internal consistency and test-retest reliability,as well as good convergent,concurrent and discriminant validity.In Study 2,the PAQ was able to successfully distinguish the MDD group and the subclinical depression group from their matched healthy controls.Conclusions The Chinese version of the PAQ is a valid and reliable instrument for comprehensively assessing alexithymia in the general population and adults with clinical/subclinical depression.
文摘Urban agriculture has been increasingly popular as a form of modern agriculture in urban settings. It includes community gardens, fruit orchards, home gardens, veggie patches, public open spaces, reserves, urban forest, and recreational landscaping. However, irrigation using urban water supply has been identified as a major constraints for the development of urban agriculture. This study presents a sustainable water management trial at Butler, a northern sub-urban development in Perth, Western Australia, for urban irrigation. The trial system consists of a number of water saving features including untreated fit-for-purpose groundwater supplied via a third pipe network, drip irrigation, local weather station, soil moisture sensors connected with a local weather station, night time irrigation, soil enhancement with conditioning and mulching, and use of native plants and vegetation. The trial outcome was compared against controlled areas in terms of irrigation efficiency and sustainable water management for urban agriculture. The study demonstrated that a fit-for-purpose irrigation along with water sensitive land management could be a sustainable alternative for urban agriculture that would achieve a significant water saving and irrigation efficiency at urban settings. However, quality of untreated groundwater can be an issue while utilizing it for irrigation, but the research has shown that it can be managed with innovative irrigation techniques. This indicates that the fit-for-purpose irrigation system with water sensitive land management practices would be highly supportive in sustainable development of urban agriculture, vegetation and recreational landscaping.
文摘Tight gas sands in Whicher Range Field of Perth Basin show large heterogeneity in reservoir characteristics and production behavior related to depositional and diagenetic features. Diagenetic events (compaction and cementation) have severely affected the pore system. In order to investigate the petrophysical characteristics, reservoir sandstone facies were correlated with core porosity and permeability and their equivalent well log responses to describe hydraulic flow units and electrofacies, respectively. Thus, very tight, tight, and sub-tight sands were differentiated. To reveal the relationship between pore system properties and depositional and diagenetic characteristics in each sand type, reservoir rock types were extracted. The identified reservoir rock types are in fact a reflection of internal reservoir heterogeneity related to pore system properties. All reservoir rock types are characterized by a compacted fabric and cemented framework. But distribution and dominance of diagenetic products in each of them depend on primary depositional composition and texture. The results show that reservoir rock typing based on three aspects of reservoir sandstones (depositional properties, diagenetic features and petrophysical characteristics) is a suitable technique for depiction of reservoir heterogeneity, recognition of reservoir units and identifying factors controlling reservoir quality of tight sandstones. This methodology can be used for the other tight reservoirs.
文摘模型劫持攻击是一种新型攻击方式,通过植入特定词语,能够隐蔽地控制模型执行与原始任务截然不同的劫持任务,使模型拥有者的训练算力成本增加的同时面临潜在的法律风险。目前,已有研究针对德-英文语言翻译模型探索了这一攻击方式,但在中文自然语言处理(natural language processing,NLP)领域尚属空白。中文语言的独特性使得其面临不同于其他语言环境的安全挑战,因此亟需开发针对中文模型的攻击评估方法。基于上述事实,提出了一种基于中文逻辑词的模型劫持攻击方法Cheater,用于评估中文模型的安全性。Cheater针对中-英文NLP任务,首先使用公共模型对劫持数据进行伪装生成过渡数据,再通过在过渡样本中嵌入中文逻辑词的方式对其进行改造生成毒性数据,最后利用毒性数据完成对目标模型的劫持。实验表明,对于Bart[large]模型,Cheater在0.5%的数据投毒率下攻击成功率可以达到90.2%。
基金supported by the National Science Foundation for Excellent Young Scholars of China (Grant No.52422809)the National Natural Science Foundation of China (Grant No.52208491)。
文摘Polypropylene fibers(PPFs) have been widely used in composite materials due to their sound crack resistance and toughness. In cement-based composites, the incorporation of PPFs can significantly improve their dynamic mechanical properties. However, cement-iron ore tailings foam composite(CIFC), a sustainable material utilizing iron ore tailings to partially replace cement, has not been investigated under dynamic loading. This study investigates the dynamic compressive behavior of CIFC with 1%–2.5% PPF content and 3–12 mm PPF lengths under various strain rates. The microstructural characteristics were analyzed prior to dynamic testing. X-ray diffraction(XRD) identified crystalline phases including CaCO_(3)Fe_(2)O_(3), SiO, C-S-H gel, and ettringite. Scanning electron microscopy(SEM) observations demonstrated that appropriate PPF_(2) parameters(e.g., C2L9, a CIFC specimen containing 2% PPF with 9 mm length) enhance fiber-matrix bonding and minimize interconnected pores and microcracks, revealing pronounced fiber bridging effects. Split Hopkinson pressure bar(SHPB) tests were then conducted at strain rates of 120–250 s^(-1), showing that the dynamic properties of CIFC were highly dependent on both strain rates and PPF parameters. Compared to other specimens, C2L9 exhibited a more intact failure pattern with superior compressive strength and energy dissipation capacity, despite showing reduced dynamic increase factor(DIF) and normalized energy dissipation(NED) values. These findings provide practical guidance for applying CIFC with varying PPF parameters in impact-resistant structural designs.
基金supported by Deep Earth Probe and Mineral Resources Exploration-National Science and Technology Major Project(Grant No.2024ZD1003705)the Beijing Nova Program(Grant No.20220484057)support from China Scholarship Council under Grant CSC No.202110300001.
文摘Stability of base-exposed backfill roof in underhand drift-and-fill mining is crucial for the safety of those working beneath.Given the commonly used primary-and-secondary mining sequence,interfaces are formed between adjacent filled drifts,which can weaken the integrity of the backfill roof.These interfaces also lead to two common drift layouts:aligned drifts and staggered drifts.However,less attention has been paid to the interfaces and the two drift layouts were not adequately distinguished in previous studies.In this paper,the interfaces between filled drifts were firstly considered to investigate the stability of backfill roof.Failure modes and strength requirements of backfill roof in aligned and staggered drifts are comprehensively investigated by FLAC3D,with a focus on considerations of varied shear parameters of the interfaces.Results show that failure modes in aligned drifts transition from block sliding to top caving,bottom caving or sloughing as the interface cohesion increases from zero to at least half of the backfill cohesion.Further increases in interface cohesion allow aligned drifts to behave as if there are no interfaces between them.The critical stability conditions of backfill roof in aligned drifts were mostly determined by the interface strength instead of the backfill strength.However,the stability of backfill roof in staggered drifts is barely affected by the interface strength.The outcomes are expected to provide references for mining engineers to optimize drift layouts and perform cost-effective backfill roof strength design at mines using underhand drift-and-fill mining method.
基金supported by the Yanzhao Gold Talent Project of Hebei Province(NO.HJZD202506)。
文摘Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association between body fat mass(FM)and OCD.Methods Summary statistics from genome-wide association studies of European ancestry were utilized to conduct two-sample Mendelian randomization analysis.Heterogeneity,horizontal pleiotropy,and sensitivity analyses were performed to assess the robustness.Results The inverse variance weighting method demonstrated that a genetically predicted decrease in FM was causally associated with an increased OCD risk[odds ratio(OR)=0.680,95%confidence interval(CI):0.528–0.875,P=0.003].Similar estimates were obtained using the weighted median approach(OR=0.633,95%CI:0.438–0.915,P=0.015).Each standard deviation increases in genetically predicted body fat percentage corresponded to a reduced OCD risk(OR=0.638,95%CI:0.455–0.896,P=0.009).The sensitivity analysis confirmed the robustness of these findings with no outlier instrument variables identified.Conclusion The negative causal association between FM and the risk of OCD suggests that the prevention or treatment of mental disorders should include not only the control of BMI but also fat distribution and body composition.
基金supported partially by the Australian Government through the Australian Research Council Centres of Excellence funding scheme(project CE200100029)。
文摘Background:Tandem gene repeats naturally occur as important genomic features and determine many traits in living organisms,like human diseases and microbial productivities of target bioproducts.Methods:Here,we developed a bacterial type-II toxin-antitoxin-mediated method to manipulate genomic integration of tandem gene repeats in Saccharomyces cerevisiae and further visualised the evolutionary trajectories of gene repeats.We designed a tri-vector system to introduce toxin-antitoxin-driven gene amplification modules.Results:This system delivered multi-copy gene integration in the form of tandem gene repeats spontaneously and independently from toxin-antitoxin-mediated selection.Inducing the toxin(RelE)expressing via a copper(II)-inducible CUP1 promoter successfully drove the in-situ gene amplification of the antitoxin(RelB)module,resulting in~40 copies of a green fluorescence reporter gene per copy of genome.Copy-number changes,copy-number increase and copy-number decrease,and stable maintenance were visualised using the green fluorescence protein and blue chromoprotein AeBlue as reporters.Copy-number increases happened spontaneously and independent on a selection pressure.Increased copy number was quickly enriched through toxin-antitoxin-mediated selection.Conclusion:In summary,the bacterial toxin-antitoxin systems provide a flexible mechanism to manipulate gene copy number in eukaryotic cells and can be exploited for synthetic biology and metabolic engineering applications.
