Background The alexithymia trait is of high clinical interest.The Perth Alexithymia Questionnaire(PAQ)was recently developed to enable detailed facet-level and valence-specific assessments of alexithymia.Aims In this ...Background The alexithymia trait is of high clinical interest.The Perth Alexithymia Questionnaire(PAQ)was recently developed to enable detailed facet-level and valence-specific assessments of alexithymia.Aims In this paper,we introduce the first Chinese version of the PAQ and examine its psychometric properties and clinical applications.Methods In Study 1,the PAQ was administered to 990 Chinese participants.We examined its factor structure,internal consistency,test-retest reliability,as well as convergent,concurrent and discriminant validity.In Study 2,four groups,including a major depressive disorder(MDD)group(n=50),a matched healthy control group for MDD(n=50),a subclinical depression group(n=50)and a matched healthy control group for subclinical depression(n=50),were recruited.Group comparisons were conducted to assess the clinical relevance of the PAQ.Results In Study 1,the intended five-factor structure of the PAQ was found to fit the data well.The PAQ showed good internal consistency and test-retest reliability,as well as good convergent,concurrent and discriminant validity.In Study 2,the PAQ was able to successfully distinguish the MDD group and the subclinical depression group from their matched healthy controls.Conclusions The Chinese version of the PAQ is a valid and reliable instrument for comprehensively assessing alexithymia in the general population and adults with clinical/subclinical depression.展开更多
Urban agriculture has been increasingly popular as a form of modern agriculture in urban settings. It includes community gardens, fruit orchards, home gardens, veggie patches, public open spaces, reserves, urban fores...Urban agriculture has been increasingly popular as a form of modern agriculture in urban settings. It includes community gardens, fruit orchards, home gardens, veggie patches, public open spaces, reserves, urban forest, and recreational landscaping. However, irrigation using urban water supply has been identified as a major constraints for the development of urban agriculture. This study presents a sustainable water management trial at Butler, a northern sub-urban development in Perth, Western Australia, for urban irrigation. The trial system consists of a number of water saving features including untreated fit-for-purpose groundwater supplied via a third pipe network, drip irrigation, local weather station, soil moisture sensors connected with a local weather station, night time irrigation, soil enhancement with conditioning and mulching, and use of native plants and vegetation. The trial outcome was compared against controlled areas in terms of irrigation efficiency and sustainable water management for urban agriculture. The study demonstrated that a fit-for-purpose irrigation along with water sensitive land management could be a sustainable alternative for urban agriculture that would achieve a significant water saving and irrigation efficiency at urban settings. However, quality of untreated groundwater can be an issue while utilizing it for irrigation, but the research has shown that it can be managed with innovative irrigation techniques. This indicates that the fit-for-purpose irrigation system with water sensitive land management practices would be highly supportive in sustainable development of urban agriculture, vegetation and recreational landscaping.展开更多
Tight gas sands in Whicher Range Field of Perth Basin show large heterogeneity in reservoir characteristics and production behavior related to depositional and diagenetic features. Diagenetic events (compaction and ce...Tight gas sands in Whicher Range Field of Perth Basin show large heterogeneity in reservoir characteristics and production behavior related to depositional and diagenetic features. Diagenetic events (compaction and cementation) have severely affected the pore system. In order to investigate the petrophysical characteristics, reservoir sandstone facies were correlated with core porosity and permeability and their equivalent well log responses to describe hydraulic flow units and electrofacies, respectively. Thus, very tight, tight, and sub-tight sands were differentiated. To reveal the relationship between pore system properties and depositional and diagenetic characteristics in each sand type, reservoir rock types were extracted. The identified reservoir rock types are in fact a reflection of internal reservoir heterogeneity related to pore system properties. All reservoir rock types are characterized by a compacted fabric and cemented framework. But distribution and dominance of diagenetic products in each of them depend on primary depositional composition and texture. The results show that reservoir rock typing based on three aspects of reservoir sandstones (depositional properties, diagenetic features and petrophysical characteristics) is a suitable technique for depiction of reservoir heterogeneity, recognition of reservoir units and identifying factors controlling reservoir quality of tight sandstones. This methodology can be used for the other tight reservoirs.展开更多
模型劫持攻击是一种新型攻击方式,通过植入特定词语,能够隐蔽地控制模型执行与原始任务截然不同的劫持任务,使模型拥有者的训练算力成本增加的同时面临潜在的法律风险。目前,已有研究针对德-英文语言翻译模型探索了这一攻击方式,但在中...模型劫持攻击是一种新型攻击方式,通过植入特定词语,能够隐蔽地控制模型执行与原始任务截然不同的劫持任务,使模型拥有者的训练算力成本增加的同时面临潜在的法律风险。目前,已有研究针对德-英文语言翻译模型探索了这一攻击方式,但在中文自然语言处理(natural language processing,NLP)领域尚属空白。中文语言的独特性使得其面临不同于其他语言环境的安全挑战,因此亟需开发针对中文模型的攻击评估方法。基于上述事实,提出了一种基于中文逻辑词的模型劫持攻击方法Cheater,用于评估中文模型的安全性。Cheater针对中-英文NLP任务,首先使用公共模型对劫持数据进行伪装生成过渡数据,再通过在过渡样本中嵌入中文逻辑词的方式对其进行改造生成毒性数据,最后利用毒性数据完成对目标模型的劫持。实验表明,对于Bart[large]模型,Cheater在0.5%的数据投毒率下攻击成功率可以达到90.2%。展开更多
Climate change is one of the most pressing global challenges and spares no nation.Bhutan,as the only carbon negative country in the world,is no exception and being in the Himalayas–a region warming faster than the gl...Climate change is one of the most pressing global challenges and spares no nation.Bhutan,as the only carbon negative country in the world,is no exception and being in the Himalayas–a region warming faster than the global average–further intensifies climate risks.This study explores how Bhutan navigates climate change through the perspectives of 41 policy influencers,including politicians,civil servants,and leaders from nongovernment organisations and the media.The findings are compared with scientific literature from the broader Himalayan region to identify shared vulnerabilities(e.g.,glacial lake outburst floods,water scarcity,and agricultural disruptions)and governance challenges(e.g.,financial constraints,geopolitical pressures,and gaps in policy implementation).The study reveals that Bhutan,like its Himalayan neighbours,prioritizes adaptation over mitigation due to immediate climate threats,despite its carbonnegative status.However,Bhutan faces unique pressures in upholding its dual commitments—maintaining 60%forest cover and carbon neutrality—amid competing development needs.While its Gross National Happiness(GNH)framework provides a holistic governance model,the analysis uncovers systemic barriers,including limited financing,transboundary climate risks,and uneven policy execution,which mirror regional struggles.The paper contributes to climate governance discourse by highlighting the risks of symbolic environmental pledges without robust implementation mechanisms,particularly for vulnerable mountain nations.It calls for integrated policies that bridge mitigation and adaptation,stronger regional cooperation,and equitable climate financing.The findings are relevant for policymakers in the Himalayas and international stakeholders advocating context-specific,justiceoriented climate strategies.展开更多
The pursuit of symmetry has long shaped discussions in sports science,particularly in sprinting,where every fraction of a second counts.Yet,the human body is inherently asymmetrical–our hearts are slightly left,most ...The pursuit of symmetry has long shaped discussions in sports science,particularly in sprinting,where every fraction of a second counts.Yet,the human body is inherently asymmetrical–our hearts are slightly left,most favour one hand or foot,and limb lengths or joint flexibilities are rarely identical.This begs the question:Why do we insist that symmetry is essential for peak sprint performance?展开更多
Solid oxide cells(SOCs)have emerged as one of the key technologies for low-carbon energy transition due to their fuel flexibility and high system efficiency.However,their long-term deployment remains hindered by mater...Solid oxide cells(SOCs)have emerged as one of the key technologies for low-carbon energy transition due to their fuel flexibility and high system efficiency.However,their long-term deployment remains hindered by material degradation and interfacial instability under high-temperature and multi-atmospheric operating conditions.In particular,achieving a balance between catalytic activity and structural stability presents a major bottleneck in material design.High-entropy materials(HEMs),with their unique configurational entropy effect,multi-principal element synergy,and tunable local defect chemistry,offer a promising pathway to overcome these limitations.This perspective reviews recent advances in the application of HEMs in SOCs,including element selection and structure tuning,machine-learning-assisted design,in situ leaching and self-assembly engineering,and high-entropy coating strategies.Special attention is paid to how HEMs leverage their multi-elemental composition and defect regulation to enhance electrode performance,stabilize interfaces,and improve tolerance to poisoning species.We further highlight the potential of data-driven approaches for accelerating HEM screening and performance optimization,and discuss the integration of high-throughput experimentation with computational modeling to enable efficient exploration of the vast compositional space.Despite the remarkable progress,key challenges remain in achieving long-term stability and reliability across diverse operating scenarios.Future research should focus on precise control of non-equimolar compositions,development of cross-scale dynamic characterization techniques,and establishment of closed-loop frameworks that couple data-driven models with experimental feedback.These efforts will pave the way toward the rational design of high-performance,durable SOC systems.展开更多
Perovskite oxides are highly promising catalysts for the combustion removal of volatile organic compounds(VOCs)due to their excellent stability,structural flexibility,and compositional versatility.This study presents ...Perovskite oxides are highly promising catalysts for the combustion removal of volatile organic compounds(VOCs)due to their excellent stability,structural flexibility,and compositional versatility.This study presents a novel perovskite oxide that exhibits enhanced catalytic activity and superior durability for toluene combustion at reduced temperatures.This improvement is achieved by phosphorus doping at the B-site of LaCoO_(3-δ)(LC)perovskite oxide,followed by post-synthesis acid etching for a proper time.The resulting catalyst demonstrates increased specific surface area,higher total pore volume,and enhanced oxygen vacancy concentration both in the bulk and on the surface.Additionally,the activity of surface lattice oxygen species is significantly improved,leading to enhanced catalytic performance in toluene combustion.Notably,the optimized catalyst shows an exceptionally low activation energy(E_(a))of 49.3 kJ mol^(-1),with a T90 reduction of over 214℃compared to the phosphorus doped LC and 190℃compared to pristine LC.Phosphorus doping plays a main role in significantly improving the long-term durability,particularly in the presence of CO_(2)and H_(2)O,while acid etching boosts the catalytic activity.This work introduces a rational and innovative strategy for optimizing VOC oxidation by improving the structure and surface chemical states of perovskite catalysts.展开更多
Stability of base-exposed backfill roof in underhand drift-and-fill mining is crucial for the safety of those working beneath.Given the commonly used primary-and-secondary mining sequence,interfaces are formed between...Stability of base-exposed backfill roof in underhand drift-and-fill mining is crucial for the safety of those working beneath.Given the commonly used primary-and-secondary mining sequence,interfaces are formed between adjacent filled drifts,which can weaken the integrity of the backfill roof.These interfaces also lead to two common drift layouts:aligned drifts and staggered drifts.However,less attention has been paid to the interfaces and the two drift layouts were not adequately distinguished in previous studies.In this paper,the interfaces between filled drifts were firstly considered to investigate the stability of backfill roof.Failure modes and strength requirements of backfill roof in aligned and staggered drifts are comprehensively investigated by FLAC3D,with a focus on considerations of varied shear parameters of the interfaces.Results show that failure modes in aligned drifts transition from block sliding to top caving,bottom caving or sloughing as the interface cohesion increases from zero to at least half of the backfill cohesion.Further increases in interface cohesion allow aligned drifts to behave as if there are no interfaces between them.The critical stability conditions of backfill roof in aligned drifts were mostly determined by the interface strength instead of the backfill strength.However,the stability of backfill roof in staggered drifts is barely affected by the interface strength.The outcomes are expected to provide references for mining engineers to optimize drift layouts and perform cost-effective backfill roof strength design at mines using underhand drift-and-fill mining method.展开更多
The human brain is a complex intelligent system composed of tens of billions of neurons interconnected through synapses,and its intricate network structure has consistently attracted numerous scientists to explore the...The human brain is a complex intelligent system composed of tens of billions of neurons interconnected through synapses,and its intricate network structure has consistently attracted numerous scientists to explore the mysteries of brain functions.However,most existing studies have only verified the biological mimicry characteristics of memristors at the single neuron-synapse level,and there is still a lack of research on memristors simulating synaptic coupling between neurons in multi-neuron networks.Based on this,this paper uses discrete memristors to couple dual discrete Rulkov neurons,and adds synaptic crosstalk between the two discrete memristors to form a neuronal network.A memristor-coupled dual-neuron map,called the Rulkov-memristor-Rulkov(R-M-R)map,is constructed to simulate synaptic connections between neurons in biological tissues.Then,the equilibrium points of the R-M-R map are studied.Subsequently,the effect of parameter variations on the dynamic performance of the R-M-R map is comprehensively analyzed using bifurcation diagram,phase diagram,Lyapunov exponent spectrum(LEs),firing diagram,and spectral entropy(SE)complexity algorithms.In the RM-R map,diverse categories of periodic,chaotic,and hyperchaotic attractors,as well as different states of firing patterns,can be observed.Additionally,different types of state transitions and coexisting attractors are discovered.Finally,the feasibility of the model in digital circuits is verified using a DSP hardware platform.In this study,the coupling principle of biological neurons is simulated,the chaotic dynamic behavior of the R-M-R map is analyzed,and a foundation is laid for deciphering the complex working mechanisms of the brain.展开更多
Objectives:To explore the use of a traditional Chinese medicine(TCM)pattern scale as an outcome measure to evaluate the management of patients with chronic low back pain(CLBP).Methods:A total of 204 participants were ...Objectives:To explore the use of a traditional Chinese medicine(TCM)pattern scale as an outcome measure to evaluate the management of patients with chronic low back pain(CLBP).Methods:A total of 204 participants were recruited and randomly allocated into three CLBP treatment groups:Tuina only,physiotherapy only,and a combined physiotherapy+Tuina group.All participants were assessed for treatment outcomes using the TCM pattern scale as a substudy to a randomized controlled trial in which the Visual Analog Scale(VAS)was the primary outcome measure.TCM pattern scores were recorded by non-TCM research assistants who were trained to administer a TCM pattern questionnaire developed by the authors in collaboration with TCM experts.Results:Most participants(83%)were classified as having kidney deficiency pattern as the primary TCM pattern at baseline.All three intervention groups showed a significant decrease in overall TCM pattern score at month 2(M2)and month 5(M5).However,when the nimodipine method was applied,none of the three treatment arms showed a statistically significant change in the effective rate,even though the parent study reported a significant decrease in VAS scores in all treatment arms.Conclusion:This study found improvements in both the dominant TCM pattern score and the overall TCM pattern score for each group.These findings suggest that TCM pattern diagnosis,including entities recognized in International Classification of Diseases,11th Revision(ICD)-11,may be used as a quantitative outcome measure to reflect response to TCM-based intervention.The TCM pattern scale reported here may potentially be applied in other chronic pain studies involving TCM patterns.Further studies are warranted to validate this scale in other clinical conditions.展开更多
Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association betw...Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association between body fat mass(FM)and OCD.Methods Summary statistics from genome-wide association studies of European ancestry were utilized to conduct two-sample Mendelian randomization analysis.Heterogeneity,horizontal pleiotropy,and sensitivity analyses were performed to assess the robustness.Results The inverse variance weighting method demonstrated that a genetically predicted decrease in FM was causally associated with an increased OCD risk[odds ratio(OR)=0.680,95%confidence interval(CI):0.528–0.875,P=0.003].Similar estimates were obtained using the weighted median approach(OR=0.633,95%CI:0.438–0.915,P=0.015).Each standard deviation increases in genetically predicted body fat percentage corresponded to a reduced OCD risk(OR=0.638,95%CI:0.455–0.896,P=0.009).The sensitivity analysis confirmed the robustness of these findings with no outlier instrument variables identified.Conclusion The negative causal association between FM and the risk of OCD suggests that the prevention or treatment of mental disorders should include not only the control of BMI but also fat distribution and body composition.展开更多
Background:Tandem gene repeats naturally occur as important genomic features and determine many traits in living organisms,like human diseases and microbial productivities of target bioproducts.Methods:Here,we develop...Background:Tandem gene repeats naturally occur as important genomic features and determine many traits in living organisms,like human diseases and microbial productivities of target bioproducts.Methods:Here,we developed a bacterial type-II toxin-antitoxin-mediated method to manipulate genomic integration of tandem gene repeats in Saccharomyces cerevisiae and further visualised the evolutionary trajectories of gene repeats.We designed a tri-vector system to introduce toxin-antitoxin-driven gene amplification modules.Results:This system delivered multi-copy gene integration in the form of tandem gene repeats spontaneously and independently from toxin-antitoxin-mediated selection.Inducing the toxin(RelE)expressing via a copper(II)-inducible CUP1 promoter successfully drove the in-situ gene amplification of the antitoxin(RelB)module,resulting in~40 copies of a green fluorescence reporter gene per copy of genome.Copy-number changes,copy-number increase and copy-number decrease,and stable maintenance were visualised using the green fluorescence protein and blue chromoprotein AeBlue as reporters.Copy-number increases happened spontaneously and independent on a selection pressure.Increased copy number was quickly enriched through toxin-antitoxin-mediated selection.Conclusion:In summary,the bacterial toxin-antitoxin systems provide a flexible mechanism to manipulate gene copy number in eukaryotic cells and can be exploited for synthetic biology and metabolic engineering applications.展开更多
基金This work was supported by a grant from the National Natural Science Foundation of China(32200906)STI 2030-Major Projects(2021ZD0201705)+2 种基金Major Project of Philosophy and Social Science Research of the Ministry of Education of China(22JZD044)Research Project of Shanghai Science and Technology Commission(20dz2260300)Fundamental Research Funds for the Central Universities and Starting Research Fund from Hangzhou Normal University.
文摘Background The alexithymia trait is of high clinical interest.The Perth Alexithymia Questionnaire(PAQ)was recently developed to enable detailed facet-level and valence-specific assessments of alexithymia.Aims In this paper,we introduce the first Chinese version of the PAQ and examine its psychometric properties and clinical applications.Methods In Study 1,the PAQ was administered to 990 Chinese participants.We examined its factor structure,internal consistency,test-retest reliability,as well as convergent,concurrent and discriminant validity.In Study 2,four groups,including a major depressive disorder(MDD)group(n=50),a matched healthy control group for MDD(n=50),a subclinical depression group(n=50)and a matched healthy control group for subclinical depression(n=50),were recruited.Group comparisons were conducted to assess the clinical relevance of the PAQ.Results In Study 1,the intended five-factor structure of the PAQ was found to fit the data well.The PAQ showed good internal consistency and test-retest reliability,as well as good convergent,concurrent and discriminant validity.In Study 2,the PAQ was able to successfully distinguish the MDD group and the subclinical depression group from their matched healthy controls.Conclusions The Chinese version of the PAQ is a valid and reliable instrument for comprehensively assessing alexithymia in the general population and adults with clinical/subclinical depression.
文摘Urban agriculture has been increasingly popular as a form of modern agriculture in urban settings. It includes community gardens, fruit orchards, home gardens, veggie patches, public open spaces, reserves, urban forest, and recreational landscaping. However, irrigation using urban water supply has been identified as a major constraints for the development of urban agriculture. This study presents a sustainable water management trial at Butler, a northern sub-urban development in Perth, Western Australia, for urban irrigation. The trial system consists of a number of water saving features including untreated fit-for-purpose groundwater supplied via a third pipe network, drip irrigation, local weather station, soil moisture sensors connected with a local weather station, night time irrigation, soil enhancement with conditioning and mulching, and use of native plants and vegetation. The trial outcome was compared against controlled areas in terms of irrigation efficiency and sustainable water management for urban agriculture. The study demonstrated that a fit-for-purpose irrigation along with water sensitive land management could be a sustainable alternative for urban agriculture that would achieve a significant water saving and irrigation efficiency at urban settings. However, quality of untreated groundwater can be an issue while utilizing it for irrigation, but the research has shown that it can be managed with innovative irrigation techniques. This indicates that the fit-for-purpose irrigation system with water sensitive land management practices would be highly supportive in sustainable development of urban agriculture, vegetation and recreational landscaping.
文摘Tight gas sands in Whicher Range Field of Perth Basin show large heterogeneity in reservoir characteristics and production behavior related to depositional and diagenetic features. Diagenetic events (compaction and cementation) have severely affected the pore system. In order to investigate the petrophysical characteristics, reservoir sandstone facies were correlated with core porosity and permeability and their equivalent well log responses to describe hydraulic flow units and electrofacies, respectively. Thus, very tight, tight, and sub-tight sands were differentiated. To reveal the relationship between pore system properties and depositional and diagenetic characteristics in each sand type, reservoir rock types were extracted. The identified reservoir rock types are in fact a reflection of internal reservoir heterogeneity related to pore system properties. All reservoir rock types are characterized by a compacted fabric and cemented framework. But distribution and dominance of diagenetic products in each of them depend on primary depositional composition and texture. The results show that reservoir rock typing based on three aspects of reservoir sandstones (depositional properties, diagenetic features and petrophysical characteristics) is a suitable technique for depiction of reservoir heterogeneity, recognition of reservoir units and identifying factors controlling reservoir quality of tight sandstones. This methodology can be used for the other tight reservoirs.
文摘模型劫持攻击是一种新型攻击方式,通过植入特定词语,能够隐蔽地控制模型执行与原始任务截然不同的劫持任务,使模型拥有者的训练算力成本增加的同时面临潜在的法律风险。目前,已有研究针对德-英文语言翻译模型探索了这一攻击方式,但在中文自然语言处理(natural language processing,NLP)领域尚属空白。中文语言的独特性使得其面临不同于其他语言环境的安全挑战,因此亟需开发针对中文模型的攻击评估方法。基于上述事实,提出了一种基于中文逻辑词的模型劫持攻击方法Cheater,用于评估中文模型的安全性。Cheater针对中-英文NLP任务,首先使用公共模型对劫持数据进行伪装生成过渡数据,再通过在过渡样本中嵌入中文逻辑词的方式对其进行改造生成毒性数据,最后利用毒性数据完成对目标模型的劫持。实验表明,对于Bart[large]模型,Cheater在0.5%的数据投毒率下攻击成功率可以达到90.2%。
文摘Climate change is one of the most pressing global challenges and spares no nation.Bhutan,as the only carbon negative country in the world,is no exception and being in the Himalayas–a region warming faster than the global average–further intensifies climate risks.This study explores how Bhutan navigates climate change through the perspectives of 41 policy influencers,including politicians,civil servants,and leaders from nongovernment organisations and the media.The findings are compared with scientific literature from the broader Himalayan region to identify shared vulnerabilities(e.g.,glacial lake outburst floods,water scarcity,and agricultural disruptions)and governance challenges(e.g.,financial constraints,geopolitical pressures,and gaps in policy implementation).The study reveals that Bhutan,like its Himalayan neighbours,prioritizes adaptation over mitigation due to immediate climate threats,despite its carbonnegative status.However,Bhutan faces unique pressures in upholding its dual commitments—maintaining 60%forest cover and carbon neutrality—amid competing development needs.While its Gross National Happiness(GNH)framework provides a holistic governance model,the analysis uncovers systemic barriers,including limited financing,transboundary climate risks,and uneven policy execution,which mirror regional struggles.The paper contributes to climate governance discourse by highlighting the risks of symbolic environmental pledges without robust implementation mechanisms,particularly for vulnerable mountain nations.It calls for integrated policies that bridge mitigation and adaptation,stronger regional cooperation,and equitable climate financing.The findings are relevant for policymakers in the Himalayas and international stakeholders advocating context-specific,justiceoriented climate strategies.
文摘The pursuit of symmetry has long shaped discussions in sports science,particularly in sprinting,where every fraction of a second counts.Yet,the human body is inherently asymmetrical–our hearts are slightly left,most favour one hand or foot,and limb lengths or joint flexibilities are rarely identical.This begs the question:Why do we insist that symmetry is essential for peak sprint performance?
基金supported by National Natural Science Foundation of China(U24A20542,52472210)Natural Science Foundation of Jiangsu Province(No.BK20221312)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX25_1706).
文摘Solid oxide cells(SOCs)have emerged as one of the key technologies for low-carbon energy transition due to their fuel flexibility and high system efficiency.However,their long-term deployment remains hindered by material degradation and interfacial instability under high-temperature and multi-atmospheric operating conditions.In particular,achieving a balance between catalytic activity and structural stability presents a major bottleneck in material design.High-entropy materials(HEMs),with their unique configurational entropy effect,multi-principal element synergy,and tunable local defect chemistry,offer a promising pathway to overcome these limitations.This perspective reviews recent advances in the application of HEMs in SOCs,including element selection and structure tuning,machine-learning-assisted design,in situ leaching and self-assembly engineering,and high-entropy coating strategies.Special attention is paid to how HEMs leverage their multi-elemental composition and defect regulation to enhance electrode performance,stabilize interfaces,and improve tolerance to poisoning species.We further highlight the potential of data-driven approaches for accelerating HEM screening and performance optimization,and discuss the integration of high-throughput experimentation with computational modeling to enable efficient exploration of the vast compositional space.Despite the remarkable progress,key challenges remain in achieving long-term stability and reliability across diverse operating scenarios.Future research should focus on precise control of non-equimolar compositions,development of cross-scale dynamic characterization techniques,and establishment of closed-loop frameworks that couple data-driven models with experimental feedback.These efforts will pave the way toward the rational design of high-performance,durable SOC systems.
基金support from the National Key Research and Development Program of China(Project No.2018YFB1502903).
文摘Perovskite oxides are highly promising catalysts for the combustion removal of volatile organic compounds(VOCs)due to their excellent stability,structural flexibility,and compositional versatility.This study presents a novel perovskite oxide that exhibits enhanced catalytic activity and superior durability for toluene combustion at reduced temperatures.This improvement is achieved by phosphorus doping at the B-site of LaCoO_(3-δ)(LC)perovskite oxide,followed by post-synthesis acid etching for a proper time.The resulting catalyst demonstrates increased specific surface area,higher total pore volume,and enhanced oxygen vacancy concentration both in the bulk and on the surface.Additionally,the activity of surface lattice oxygen species is significantly improved,leading to enhanced catalytic performance in toluene combustion.Notably,the optimized catalyst shows an exceptionally low activation energy(E_(a))of 49.3 kJ mol^(-1),with a T90 reduction of over 214℃compared to the phosphorus doped LC and 190℃compared to pristine LC.Phosphorus doping plays a main role in significantly improving the long-term durability,particularly in the presence of CO_(2)and H_(2)O,while acid etching boosts the catalytic activity.This work introduces a rational and innovative strategy for optimizing VOC oxidation by improving the structure and surface chemical states of perovskite catalysts.
基金supported by Deep Earth Probe and Mineral Resources Exploration-National Science and Technology Major Project(Grant No.2024ZD1003705)the Beijing Nova Program(Grant No.20220484057)support from China Scholarship Council under Grant CSC No.202110300001.
文摘Stability of base-exposed backfill roof in underhand drift-and-fill mining is crucial for the safety of those working beneath.Given the commonly used primary-and-secondary mining sequence,interfaces are formed between adjacent filled drifts,which can weaken the integrity of the backfill roof.These interfaces also lead to two common drift layouts:aligned drifts and staggered drifts.However,less attention has been paid to the interfaces and the two drift layouts were not adequately distinguished in previous studies.In this paper,the interfaces between filled drifts were firstly considered to investigate the stability of backfill roof.Failure modes and strength requirements of backfill roof in aligned and staggered drifts are comprehensively investigated by FLAC3D,with a focus on considerations of varied shear parameters of the interfaces.Results show that failure modes in aligned drifts transition from block sliding to top caving,bottom caving or sloughing as the interface cohesion increases from zero to at least half of the backfill cohesion.Further increases in interface cohesion allow aligned drifts to behave as if there are no interfaces between them.The critical stability conditions of backfill roof in aligned drifts were mostly determined by the interface strength instead of the backfill strength.However,the stability of backfill roof in staggered drifts is barely affected by the interface strength.The outcomes are expected to provide references for mining engineers to optimize drift layouts and perform cost-effective backfill roof strength design at mines using underhand drift-and-fill mining method.
基金supported by the National Natural Science Foundation of China(Grant No.62571079)the Technological Innovation Projects in the Field of Artificial Intelligence in Liaoning Province(Grant No.2023JH26/10300011)+1 种基金the Basic Scientific Research Projects in the Department of Education of Liaoning Province(Grant No.LJ212410152049)the Liaoning Provincial Science and Technology Plan Joint Project(Grant No.2025-BSLH-041)。
文摘The human brain is a complex intelligent system composed of tens of billions of neurons interconnected through synapses,and its intricate network structure has consistently attracted numerous scientists to explore the mysteries of brain functions.However,most existing studies have only verified the biological mimicry characteristics of memristors at the single neuron-synapse level,and there is still a lack of research on memristors simulating synaptic coupling between neurons in multi-neuron networks.Based on this,this paper uses discrete memristors to couple dual discrete Rulkov neurons,and adds synaptic crosstalk between the two discrete memristors to form a neuronal network.A memristor-coupled dual-neuron map,called the Rulkov-memristor-Rulkov(R-M-R)map,is constructed to simulate synaptic connections between neurons in biological tissues.Then,the equilibrium points of the R-M-R map are studied.Subsequently,the effect of parameter variations on the dynamic performance of the R-M-R map is comprehensively analyzed using bifurcation diagram,phase diagram,Lyapunov exponent spectrum(LEs),firing diagram,and spectral entropy(SE)complexity algorithms.In the RM-R map,diverse categories of periodic,chaotic,and hyperchaotic attractors,as well as different states of firing patterns,can be observed.Additionally,different types of state transitions and coexisting attractors are discovered.Finally,the feasibility of the model in digital circuits is verified using a DSP hardware platform.In this study,the coupling principle of biological neurons is simulated,the chaotic dynamic behavior of the R-M-R map is analyzed,and a foundation is laid for deciphering the complex working mechanisms of the brain.
基金financially supported by the HEAD foundation(IO number GRTHF0000101).
文摘Objectives:To explore the use of a traditional Chinese medicine(TCM)pattern scale as an outcome measure to evaluate the management of patients with chronic low back pain(CLBP).Methods:A total of 204 participants were recruited and randomly allocated into three CLBP treatment groups:Tuina only,physiotherapy only,and a combined physiotherapy+Tuina group.All participants were assessed for treatment outcomes using the TCM pattern scale as a substudy to a randomized controlled trial in which the Visual Analog Scale(VAS)was the primary outcome measure.TCM pattern scores were recorded by non-TCM research assistants who were trained to administer a TCM pattern questionnaire developed by the authors in collaboration with TCM experts.Results:Most participants(83%)were classified as having kidney deficiency pattern as the primary TCM pattern at baseline.All three intervention groups showed a significant decrease in overall TCM pattern score at month 2(M2)and month 5(M5).However,when the nimodipine method was applied,none of the three treatment arms showed a statistically significant change in the effective rate,even though the parent study reported a significant decrease in VAS scores in all treatment arms.Conclusion:This study found improvements in both the dominant TCM pattern score and the overall TCM pattern score for each group.These findings suggest that TCM pattern diagnosis,including entities recognized in International Classification of Diseases,11th Revision(ICD)-11,may be used as a quantitative outcome measure to reflect response to TCM-based intervention.The TCM pattern scale reported here may potentially be applied in other chronic pain studies involving TCM patterns.Further studies are warranted to validate this scale in other clinical conditions.
基金supported by the Yanzhao Gold Talent Project of Hebei Province(NO.HJZD202506)。
文摘Objective Previous studies link lower body mass index(BMI)with increased obsessive-compulsive disorder(OCD)risk,yet other body mass indicators may be more etioloically relevant.We dissected the causal association between body fat mass(FM)and OCD.Methods Summary statistics from genome-wide association studies of European ancestry were utilized to conduct two-sample Mendelian randomization analysis.Heterogeneity,horizontal pleiotropy,and sensitivity analyses were performed to assess the robustness.Results The inverse variance weighting method demonstrated that a genetically predicted decrease in FM was causally associated with an increased OCD risk[odds ratio(OR)=0.680,95%confidence interval(CI):0.528–0.875,P=0.003].Similar estimates were obtained using the weighted median approach(OR=0.633,95%CI:0.438–0.915,P=0.015).Each standard deviation increases in genetically predicted body fat percentage corresponded to a reduced OCD risk(OR=0.638,95%CI:0.455–0.896,P=0.009).The sensitivity analysis confirmed the robustness of these findings with no outlier instrument variables identified.Conclusion The negative causal association between FM and the risk of OCD suggests that the prevention or treatment of mental disorders should include not only the control of BMI but also fat distribution and body composition.
基金supported partially by the Australian Government through the Australian Research Council Centres of Excellence funding scheme(project CE200100029)。
文摘Background:Tandem gene repeats naturally occur as important genomic features and determine many traits in living organisms,like human diseases and microbial productivities of target bioproducts.Methods:Here,we developed a bacterial type-II toxin-antitoxin-mediated method to manipulate genomic integration of tandem gene repeats in Saccharomyces cerevisiae and further visualised the evolutionary trajectories of gene repeats.We designed a tri-vector system to introduce toxin-antitoxin-driven gene amplification modules.Results:This system delivered multi-copy gene integration in the form of tandem gene repeats spontaneously and independently from toxin-antitoxin-mediated selection.Inducing the toxin(RelE)expressing via a copper(II)-inducible CUP1 promoter successfully drove the in-situ gene amplification of the antitoxin(RelB)module,resulting in~40 copies of a green fluorescence reporter gene per copy of genome.Copy-number changes,copy-number increase and copy-number decrease,and stable maintenance were visualised using the green fluorescence protein and blue chromoprotein AeBlue as reporters.Copy-number increases happened spontaneously and independent on a selection pressure.Increased copy number was quickly enriched through toxin-antitoxin-mediated selection.Conclusion:In summary,the bacterial toxin-antitoxin systems provide a flexible mechanism to manipulate gene copy number in eukaryotic cells and can be exploited for synthetic biology and metabolic engineering applications.
