The multi-piped freezing method is usually applied in artificial ground freezing （AGF） projects to fulfill special construction requirements, such as two-, three-, or four-piped freezing. Based on potential superpos...The multi-piped freezing method is usually applied in artificial ground freezing （AGF） projects to fulfill special construction requirements, such as two-, three-, or four-piped freezing. Based on potential superposition theory, this paper gives analytical solutions to steady-state frozen temperature for two, three, and four freezing pipes with different temperatures and arranged at random. Specific solutions are derived for some particular arrangements, such as three freezing pipes in a linear arrangement with equal or unequal spacing, right and isosceles triangle arrangements, four freezing pipes in a linear arrangement with equal spacing, and rhombus and rectangle arrangements. A comparison between the analytical solutions and numerical thermal analysis shows that the analytical solutions are sufficiently precise. As a part of the theory of AGF, the analytical solutions of temperature fields for multi-piped freezing with arbitrary layouts and different temperatures of freezing pipes are approached for the first time.展开更多
This study explores the structures of the correlations between infrared(IR)brightness temperatures(BTs)from the three water vapor channels of the Advanced Baseline Imager(ABI)onboard the GOES-16 satellite and the atmo...This study explores the structures of the correlations between infrared(IR)brightness temperatures(BTs)from the three water vapor channels of the Advanced Baseline Imager(ABI)onboard the GOES-16 satellite and the atmospheric state.Ensemble-based data assimilation techniques such as the ensemble Kalman filter(EnKF)rely on correlations to propagate innovations of BTs to increments of model state variables.Because the three water vapor channels are sensitive to moisture in different layers of the troposphere,the heights of the strongest correlations between these channels and moisture in clear-sky regions are closely related to the peaks of their respective weighting functions.In cloudy regions,the strongest correlations appear at the cloud tops of deep clouds,and ice hydrometeors generally have stronger correlations with BT than liquid hydrometeors.The magnitudes of the correlations decrease from the peak value in a column with both vertical and horizontal distance.Just how the correlations decrease depend on both the cloud scenes and the cloud structures,as well as the model variables.Horizontal correlations between BTs and moisture,as well as hydrometeors,in fully cloudy regions decrease to almost 0 at about 30 km.The horizontal correlations with atmospheric state variables in clear-sky regions are broader,maintaining non-zero values out to~100 km.The results in this study provide information on the proper choice of cut-off radii in horizontal and vertical localization schemes for the assimilation of BTs.They also provide insights on the most efficient and effective use of the different water vapor channels.展开更多
In the United States,an unexpected and severe increase in coal miners’lung diseases in the late 1990s prompted researchers to investigate the causes of the disease resurgence.This study aims to scrutinize the effects...In the United States,an unexpected and severe increase in coal miners’lung diseases in the late 1990s prompted researchers to investigate the causes of the disease resurgence.This study aims to scrutinize the effects of various mining parameters,including coal rank,mine size,mine operation type,coal seam height,and geographical location on the prevalence of coal worker’s pneumoconiosis(CWP)in surface and underground coal mines.A comprehensive dataset was created using the U.S.Mine Safety and Health Administration(MSHA)Employment and Accident/Injury databases.The information was merged based on the mine ID by utilizing SQL data management software.A total number of 123,589 mine-year observations were included in the statistical analysis.Generalized Estimating Equation(GEE)model was used to conduct a statistical analysis on a total of 29,707,and 32,643 mine-year observations for underground and surface coal mines,respectively.The results of the econometrics approach revealed that coal workers in underground coal mines are at a greater risk of CWP comparing to those of surface coal operations.Furthermore,underground coal mines in the Appalachia and Interior regions are at a higher risk of CWP prevalence than the Western region.Surface coal mines in the Appalachian coal region are more likely to CWP development than miners in the Western region.The analysis also indicated that coal workers working in smaller mines are more vulnerable to CWP than those in large mine sizes.Furthermore,coal workers in thin-seam underground mine operations are more likely to develop CWP.展开更多
Objective:To summarize the recent literature discussing focal therapy for localized prostate cancer.Methods:A thorough literature review was performed using PubMed to identify recent studies involving focal therapy fo...Objective:To summarize the recent literature discussing focal therapy for localized prostate cancer.Methods:A thorough literature review was performed using PubMed to identify recent studies involving focal therapy for the treatment of localized prostate cancer.Results:In an effort to decrease the morbidity associated with prostate cancer treatment,many urologists are turning to focal therapy as an alternative treatment option.With this approach,the cancer bearing portion of the prostate is targeted while leaving the benign tissue untouched.Multiparametric magnetic resonance imaging remains the gold standard for visualization during focal therapy,but new imaging modalities such as prostate specific membrane antigen/positron emission tomography and contrast enhanced ultrasound are being investigated.Furthermore,several biomarkers,such as prostate cancer antigen 3 and prostate health index,are used in conjunction with imaging to improve risk stratification prior to focal therapy.Lastly,there are several novel technologies such as nanoparticles and transurethral devices that are under investigation for use in focal therapy.Conclusion:Focal therapy is proving to be a promising option for the treatment of localized prostate cancer.However,further study is needed to determine the true efficacy of these exciting new technologies.展开更多
Partnerships between U.S. universities and industries have existed for several decades and in recent years have become generally more varied, wider in scope, more aggressive and experimental and higher in public visib...Partnerships between U.S. universities and industries have existed for several decades and in recent years have become generally more varied, wider in scope, more aggressive and experimental and higher in public visibility. In addition, in the last few decades, public and private interests have advocated for government policies and laws to globally promote the commercialization of university science. This paper examines the persistence or convergence of the two cultures of science and the implications of this commercialization for university-industry relationships in agriculture biotechnology. The perceptions and values of over 200 U.S. university and industry scientists, managers and administrators who participate in or oversee research collaborations in agricultural biotechnology were analyzed. The findings revealed that the participants in these research relationships continue to perceive very distinct cultures of science and identify a wide range of concerns and disadvantages of these partnerships. Several actions were discussed to ensure that the two cultures serve complementary roles and that they maximize the public benefits from these increasing collaborations.展开更多
This study demonstrated using yttrium(Y)as an indicator to estimate the total rare earth element and Y contents(REY)in coal-associated samples and to facilitate selection of samples with high REY assays in a fast and ...This study demonstrated using yttrium(Y)as an indicator to estimate the total rare earth element and Y contents(REY)in coal-associated samples and to facilitate selection of samples with high REY assays in a fast and inexpensive manner.More than 10 anthracite-associated samples were collected from each of three Pennsylvanian sites(sites B,J and C)based on Thorium gamma ray logging suggesting high REY content.Several samples from each site were analyzed by ICP-MS to determine the rare earth distribution patterns and to establish the site-specific linear equations of Y and REY.The Y contents of the remaining samples were measured by a portable X-ray fluorescence analyzer,and the REY values were estimated based on the site-specific linear equation developed earlier.R-squared values above 0.70 were obtained for all the estimation equations from all three sites on both a whole sample basis and an ash basis.Previously,ash content has been widely used as an indicator of high REY content.This may not be applicable for a specific site.Site B in this study is an example where ash contents could not be statistically correlated with REY,so using Y for estimation is more applicable.The demonstrated sample screening process is suitable for samples from sites that share more similar distribution patterns(either MREY or LREY or HREY)as well as for samples from sites that share multiple distribution patterns(LREY/MREY/HREY)depending on the desirable accuracy.The demonstrated process lowers the analytical cost from$70 to 80 dollars per sample to$10-15 per sample while significantly reducing the processing time and acid consumption for ICP digestion.This is particularly true when a relatively large sample size is involved,for example,100 samples from one site analyzed by ICP-MS/OES.展开更多
The efficacy of limestone sand and pelletized lime for remediation of soil acidity was compared in order to determine if limestone sand was a more cost-effective alternative to pelletized lime. Between fall of 2002 an...The efficacy of limestone sand and pelletized lime for remediation of soil acidity was compared in order to determine if limestone sand was a more cost-effective alternative to pelletized lime. Between fall of 2002 and spring 2003, two forested sites in Pennsylvania were clear cut and fenced. Pelletized lime and limestone sand were applied to separate 400-m2 plots within the sites at rates of 2170 kg·ha-1 and 4335 kg·ha-1, respectively. Two additional 400-m2 plots were used as controls. A paired before-after control-impact study design was used to assess changes in soil, soil solution, vegetation and biomass after lime application. Soil samples were collected from the Oi, Oe + Oa, and A horizons before and after lime application. Woody and herbaceous vegetation was harvested from 1-m2 sub-plots before and after liming and bi-weekly soil solution samples were collected for six months following lime application. Analysis of variance procedures were used to compare changes in the treatment plots over time. Changes in soil chemistry following lime application were comparable on the limestone sand and pelletized lime plots. There was a significant increase in exchangeable Mg and Mg saturation in the Oe + Oa horizon on all of the lime treatment plots relative to controls, but a greater percentage of applied Ca and Mg was exchangeable in the O-horizon in pelletized lime plots nine months after liming. Plant biomass did not increase on the lime treatment plots relative to the control one year post treatment. The majority of applied Ca and Mg from pelletized lime and limestone sand remained in the litter layer, with little movement into the A-horizon after one growing season. These results indicated that the application of limestone sand at two times the rate of pelletized lime produced comparable changes in soil and soil solution chemistry at a fraction of the cost.展开更多
In the confined spaces of underground mines,the exposure of over 10,000 miners in the U.S.to diesel exhaust and diesel particulate matter(DPM)is an occupational inevitability,particularly in metal and nonmetal mineral...In the confined spaces of underground mines,the exposure of over 10,000 miners in the U.S.to diesel exhaust and diesel particulate matter(DPM)is an occupational inevitability,particularly in metal and nonmetal mineral extraction.These workers routinely operate amidst diesel-powered equipment,often outdated and highly polluting,extracting resources such as limestone,gold,and salt.The acute health effects of such exposure are significant,leading to symptoms like headaches and flu-like conditions,with the impact being more pronounced in these closed work environments.This review scrutinizes DPM's hazard in the mining sector,consolidating the extant knowledge and exploring ongoing research.It encapsulates our understanding of DPM's physicochemical properties,existing sampling methods,health ramifications,and mitigation technologies.Moreover,it underscores the necessity for further study in areas such as the evolution of DPM's physicochemical attributes,from its genesis at high-pressure,high-temperature conditions within diesel engines to its emission into the mine atmosphere.A key research gap is the intricate interaction of DPM with specific characteristics of the mine environment-such as relative humidity,ambient temperature,the presence of other mineral dust,and the dynamics of ventilation air.These factors can significantly alter the physicochemical profile of DPM,infuencing both its in-mine transport and its deposition behavior.Consequently,this can affect the respiratory health of miners,modifying the toxicity and the respiratory deposition of DPM particles.Identified research imperatives include(1)the advancement of instrumentation for accurate number measurement of DPM to replace or supplement traditional gravimetric methods;(2)the development of long-lasting,cost-effective control technologies tailored for the mining industry;(3)an in-depth investigation of DPM interactions within the unique mine microclimate,considering the critical components like humidity and other aerosols;and(4)understanding the differential impact of DPM in mining compared to other industries,informing the creation of mining-specific health and safety protocols.This review's findings underscore the urgency to enhance emission control and exposure prevention strategies,paving the way for a healthier underground mining work environment.展开更多
BACKGROUND The long-term impact of vitamin D deficiency and metabolic syndrome(MetS)on cardiovascular disease(CVD)and all-cause mortality are still a matter of debate.AIM To test the hypotheses that lower serum 25 hyd...BACKGROUND The long-term impact of vitamin D deficiency and metabolic syndrome(MetS)on cardiovascular disease(CVD)and all-cause mortality are still a matter of debate.AIM To test the hypotheses that lower serum 25 hydroxyvitamin D[25(OH)D]concentrations(a marker of vitamin D level)and MetS have a long-term impact on the risk of CVD and all-cause mortality,and individuals with vitamin D deficiency can be identified by multiple factors.METHODS A sample of 9094 adults,20 to 90 years of age,who participated in the Third National Health and Nutrition Examination Survey(NHANES III,1988 to 1994)were followed through December 2015 was analyzed.The associations of serum 25(OH)D concentrations and MetS with CVD and all-cause mortality were analyzed longitudinally using Cox regression models.Classification and regression tree(CART)for machine learning was applied to classify individuals with vitamin D deficiency.RESULTS Of 9094 participants,30%had serum 25(OH)D concentrations<20 ng/mL(defined as vitamin D deficiency),39%had serum 25(OH)D concentrations between 20 to 29 ng/mL(insufficiency),and 31%had serum 25(OH)D concentrations≥30 ng/mL(sufficiency).Prevalence of MetS was 28.4%.During a mean of 18 years follow-up,vitamin D deficiency and MetS were significantly associated with increased risk of CVD and all-cause mortality.Subjects with both vitamin D deficiency and MetS had the highest risk of CVD mortality(HR=1.77,95%CI:1.22-2.58)and all-cause mortality(HR=1.62,95%CI:1.26-2.09),followed by those with both vitamin D insufficiency and MetS for CVD mortality(HR=1.59,95%CI:1.12-2.24),and all-cause mortality(HR=1.41,95%CI:1.08-1.85).Meanwhile,vitamin D sufficiency significantly decreased the risk of CVD and all-cause mortality for those who even had MetS.Among the total study sample,CART analysis suggests that being non-Hispanic Black,having lower serum folate level,and being female were the first three predictors for those with serum 25(OH)D deficiency.CONCLUSION Vitamin D deficiency and MetS were significantly associated with increased risk of CVD and allcause mortality.There was a significant joint effect of vitamin D deficiency and MetS on the risk of mortality.Findings of the CART analysis may be useful to identify individuals positioned to benefit from interventions to reduce the risk of CVD and all-cause mortality.展开更多
The focus of our investigation is to evaluate one of the four contributing terms to the coulombic potential energy of an H<sub>2</sub> molecule. Specifically, we are interested in the term describing the e...The focus of our investigation is to evaluate one of the four contributing terms to the coulombic potential energy of an H<sub>2</sub> molecule. Specifically, we are interested in the term describing the electronic interaction of the charge distribution of one of the hydrogen atoms with the proton of the second atom. Quantum mechanics provides the charge distribution;hence, the evaluation of this term is a semi-classic quantum physics issue. For states other than the ground state the charge distributions are not spherically symmetric;they are functions of the radial and the angular coordinates. For the excited states we develop exact analytic expressions conducive to the potential energies. Because of the functional complexities of the wave functions, the evaluation of the core integrals is carried out utilizing symbolic capabilities of Mathematica [1]. Plots of these energies vs. the distance between the two protons reveal global features.展开更多
Particle-fluid two-phase flows in rock fractures and fracture networks play a pivotal role in determining the efficiency and effectiveness of hydraulic fracturing operations,a vital component in unconventional oil and...Particle-fluid two-phase flows in rock fractures and fracture networks play a pivotal role in determining the efficiency and effectiveness of hydraulic fracturing operations,a vital component in unconventional oil and gas extraction.Central to this phenomenon is the transport of proppants,tiny solid particles injected into the fractures to prevent them from closing once the injection is stopped.However,effective transport and deposition of proppant is critical in keeping fracture pathways open,especially in lowpermeability reservoirs.This review explores,then quantifies,the important role of fluid inertia and turbulent flows in governing proppant transport.While traditional models predominantly assume and then characterise flow as laminar,this may not accurately capture the complexities inherent in realworld hydraulic fracturing and proppant emplacement.Recent investigations highlight the paramount importance of fluid inertia,especially at the high Reynolds numbers typically associated with fracturing operations.Fluid inertia,often overlooked,introduces crucial forces that influence particle settling velocities,particle-particle interactions,and the eventual deposition of proppants within fractures.With their inherent eddies and transient and chaotic nature,turbulent flows introduce additional complexities to proppant transport,crucially altering proppant settling velocities and dispersion patterns.The following comprehensive survey of experimental,numerical,and analytical studies elucidates controls on the intricate dynamics of proppant transport under fluid inertia and turbulence-towards providing a holistic understanding of the current state-of-the-art,guiding future research directions,and optimising hydraulic fracturing practices.展开更多
Clayey-silt natural gas hydrate reservoirs in the South China Sea exhibit loose and unconsolidated structures, heterogeneous pore structures, high clay mineral contents, and strong hydrophilicity. These characteristic...Clayey-silt natural gas hydrate reservoirs in the South China Sea exhibit loose and unconsolidated structures, heterogeneous pore structures, high clay mineral contents, and strong hydrophilicity. These characteristics complicate the gas-water two-phase flow process in porous media following hydrate decomposition, posing challenges for efficient development. This study examines the transport response of clayey-silt reservoir samples from the Shenhu area using gas-water two-phase flow experiments and CT scanning to explore changes in pore structure, gas-water distribution, and relative permeability under varying flow conditions. The results indicate that pore heterogeneity significantly influences flow characteristics. Gas preferentially displaces water in larger pores, forming fracture-like pores, which serve as preferential flow channels for gas migration. The preferential flow channels enhance gas-phase permeability up to 19 times that of the water phase when fluid pressures exceed total stresses. However,small pores retain liquid, leading to a high residual water saturation of 0.561. CT imaging reveals that these hydro-fractures improve gas permeability but also confine gas flow to specific channels. Pore network analysis shows that gas injection expands the pore-throat network, enhancing connectivity and forming fracture-like pores. Residual water remains trapped in smaller pores and throats, while structural changes, including new fractures, improve gas flow pathways and overall connectivity. Relative permeability curves demonstrate a narrow gas-water cocurrent-flow zone, a right-shifted iso-permeability point and high reservoir capillary pressure, indicating a strong "water-blocking" effect. The findings suggest that optimizing reservoir stimulation techniques to enhance fracture formation, reduce residual water saturation, and improve gas flow capacity is critical for efficient hydrate reservoir development.展开更多
High-water-cut mature reservoirs typically serve as the“ballast”for ensuring China’s annual crude oil production of 200 million tons.Despite the use of water flooding and chemical methods,over 40%of crude oil remai...High-water-cut mature reservoirs typically serve as the“ballast”for ensuring China’s annual crude oil production of 200 million tons.Despite the use of water flooding and chemical methods,over 40%of crude oil remains unexploited.It is critical to develop efficient revolutionary technologies to further enhance oil recovery(EOR)by a large percentage in high-water-cut mature reservoirs.To address this issue,the potential of vertical remaining oil in Daqing Oilfield is first analyzed from massive monitoring data.Using molecular dynamics simulation to design optimal synthetic routine,a copolymer without flu-orine or silicon is synthesized by modifying vinyl acetate(VAc)with maleic anhydride(MA)and styrene(St),and treated as a supercritical CO_(2)(scCO_(2))thickener.The underlying EOR mechanism of the scCO_(2) thickener is thereafter clarified by high-temperature,high-pressure oil displacement experiments.The EOR effect by thickened scCO_(2) flooding in a typical high-water-cut mature reservoir is predicted,and future technological advancements of the technique are ultimately discussed.Results show that the ver-tical remaining oil enriched in weakly swept zones is a primary target for further EOR in high-water-cut mature reservoirs.The copolymer typically exhibits good solubility,strong dispersion stability,and high thickening effect in scCO_(2).Under an ambient pressure of 10 MPa and a temperature of 50℃,the disso-lution of copolymer at a mass concentration of 0.2%can effectively increase the viscosity of scCO_(2) by 39.4 times.Due to the synergistic effect between expanding vertical swept volume and inhibiting gas channel-ing,crude oil recovery can be further enhanced by 23.1%for a typical high-water-cut mature reservoir when the scCO_(2) viscosity is increased by 50 times.Our understandings demonstrate that the thickened scCO_(2) flooding technology has significant technical advantages in high-water-cut mature reservoirs,with challenges and future development directions in field-scale applications also highlighted.展开更多
BACKGROUND: Sepsis, a common acute and critical disease, leads to 11 million deaths annually worldwide. Probiotics are living microorganisms that are beneficial to the host and may benefit sepsis outcomes, but their e...BACKGROUND: Sepsis, a common acute and critical disease, leads to 11 million deaths annually worldwide. Probiotics are living microorganisms that are beneficial to the host and may benefit sepsis outcomes, but their effects are stil inconclusive. This study aimed to evaluate the overal eff ect of probiotics on the prognosis of patients with sepsis.DATA RESOURCES: We searched several sources for published/presented studies, including Pub Med, EMBASE, Web of Science, the Cochrane Library and the US National Library of Medicine Clinical Trials Register(www.clinicaltrials.gov) updated through July 30, 2023, to identify all relevant randomized controlled trials(RCTs) or observational studies that assessed the effectiveness of probiotics or synbiotics in patients with sepsis and reported mortality. We focused primarily on mortality during the study period and analyzed secondary outcomes, including 28-day mortality, in-intensive care unit(ICU) mortality and other outcomes.RESULTS: Data from 405 patients in five RCTs and 108 patients in one cohort study were included in the analysis. The overall quality of the studies was satisfactory, but clinical heterogeneity existed. All adult studies reported a tendency for probiotics to reduce the mortality of patients with sepsis, and most studies reported a decreasing trend in the incidence of infectious complications, length of ICU stay and duration of antibiotic use. There was only one RCT involving children.CONCLUSION: Probiotics show promise for improving the prognosis of patients with sepsis, including reducing mortality and the incidence of infectious complications, particularly in adult patients. Despite the limited number of studies, especially in children, these findings will be encouraging for clinical practice in the treatment of sepsis and suggest that gut microbiota-targeted therapy may improve the prognosis of patients with sepsis.展开更多
Nitrogen(N)uptake is regulated by water availability,and a water deficit can limit crop N responses by reducing N uptake and utilization.The complex and multifaceted interplay between water availability and the crop N...Nitrogen(N)uptake is regulated by water availability,and a water deficit can limit crop N responses by reducing N uptake and utilization.The complex and multifaceted interplay between water availability and the crop N response makes it difficult to predict and quantify the effect of water deficit on crop N status.The nitrogen nutrition index(NNI)has been widely used to accurately diagnose crop N status and to evaluate the effectiveness of N application.The decline of NNI under water-limiting conditions has been documented,although the underlying mechanism governing this decline is not fully understood.This study aimed to elucidate the reason for the decline of NNI under waterlimiting conditions and to provide insights into the accurate utilization of NNI for assessing crop N status under different water-N interaction treatments.Rainout shelter experiments were conducted over three growing seasons from 2018 to 2021 under different N(75 and 225 kg N ha^(-1),low N and high N)and water(120 to 510 mm,W0 to W3)co-limitation treatments.Plant N accumulation,shoot biomass(SB),plant N concentration(%N),soil nitrate-N content,actual evapotranspiration(ET_a),and yield were recorded at the stem elongation,booting,anthesis and grain filling stages.Compared to W0,W1 to W3 treatments exhibited NNI values that were greater by 10.2 to 20.5%,12.6to 24.8%,14 to 24.8%,and 16.8 to 24.8%at stem elongation,booting,anthesis,and grain filling,respectively,across the 2018-2021 seasons.This decline in NNI under water-limiting conditions stemmed from two main factors.First,reduced ET_(a) and SB led to a greater critical N concentration(%N_(c))under water-limiting conditions,which contributed to the decline in NNI primarily under high N conditions.Second,changes in plant%N played a more significant role under low N conditions.Plant N accumulation exhibited a positive allometric relationship with SB and a negative relationship with soil nitrate-N content under water-limiting conditions,indicating co-regulation by SB and the soil nitrate-N content.However,this regulation was influenced by water availability.Plant N accumulation sourced from the soil nitrate-N content reflects soil N availability.Greater soil water availability facilitated greater absorption of soil nitrate-N into the plants,leading to a positive correlation between plant N accumulation and ET_(a)across the different water-N interaction treatments.Therefore,considering the impact of soil water availability is crucial when assessing soil N availability under water-limiting conditions.The findings of this study provide valuable insights into the factors contributing to the decline in NNI among different water-N interaction treatments and can contribute to the more accurate utilization of NNI for assessing winter wheat N status.展开更多
Geological sequestration of CO_(2)is critical for deep decarbonization,but the geomechanical stability of coal reservoirs remains a major challenge.This study integrates nanoindentation,XRD/SEM-EDS chemo physical char...Geological sequestration of CO_(2)is critical for deep decarbonization,but the geomechanical stability of coal reservoirs remains a major challenge.This study integrates nanoindentation,XRD/SEM-EDS chemo physical characterization and 4D CT visualization to investigate the time-evolving mechanical degradation of bituminous coals with ScCO_(2)injection.The main results show that 4 d of ScCO_(2)treatment caused 50.47%–80.99%increase in load–displacement deformation and 26.92%–76.17%increase in creep depth at peak load,accompanied by 55.01%–63.38%loss in elastic modulus and 52.83%–74.81%reduction in hardness.The degradation exhibited biphasic kinetics,characterized by rapid surface-driven weakening(0–2 d),followed by stabilized matrix-scale pore homogenization(2–4 d).ScCO_(2)preferentially dissolved carbonate minerals(dolomite),driving pore network expansion and interfacial debonding,while silicate minerals resisted dissolution but promoted structural homogenization.These coupled geochemical-mechanical processes reduced the mechanical heterogeneity of the coal and altered its failure modes.The results establish a predictive framework for reservoir stability assessment and provide actionable insights for optimizing CO_(2)enhanced coalbed methane recovery.展开更多
基金Project supported by the National Natural Science Foundation of China （Nos. 51178336 and 51478340）, the Natural Science Foundation of Zhejiang Province, China （No. LZ13E080002）, and the China Ministry of Communications Construction Science ＆ Technology Projects （No. 2013318R11300）
文摘The multi-piped freezing method is usually applied in artificial ground freezing （AGF） projects to fulfill special construction requirements, such as two-, three-, or four-piped freezing. Based on potential superposition theory, this paper gives analytical solutions to steady-state frozen temperature for two, three, and four freezing pipes with different temperatures and arranged at random. Specific solutions are derived for some particular arrangements, such as three freezing pipes in a linear arrangement with equal or unequal spacing, right and isosceles triangle arrangements, four freezing pipes in a linear arrangement with equal spacing, and rhombus and rectangle arrangements. A comparison between the analytical solutions and numerical thermal analysis shows that the analytical solutions are sufficiently precise. As a part of the theory of AGF, the analytical solutions of temperature fields for multi-piped freezing with arbitrary layouts and different temperatures of freezing pipes are approached for the first time.
基金supported by the NASA under awards NNX15AQ51G and 80NSSC19K0728the ONR under award N000141812517the NOAA Office of Weather and Air Quality under award NA18OAR4590369.
文摘This study explores the structures of the correlations between infrared(IR)brightness temperatures(BTs)from the three water vapor channels of the Advanced Baseline Imager(ABI)onboard the GOES-16 satellite and the atmospheric state.Ensemble-based data assimilation techniques such as the ensemble Kalman filter(EnKF)rely on correlations to propagate innovations of BTs to increments of model state variables.Because the three water vapor channels are sensitive to moisture in different layers of the troposphere,the heights of the strongest correlations between these channels and moisture in clear-sky regions are closely related to the peaks of their respective weighting functions.In cloudy regions,the strongest correlations appear at the cloud tops of deep clouds,and ice hydrometeors generally have stronger correlations with BT than liquid hydrometeors.The magnitudes of the correlations decrease from the peak value in a column with both vertical and horizontal distance.Just how the correlations decrease depend on both the cloud scenes and the cloud structures,as well as the model variables.Horizontal correlations between BTs and moisture,as well as hydrometeors,in fully cloudy regions decrease to almost 0 at about 30 km.The horizontal correlations with atmospheric state variables in clear-sky regions are broader,maintaining non-zero values out to~100 km.The results in this study provide information on the proper choice of cut-off radii in horizontal and vertical localization schemes for the assimilation of BTs.They also provide insights on the most efficient and effective use of the different water vapor channels.
基金This study is funded by the National Institute for Occupational Safety and Health(NIOSH)[75D30119C06390].The authors would like to thank Dr.Arvin Ebrahimkhanlou for all precise technical comments related to statistical analysis.
文摘In the United States,an unexpected and severe increase in coal miners’lung diseases in the late 1990s prompted researchers to investigate the causes of the disease resurgence.This study aims to scrutinize the effects of various mining parameters,including coal rank,mine size,mine operation type,coal seam height,and geographical location on the prevalence of coal worker’s pneumoconiosis(CWP)in surface and underground coal mines.A comprehensive dataset was created using the U.S.Mine Safety and Health Administration(MSHA)Employment and Accident/Injury databases.The information was merged based on the mine ID by utilizing SQL data management software.A total number of 123,589 mine-year observations were included in the statistical analysis.Generalized Estimating Equation(GEE)model was used to conduct a statistical analysis on a total of 29,707,and 32,643 mine-year observations for underground and surface coal mines,respectively.The results of the econometrics approach revealed that coal workers in underground coal mines are at a greater risk of CWP comparing to those of surface coal operations.Furthermore,underground coal mines in the Appalachia and Interior regions are at a higher risk of CWP prevalence than the Western region.Surface coal mines in the Appalachian coal region are more likely to CWP development than miners in the Western region.The analysis also indicated that coal workers working in smaller mines are more vulnerable to CWP than those in large mine sizes.Furthermore,coal workers in thin-seam underground mine operations are more likely to develop CWP.
文摘Objective:To summarize the recent literature discussing focal therapy for localized prostate cancer.Methods:A thorough literature review was performed using PubMed to identify recent studies involving focal therapy for the treatment of localized prostate cancer.Results:In an effort to decrease the morbidity associated with prostate cancer treatment,many urologists are turning to focal therapy as an alternative treatment option.With this approach,the cancer bearing portion of the prostate is targeted while leaving the benign tissue untouched.Multiparametric magnetic resonance imaging remains the gold standard for visualization during focal therapy,but new imaging modalities such as prostate specific membrane antigen/positron emission tomography and contrast enhanced ultrasound are being investigated.Furthermore,several biomarkers,such as prostate cancer antigen 3 and prostate health index,are used in conjunction with imaging to improve risk stratification prior to focal therapy.Lastly,there are several novel technologies such as nanoparticles and transurethral devices that are under investigation for use in focal therapy.Conclusion:Focal therapy is proving to be a promising option for the treatment of localized prostate cancer.However,further study is needed to determine the true efficacy of these exciting new technologies.
基金part of the project Public Goods and the University-Industry Relationships in Agricultural Biotechnology funded by the Cooperative States Research,Education,and Extension Service of USDA under IFAFS Agreement 2001-52100-11217. Any opinions,findings,conclusions,or recommendations are those of the authors and do not necessarily reflect the view of the U.S. Department of Agriculture
文摘Partnerships between U.S. universities and industries have existed for several decades and in recent years have become generally more varied, wider in scope, more aggressive and experimental and higher in public visibility. In addition, in the last few decades, public and private interests have advocated for government policies and laws to globally promote the commercialization of university science. This paper examines the persistence or convergence of the two cultures of science and the implications of this commercialization for university-industry relationships in agriculture biotechnology. The perceptions and values of over 200 U.S. university and industry scientists, managers and administrators who participate in or oversee research collaborations in agricultural biotechnology were analyzed. The findings revealed that the participants in these research relationships continue to perceive very distinct cultures of science and identify a wide range of concerns and disadvantages of these partnerships. Several actions were discussed to ensure that the two cultures serve complementary roles and that they maximize the public benefits from these increasing collaborations.
基金the Department of Energy[Grant Number DE-FE-0030146]。
文摘This study demonstrated using yttrium(Y)as an indicator to estimate the total rare earth element and Y contents(REY)in coal-associated samples and to facilitate selection of samples with high REY assays in a fast and inexpensive manner.More than 10 anthracite-associated samples were collected from each of three Pennsylvanian sites(sites B,J and C)based on Thorium gamma ray logging suggesting high REY content.Several samples from each site were analyzed by ICP-MS to determine the rare earth distribution patterns and to establish the site-specific linear equations of Y and REY.The Y contents of the remaining samples were measured by a portable X-ray fluorescence analyzer,and the REY values were estimated based on the site-specific linear equation developed earlier.R-squared values above 0.70 were obtained for all the estimation equations from all three sites on both a whole sample basis and an ash basis.Previously,ash content has been widely used as an indicator of high REY content.This may not be applicable for a specific site.Site B in this study is an example where ash contents could not be statistically correlated with REY,so using Y for estimation is more applicable.The demonstrated sample screening process is suitable for samples from sites that share more similar distribution patterns(either MREY or LREY or HREY)as well as for samples from sites that share multiple distribution patterns(LREY/MREY/HREY)depending on the desirable accuracy.The demonstrated process lowers the analytical cost from$70 to 80 dollars per sample to$10-15 per sample while significantly reducing the processing time and acid consumption for ICP digestion.This is particularly true when a relatively large sample size is involved,for example,100 samples from one site analyzed by ICP-MS/OES.
文摘The efficacy of limestone sand and pelletized lime for remediation of soil acidity was compared in order to determine if limestone sand was a more cost-effective alternative to pelletized lime. Between fall of 2002 and spring 2003, two forested sites in Pennsylvania were clear cut and fenced. Pelletized lime and limestone sand were applied to separate 400-m2 plots within the sites at rates of 2170 kg·ha-1 and 4335 kg·ha-1, respectively. Two additional 400-m2 plots were used as controls. A paired before-after control-impact study design was used to assess changes in soil, soil solution, vegetation and biomass after lime application. Soil samples were collected from the Oi, Oe + Oa, and A horizons before and after lime application. Woody and herbaceous vegetation was harvested from 1-m2 sub-plots before and after liming and bi-weekly soil solution samples were collected for six months following lime application. Analysis of variance procedures were used to compare changes in the treatment plots over time. Changes in soil chemistry following lime application were comparable on the limestone sand and pelletized lime plots. There was a significant increase in exchangeable Mg and Mg saturation in the Oe + Oa horizon on all of the lime treatment plots relative to controls, but a greater percentage of applied Ca and Mg was exchangeable in the O-horizon in pelletized lime plots nine months after liming. Plant biomass did not increase on the lime treatment plots relative to the control one year post treatment. The majority of applied Ca and Mg from pelletized lime and limestone sand remained in the litter layer, with little movement into the A-horizon after one growing season. These results indicated that the application of limestone sand at two times the rate of pelletized lime produced comparable changes in soil and soil solution chemistry at a fraction of the cost.
基金supported by The National Institute of Occupational Safety and Health(NIOSH)under contract No.75D30119C05743.
文摘In the confined spaces of underground mines,the exposure of over 10,000 miners in the U.S.to diesel exhaust and diesel particulate matter(DPM)is an occupational inevitability,particularly in metal and nonmetal mineral extraction.These workers routinely operate amidst diesel-powered equipment,often outdated and highly polluting,extracting resources such as limestone,gold,and salt.The acute health effects of such exposure are significant,leading to symptoms like headaches and flu-like conditions,with the impact being more pronounced in these closed work environments.This review scrutinizes DPM's hazard in the mining sector,consolidating the extant knowledge and exploring ongoing research.It encapsulates our understanding of DPM's physicochemical properties,existing sampling methods,health ramifications,and mitigation technologies.Moreover,it underscores the necessity for further study in areas such as the evolution of DPM's physicochemical attributes,from its genesis at high-pressure,high-temperature conditions within diesel engines to its emission into the mine atmosphere.A key research gap is the intricate interaction of DPM with specific characteristics of the mine environment-such as relative humidity,ambient temperature,the presence of other mineral dust,and the dynamics of ventilation air.These factors can significantly alter the physicochemical profile of DPM,infuencing both its in-mine transport and its deposition behavior.Consequently,this can affect the respiratory health of miners,modifying the toxicity and the respiratory deposition of DPM particles.Identified research imperatives include(1)the advancement of instrumentation for accurate number measurement of DPM to replace or supplement traditional gravimetric methods;(2)the development of long-lasting,cost-effective control technologies tailored for the mining industry;(3)an in-depth investigation of DPM interactions within the unique mine microclimate,considering the critical components like humidity and other aerosols;and(4)understanding the differential impact of DPM in mining compared to other industries,informing the creation of mining-specific health and safety protocols.This review's findings underscore the urgency to enhance emission control and exposure prevention strategies,paving the way for a healthier underground mining work environment.
文摘BACKGROUND The long-term impact of vitamin D deficiency and metabolic syndrome(MetS)on cardiovascular disease(CVD)and all-cause mortality are still a matter of debate.AIM To test the hypotheses that lower serum 25 hydroxyvitamin D[25(OH)D]concentrations(a marker of vitamin D level)and MetS have a long-term impact on the risk of CVD and all-cause mortality,and individuals with vitamin D deficiency can be identified by multiple factors.METHODS A sample of 9094 adults,20 to 90 years of age,who participated in the Third National Health and Nutrition Examination Survey(NHANES III,1988 to 1994)were followed through December 2015 was analyzed.The associations of serum 25(OH)D concentrations and MetS with CVD and all-cause mortality were analyzed longitudinally using Cox regression models.Classification and regression tree(CART)for machine learning was applied to classify individuals with vitamin D deficiency.RESULTS Of 9094 participants,30%had serum 25(OH)D concentrations<20 ng/mL(defined as vitamin D deficiency),39%had serum 25(OH)D concentrations between 20 to 29 ng/mL(insufficiency),and 31%had serum 25(OH)D concentrations≥30 ng/mL(sufficiency).Prevalence of MetS was 28.4%.During a mean of 18 years follow-up,vitamin D deficiency and MetS were significantly associated with increased risk of CVD and all-cause mortality.Subjects with both vitamin D deficiency and MetS had the highest risk of CVD mortality(HR=1.77,95%CI:1.22-2.58)and all-cause mortality(HR=1.62,95%CI:1.26-2.09),followed by those with both vitamin D insufficiency and MetS for CVD mortality(HR=1.59,95%CI:1.12-2.24),and all-cause mortality(HR=1.41,95%CI:1.08-1.85).Meanwhile,vitamin D sufficiency significantly decreased the risk of CVD and all-cause mortality for those who even had MetS.Among the total study sample,CART analysis suggests that being non-Hispanic Black,having lower serum folate level,and being female were the first three predictors for those with serum 25(OH)D deficiency.CONCLUSION Vitamin D deficiency and MetS were significantly associated with increased risk of CVD and allcause mortality.There was a significant joint effect of vitamin D deficiency and MetS on the risk of mortality.Findings of the CART analysis may be useful to identify individuals positioned to benefit from interventions to reduce the risk of CVD and all-cause mortality.
文摘The focus of our investigation is to evaluate one of the four contributing terms to the coulombic potential energy of an H<sub>2</sub> molecule. Specifically, we are interested in the term describing the electronic interaction of the charge distribution of one of the hydrogen atoms with the proton of the second atom. Quantum mechanics provides the charge distribution;hence, the evaluation of this term is a semi-classic quantum physics issue. For states other than the ground state the charge distributions are not spherically symmetric;they are functions of the radial and the angular coordinates. For the excited states we develop exact analytic expressions conducive to the potential energies. Because of the functional complexities of the wave functions, the evaluation of the core integrals is carried out utilizing symbolic capabilities of Mathematica [1]. Plots of these energies vs. the distance between the two protons reveal global features.
基金the Australian Research Council Discovery Project(ARC DP 220100851)scheme and would acknowledge that.
文摘Particle-fluid two-phase flows in rock fractures and fracture networks play a pivotal role in determining the efficiency and effectiveness of hydraulic fracturing operations,a vital component in unconventional oil and gas extraction.Central to this phenomenon is the transport of proppants,tiny solid particles injected into the fractures to prevent them from closing once the injection is stopped.However,effective transport and deposition of proppant is critical in keeping fracture pathways open,especially in lowpermeability reservoirs.This review explores,then quantifies,the important role of fluid inertia and turbulent flows in governing proppant transport.While traditional models predominantly assume and then characterise flow as laminar,this may not accurately capture the complexities inherent in realworld hydraulic fracturing and proppant emplacement.Recent investigations highlight the paramount importance of fluid inertia,especially at the high Reynolds numbers typically associated with fracturing operations.Fluid inertia,often overlooked,introduces crucial forces that influence particle settling velocities,particle-particle interactions,and the eventual deposition of proppants within fractures.With their inherent eddies and transient and chaotic nature,turbulent flows introduce additional complexities to proppant transport,crucially altering proppant settling velocities and dispersion patterns.The following comprehensive survey of experimental,numerical,and analytical studies elucidates controls on the intricate dynamics of proppant transport under fluid inertia and turbulence-towards providing a holistic understanding of the current state-of-the-art,guiding future research directions,and optimising hydraulic fracturing practices.
基金the National Natural Science Foundation of China (Nos. 42302143, 42172159)China Geological Survey Project (No. DD20211350)support from the G. Albert Shoemaker endowment
文摘Clayey-silt natural gas hydrate reservoirs in the South China Sea exhibit loose and unconsolidated structures, heterogeneous pore structures, high clay mineral contents, and strong hydrophilicity. These characteristics complicate the gas-water two-phase flow process in porous media following hydrate decomposition, posing challenges for efficient development. This study examines the transport response of clayey-silt reservoir samples from the Shenhu area using gas-water two-phase flow experiments and CT scanning to explore changes in pore structure, gas-water distribution, and relative permeability under varying flow conditions. The results indicate that pore heterogeneity significantly influences flow characteristics. Gas preferentially displaces water in larger pores, forming fracture-like pores, which serve as preferential flow channels for gas migration. The preferential flow channels enhance gas-phase permeability up to 19 times that of the water phase when fluid pressures exceed total stresses. However,small pores retain liquid, leading to a high residual water saturation of 0.561. CT imaging reveals that these hydro-fractures improve gas permeability but also confine gas flow to specific channels. Pore network analysis shows that gas injection expands the pore-throat network, enhancing connectivity and forming fracture-like pores. Residual water remains trapped in smaller pores and throats, while structural changes, including new fractures, improve gas flow pathways and overall connectivity. Relative permeability curves demonstrate a narrow gas-water cocurrent-flow zone, a right-shifted iso-permeability point and high reservoir capillary pressure, indicating a strong "water-blocking" effect. The findings suggest that optimizing reservoir stimulation techniques to enhance fracture formation, reduce residual water saturation, and improve gas flow capacity is critical for efficient hydrate reservoir development.
基金the National Natural Science Foundation of China(U22B6005,52174043,52474035)the Beijing Natural Science Foundation(3242019)the China National Petroleum Corporation(CNPC)Innovation Foundation(2022DQ02-0208 and 2024DQ02-0114).
文摘High-water-cut mature reservoirs typically serve as the“ballast”for ensuring China’s annual crude oil production of 200 million tons.Despite the use of water flooding and chemical methods,over 40%of crude oil remains unexploited.It is critical to develop efficient revolutionary technologies to further enhance oil recovery(EOR)by a large percentage in high-water-cut mature reservoirs.To address this issue,the potential of vertical remaining oil in Daqing Oilfield is first analyzed from massive monitoring data.Using molecular dynamics simulation to design optimal synthetic routine,a copolymer without flu-orine or silicon is synthesized by modifying vinyl acetate(VAc)with maleic anhydride(MA)and styrene(St),and treated as a supercritical CO_(2)(scCO_(2))thickener.The underlying EOR mechanism of the scCO_(2) thickener is thereafter clarified by high-temperature,high-pressure oil displacement experiments.The EOR effect by thickened scCO_(2) flooding in a typical high-water-cut mature reservoir is predicted,and future technological advancements of the technique are ultimately discussed.Results show that the ver-tical remaining oil enriched in weakly swept zones is a primary target for further EOR in high-water-cut mature reservoirs.The copolymer typically exhibits good solubility,strong dispersion stability,and high thickening effect in scCO_(2).Under an ambient pressure of 10 MPa and a temperature of 50℃,the disso-lution of copolymer at a mass concentration of 0.2%can effectively increase the viscosity of scCO_(2) by 39.4 times.Due to the synergistic effect between expanding vertical swept volume and inhibiting gas channel-ing,crude oil recovery can be further enhanced by 23.1%for a typical high-water-cut mature reservoir when the scCO_(2) viscosity is increased by 50 times.Our understandings demonstrate that the thickened scCO_(2) flooding technology has significant technical advantages in high-water-cut mature reservoirs,with challenges and future development directions in field-scale applications also highlighted.
基金supported by the National High Level Hospital Clinical Research Funding (2022-PUMCH-B-109)Chinese Academy of Medical Science Innovation Fund for Medical Sciences (CIFMS)(2021-I2M-1-020)。
文摘BACKGROUND: Sepsis, a common acute and critical disease, leads to 11 million deaths annually worldwide. Probiotics are living microorganisms that are beneficial to the host and may benefit sepsis outcomes, but their effects are stil inconclusive. This study aimed to evaluate the overal eff ect of probiotics on the prognosis of patients with sepsis.DATA RESOURCES: We searched several sources for published/presented studies, including Pub Med, EMBASE, Web of Science, the Cochrane Library and the US National Library of Medicine Clinical Trials Register(www.clinicaltrials.gov) updated through July 30, 2023, to identify all relevant randomized controlled trials(RCTs) or observational studies that assessed the effectiveness of probiotics or synbiotics in patients with sepsis and reported mortality. We focused primarily on mortality during the study period and analyzed secondary outcomes, including 28-day mortality, in-intensive care unit(ICU) mortality and other outcomes.RESULTS: Data from 405 patients in five RCTs and 108 patients in one cohort study were included in the analysis. The overall quality of the studies was satisfactory, but clinical heterogeneity existed. All adult studies reported a tendency for probiotics to reduce the mortality of patients with sepsis, and most studies reported a decreasing trend in the incidence of infectious complications, length of ICU stay and duration of antibiotic use. There was only one RCT involving children.CONCLUSION: Probiotics show promise for improving the prognosis of patients with sepsis, including reducing mortality and the incidence of infectious complications, particularly in adult patients. Despite the limited number of studies, especially in children, these findings will be encouraging for clinical practice in the treatment of sepsis and suggest that gut microbiota-targeted therapy may improve the prognosis of patients with sepsis.
基金supported by the National Natural Science Foundation of China(51609247)the Henan Provincial Natural Science Foundation,China(222300420589,202300410553)+4 种基金the Central Public-interest Scientific Institution Basal Research Fund,China(FIRI2022-22)the Science&Technology Fundamental Resources Investigation Program,China(2022FY101601)the Science and Technology Project of Xinxiang City,Henan Province,China(GG2021024)the Major Special Science and Technology Project of Henan Province,China(221100110700)the Joint Fund of Science and Technology Research and Development Plan of Henan Province,China(Superior Discipline Cultivation)(222301420104)。
文摘Nitrogen(N)uptake is regulated by water availability,and a water deficit can limit crop N responses by reducing N uptake and utilization.The complex and multifaceted interplay between water availability and the crop N response makes it difficult to predict and quantify the effect of water deficit on crop N status.The nitrogen nutrition index(NNI)has been widely used to accurately diagnose crop N status and to evaluate the effectiveness of N application.The decline of NNI under water-limiting conditions has been documented,although the underlying mechanism governing this decline is not fully understood.This study aimed to elucidate the reason for the decline of NNI under waterlimiting conditions and to provide insights into the accurate utilization of NNI for assessing crop N status under different water-N interaction treatments.Rainout shelter experiments were conducted over three growing seasons from 2018 to 2021 under different N(75 and 225 kg N ha^(-1),low N and high N)and water(120 to 510 mm,W0 to W3)co-limitation treatments.Plant N accumulation,shoot biomass(SB),plant N concentration(%N),soil nitrate-N content,actual evapotranspiration(ET_a),and yield were recorded at the stem elongation,booting,anthesis and grain filling stages.Compared to W0,W1 to W3 treatments exhibited NNI values that were greater by 10.2 to 20.5%,12.6to 24.8%,14 to 24.8%,and 16.8 to 24.8%at stem elongation,booting,anthesis,and grain filling,respectively,across the 2018-2021 seasons.This decline in NNI under water-limiting conditions stemmed from two main factors.First,reduced ET_(a) and SB led to a greater critical N concentration(%N_(c))under water-limiting conditions,which contributed to the decline in NNI primarily under high N conditions.Second,changes in plant%N played a more significant role under low N conditions.Plant N accumulation exhibited a positive allometric relationship with SB and a negative relationship with soil nitrate-N content under water-limiting conditions,indicating co-regulation by SB and the soil nitrate-N content.However,this regulation was influenced by water availability.Plant N accumulation sourced from the soil nitrate-N content reflects soil N availability.Greater soil water availability facilitated greater absorption of soil nitrate-N into the plants,leading to a positive correlation between plant N accumulation and ET_(a)across the different water-N interaction treatments.Therefore,considering the impact of soil water availability is crucial when assessing soil N availability under water-limiting conditions.The findings of this study provide valuable insights into the factors contributing to the decline in NNI among different water-N interaction treatments and can contribute to the more accurate utilization of NNI for assessing winter wheat N status.
基金supported by the National Natural Science Foundation of China(Nos.52204206 and U24A2090)the Fundamental Research Funds for the Central Universities of China(No.2023CDJXY-006).
文摘Geological sequestration of CO_(2)is critical for deep decarbonization,but the geomechanical stability of coal reservoirs remains a major challenge.This study integrates nanoindentation,XRD/SEM-EDS chemo physical characterization and 4D CT visualization to investigate the time-evolving mechanical degradation of bituminous coals with ScCO_(2)injection.The main results show that 4 d of ScCO_(2)treatment caused 50.47%–80.99%increase in load–displacement deformation and 26.92%–76.17%increase in creep depth at peak load,accompanied by 55.01%–63.38%loss in elastic modulus and 52.83%–74.81%reduction in hardness.The degradation exhibited biphasic kinetics,characterized by rapid surface-driven weakening(0–2 d),followed by stabilized matrix-scale pore homogenization(2–4 d).ScCO_(2)preferentially dissolved carbonate minerals(dolomite),driving pore network expansion and interfacial debonding,while silicate minerals resisted dissolution but promoted structural homogenization.These coupled geochemical-mechanical processes reduced the mechanical heterogeneity of the coal and altered its failure modes.The results establish a predictive framework for reservoir stability assessment and provide actionable insights for optimizing CO_(2)enhanced coalbed methane recovery.
