This study addresses challenges in fetal magnetic resonance imaging (MRI) related to motion artifacts, maternal respiration, and hardware limitations. To enhance MRI quality, we employ deep learning techniques, specif...This study addresses challenges in fetal magnetic resonance imaging (MRI) related to motion artifacts, maternal respiration, and hardware limitations. To enhance MRI quality, we employ deep learning techniques, specifically utilizing Cycle GAN. Synthetic pairs of images, simulating artifacts in fetal MRI, are generated to train the model. Our primary contribution is the use of Cycle GAN for fetal MRI restoration, augmented by artificially corrupted data. We compare three approaches (supervised Cycle GAN, Pix2Pix, and Mobile Unet) for artifact removal. Experimental results demonstrate that the proposed supervised Cycle GAN effectively removes artifacts while preserving image details, as validated through Structural Similarity Index Measure (SSIM) and normalized Mean Absolute Error (MAE). The method proves comparable to alternatives but avoids the generation of spurious regions, which is crucial for medical accuracy.展开更多
This paper presented the new sanitary and health protocols implemented by cruise companies in order to internationally resuming the industry. The perception of Brazilians regarding these new protocols was identified t...This paper presented the new sanitary and health protocols implemented by cruise companies in order to internationally resuming the industry. The perception of Brazilians regarding these new protocols was identified through a quantitative survey with a sample of 412 Brazilian respondents, carried out between May and June 2021. As main results, sanitary and health protocols that do not affect their experiences on board were identified, as well as those protocols that compromised the experience perceived by the future traveler. The respondents’ propensity to travel on cruise ships and their perceptions about the influence of the ship size, the number of ports of call, nationalities on board, the number of vips, among other aspects, were also analyzed. Finally, in the final section of this paper, we presented an estimation of the expected number of cruisers for the 21/22 cruising season in Brazil, based on a kind Bayesian argument, considering different scenarios for the forthcoming season.展开更多
The aim of the article is to examine the role of the Yogyakarta Principles in the new era of globalization.The Principles could be assimilated for their modesty and multiple points of entry in the global system.Howeve...The aim of the article is to examine the role of the Yogyakarta Principles in the new era of globalization.The Principles could be assimilated for their modesty and multiple points of entry in the global system.However,they have not necessarily created formal protections for sexual minorities that keep being abused globally because conservative elites share goals and tactics among themselves to repress these minorities.展开更多
One of the reasons for the great success of the finite element method is its versatility to deal with different types of geometries. This is particularly true of problems posed in curved domains. Nevertheless it is we...One of the reasons for the great success of the finite element method is its versatility to deal with different types of geometries. This is particularly true of problems posed in curved domains. Nevertheless it is well-known that, for standard variational formulations, the optimal approximation properties known to hold for polytopic domains are lost, if meshes consisting of ordinary elements are still used in the case of curved domains. That is why method’s isoparametric version for meshes consisting of curved triangles or tetrahedra has been widely employed, especially in case Dirichlet boundary conditions are prescribed all over a curved boundary. However, besides geometric inconveniences, the isoparametric technique helplessly requires the manipulation of rational functions and the use of numerical integration. In this work we consider a simple alternative that bypasses these drawbacks, without eroding qualitative approximation properties. More specifically we work with a variational formulation leading to high order finite element methods based only on polynomial algebra, since they do not require the use of curved elements. Application of the new approach to Lagrange methods of arbitrary order illustrates its potential to take the best advantage of finite-element discretizations in the solution of wide classes of problems posed in curved domains.展开更多
This paper discusses the suitability of using TSA （thermoelastic stress analysis） as an advanced tool to detect damaged areas and highly stressed （hot spot） areas in structural components. Such components can be, ...This paper discusses the suitability of using TSA （thermoelastic stress analysis） as an advanced tool to detect damaged areas and highly stressed （hot spot） areas in structural components. Such components can be, for example, parts of large structural panels built of welded metallic or composite materials. Besides detecting hot spot areas, it is expected that stresses in these areas can be suitably quantified and processed in order to predict crack initiation and propagation due to in-service loads. The paper starts with references to selected review and application articles on the subject. Two simple laboratory experiments are presented which illustrate the quality of the results that can be achieved using TSA. In the first experiment, a stainless steel T-joint designed to model a welded structural component is analysed. The T-joint had a machine-notched crack-like flaw close to the component＇s weld toe. The qualitative and quantitative experimental results determined along four specified areas of the T-joint model showed that TSA can indeed be used as a tool to detect loaded cracks and hot spots in large metallic structures, and that stresses can be accurately evaluated. In the second experiment, a prismatic bar made of CFRE （carbon fibre-reinforced-epoxy） was tested to locate three subsurface areas of damage introduced beforehand into the component. Two of these inside damaged areas were detected to be 3.1 mm and 7.1 mm from the observed surface. The positive results achieved with the two lab experiments, along with a review of the selected research publications, indicate that TSA application can be extended to the real-world field of structural components. Topics to be addressed in this research field should have to do with components that work under random or quasi-cyclic service loading, problems where adiabatic conditions do not prevail, and reduction of the cost of infra-red cameras.展开更多
This paper uses the TSA （therrnoelastic stress analysis） technique to determine the stress concentration factor （Kt） of a U-notch in an aluminum plate, and then compares the results with those obtained from a FEA ...This paper uses the TSA （therrnoelastic stress analysis） technique to determine the stress concentration factor （Kt） of a U-notch in an aluminum plate, and then compares the results with those obtained from a FEA （finite elements analysis） of the same specimen. In order to do so, it devises a calculation procedure to extrapolate the thermoelastic data near the tip of the notch and then applies the resulting algorithm to seven distinct experiments that had different loading frequencies, mean loads and load ranges. The overall positive results suggest that the technique may be suitable for Kt measurements in real-world structures. A discussion about the calibration factor of the thermoelastic data is included by confronting the calibration results using independent tensile uniaxial tests and using the U-notch TSA and FEA paired specimen data.展开更多
Objectives: The purpose of this study was to evaluate and compare the use of propinox hydrochloride and scopolamine hydrochloride in patients presenting abdominal colic (abdominal pain), in terms of treatment efficacy...Objectives: The purpose of this study was to evaluate and compare the use of propinox hydrochloride and scopolamine hydrochloride in patients presenting abdominal colic (abdominal pain), in terms of treatment efficacy and tolerability. Material & Methods: This was an analytical, retrospective, comparative study based on hospital records of outpatients treated at Serviço de Clínica Médica do Hospital das Clínicas Costantino Otaviano (HCTCO) and at Santa Casa de Misericórdia do Rio de Janeiro, from 1988-1998. Subjects were divided into two groups: patients from Group 1 were treated with propinox hydrochloride, while patients from Group 2 were treated with scopolamine hydrochloride. Statistical analysis was performed using GraphPad Prism version 5.0. For comparison of categorical variables, we used the chi-squared or Fisher’s test, while continuous variables were analyzed using ANOVA or the Student’s T test. Results: A total of 1042 subjects were included, of which 525 were allocated to Group 1 and 517 to Group 2. Mean treatment duration was 9.166 days (±4.208) in Group 1 and 8.795 days (±5.052) in Group 2, with no statistically significant difference in treatment duration between the two groups (p = 0.198). All subjects in Group 1 were treated with propinox 10 mg (2 coated tablets, three times per day) while all subjects in Group 2 were treated with scopolamine hydrochloride 10 mg (2 coated tablets, three times per day). There were no statistically significant between-group differences in weight, BMI, heart rate, and respiratory rate at pre- and post-treatment;with the exception of higher post-treatment systolic blood pressure in Group 1, blood pressure measures also remained homogenous. Adverse events were reported among both treatment groups with no significant between-group difference in incidence (p = 0566). At pretreatment, pain intensity was more severe in Group 1 (p = 0.0257), while at post-treatment, there was no statistically significant difference between the two treatment groups (p = 0.895). There was a statistically significant improvement in pain intensity within both treatment groups (χ<sup>2</sup> = 631.4;df = 3;p < 0.0001 for Group 1 and χ<sup>2</sup> = 554.3;df = 3;p < 0.0001 for Group 2). Conclusion: The results obtained in this study indicate a therapeutic equivalence between propinox hydrochloride and scopolamine hydrochloride. Both treatments demonstrated good efficacy and tolerability in the treatment of abdominal colic pain, in the population evaluated.展开更多
The investment levels in electricity production capacity from variable Renewable Energy Sources have substantially grown in Brazil over the last decades,following the worldwide-seeking-goal of a carbon-neutral economy...The investment levels in electricity production capacity from variable Renewable Energy Sources have substantially grown in Brazil over the last decades,following the worldwide-seeking-goal of a carbon-neutral economy and the country’s incentives in diversifying its generation mix.From a long-term perspective,the current non-storable capability of renewable energy sources requires an adequate uncertainty characterization over the years.In this context,the main objective of this work is to provide a thorough descriptive analytics of the time-linked hourly-based daily dynamics of wind speed and solar irradiance in the main resourceful regions of Brazil.Leveraging on unsupervised Machine Learning methods,we focus on identifying similar days over the years,Representative Days,that can depict the fundamental underlying behaviour of each source.The analysis is based on a historical dataset of different sites with the highest potential and installed capacity of each source spread over the country:three in the Northeast and one in the South Regions,for wind speed;and three in the Northeast and one in the Southeast Regions,for solar irradiance.We use two Partitioning Methods(𝐾-Means and𝐾-Medoids),the Hierarchical Ward’s Method,and a Model-Based Method(Self-Organizing Maps).We identified that wind speed and solar irradiance can be effectively represented,respectively,by only two representative days,and two or three days,depending on the region and method(segments data with respect to the intensity of each source).Analysis with higher Representative Days highlighted important hidden patterns such as different wind speed modulations and solar irradiance peak-hours along the days.展开更多
Singular spectrum analysis （SSA） is a technique that decomposes a time series into a set of components, such as, trend, harmonics, and residuals. Leaving out the residual components and adding up the others, the tim...Singular spectrum analysis （SSA） is a technique that decomposes a time series into a set of components, such as, trend, harmonics, and residuals. Leaving out the residual components and adding up the others, the time series can be smoothed. This procedure has been used to model Brazilian electricity consumption and flow series. The PAR（p）, periodic autoregressive models, has been broadly used in modelling energy series in Brazil. This paper presents an approach of this decomposition method, by fitting the PAR（p）, considering its multivariate version known as multivariate SSA （MSSA）. The method was applied to a vector of two wind speed series recorded at two locations in the Brazilian Northeast region. The obtained results, when compared to the univariate decomposition of each series, were far superior, showing that the spatial correlation between the two series were considered by MSSA decomposition stage.展开更多
The product of the ∧0/b （-B/0） differential production cross-section and the branching fraction of the decay ∧0/b→ J/ψ pK-（-B/0→ J/ψ-K＊（892）0）is measured as a function of the beauty hadron transverse mome...The product of the ∧0/b （-B/0） differential production cross-section and the branching fraction of the decay ∧0/b→ J/ψ pK-（-B/0→ J/ψ-K＊（892）0）is measured as a function of the beauty hadron transverse momentum, PT, and rapidity, y. The kinematic region of the measurements is pT〈20 GeV/c and 2.0 〈g〈4.5.The measurements use a data sample corresponding to an integrated luminosity of 3fb-1 collected by the LHCb detector in pp collisions at centre-of-mass energies √s=7 TeV in 2011 and √s=8 TeV in 2012. Based on previous LHCb results of the fragmentation fraction ratio,f∧0/b/fd,the branching fraction of the decay ∧0/b→ J/ψ pK-is measured to be B（∧0/b→ J/ψ pK-）=（3.17±0.04±0.07±0.34＋0.45/-0.28）×10-4,where the first uncertainty is statistical, the second is systematic, the third is due to the uncertainty on the branching fraction of the decay -B/0 →J/ψ-K＊（892）0,and the fourth is due to the knowledge of f∧0/b/fd.The sum of the asymmetries in the production and decay between ∧0/b and ∧0/bis also measured as a function of PT and y.The previously published branching fraction of ∧0/b→ J/ψ pπ-,relative to that of ∧0/b→ J/ψ pK-,is updated. The branching fractions of ∧0/b→P＋c（→ J/ψp）K-are determined.展开更多
First evidence of a structure in the J/ψΛinvariant mass distribution is obtained from an amplitude analysis of■b^(-)J/ψΛK^(-)decays.The observed structure is consistent with being due to a charmonium pentaquark w...First evidence of a structure in the J/ψΛinvariant mass distribution is obtained from an amplitude analysis of■b^(-)J/ψΛK^(-)decays.The observed structure is consistent with being due to a charmonium pentaquark with strangeness with a significance of 3.1r including systematic uncertainties and lookelsewhere effect.Its mass and width are determined to be 4458:8±2:9t4:7-1:1 MeV and 17:3±6:5t8:0-5:7 MeV,respectively,where the quoted uncertainties are statistical and systematic.The structure is also consistent with being due to two resonances.In addition,the narrow excited■^(-)states,N■(1690)and■(1820),are seen for the first time in a■b^(-)decay,and their masses and widths are measured with improved precision.The analysis is performed using pp collision data corresponding to a total integrated luminosity of 9 fb^(-1),collected with the LHCb experiment at centre-of-mass energies of 7,8 and 13 TeV.展开更多
A first search for the Ξ_(bc)^(+)J/ψΞ_(c)^(+) decay is performed by the LHCb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of 9 fb−1 recorded at centre-of-mass...A first search for the Ξ_(bc)^(+)J/ψΞ_(c)^(+) decay is performed by the LHCb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of 9 fb−1 recorded at centre-of-mass energies of 7, 8, and 13 TeV. Two peaking structures are seen with a local (global) significance of 4.3(2.8) and 4.1(2.4) standard deviations at masses of 6571 and 6694 MeV/c2, respectively. Upper limits are set on the Ξ+bc baryon production cross-section times the branching fraction relative to that of the B+c→J/ψD+s decay at centre-of-mass energies of 8 and 13 TeV, in the Ξ+bc and in the B+c rapidity and transverse-momentum ranges from 2.0 to 4.5 and 0 to 20GeV/c, respectively. Upper limits are presented as a function of the Ξ+bc mass and lifetime.展开更多
A search for the rare decays W^(+)→D_(s)^(+)γ and Z→D0γis performed using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of 13TeV,corresponding to an integrated luminosity...A search for the rare decays W^(+)→D_(s)^(+)γ and Z→D0γis performed using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of 13TeV,corresponding to an integrated luminosity of 2.0fb−1.No significant signal is observed for either decay mode and upper limits on their branching fractions are set using W^(+)→D_(s)^(+)γ and Z→μ+μ−decays as normalization channels.The upper limits are 6.5×10^(−4) and 2.1×10^(−3) at 95% confidence level for the W^(+)→D_(s)^(+)γ and Z→D^(0)γ decay modes,respectively.This is the first reported search for the Z→D^(0)γ decay,while the upper limit on the W+→D+sγbranching fraction improves upon the previous best limit.展开更多
A search for the doubly charmed baryon ■^+cc is performed through its decay to theΛ^+c K^-π^+ final state,using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7,8 and 13...A search for the doubly charmed baryon ■^+cc is performed through its decay to theΛ^+c K^-π^+ final state,using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7,8 and 13 TeV.The data correspond to a total integrated luminosity of 9 fb^-1.No significant signal is observed in the mass range from 3.4 to 3.8 GeV/c^2.Upper limits are set at 95%credibility level on the ratio of the ■^+cc production cross-section times the branching fraction to that ofΛ^+c and ■^++cc baryons.The limits are determined as functions of the ■^+cc mass for different lifetime hypotheses,in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 4 to 15 GeV/c.展开更多
The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4<pT<15GeV/c and the rapidity range2.0<y<4.5.The data used in...The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4<pT<15GeV/c and the rapidity range2.0<y<4.5.The data used in this measurement correspond to an integrated luminosity of 1.7fb^-1,recorded by the LHCb experiment during 2016.The ratio of the ■ production cross-section times the branching fraction of the■→∧^+cK^-π^+ π^+decay relative to the prompt ∧^+c production cross-section is found to be(2.22±0.27±0.29)×10^-4,assuming the central value of the measured lifetime,where the first uncertainty is statistical and the second systematic.展开更多
The first search for the doubly heavyΩ^(0)_(bc)baryon and a search for the E^(0)_(bc)baryon are performed using pp collision data collected via the LHCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 T...The first search for the doubly heavyΩ^(0)_(bc)baryon and a search for the E^(0)_(bc)baryon are performed using pp collision data collected via the LHCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 TeV,corresponding to an integrated luminosity of 5.2 fb^(-1).The baryons are reconstructed via their decays to Λ^(+)_(c)π^(-)and E^(+)_(c)π^(-).No significant excess is fbund for invariant masses between 6700 and 7300 MeV/c^(2),in a rapidity range from 2.0 to 4.5 and a transverse momentum range from 2 to 20 MeV/c.Upper limits are set on the ratio of the Ω^(0)_(bc)and E^(0)_(bc)production cross-section times the branching fraction to Λ^(+)_(c)π^(-)(E^(+)_(c)π^(-))relative to that of the Λ^(0)_(b)(E^(0)_(b))baryon,for different lifetime hypotheses,at 95%confidence level.The upper limits range from 0.5 x 10^(-4)to 2.5 x 10^(-4)for theΩ^(0)_(bc)→Λ^(+)_(c)π^(-)(E^(0)_(bc)→Λ^(+)_(c)π^(-))decay,and from 1.4x 10^(-3)to 6.9 x 10^(-3)for theΩ^(0)_(bc)→E^(+)_(c)π^(-)(E^(0)_(bc)→E^(+)_(c)π^(-))decay,depending on the considered mass and lifetime of theΩ^(0)_(bc)(E^(0)_(bc))baryon.展开更多
A search for the rare decay B^(0)→J/ψФis performed using Pp collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7,8 and 13 TeV,corresponding to an integrated luminosity of9 fb.No signific...A search for the rare decay B^(0)→J/ψФis performed using Pp collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7,8 and 13 TeV,corresponding to an integrated luminosity of9 fb.No significant signal of the decay is observed and an upper limitof 1.1x 10^(-7)at 90%confidence level is set on the branching fraction.展开更多
文摘This study addresses challenges in fetal magnetic resonance imaging (MRI) related to motion artifacts, maternal respiration, and hardware limitations. To enhance MRI quality, we employ deep learning techniques, specifically utilizing Cycle GAN. Synthetic pairs of images, simulating artifacts in fetal MRI, are generated to train the model. Our primary contribution is the use of Cycle GAN for fetal MRI restoration, augmented by artificially corrupted data. We compare three approaches (supervised Cycle GAN, Pix2Pix, and Mobile Unet) for artifact removal. Experimental results demonstrate that the proposed supervised Cycle GAN effectively removes artifacts while preserving image details, as validated through Structural Similarity Index Measure (SSIM) and normalized Mean Absolute Error (MAE). The method proves comparable to alternatives but avoids the generation of spurious regions, which is crucial for medical accuracy.
文摘This paper presented the new sanitary and health protocols implemented by cruise companies in order to internationally resuming the industry. The perception of Brazilians regarding these new protocols was identified through a quantitative survey with a sample of 412 Brazilian respondents, carried out between May and June 2021. As main results, sanitary and health protocols that do not affect their experiences on board were identified, as well as those protocols that compromised the experience perceived by the future traveler. The respondents’ propensity to travel on cruise ships and their perceptions about the influence of the ship size, the number of ports of call, nationalities on board, the number of vips, among other aspects, were also analyzed. Finally, in the final section of this paper, we presented an estimation of the expected number of cruisers for the 21/22 cruising season in Brazil, based on a kind Bayesian argument, considering different scenarios for the forthcoming season.
文摘The aim of the article is to examine the role of the Yogyakarta Principles in the new era of globalization.The Principles could be assimilated for their modesty and multiple points of entry in the global system.However,they have not necessarily created formal protections for sexual minorities that keep being abused globally because conservative elites share goals and tactics among themselves to repress these minorities.
文摘One of the reasons for the great success of the finite element method is its versatility to deal with different types of geometries. This is particularly true of problems posed in curved domains. Nevertheless it is well-known that, for standard variational formulations, the optimal approximation properties known to hold for polytopic domains are lost, if meshes consisting of ordinary elements are still used in the case of curved domains. That is why method’s isoparametric version for meshes consisting of curved triangles or tetrahedra has been widely employed, especially in case Dirichlet boundary conditions are prescribed all over a curved boundary. However, besides geometric inconveniences, the isoparametric technique helplessly requires the manipulation of rational functions and the use of numerical integration. In this work we consider a simple alternative that bypasses these drawbacks, without eroding qualitative approximation properties. More specifically we work with a variational formulation leading to high order finite element methods based only on polynomial algebra, since they do not require the use of curved elements. Application of the new approach to Lagrange methods of arbitrary order illustrates its potential to take the best advantage of finite-element discretizations in the solution of wide classes of problems posed in curved domains.
文摘This paper discusses the suitability of using TSA （thermoelastic stress analysis） as an advanced tool to detect damaged areas and highly stressed （hot spot） areas in structural components. Such components can be, for example, parts of large structural panels built of welded metallic or composite materials. Besides detecting hot spot areas, it is expected that stresses in these areas can be suitably quantified and processed in order to predict crack initiation and propagation due to in-service loads. The paper starts with references to selected review and application articles on the subject. Two simple laboratory experiments are presented which illustrate the quality of the results that can be achieved using TSA. In the first experiment, a stainless steel T-joint designed to model a welded structural component is analysed. The T-joint had a machine-notched crack-like flaw close to the component＇s weld toe. The qualitative and quantitative experimental results determined along four specified areas of the T-joint model showed that TSA can indeed be used as a tool to detect loaded cracks and hot spots in large metallic structures, and that stresses can be accurately evaluated. In the second experiment, a prismatic bar made of CFRE （carbon fibre-reinforced-epoxy） was tested to locate three subsurface areas of damage introduced beforehand into the component. Two of these inside damaged areas were detected to be 3.1 mm and 7.1 mm from the observed surface. The positive results achieved with the two lab experiments, along with a review of the selected research publications, indicate that TSA application can be extended to the real-world field of structural components. Topics to be addressed in this research field should have to do with components that work under random or quasi-cyclic service loading, problems where adiabatic conditions do not prevail, and reduction of the cost of infra-red cameras.
文摘This paper uses the TSA （therrnoelastic stress analysis） technique to determine the stress concentration factor （Kt） of a U-notch in an aluminum plate, and then compares the results with those obtained from a FEA （finite elements analysis） of the same specimen. In order to do so, it devises a calculation procedure to extrapolate the thermoelastic data near the tip of the notch and then applies the resulting algorithm to seven distinct experiments that had different loading frequencies, mean loads and load ranges. The overall positive results suggest that the technique may be suitable for Kt measurements in real-world structures. A discussion about the calibration factor of the thermoelastic data is included by confronting the calibration results using independent tensile uniaxial tests and using the U-notch TSA and FEA paired specimen data.
文摘Objectives: The purpose of this study was to evaluate and compare the use of propinox hydrochloride and scopolamine hydrochloride in patients presenting abdominal colic (abdominal pain), in terms of treatment efficacy and tolerability. Material & Methods: This was an analytical, retrospective, comparative study based on hospital records of outpatients treated at Serviço de Clínica Médica do Hospital das Clínicas Costantino Otaviano (HCTCO) and at Santa Casa de Misericórdia do Rio de Janeiro, from 1988-1998. Subjects were divided into two groups: patients from Group 1 were treated with propinox hydrochloride, while patients from Group 2 were treated with scopolamine hydrochloride. Statistical analysis was performed using GraphPad Prism version 5.0. For comparison of categorical variables, we used the chi-squared or Fisher’s test, while continuous variables were analyzed using ANOVA or the Student’s T test. Results: A total of 1042 subjects were included, of which 525 were allocated to Group 1 and 517 to Group 2. Mean treatment duration was 9.166 days (±4.208) in Group 1 and 8.795 days (±5.052) in Group 2, with no statistically significant difference in treatment duration between the two groups (p = 0.198). All subjects in Group 1 were treated with propinox 10 mg (2 coated tablets, three times per day) while all subjects in Group 2 were treated with scopolamine hydrochloride 10 mg (2 coated tablets, three times per day). There were no statistically significant between-group differences in weight, BMI, heart rate, and respiratory rate at pre- and post-treatment;with the exception of higher post-treatment systolic blood pressure in Group 1, blood pressure measures also remained homogenous. Adverse events were reported among both treatment groups with no significant between-group difference in incidence (p = 0566). At pretreatment, pain intensity was more severe in Group 1 (p = 0.0257), while at post-treatment, there was no statistically significant difference between the two treatment groups (p = 0.895). There was a statistically significant improvement in pain intensity within both treatment groups (χ<sup>2</sup> = 631.4;df = 3;p < 0.0001 for Group 1 and χ<sup>2</sup> = 554.3;df = 3;p < 0.0001 for Group 2). Conclusion: The results obtained in this study indicate a therapeutic equivalence between propinox hydrochloride and scopolamine hydrochloride. Both treatments demonstrated good efficacy and tolerability in the treatment of abdominal colic pain, in the population evaluated.
文摘The investment levels in electricity production capacity from variable Renewable Energy Sources have substantially grown in Brazil over the last decades,following the worldwide-seeking-goal of a carbon-neutral economy and the country’s incentives in diversifying its generation mix.From a long-term perspective,the current non-storable capability of renewable energy sources requires an adequate uncertainty characterization over the years.In this context,the main objective of this work is to provide a thorough descriptive analytics of the time-linked hourly-based daily dynamics of wind speed and solar irradiance in the main resourceful regions of Brazil.Leveraging on unsupervised Machine Learning methods,we focus on identifying similar days over the years,Representative Days,that can depict the fundamental underlying behaviour of each source.The analysis is based on a historical dataset of different sites with the highest potential and installed capacity of each source spread over the country:three in the Northeast and one in the South Regions,for wind speed;and three in the Northeast and one in the Southeast Regions,for solar irradiance.We use two Partitioning Methods(𝐾-Means and𝐾-Medoids),the Hierarchical Ward’s Method,and a Model-Based Method(Self-Organizing Maps).We identified that wind speed and solar irradiance can be effectively represented,respectively,by only two representative days,and two or three days,depending on the region and method(segments data with respect to the intensity of each source).Analysis with higher Representative Days highlighted important hidden patterns such as different wind speed modulations and solar irradiance peak-hours along the days.
文摘Singular spectrum analysis （SSA） is a technique that decomposes a time series into a set of components, such as, trend, harmonics, and residuals. Leaving out the residual components and adding up the others, the time series can be smoothed. This procedure has been used to model Brazilian electricity consumption and flow series. The PAR（p）, periodic autoregressive models, has been broadly used in modelling energy series in Brazil. This paper presents an approach of this decomposition method, by fitting the PAR（p）, considering its multivariate version known as multivariate SSA （MSSA）. The method was applied to a vector of two wind speed series recorded at two locations in the Brazilian Northeast region. The obtained results, when compared to the univariate decomposition of each series, were far superior, showing that the spatial correlation between the two series were considered by MSSA decomposition stage.
基金Supported by CERN and national agencies:CAPES,CNPq,FAPERJ and FINEP(Brazil)NSFC(China)+17 种基金CNRS/IN2P3(France)BMBF,DFG,HGF and MPG(Germany)INFN(Italy)FOM and NWO(The Netherlands)MNi SW and NCN(Poland)MEN/IFA(Romania)Min ES and FANO(Russia)Min ECo(Spain)SNSF and SER(Switzerland)NASU(Ukraine)STFC(United Kingdom)NSF(USA)supported by IN2P3(France),KIT and BMBF(Germany),INFN(Italy),NWOSURF(The Netherlands),PIC(Spain),Grid PP(United Kingdom)support from EPLANET,Marie Sk lodowska-Curie ActionsERC(European Union),Conseil général de Haute-Savoie,Labex ENIGMASS and OCEVU,RégionAuvergne(France),RFBR(Russia),Xunta GalGENCAT(Spain),Royal Society and Royal Commission for the Exhibition of 1851(United Kingdom)
文摘The product of the ∧0/b （-B/0） differential production cross-section and the branching fraction of the decay ∧0/b→ J/ψ pK-（-B/0→ J/ψ-K＊（892）0）is measured as a function of the beauty hadron transverse momentum, PT, and rapidity, y. The kinematic region of the measurements is pT〈20 GeV/c and 2.0 〈g〈4.5.The measurements use a data sample corresponding to an integrated luminosity of 3fb-1 collected by the LHCb detector in pp collisions at centre-of-mass energies √s=7 TeV in 2011 and √s=8 TeV in 2012. Based on previous LHCb results of the fragmentation fraction ratio,f∧0/b/fd,the branching fraction of the decay ∧0/b→ J/ψ pK-is measured to be B（∧0/b→ J/ψ pK-）=（3.17±0.04±0.07±0.34＋0.45/-0.28）×10-4,where the first uncertainty is statistical, the second is systematic, the third is due to the uncertainty on the branching fraction of the decay -B/0 →J/ψ-K＊（892）0,and the fourth is due to the knowledge of f∧0/b/fd.The sum of the asymmetries in the production and decay between ∧0/b and ∧0/bis also measured as a function of PT and y.The previously published branching fraction of ∧0/b→ J/ψ pπ-,relative to that of ∧0/b→ J/ψ pK-,is updated. The branching fractions of ∧0/b→P＋c（→ J/ψp）K-are determined.
文摘First evidence of a structure in the J/ψΛinvariant mass distribution is obtained from an amplitude analysis of■b^(-)J/ψΛK^(-)decays.The observed structure is consistent with being due to a charmonium pentaquark with strangeness with a significance of 3.1r including systematic uncertainties and lookelsewhere effect.Its mass and width are determined to be 4458:8±2:9t4:7-1:1 MeV and 17:3±6:5t8:0-5:7 MeV,respectively,where the quoted uncertainties are statistical and systematic.The structure is also consistent with being due to two resonances.In addition,the narrow excited■^(-)states,N■(1690)and■(1820),are seen for the first time in a■b^(-)decay,and their masses and widths are measured with improved precision.The analysis is performed using pp collision data corresponding to a total integrated luminosity of 9 fb^(-1),collected with the LHCb experiment at centre-of-mass energies of 7,8 and 13 TeV.
基金The project support from CERN and from the national agencies:CAPES,CNPq,FAPERJ and FINEP(Brazil)MOST and NSFC(China)+18 种基金CNRS/IN2P3(France)BMBF,DFG and MPG(Germany)INFN(Italy)NWO(Netherlands)MNiSW and NCN(Poland)MEN/IFA(Romania)MICINN(Spain)SNSF and SER(Switzerland)NASU(Ukraine)STFC(United Kingdom)DOE NP and NSF(USA).We acknowledge the computing resources that are provided by CERN,IN2P3(France),KIT and DESY(Germany),INFN(Italy),SURF(Netherlands),PIC(Spain),GridPP(United Kingdom),CSCS(Switzerland),IFIN-HH(Romania),CBPF(Brazil),Polish WLCG(Poland)and NERSC(USA).Individual groups or members have received support from ARC and ARDC(Australia)Minciencias(Colombia)AvH Foundation(Germany)EPLANET,Marie Sklodowska-Curie Actions and ERC(European Union)A*MIDEX,ANR,IPhU and Labex P2IO,and Région Auvergne-RhôneAlpes(France)Key Research Program of Frontier Sciences of CAS,CAS PIFI,CAS CCEPP,Fundamental Research Funds for the Central Universities,and Sci.&Tech.Program of Guangzhou(China)GVA,XuntaGal,GENCAT and Prog.Atracción Talento,CM(Spain)SRC(Sweden)the Leverhulme Trust,the Royal Society and UKRI(United Kingdom).
文摘A first search for the Ξ_(bc)^(+)J/ψΞ_(c)^(+) decay is performed by the LHCb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of 9 fb−1 recorded at centre-of-mass energies of 7, 8, and 13 TeV. Two peaking structures are seen with a local (global) significance of 4.3(2.8) and 4.1(2.4) standard deviations at masses of 6571 and 6694 MeV/c2, respectively. Upper limits are set on the Ξ+bc baryon production cross-section times the branching fraction relative to that of the B+c→J/ψD+s decay at centre-of-mass energies of 8 and 13 TeV, in the Ξ+bc and in the B+c rapidity and transverse-momentum ranges from 2.0 to 4.5 and 0 to 20GeV/c, respectively. Upper limits are presented as a function of the Ξ+bc mass and lifetime.
文摘A search for the rare decays W^(+)→D_(s)^(+)γ and Z→D0γis performed using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of 13TeV,corresponding to an integrated luminosity of 2.0fb−1.No significant signal is observed for either decay mode and upper limits on their branching fractions are set using W^(+)→D_(s)^(+)γ and Z→μ+μ−decays as normalization channels.The upper limits are 6.5×10^(−4) and 2.1×10^(−3) at 95% confidence level for the W^(+)→D_(s)^(+)γ and Z→D^(0)γ decay modes,respectively.This is the first reported search for the Z→D^(0)γ decay,while the upper limit on the W+→D+sγbranching fraction improves upon the previous best limit.
基金support from CERN and from the national agencies:CAPES,CNPq，FAPERJ and FINEP(Brazil)MOST and NSFC(China)+11 种基金CNRS/IN2P3(France)BMBF,DFG and MPG(Germany)INFN(Italy)KWO(Netherlands)MNiSW and NCN(Poland)MEN/IFA(Romania)MinES and FASO(Russia)MinECo(Spain)SNSF and SER(Switzerland)NASU(Ukraine)STFC(United Kingdom)NSF(USA).
文摘A search for the doubly charmed baryon ■^+cc is performed through its decay to theΛ^+c K^-π^+ final state,using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7,8 and 13 TeV.The data correspond to a total integrated luminosity of 9 fb^-1.No significant signal is observed in the mass range from 3.4 to 3.8 GeV/c^2.Upper limits are set at 95%credibility level on the ratio of the ■^+cc production cross-section times the branching fraction to that ofΛ^+c and ■^++cc baryons.The limits are determined as functions of the ■^+cc mass for different lifetime hypotheses,in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 4 to 15 GeV/c.
基金Supported by CERNnational agencies:CAPES+30 种基金CNPqFAPERJFINEP(Brazil)MOSTNSFC(China)CNRS/IN2P3(France)BMBFDFGMPG(Germany)INFN(Italy)NWO(Netherlands)MNiSWNCN(Poland)MEN/IFA(Romania)MSHE(Russia)MinECo(Spain)SNSFSER(Switzerland)NASU(Ukraine)STFC(United Kingdom)DOE NPNSF(USA)Key Research Program of Frontier Sciences of CAS,CAS PIFIthe Thousand Talents Program(China)RFBRRSFYandex LLC(Russia)GVAXuntaGalGENCAT(Spain)the Royal Society and the Leverhulme Trust(United Kingdom)
文摘The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4<pT<15GeV/c and the rapidity range2.0<y<4.5.The data used in this measurement correspond to an integrated luminosity of 1.7fb^-1,recorded by the LHCb experiment during 2016.The ratio of the ■ production cross-section times the branching fraction of the■→∧^+cK^-π^+ π^+decay relative to the prompt ∧^+c production cross-section is found to be(2.22±0.27±0.29)×10^-4,assuming the central value of the measured lifetime,where the first uncertainty is statistical and the second systematic.
基金CAPES,CNPq,FAPERJ and FINEP(Brazil)MOST and NSFC(China)+18 种基金CNRS/IN2P3(France)BMBF,DFG,MPG(Germany)INFN(Italy)NWO(Netherlands)MNiSW,NCN(Poland)MEN/IFA(Romania)MSHE(Russia)MICINN(Spain)SNSF,SER(Switzerland)NASU(Ukraine)STFC(United Kingdom)DOE NP,NSF(USA).We acknowledge the computing resources that are provided by CERN,IN2P3(France),KIT and DESY(Germany),INFN(Italy),SURF(Netherlands),PIC(Spain),GridPP(United Kingdom),RRCKI and Yandex LLC(Russia),CSCS(Switzerland),IFIN-HH(Romania),CBPF(Brazil),PL-GRID(Poland)and NERSC(USA)AvH Foundation(Germany)EPLANET,Marie Sklodowska-Curie Actions and ERC(European Union)A*MIDEX,ANR,Labex P2IO and OCEVU,Region Auvergne-Rhdne-Alpes(France)Key Research Program of Frontier Sciences of CAS,CAS PIFI,CAS CCEPP,Fundamental Research Funds for the Central Universities,and Sci.Tech.Program of Guangzhou(China)RFBR,RSF and Yandex LLC(Russia)GVA,XuntaGal,GENCAT(Spain)the Leverhulme Trust,the Royal Society and UKRI(United Kingdom)。
文摘The first search for the doubly heavyΩ^(0)_(bc)baryon and a search for the E^(0)_(bc)baryon are performed using pp collision data collected via the LHCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 TeV,corresponding to an integrated luminosity of 5.2 fb^(-1).The baryons are reconstructed via their decays to Λ^(+)_(c)π^(-)and E^(+)_(c)π^(-).No significant excess is fbund for invariant masses between 6700 and 7300 MeV/c^(2),in a rapidity range from 2.0 to 4.5 and a transverse momentum range from 2 to 20 MeV/c.Upper limits are set on the ratio of the Ω^(0)_(bc)and E^(0)_(bc)production cross-section times the branching fraction to Λ^(+)_(c)π^(-)(E^(+)_(c)π^(-))relative to that of the Λ^(0)_(b)(E^(0)_(b))baryon,for different lifetime hypotheses,at 95%confidence level.The upper limits range from 0.5 x 10^(-4)to 2.5 x 10^(-4)for theΩ^(0)_(bc)→Λ^(+)_(c)π^(-)(E^(0)_(bc)→Λ^(+)_(c)π^(-))decay,and from 1.4x 10^(-3)to 6.9 x 10^(-3)for theΩ^(0)_(bc)→E^(+)_(c)π^(-)(E^(0)_(bc)→E^(+)_(c)π^(-))decay,depending on the considered mass and lifetime of theΩ^(0)_(bc)(E^(0)_(bc))baryon.
基金support from AvH Foundation(Germany)EPLANET,Marie Sk lodowska-Curie Actions and ERC(European Union)+11 种基金A*MIDEXANRLabex P2IOOCEVURégion Auvergne-Rh?ne-Alpes(France)Key Research Program of Frontier Sciences of CASCAS PIFIThousand Talents ProgramSci.&Tech.Program of Guangzhou(China)RFBR,RSF and Yandex LLC(Russia)GVA,Xunta Gal and GENCAT(Spain)the Royal Society and the Leverhulme Trust(United Kingdom)。
文摘A search for the rare decay B^(0)→J/ψФis performed using Pp collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7,8 and 13 TeV,corresponding to an integrated luminosity of9 fb.No significant signal of the decay is observed and an upper limitof 1.1x 10^(-7)at 90%confidence level is set on the branching fraction.
