Cilia play a wide range of critical roles in regulating cell motility,sensory signaling and metazoan development(Goetz and Anderson,2010;Reiter and Leroux,2017).Both motile cilia and pri-mary cilia consist of a basal ...Cilia play a wide range of critical roles in regulating cell motility,sensory signaling and metazoan development(Goetz and Anderson,2010;Reiter and Leroux,2017).Both motile cilia and pri-mary cilia consist of a basal body and a microtubule-based axoneme that is encompassed within the ciliary membrane.The formationand maintenance of ciliary structure depends on bidirectional intraflagellar transport(IFT):the kinesin-2 family motor proteins deliver ciliary precursors bound to the IFT particle protein complex from the ciliary base to the tip and the cytoplasmic dynein-2 recy-cles the anterograde IFT-protein machinery and ciliary turnover products back to the base(Scholey,2013;Reiter and Leroux,2017).Defects of ciliary structure and function lead to more than 35 types of systemic disorders in most human organ systems.which are collectively called ciliopathies(Reiter and Leroux,2017).187 established and 241 candidate ciliopathy-associated genes have been identified from the human genome(Reiter and Leroux,2017).展开更多
Structural and functional alterations of synaptic connections underlay experience-dependent neuronal plasticity and are crucial for many brain functions, including learning and memory. Their defects, on the other hand...Structural and functional alterations of synaptic connections underlay experience-dependent neuronal plasticity and are crucial for many brain functions, including learning and memory. Their defects, on the other hand, have been asso- ciated with neurological disorders such as autism. Although the molecular mechanism underlying long-term functional alterations of synaptic connections, including LTP and LTD, are becoming increasingly clear, the molecular mechanism for structural plasticity, such as spine pruning, remains largely unknown, especially in vivo.展开更多
基金supported by the National Key R&D Program of China(2017YFA0503501)the National Natural Science Foundation of China(Nos.31525015,31730052 and 31671444)
文摘Cilia play a wide range of critical roles in regulating cell motility,sensory signaling and metazoan development(Goetz and Anderson,2010;Reiter and Leroux,2017).Both motile cilia and pri-mary cilia consist of a basal body and a microtubule-based axoneme that is encompassed within the ciliary membrane.The formationand maintenance of ciliary structure depends on bidirectional intraflagellar transport(IFT):the kinesin-2 family motor proteins deliver ciliary precursors bound to the IFT particle protein complex from the ciliary base to the tip and the cytoplasmic dynein-2 recy-cles the anterograde IFT-protein machinery and ciliary turnover products back to the base(Scholey,2013;Reiter and Leroux,2017).Defects of ciliary structure and function lead to more than 35 types of systemic disorders in most human organ systems.which are collectively called ciliopathies(Reiter and Leroux,2017).187 established and 241 candidate ciliopathy-associated genes have been identified from the human genome(Reiter and Leroux,2017).
文摘Structural and functional alterations of synaptic connections underlay experience-dependent neuronal plasticity and are crucial for many brain functions, including learning and memory. Their defects, on the other hand, have been asso- ciated with neurological disorders such as autism. Although the molecular mechanism underlying long-term functional alterations of synaptic connections, including LTP and LTD, are becoming increasingly clear, the molecular mechanism for structural plasticity, such as spine pruning, remains largely unknown, especially in vivo.
