Amyloidosis is a group of diseases caused by the abnormal accumulation of amyloid fibrils(misfolded protein aggregates)in various human tissues.These amyloid deposits can interfere with normal organ function and lead ...Amyloidosis is a group of diseases caused by the abnormal accumulation of amyloid fibrils(misfolded protein aggregates)in various human tissues.These amyloid deposits can interfere with normal organ function and lead to severe health issues.Amyloid plaque formation in the brain is linked to neurodegenerative diseases,including Tau and Aβplaques in Alzheimer’s disease,α-synuclein plaques in Parkinson’s disease,and huntingtin plaques in Huntington’s disease.Although this condition is typically associated with aging,certain mutations in amyloid-forming proteins can trigger early-onset amyloidosis(Hatami et al.,2017).Given its progressive and life-threatening nature,early detection and treatment are crucial.展开更多
基金supported in part by a CIFRE PhD fellowship through the“Association Nationale de la Recherche et de la Technologie”(ANRT)program,in collaboration between PROTERA and“Center National de la Recherche Scientifique”(CNRS)to VGby EU COST Action ML4NGP CA21160 to VG and AVK+1 种基金the Fondation pour la Recherche Médicale(grant MND202310017898)to AVKthe AFM-Téléthon(grant n°28988)to AVK.
文摘Amyloidosis is a group of diseases caused by the abnormal accumulation of amyloid fibrils(misfolded protein aggregates)in various human tissues.These amyloid deposits can interfere with normal organ function and lead to severe health issues.Amyloid plaque formation in the brain is linked to neurodegenerative diseases,including Tau and Aβplaques in Alzheimer’s disease,α-synuclein plaques in Parkinson’s disease,and huntingtin plaques in Huntington’s disease.Although this condition is typically associated with aging,certain mutations in amyloid-forming proteins can trigger early-onset amyloidosis(Hatami et al.,2017).Given its progressive and life-threatening nature,early detection and treatment are crucial.
