2012年，PEC公司从两部农民电气公司（Western Farmers Electric Cooperative）购入15座配电变电站。在此之前，PEC已经拥有6座配电变电站和30英里（48km）长的输电线路。因此，这次采购之后，变电站占PEC资产的比例大幅上升．这在技术...2012年，PEC公司从两部农民电气公司（Western Farmers Electric Cooperative）购入15座配电变电站。在此之前，PEC已经拥有6座配电变电站和30英里（48km）长的输电线路。因此，这次采购之后，变电站占PEC资产的比例大幅上升．这在技术上和管理上给PEC带来了严峻的挑战。展开更多
We develop a long-term dynamic model for controlling invasive species using the theory of cooperative games. The model is applied to control of invasive buffelgrass in the Arizona desert, which directly competes with ...We develop a long-term dynamic model for controlling invasive species using the theory of cooperative games. The model is applied to control of invasive buffelgrass in the Arizona desert, which directly competes with indigenous species and can increase wildfire risk. Interest groups care about damages to three threatened resources: saguaro, cactus, riparian vegetation, and buildings. The model optimally allocates labor and a budget to protect these resources by controlling the buffelgrass population over a multi-period planning horizon. The solution is based on computing the Shapley values for the interest groups. A homeowner strategy of creating defensible space around structures to protect against wildfire affords less protection to the other resources. A similar result holds for protection of saguaros, which are also spatially concentrated. Under the optimal solution, groups caring about spatially-dispersed, riparian vegetation would compensate homeowners and groups caring about saguaros for a reallocation of resources toward greater protection of dispersed vegetation. Results highlight the importance of the spatial configuration of players and the resources they wish to protect in invasive species control problems.展开更多
Low carbohydrate diet(LCD)and nutrition is a very popular topic in the nutritional scientific literature.Main reason is that it is an old established therapy in intractable epilepsy and there are plenty of positive pr...Low carbohydrate diet(LCD)and nutrition is a very popular topic in the nutritional scientific literature.Main reason is that it is an old established therapy in intractable epilepsy and there are plenty of positive preclinical and sporadic clinical results in other disorders,including certain cancers.The problem is that a)the metabolic background of this therapy is not elucidated enough,b)animal studies and human experiences are sometimes divergent,c)there are negative human results and d)the clinical studies are not comparable because of the wide variety of study design and conclusion regarding the indication,the composition of diet and duration of treatment can not be drawn.This publication reviews the current situation and gives some hints to the solution.展开更多
In this communication, a short overview about congenital abdominal wall defects—laparoschisis is given. Focusing on all day clinical practice, possible surgical therapies and best postpartal care for these critically...In this communication, a short overview about congenital abdominal wall defects—laparoschisis is given. Focusing on all day clinical practice, possible surgical therapies and best postpartal care for these critically ill newborn babies are presented for the obstetrician in charge from a neonatal surgeon’s viewpoint.展开更多
Background: We monitored changes in salivary creatine pre-and post-high-intensity exercise in young adults while also investigating the potential correlation between salivary and serum creatine levels.Method: Saliva a...Background: We monitored changes in salivary creatine pre-and post-high-intensity exercise in young adults while also investigating the potential correlation between salivary and serum creatine levels.Method: Saliva and serum samples were collected before and immediately after an incremental running-toexhaustion treadmill test in fifteen young adults(mean age [23.9 ± 2.9] years, eight females), with samples analyzed for guanidinoacetic acid, creatine, and creatinine using a liquid chromatography–tandem mass spectrometry method.Results: Following exercise, there was a substantial elevation in salivary creatine levels from(17.5 ± 14.2)μmol·L^(-1) to(43.6 ± 30.4) μmol·L^(-1)(p < 0.001), coupled with a significant increase in salivary creatinine from(11.3 ± 5.8) μmol·L^(-1) to(17.0 ± 9.3) μmol·L^(-1)(p = 0.04). In contrast, serum creatine levels were unaffected by exercise(p = 0.80), while creatinine levels exhibited a strong tendency to decrease post-exercise(from [81.8 ±17.5] μmol·L^(-1) to [73.1 ± 11.6] μmol·L^(-1);p = 0.06). A comparison of the slopes of the two regression lines(saliva vs. serum) revealed significant differences for both creatine(p = 0.01) and creatinine(p = 0.03).Conclusions: The above findings suggest a potential difference in the dynamics of creatine metabolites in these two bodily fluids, both pre and post-exercise.展开更多
The“hallmarks of cancer”concept provides a valuable framework for understanding fundamental organizing principles common to various cancers.However,without a consensus gene set for cancer hallmarks,data comparison a...The“hallmarks of cancer”concept provides a valuable framework for understanding fundamental organizing principles common to various cancers.However,without a consensus gene set for cancer hallmarks,data comparison and integration result in diverse biological interpretations across studies.Therefore,we aimed to form a consensus cancer hallmark gene set by merging data from available mapping resources and establishing a framework for mining these gene sets.By consolidating data from seven projects,6763 genes associated with 10 cancer hallmarks were identified.A cancer hallmarks enrichment analysis was performed for prognostic genes associated with overall survival across 12 types of solid tumors.“Tissue invasion and metastasis”was most prominent in cancers of the stomach(P=2.2×10^(−11)),pancreas(P=4.2×10^(−9)),bladder(P=3.3×10^(−8)),and ovaries(P=0.0007),aligning with their heightened potential to spread.“Sustained angiogenesis”was most prominent in squamous cell carcinomas of the lung(P=2.5×10^(−7)),while“genome instability”showed strong enrichment in lung adenocarcinomas(LUADs)(P=1.5×10^(−8))and cancers of the liver(P=5.5×10^(−10)),pancreas(P=2.1×10^(−5)),and kidney(P=0.018).Pancreatic cancers displayed the highest enrichment of hallmarks,emphasizing the disease's complexity,while in melanomas and cancers of the liver,prostate,and kidney,a single hallmark was enriched among the prognostic markers of survival.Additionally,an online tool(www.cancerhallmarks.com)that allows the identification of cancer-associated hallmarks from new gene sets was established.In summary,our aim of establishing a consensus list of cancer hallmark genes was achieved.Furthermore,the analysis of survival-associated genes revealed a unique pattern of hallmark enrichment with potential pharmacological implications in different tumor types.展开更多
Deuterium-depleted water (DDW) is a new promising agent in cancer therapy. The efficiency of the method is based on the discovery, that cancer cells are extremely sensitive to depletion of deuterium (D) and might caus...Deuterium-depleted water (DDW) is a new promising agent in cancer therapy. The efficiency of the method is based on the discovery, that cancer cells are extremely sensitive to depletion of deuterium (D) and might cause necrosis of the tumour. The purpose of this study was to show the efficacy of D-depletion in prostate cancer (PC) patients. In the double blind, four-month-long, randomized Phase II clinical trial the daily water intake was replaced with DDW in 22 PC patients. Other 22 PC patients took normal water while both groups received the same forms of conventional treatment. In the retrospective study, 91 DDW-treated PC patients were evaluated and median survival time (MST) in the subgroups was calculated. The time course of changes in DDW dose and PSA is presented in two cases. In the prospective trial seven patients in the treated group and one patient in the placebo group achieved partial response (p = 0.046). In the treated group, the net decrease in the prostate volume was three times higher (160.3 cm3 vs. 54.0 cm3;p = 0.0019), urination complaints ceased at a higher rate (8 vs. 0 patients, p = 0.0041), and the one-year survival rate was also higher (2 vs. 9 deaths;p = 0.034). The 91 retrospectively evaluated patients achieved an MST of 11.02 years, despite the fact that 46 of them suffered from distant metastasis. In the two monitored patients, drop of PSA level correlated with the DDW intake. In summary, D-depletion prolonged MST in patients with PC. The method proved to be safe thus its integration in the PC cure as an adjuvant or complementary therapy would be considered.展开更多
文摘2012年，PEC公司从两部农民电气公司（Western Farmers Electric Cooperative）购入15座配电变电站。在此之前，PEC已经拥有6座配电变电站和30英里（48km）长的输电线路。因此，这次采购之后，变电站占PEC资产的比例大幅上升．这在技术上和管理上给PEC带来了严峻的挑战。
文摘We develop a long-term dynamic model for controlling invasive species using the theory of cooperative games. The model is applied to control of invasive buffelgrass in the Arizona desert, which directly competes with indigenous species and can increase wildfire risk. Interest groups care about damages to three threatened resources: saguaro, cactus, riparian vegetation, and buildings. The model optimally allocates labor and a budget to protect these resources by controlling the buffelgrass population over a multi-period planning horizon. The solution is based on computing the Shapley values for the interest groups. A homeowner strategy of creating defensible space around structures to protect against wildfire affords less protection to the other resources. A similar result holds for protection of saguaros, which are also spatially concentrated. Under the optimal solution, groups caring about spatially-dispersed, riparian vegetation would compensate homeowners and groups caring about saguaros for a reallocation of resources toward greater protection of dispersed vegetation. Results highlight the importance of the spatial configuration of players and the resources they wish to protect in invasive species control problems.
文摘Low carbohydrate diet(LCD)and nutrition is a very popular topic in the nutritional scientific literature.Main reason is that it is an old established therapy in intractable epilepsy and there are plenty of positive preclinical and sporadic clinical results in other disorders,including certain cancers.The problem is that a)the metabolic background of this therapy is not elucidated enough,b)animal studies and human experiences are sometimes divergent,c)there are negative human results and d)the clinical studies are not comparable because of the wide variety of study design and conclusion regarding the indication,the composition of diet and duration of treatment can not be drawn.This publication reviews the current situation and gives some hints to the solution.
文摘In this communication, a short overview about congenital abdominal wall defects—laparoschisis is given. Focusing on all day clinical practice, possible surgical therapies and best postpartal care for these critically ill newborn babies are presented for the obstetrician in charge from a neonatal surgeon’s viewpoint.
文摘Background: We monitored changes in salivary creatine pre-and post-high-intensity exercise in young adults while also investigating the potential correlation between salivary and serum creatine levels.Method: Saliva and serum samples were collected before and immediately after an incremental running-toexhaustion treadmill test in fifteen young adults(mean age [23.9 ± 2.9] years, eight females), with samples analyzed for guanidinoacetic acid, creatine, and creatinine using a liquid chromatography–tandem mass spectrometry method.Results: Following exercise, there was a substantial elevation in salivary creatine levels from(17.5 ± 14.2)μmol·L^(-1) to(43.6 ± 30.4) μmol·L^(-1)(p < 0.001), coupled with a significant increase in salivary creatinine from(11.3 ± 5.8) μmol·L^(-1) to(17.0 ± 9.3) μmol·L^(-1)(p = 0.04). In contrast, serum creatine levels were unaffected by exercise(p = 0.80), while creatinine levels exhibited a strong tendency to decrease post-exercise(from [81.8 ±17.5] μmol·L^(-1) to [73.1 ± 11.6] μmol·L^(-1);p = 0.06). A comparison of the slopes of the two regression lines(saliva vs. serum) revealed significant differences for both creatine(p = 0.01) and creatinine(p = 0.03).Conclusions: The above findings suggest a potential difference in the dynamics of creatine metabolites in these two bodily fluids, both pre and post-exercise.
基金supported by the National Research,Development,and Innovation Office,Hungary(PharmaLab,Grant No.:RRF-2.3.1-21-2022-00015)Otília Menyhart was supported by the Janos Bolyai Scholarship of the Hungarian Academy of Sciences and the Hungarian Scientific Research Fund(Grant No.:OTKA FK147194)support of ELIXIR Hungary(www.bioinformatics.hu)is acknowledged.
文摘The“hallmarks of cancer”concept provides a valuable framework for understanding fundamental organizing principles common to various cancers.However,without a consensus gene set for cancer hallmarks,data comparison and integration result in diverse biological interpretations across studies.Therefore,we aimed to form a consensus cancer hallmark gene set by merging data from available mapping resources and establishing a framework for mining these gene sets.By consolidating data from seven projects,6763 genes associated with 10 cancer hallmarks were identified.A cancer hallmarks enrichment analysis was performed for prognostic genes associated with overall survival across 12 types of solid tumors.“Tissue invasion and metastasis”was most prominent in cancers of the stomach(P=2.2×10^(−11)),pancreas(P=4.2×10^(−9)),bladder(P=3.3×10^(−8)),and ovaries(P=0.0007),aligning with their heightened potential to spread.“Sustained angiogenesis”was most prominent in squamous cell carcinomas of the lung(P=2.5×10^(−7)),while“genome instability”showed strong enrichment in lung adenocarcinomas(LUADs)(P=1.5×10^(−8))and cancers of the liver(P=5.5×10^(−10)),pancreas(P=2.1×10^(−5)),and kidney(P=0.018).Pancreatic cancers displayed the highest enrichment of hallmarks,emphasizing the disease's complexity,while in melanomas and cancers of the liver,prostate,and kidney,a single hallmark was enriched among the prognostic markers of survival.Additionally,an online tool(www.cancerhallmarks.com)that allows the identification of cancer-associated hallmarks from new gene sets was established.In summary,our aim of establishing a consensus list of cancer hallmark genes was achieved.Furthermore,the analysis of survival-associated genes revealed a unique pattern of hallmark enrichment with potential pharmacological implications in different tumor types.
文摘Deuterium-depleted water (DDW) is a new promising agent in cancer therapy. The efficiency of the method is based on the discovery, that cancer cells are extremely sensitive to depletion of deuterium (D) and might cause necrosis of the tumour. The purpose of this study was to show the efficacy of D-depletion in prostate cancer (PC) patients. In the double blind, four-month-long, randomized Phase II clinical trial the daily water intake was replaced with DDW in 22 PC patients. Other 22 PC patients took normal water while both groups received the same forms of conventional treatment. In the retrospective study, 91 DDW-treated PC patients were evaluated and median survival time (MST) in the subgroups was calculated. The time course of changes in DDW dose and PSA is presented in two cases. In the prospective trial seven patients in the treated group and one patient in the placebo group achieved partial response (p = 0.046). In the treated group, the net decrease in the prostate volume was three times higher (160.3 cm3 vs. 54.0 cm3;p = 0.0019), urination complaints ceased at a higher rate (8 vs. 0 patients, p = 0.0041), and the one-year survival rate was also higher (2 vs. 9 deaths;p = 0.034). The 91 retrospectively evaluated patients achieved an MST of 11.02 years, despite the fact that 46 of them suffered from distant metastasis. In the two monitored patients, drop of PSA level correlated with the DDW intake. In summary, D-depletion prolonged MST in patients with PC. The method proved to be safe thus its integration in the PC cure as an adjuvant or complementary therapy would be considered.
