Breast cancer remains the primary cause of cancer-related mortality for women globally;therefore,further breakthroughs in treatment approaches are crucial.Palbociclib,ribociclib,and abemaciclib are among the Cyclin-de...Breast cancer remains the primary cause of cancer-related mortality for women globally;therefore,further breakthroughs in treatment approaches are crucial.Palbociclib,ribociclib,and abemaciclib are among the Cyclin-dependent kinase 4 and 6(CDK4/6)inhibitors that have become an innovative family of targeted therapy for hormone receptor-positive,Human Epidermal Growth factor receptor 2(HR+/HER2-)breast cancer.These inhibitors work by preventing the action of CDK4/6,which are crucial in the regulation of the cell cycle.Leading cancer cells to cell cycle arrest and undergo apoptosis.When these inhibitors are used with endocrine medicines like letrozole and fulvestrant,clinical trials lead positive impact in progression-free survival and,in a few cases,complete survival.However,despite their effectiveness,resistance mechanisms are primary and current acquired problems,requiring combined approaches with additional targeted medicines and continuous investigation into innovative therapeutic plans.To maintain patient compliance and quality of life,common side effects such as tiredness,gastrointestinal problems,and neutropenia need to be effectively managed.There is hopefulness for wider oncological applications as next-generation CDK inhibitor development and adaptive clinical trials continue to test their potential beyond breast cancer.CDK4/6 inhibitors continue to be a key part of breast cancer treatment as cancer biology advances,marking a major advancement towards more potent and customized cancer medicines.This review aims to provide current evidence on CDK4/6 inhibitors in HR+/HER2-breast cancer,highlighting their mechanisms,interaction with endocrine resistance,combination strategies,and emerging biomarkers guiding personalized therapy.展开更多
Chalcogenide perovskites(CPs)based on zirconium(Zr)and hafnium(Hf)are becoming increasingly attractive as a new class of materials for next-generation solar cells.CPs with the ABX_(3) structure stand out due to their ...Chalcogenide perovskites(CPs)based on zirconium(Zr)and hafnium(Hf)are becoming increasingly attractive as a new class of materials for next-generation solar cells.CPs with the ABX_(3) structure stand out due to their attractive optical and electrical properties,such as efficient light absorption,direct bandgaps in the range of 1.1–2.1 eV,and remarkable defect tolerance,making them a compelling alternative to hybrid and double perovskites for solar energy conversion.Although theoretical studies have progressed rapidly,experimental verification still faces challenges such as the high synthesis temperatures required(>900℃),particularly in producing high-quality,phase-pure thin films and scalable solution-based processes.In this review,we aim to provide a comprehensive overview of the progress and remaining obstacles in advancing CP-based materials and devices.First,we describe the structure and composition as well as the different CPs in which the B site is occupied by Zr and Hf.Second,we summarize the methods used and the challenges that researchers face in producing an effective device.We highlight the main features that make CPs a preferred option for photovoltaic and other applications.Third,we look at the progress made in simulating solar cells that can achieve a power conversion efficiency(PCE)of over 30%using SCAPS-1D software.In the end,challenges and future research directions toward the development of CP materials and devices are provided.Overall,this review will serve as a valuable resource for researchers in selecting suitable strategies to achieve high-performance optoelectronic devices.展开更多
Precise forecasts of wildfire danger are crucial for proactive fuel management and emergency responses,yet they pose a challenge at the subseasonal scale due to limitations in prediction capabilities and a gap between...Precise forecasts of wildfire danger are crucial for proactive fuel management and emergency responses,yet they pose a challenge at the subseasonal scale due to limitations in prediction capabilities and a gap between forecast outputs and the needs of decision-makers.This study introduces an innovative hybrid modeling framework that integrates artificial intelligence(AI)with climate dynamic prediction systems to accurately forecast High Fire-Danger Days(HFDDs)for the following month.These HFDDs are derived from historical satellite fire data and the optimum fire danger index,with a particular focus on Southwest China as a case study.The AI module,based on the ResNet-18 neural network model,integrates observational and physically constrained analysis to establish links between HFDDs and optimal predictors of atmospheric circulation from both the concurrent and preceding months.Leveraging climate dynamical forecasting,this hybrid model provides more reliable deterministic predictions for monthly HFDDs than conventional methods that rely solely on terrestrial variables such as precipitation.More importantly,the integration of dynamical ensemble prediction enhances the model’s capability for skillful probabilistic predictions of HFDDs,facilitating the creation of customized fire danger outlooks and emergency action maps tailored to stakeholders’needs.The model’s added economic value was also evaluated,demonstrating its potential to improve decision-making in disaster management and bridge the“last-mile gap”in climate service delivery.This work contributes to the Seamless Prediction and Services for Sustainable Natural and Built Environment(SEPRESS)Program(2025–32),under the United Nations Educational Scientific and Cultural Organization(UNESCO)International Decade of Sciences for Sustainable Development(2024–33).展开更多
BACKGROUND Various stone factors can affect the net results of shock wave lithotripsy(SWL).Recently a new factor called variation coefficient of stone density(VCSD)is being considered to have an impact on stone free r...BACKGROUND Various stone factors can affect the net results of shock wave lithotripsy(SWL).Recently a new factor called variation coefficient of stone density(VCSD)is being considered to have an impact on stone free rates.AIM To assess the role of VCSD in determining success of SWL in urinary calculi.METHODS Charts review was utilized for collection of data variables.The patients were subjected to SWL,using an electromagnetic lithotripter.Mean stone density(MSD),stone heterogeneity index(SHI),and VCSD were calculated by generating regions of interest on computed tomography(CT)images.Role of these factors were determined by applying the relevant statistical tests for continuous and categorical variables and a P value of<0.05 was gauged to be statistically significant.RESULTS There were a total of 407 patients included in the analysis.The mean age of the subjects in this study was 38.89±14.61 years.In total,165 out of the 407 patients could not achieve stone free status.The successful group had a significantly lower stone volume as compared to the unsuccessful group(P<0.0001).Skin to stone distance was not dissimilar among the two groups(P=0.47).MSD was significantly lower in the successful group(P<0.0001).SHI and VCSD were both significantly higher in the successful group(P<0.0001).CONCLUSION VCSD,a useful CT based parameter,can be utilized to gauge stone fragility and hence the prediction of SWL outcomes.展开更多
The Northeast region is the main producer of guava in Brazil,generating employment and income.However,water availability means that producer’s resort to using water with high salinity,which harms plant development,es...The Northeast region is the main producer of guava in Brazil,generating employment and income.However,water availability means that producer’s resort to using water with high salinity,which harms plant development,especially during the seedling formation phase.The adoption of techniques that mitigate the deleterious effect of salinity is increasingly necessary,such as the use of elicitors such as ascorbic acid.The purpose of this study was to analyze the morphophysiology of guava seedlings under saline and ascorbic acid levels.The study was carried out by applying treatments composed of five saline levels(SL=0.3;1.3;2.3;3.3 and 4.3 dS m^(-1))and four levels of ascorbic acid—AA(0,200,400,and 600 mg L^(-1)),in a 5×4 factorial arrangement,adopting a randomized block design.Gas exchange and growth of guava seedlings are limited from 0.3 dS m^(-1).Using 400 mg L^(-1)of AA reduces damage from salinity on stomatal conductance,transpiration,and net assimilation rate up to the estimated SL of 1.80 dS m^(-1).In contrast,AA level 412 mg L^(-1)increased instantaneous water use efficiency up to the salinity of 2.3 dS m^(-1).AA level of 600 mg L^(-1)attenuated salt stress effects on leaf area and height/stem diameter ratio up to SL of 2.05 dS m^(-1).The number of leaves and the absolute and relative growth rates were stimulated by AA under the lowest saline level.展开更多
Tomato reproductive success and yield are particularly vulnerable to the negative effect of heat stress leading to stigma exsertion(protrusion)and lower pollen viability,both interfering with fertilization.Thus,unders...Tomato reproductive success and yield are particularly vulnerable to the negative effect of heat stress leading to stigma exsertion(protrusion)and lower pollen viability,both interfering with fertilization.Thus,understanding the regulation of these two traits in tomato is crucial for the yield and quality of the crop.Here,we found that knocking out the tomato MADS-domain transcription factor FRUITFULL2(FUL2)function leads to a higher incidence of parthenocarpy in tomato.This phenotype was primarily due to impeded selfpollination as a consequence of the higher frequency of stigma exsertion and lower fertilization rates due to reduced pollen quality.Stigma exsertion in ful2 mutants,in contrast to heat stress-induced exsertion,was caused by style elongation,particularly in the younger flowers of a truss.Interestingly,Quantitative Trait Loci for style elongation,stigma exsertion,and pollen viability map close to the position of FUL2 on chromosome 3,making it a candidate gene underlying these QTLs.At the molecular level,ful2 mutant styles have higher expression of Style2.1 and SE3.1,which are known as positive regulators of style length.In addition,after reducing the impact of style exsertion and low pollen quality by manual pollination with wild-type pollen,ful2 mutants exhibited reduced fruit size independent of seed number.This study reveals the contributions of flower number,style length,and pollen quality,as affected by FUL2,to tomato fertility and fruit size.展开更多
Polyploidy,or whole-genome duplication,is an important evolutionary process that has shaped the genomes and traits of many plants,including numerous important crops.The Brassica genus,which includes diverse vegetables...Polyploidy,or whole-genome duplication,is an important evolutionary process that has shaped the genomes and traits of many plants,including numerous important crops.The Brassica genus,which includes diverse vegetables and oilseeds,is a key model system for studying how polyploidy affects plant diversification and domestication.This review summarizes the current understanding of how multiple rounds of ancient and more recent polyploidization events laid the foundation for the wide diversity seen in Brassica.We discuss the key outcomes through which polyploidy facilitates the accumulation of genetic variation,including genomic buffering that enables mutation retention.Furthermore,we explore the significant roles of interspecies and interploidy introgression in introducing external genetic novelty.We highlight homoeologous exchange(HE)as a critical mechanism unique to allopolyploids,driving substantial genomic rearrangements including presence-absence variations and gene dosage alterations that directly contribute to significant phenotypic innovation and adaptation in Brassica.Together,these polyploidy-associated processes have led to the extensive range of genomic variations that shaped great morphological diversification in the domestication of Brassica.By integrating insights from genomics,genetics,and evolutionary biology,this review shows how polyploidy has been central to Brassica's success and agricultural value.We also suggest future research areas to better understand polyploid evolution and improve crop breeding.展开更多
In this article,we have modeled the astroclimatic parameters using data from the fifth reanalysis series(ERA5)from the European Centre for Medium-Range Weather Forecasts over the period 2010-2020.These data have been ...In this article,we have modeled the astroclimatic parameters using data from the fifth reanalysis series(ERA5)from the European Centre for Medium-Range Weather Forecasts over the period 2010-2020.These data have been projected onto the site of the Roque de los Muchachos Observatory(ORM).The analysis covers the main parameters influencing the quality of astronomical observation,notably the vertical profiles of temperature,potential temperature,and optical turbulence(C_(n)~2),as well as the vertical wind distributions and seasonal behaviors of atmospheric turbulence,which are treated in detail by specifying the wind speed at the 200 hPa level(V200).Around this level,the wind at high altitude presents moderate speeds and a generally stable direction,conditions favorable for adaptive optics.The thermal profiles show good agreement with standard atmospheric models,with a well-defined tropopause and a stable stratosphere,as well as the integrated parameters such as seeing(free and total),isoplanatic angle,and coherence time.The results reveal a stratified and stable atmosphere,with turbulence predominantly concentrated in the lower troposphere.The thermal profiles show a good agreement with standard atmospheric models,with a well-defined tropopause and a stable stratosphere.The seasonality of the astroclimatic parameters indicates conditions particularly favorable for observation during the winter months,with the median of free seeing,total seeing,isoplanatic angle and a coherence time as respectively 0″.48,0″.72,2″,and 6 ms.These results confirm the strong potential of ORM as a reference astronomical site,capable of hosting high-precision observation instruments.The methodological approach employed also provides a replicable basis for the characterization of other candidate sites for the installation of ground-based telescopes.As a preliminary study,this work establishes a scientific basis for further on-site monitoring and detailed characterization of the ORM site.展开更多
We study the confinement of a spinless charged particle to a spherical quantum dot under the influence of a linear electric field.The spherical quantum dot is described by a short-range potential given by the power-ex...We study the confinement of a spinless charged particle to a spherical quantum dot under the influence of a linear electric field.The spherical quantum dot is described by a short-range potential given by the power-exponential potential.Then,by analysing the region near the spherical quantum dot centre,we discuss two cases where the energy levels can be obtained for s-waves and how the linear electric field modifies the spectrum of energy of the spherical quantum dot.展开更多
In Morocco,hydrological and hydrobiological surveys of wadis,river and stream are rare.In this research,we plan to attempt to characterize the physico-chemistry of surface waters of sixteen stations sampled at the lev...In Morocco,hydrological and hydrobiological surveys of wadis,river and stream are rare.In this research,we plan to attempt to characterize the physico-chemistry of surface waters of sixteen stations sampled at the level of the Sebou basin during the period 2013-2023.The diagnosis showed that this natural watercourse is highly enriched in oce-anic salts.A large fluctuation in the chemical nature of the waters was recorded,as well as electrical conductivity(EC),which oscillates between 629 and 22,766μS/cm.Hydrogen Potential ranges from 8.01 to 8.79 while remaining basic.Nitrate(NO3-)concentrations range from a maximum of 886.9 mg/l to a minimum of 0.24 mg/l.Similarly,the am-monium concentration varies from 0.04 to 15.34 mg/l.It was also noted that the waters were very rich in chloride ions(860.27 to 145.55 mg/l),in sodium Na+ion(51 to 2,530 mg/l),in sulfate ions SO4--(441.4 to 37.62 mg/l),in calcium ions Ca2+(97.6 to 1,072.8 mg/l)and in magnesium ions Mg2+(631.2 to 17.28 mg/l)which explains the high hardness of these waters.The concentrations of potassium ions(K+)range from 2.54 to 17.55 mg/l.The high alkalinity is due to the high concentrations of bicarbonate ions(75.64 to 362.34 mg/l).Our study concludes that the waters of the Sebou re-main below the irrigation threshold authorized by Moroccan law when moving away from its Atlantic estuary.They are too degraded and we suggest that urban and industrial wastewater be pre-treated as a priority to reduce natural environment.展开更多
This study investigates the corrosion inhibition potential of Datura stramonium seed extracts on mild steel in 1.0 mol·L^(-1)HCl and 0.5 mol·L^(-1)H_(2)SO_(4),utilizing both ethanolic and aqueous extracts as...This study investigates the corrosion inhibition potential of Datura stramonium seed extracts on mild steel in 1.0 mol·L^(-1)HCl and 0.5 mol·L^(-1)H_(2)SO_(4),utilizing both ethanolic and aqueous extracts as ecofriendly inhibitors.Electrochemical techniques,thermodynamic studies,and quantum chemical calculations were employed to evaluate the adsorption mechanism and inhibitory action at the metal/electrolyte interface.Maximum inhibition efficie ncies of 93.1%in HCl and 97.7%in H_(2)SO_(4) were achieved with the ethanolic extract at a concentration of 0.2 g·L^(-1),while the aqueous extract demonstrated 93.8%inhibition in HCl and 96.6%in H_(2)SO_(4).Polarization curves indicated mixed-type inhibition with a slight anodic bias.The thermodynamic analysis of two extracts in both environments indicated that the K_(ads)increased and that theΔG_(ads)were close to-40 kJ·mol^(-1),suggesting that the adsorption followed the Langmuir isotherm,indicating a combination of physical and chemical adsorption.SEM/EDX analysis confirmed the formation of a protective layer,while quantum chemical studies further validated strong adsorption,evidenced by a lowΔE of 2.396 eV and an adsorption energy of-878 kcal·mol^(-1)(1kcal·mol^(-1)=4.18 kJ·mol^(-1)).These results demonstrate that Datura stramonium extracts are promising inhibitors,particularly in sulfuric acid,for industrial applications.Reason:Improved clarity,vocabulary,and technical accuracy while maintaining the original meaning.展开更多
Rice(Oryza sativa L.)farmers face challenges with metal accumulation in grain,with nickel(Ni)recently emerging as a concern due to its potential to exceed legal limits,alongside cadmium(Cd).Information on Ni behaviour...Rice(Oryza sativa L.)farmers face challenges with metal accumulation in grain,with nickel(Ni)recently emerging as a concern due to its potential to exceed legal limits,alongside cadmium(Cd).Information on Ni behaviour and its interaction with Cd remains limited.Selenium(Se)is commonly used for rice biofortification and can reduce the accumulation of toxic metals in plants.Therefore,this study investigates how Ni and Cd influence mutual accumulation in rice and examines the impact of different Se forms on their interactions.Plants were grown hydroponically with various combinations of Cd(5 or 20μmol/L),Ni(20μmol/L),and Se(5μmol/L)as selenate(Se^(6+))or selenite(Se^(4+))for 7 d.Plant growth,lipid peroxidation,and element accumulation were measured,and the distribution of Se and Ni in tissues was assayed using synchrotron-basedμXRF 2D imaging.Cd and Ni were toxic to rice,reducing leaf and root biomass by 40%‒50%and inducing oxidative stress.However,their combined presence did not further exacerbate leaf growth reduction.Cd reduced root Ni accumulation by approximately 50%at equimolar concentrations,likely due to competitive inhibition at shared transport sites.Se promoted root growth in the presence of Ni and low Cd,suggesting an antioxidant role in mitigating metal-induced stress.However,high doses of Ni and Cd together significantly reduced Se accumulation(by 60%and 77%for Se^(4+)in roots and Se^(6+)in leaves,respectively)and caused severe oxidative stress in the presence of Se^(4+).The effectiveness of Se biofortification varied depending on the Se form:Se^(6+)was more effective at reducing Ni accumulation,while Se^(4+)effectively reduced Cd accumulation(by 45%‒75%)at low concentrations and Ni accumulation in the absence of Cd(by 50%).In conclusion,this study demonstrates that Se can mitigate Cd and Ni accumulation in rice.However,the co-presence of Cd and Ni may compromise Se enrichment in rice,highlighting the complexity of their interactions.展开更多
Fruit quality traits play an important role in consumption of kiwiberry(Actinidia arguta).The genetic basis of fruit quality traits in this woody,perennial and dioecious fruit crop remains largely unknown.This study a...Fruit quality traits play an important role in consumption of kiwiberry(Actinidia arguta).The genetic basis of fruit quality traits in this woody,perennial and dioecious fruit crop remains largely unknown.This study aimed to identify the underlying genetic basis of fruit quality traits in A.arguta,using a single nucleotide polymorphism(SNP)genetic linkage map previously developed in a tetraploid F1 population of‘Ruby-3’בKuiLv-M’.The F1 population was phenotyped over three years(2020–2022)for fruit quality traits,including skin color,flesh color,fruit weight,fruit diameter,total soluble solids,fruit longitudinal diameter and fruit shape index.A total of nine QTLs were detected for five traits,explaining 10%–32%of the trait variation.For fruit color,the support interval of a major QTL on LG9 contained an MYB transcription factor MYB110,which was previously demonstrated to control color regulation in kiwifruit,thus suggesting that the MYB110 is the candidate gene for fruit color in kiwiberry.The linked marker for fruit color was validated in an F1 population and 25 kiwiberry cultivars.In conclusion,the knowledge obtained through the QTL mapping is applicable to improve the efficiency and cost-effectiveness in kiwiberry breeding.展开更多
Essential oils(EOs)derived from medicinal plants are gaining recognition as sustainable alternatives to synthetic fungicides in the management of plant pathogens.This study investigates the chemical composition,chroma...Essential oils(EOs)derived from medicinal plants are gaining recognition as sustainable alternatives to synthetic fungicides in the management of plant pathogens.This study investigates the chemical composition,chromatographic profile,and antifungal of Mentha rotundifolia essential oil against Fusarium oxysporum f.sp.albedinis(Foa),the pathogen responsible for Bayoud disease in date palm.The oil was extracted through hydrodistillation and characterized using thin-layer chromatography(TLC)and gas chromatography–mass spectrometry(GC-MS),revealing multiple fractions corresponding to terpenoid constituents and 23 chemical constituents,predominantly oxygenated monoterpenes(68.51%),with piperitenone oxide as the major component(62.53%).The antifungal efficacy was evaluated against ten(10)isolates of F.o.a across seven(07)concentrations different concentrations.(0;0.25;0.5;0.75;1;1.25;1.5μL/mL).The results obtained show a progressive decrease in the diameters of the colonies of F.o.a isolates by increasing the doses of EOMR.The percentage of inhibition varies from 7.82 to 83.41%;However,the dose of 1.75μL/mL showed 100%inhibition for all F.o.a isolates tested.These outcomes demonstrate the potential of M.rotundifolia essential oil as a natural,environmentally friendly antifungal agent,supporting its application in sustainable management strategies for Bayoud disease in date palm.展开更多
基金funded by School of Medical Sciences and Universiti Sains Malaysia。
文摘Breast cancer remains the primary cause of cancer-related mortality for women globally;therefore,further breakthroughs in treatment approaches are crucial.Palbociclib,ribociclib,and abemaciclib are among the Cyclin-dependent kinase 4 and 6(CDK4/6)inhibitors that have become an innovative family of targeted therapy for hormone receptor-positive,Human Epidermal Growth factor receptor 2(HR+/HER2-)breast cancer.These inhibitors work by preventing the action of CDK4/6,which are crucial in the regulation of the cell cycle.Leading cancer cells to cell cycle arrest and undergo apoptosis.When these inhibitors are used with endocrine medicines like letrozole and fulvestrant,clinical trials lead positive impact in progression-free survival and,in a few cases,complete survival.However,despite their effectiveness,resistance mechanisms are primary and current acquired problems,requiring combined approaches with additional targeted medicines and continuous investigation into innovative therapeutic plans.To maintain patient compliance and quality of life,common side effects such as tiredness,gastrointestinal problems,and neutropenia need to be effectively managed.There is hopefulness for wider oncological applications as next-generation CDK inhibitor development and adaptive clinical trials continue to test their potential beyond breast cancer.CDK4/6 inhibitors continue to be a key part of breast cancer treatment as cancer biology advances,marking a major advancement towards more potent and customized cancer medicines.This review aims to provide current evidence on CDK4/6 inhibitors in HR+/HER2-breast cancer,highlighting their mechanisms,interaction with endocrine resistance,combination strategies,and emerging biomarkers guiding personalized therapy.
基金the“Initiative on Energy Research”,founded by the University Mohammed VI Polytechnic,for the financial support through the project“Toward efficient,stable,environmentally friendly,and scalable Perovskite Solar Cells”the financial support from DAAD and BMZ through the WE-AFRICA project+1 种基金the U.S.Department of Energy,Office of Science,Basic Energy Sciences,Early Career Program,under Award No.DOE DESC0025350the National Academies of Sciences,Engineering,and Medicine for their support through the U.S.-Africa Frontiers Fellowship。
文摘Chalcogenide perovskites(CPs)based on zirconium(Zr)and hafnium(Hf)are becoming increasingly attractive as a new class of materials for next-generation solar cells.CPs with the ABX_(3) structure stand out due to their attractive optical and electrical properties,such as efficient light absorption,direct bandgaps in the range of 1.1–2.1 eV,and remarkable defect tolerance,making them a compelling alternative to hybrid and double perovskites for solar energy conversion.Although theoretical studies have progressed rapidly,experimental verification still faces challenges such as the high synthesis temperatures required(>900℃),particularly in producing high-quality,phase-pure thin films and scalable solution-based processes.In this review,we aim to provide a comprehensive overview of the progress and remaining obstacles in advancing CP-based materials and devices.First,we describe the structure and composition as well as the different CPs in which the B site is occupied by Zr and Hf.Second,we summarize the methods used and the challenges that researchers face in producing an effective device.We highlight the main features that make CPs a preferred option for photovoltaic and other applications.Third,we look at the progress made in simulating solar cells that can achieve a power conversion efficiency(PCE)of over 30%using SCAPS-1D software.In the end,challenges and future research directions toward the development of CP materials and devices are provided.Overall,this review will serve as a valuable resource for researchers in selecting suitable strategies to achieve high-performance optoelectronic devices.
基金J.YANG was supported by funding from the National Natural Science Foundation of China(Grant Nos.42475022,42261144671)the National Key R&D Program of China(Project No.2024YFC3013100)+2 种基金the Fundamental Research Funds for the Central UniversitiesM.LU was supported by the Otto Poon Centre of Climate Resilience and Sustainability at HKUST and the Hong Kong Research Grant Committee(Project No.16300424)Data processing and storage were supported by the National Key Scientific and Technological Infrastructure project“Earth System Numerical Simulation Facility”(EarthLab).
文摘Precise forecasts of wildfire danger are crucial for proactive fuel management and emergency responses,yet they pose a challenge at the subseasonal scale due to limitations in prediction capabilities and a gap between forecast outputs and the needs of decision-makers.This study introduces an innovative hybrid modeling framework that integrates artificial intelligence(AI)with climate dynamic prediction systems to accurately forecast High Fire-Danger Days(HFDDs)for the following month.These HFDDs are derived from historical satellite fire data and the optimum fire danger index,with a particular focus on Southwest China as a case study.The AI module,based on the ResNet-18 neural network model,integrates observational and physically constrained analysis to establish links between HFDDs and optimal predictors of atmospheric circulation from both the concurrent and preceding months.Leveraging climate dynamical forecasting,this hybrid model provides more reliable deterministic predictions for monthly HFDDs than conventional methods that rely solely on terrestrial variables such as precipitation.More importantly,the integration of dynamical ensemble prediction enhances the model’s capability for skillful probabilistic predictions of HFDDs,facilitating the creation of customized fire danger outlooks and emergency action maps tailored to stakeholders’needs.The model’s added economic value was also evaluated,demonstrating its potential to improve decision-making in disaster management and bridge the“last-mile gap”in climate service delivery.This work contributes to the Seamless Prediction and Services for Sustainable Natural and Built Environment(SEPRESS)Program(2025–32),under the United Nations Educational Scientific and Cultural Organization(UNESCO)International Decade of Sciences for Sustainable Development(2024–33).
文摘BACKGROUND Various stone factors can affect the net results of shock wave lithotripsy(SWL).Recently a new factor called variation coefficient of stone density(VCSD)is being considered to have an impact on stone free rates.AIM To assess the role of VCSD in determining success of SWL in urinary calculi.METHODS Charts review was utilized for collection of data variables.The patients were subjected to SWL,using an electromagnetic lithotripter.Mean stone density(MSD),stone heterogeneity index(SHI),and VCSD were calculated by generating regions of interest on computed tomography(CT)images.Role of these factors were determined by applying the relevant statistical tests for continuous and categorical variables and a P value of<0.05 was gauged to be statistically significant.RESULTS There were a total of 407 patients included in the analysis.The mean age of the subjects in this study was 38.89±14.61 years.In total,165 out of the 407 patients could not achieve stone free status.The successful group had a significantly lower stone volume as compared to the unsuccessful group(P<0.0001).Skin to stone distance was not dissimilar among the two groups(P=0.47).MSD was significantly lower in the successful group(P<0.0001).SHI and VCSD were both significantly higher in the successful group(P<0.0001).CONCLUSION VCSD,a useful CT based parameter,can be utilized to gauge stone fragility and hence the prediction of SWL outcomes.
基金supported by CNPq(National Council for Scientific and Technological Development—Processo:151057/2024-9),CAPES(Coordination for the Improvement of Higher Education Personnel)financial code—001,and UFCG(Universidade Federal de Campina Grande).
文摘The Northeast region is the main producer of guava in Brazil,generating employment and income.However,water availability means that producer’s resort to using water with high salinity,which harms plant development,especially during the seedling formation phase.The adoption of techniques that mitigate the deleterious effect of salinity is increasingly necessary,such as the use of elicitors such as ascorbic acid.The purpose of this study was to analyze the morphophysiology of guava seedlings under saline and ascorbic acid levels.The study was carried out by applying treatments composed of five saline levels(SL=0.3;1.3;2.3;3.3 and 4.3 dS m^(-1))and four levels of ascorbic acid—AA(0,200,400,and 600 mg L^(-1)),in a 5×4 factorial arrangement,adopting a randomized block design.Gas exchange and growth of guava seedlings are limited from 0.3 dS m^(-1).Using 400 mg L^(-1)of AA reduces damage from salinity on stomatal conductance,transpiration,and net assimilation rate up to the estimated SL of 1.80 dS m^(-1).In contrast,AA level 412 mg L^(-1)increased instantaneous water use efficiency up to the salinity of 2.3 dS m^(-1).AA level of 600 mg L^(-1)attenuated salt stress effects on leaf area and height/stem diameter ratio up to SL of 2.05 dS m^(-1).The number of leaves and the absolute and relative growth rates were stimulated by AA under the lowest saline level.
基金supported by a fellowship from the China Scholarship Council(CSC),award nr.202106300012 to X.W.from EU-RISE Evofruland:grant agreement no.101007738 to X.W.
文摘Tomato reproductive success and yield are particularly vulnerable to the negative effect of heat stress leading to stigma exsertion(protrusion)and lower pollen viability,both interfering with fertilization.Thus,understanding the regulation of these two traits in tomato is crucial for the yield and quality of the crop.Here,we found that knocking out the tomato MADS-domain transcription factor FRUITFULL2(FUL2)function leads to a higher incidence of parthenocarpy in tomato.This phenotype was primarily due to impeded selfpollination as a consequence of the higher frequency of stigma exsertion and lower fertilization rates due to reduced pollen quality.Stigma exsertion in ful2 mutants,in contrast to heat stress-induced exsertion,was caused by style elongation,particularly in the younger flowers of a truss.Interestingly,Quantitative Trait Loci for style elongation,stigma exsertion,and pollen viability map close to the position of FUL2 on chromosome 3,making it a candidate gene underlying these QTLs.At the molecular level,ful2 mutant styles have higher expression of Style2.1 and SE3.1,which are known as positive regulators of style length.In addition,after reducing the impact of style exsertion and low pollen quality by manual pollination with wild-type pollen,ful2 mutants exhibited reduced fruit size independent of seed number.This study reveals the contributions of flower number,style length,and pollen quality,as affected by FUL2,to tomato fertility and fruit size.
基金supported by the National Key Research and Development Program of China(Grant No.2021YFF1000104)the Agricultural Science and Technology Innovation Program(ASTIP),Beijing Municipal Science and Technology Project(Grant No.Z231100003723009)+4 种基金the Central Public-interest Scientific Institution Basal Research Fund(Grant No.Y2023PT16)TKI project(Grant No.KV1605-004)support from the China Scholarship Councilthe NPO bursary funding from Wageningen universitythe scholarship from Institute of vegetables and flowers,CAAS.
文摘Polyploidy,or whole-genome duplication,is an important evolutionary process that has shaped the genomes and traits of many plants,including numerous important crops.The Brassica genus,which includes diverse vegetables and oilseeds,is a key model system for studying how polyploidy affects plant diversification and domestication.This review summarizes the current understanding of how multiple rounds of ancient and more recent polyploidization events laid the foundation for the wide diversity seen in Brassica.We discuss the key outcomes through which polyploidy facilitates the accumulation of genetic variation,including genomic buffering that enables mutation retention.Furthermore,we explore the significant roles of interspecies and interploidy introgression in introducing external genetic novelty.We highlight homoeologous exchange(HE)as a critical mechanism unique to allopolyploids,driving substantial genomic rearrangements including presence-absence variations and gene dosage alterations that directly contribute to significant phenotypic innovation and adaptation in Brassica.Together,these polyploidy-associated processes have led to the extensive range of genomic variations that shaped great morphological diversification in the domestication of Brassica.By integrating insights from genomics,genetics,and evolutionary biology,this review shows how polyploidy has been central to Brassica's success and agricultural value.We also suggest future research areas to better understand polyploid evolution and improve crop breeding.
文摘In this article,we have modeled the astroclimatic parameters using data from the fifth reanalysis series(ERA5)from the European Centre for Medium-Range Weather Forecasts over the period 2010-2020.These data have been projected onto the site of the Roque de los Muchachos Observatory(ORM).The analysis covers the main parameters influencing the quality of astronomical observation,notably the vertical profiles of temperature,potential temperature,and optical turbulence(C_(n)~2),as well as the vertical wind distributions and seasonal behaviors of atmospheric turbulence,which are treated in detail by specifying the wind speed at the 200 hPa level(V200).Around this level,the wind at high altitude presents moderate speeds and a generally stable direction,conditions favorable for adaptive optics.The thermal profiles show good agreement with standard atmospheric models,with a well-defined tropopause and a stable stratosphere,as well as the integrated parameters such as seeing(free and total),isoplanatic angle,and coherence time.The results reveal a stratified and stable atmosphere,with turbulence predominantly concentrated in the lower troposphere.The thermal profiles show a good agreement with standard atmospheric models,with a well-defined tropopause and a stable stratosphere.The seasonality of the astroclimatic parameters indicates conditions particularly favorable for observation during the winter months,with the median of free seeing,total seeing,isoplanatic angle and a coherence time as respectively 0″.48,0″.72,2″,and 6 ms.These results confirm the strong potential of ORM as a reference astronomical site,capable of hosting high-precision observation instruments.The methodological approach employed also provides a replicable basis for the characterization of other candidate sites for the installation of ground-based telescopes.As a preliminary study,this work establishes a scientific basis for further on-site monitoring and detailed characterization of the ORM site.
文摘We study the confinement of a spinless charged particle to a spherical quantum dot under the influence of a linear electric field.The spherical quantum dot is described by a short-range potential given by the power-exponential potential.Then,by analysing the region near the spherical quantum dot centre,we discuss two cases where the energy levels can be obtained for s-waves and how the linear electric field modifies the spectrum of energy of the spherical quantum dot.
文摘In Morocco,hydrological and hydrobiological surveys of wadis,river and stream are rare.In this research,we plan to attempt to characterize the physico-chemistry of surface waters of sixteen stations sampled at the level of the Sebou basin during the period 2013-2023.The diagnosis showed that this natural watercourse is highly enriched in oce-anic salts.A large fluctuation in the chemical nature of the waters was recorded,as well as electrical conductivity(EC),which oscillates between 629 and 22,766μS/cm.Hydrogen Potential ranges from 8.01 to 8.79 while remaining basic.Nitrate(NO3-)concentrations range from a maximum of 886.9 mg/l to a minimum of 0.24 mg/l.Similarly,the am-monium concentration varies from 0.04 to 15.34 mg/l.It was also noted that the waters were very rich in chloride ions(860.27 to 145.55 mg/l),in sodium Na+ion(51 to 2,530 mg/l),in sulfate ions SO4--(441.4 to 37.62 mg/l),in calcium ions Ca2+(97.6 to 1,072.8 mg/l)and in magnesium ions Mg2+(631.2 to 17.28 mg/l)which explains the high hardness of these waters.The concentrations of potassium ions(K+)range from 2.54 to 17.55 mg/l.The high alkalinity is due to the high concentrations of bicarbonate ions(75.64 to 362.34 mg/l).Our study concludes that the waters of the Sebou re-main below the irrigation threshold authorized by Moroccan law when moving away from its Atlantic estuary.They are too degraded and we suggest that urban and industrial wastewater be pre-treated as a priority to reduce natural environment.
基金supported by the NRF(National Research Foundation)of Koreafunded by the Basic Science Research Program through the Ministry of Education(2020R1I1A3052258)carried out with the support of the“2024 System Semiconductor Technology Development Support Project”of Chungbuk Technopark。
文摘This study investigates the corrosion inhibition potential of Datura stramonium seed extracts on mild steel in 1.0 mol·L^(-1)HCl and 0.5 mol·L^(-1)H_(2)SO_(4),utilizing both ethanolic and aqueous extracts as ecofriendly inhibitors.Electrochemical techniques,thermodynamic studies,and quantum chemical calculations were employed to evaluate the adsorption mechanism and inhibitory action at the metal/electrolyte interface.Maximum inhibition efficie ncies of 93.1%in HCl and 97.7%in H_(2)SO_(4) were achieved with the ethanolic extract at a concentration of 0.2 g·L^(-1),while the aqueous extract demonstrated 93.8%inhibition in HCl and 96.6%in H_(2)SO_(4).Polarization curves indicated mixed-type inhibition with a slight anodic bias.The thermodynamic analysis of two extracts in both environments indicated that the K_(ads)increased and that theΔG_(ads)were close to-40 kJ·mol^(-1),suggesting that the adsorption followed the Langmuir isotherm,indicating a combination of physical and chemical adsorption.SEM/EDX analysis confirmed the formation of a protective layer,while quantum chemical studies further validated strong adsorption,evidenced by a lowΔE of 2.396 eV and an adsorption energy of-878 kcal·mol^(-1)(1kcal·mol^(-1)=4.18 kJ·mol^(-1)).These results demonstrate that Datura stramonium extracts are promising inhibitors,particularly in sulfuric acid,for industrial applications.Reason:Improved clarity,vocabulary,and technical accuracy while maintaining the original meaning.
基金funded by the European Union’s Horizon 2022 research and innovation program under the Marie SKŁODOWSKA-CURIE Individual Fellowship(Grant No.101105237).
文摘Rice(Oryza sativa L.)farmers face challenges with metal accumulation in grain,with nickel(Ni)recently emerging as a concern due to its potential to exceed legal limits,alongside cadmium(Cd).Information on Ni behaviour and its interaction with Cd remains limited.Selenium(Se)is commonly used for rice biofortification and can reduce the accumulation of toxic metals in plants.Therefore,this study investigates how Ni and Cd influence mutual accumulation in rice and examines the impact of different Se forms on their interactions.Plants were grown hydroponically with various combinations of Cd(5 or 20μmol/L),Ni(20μmol/L),and Se(5μmol/L)as selenate(Se^(6+))or selenite(Se^(4+))for 7 d.Plant growth,lipid peroxidation,and element accumulation were measured,and the distribution of Se and Ni in tissues was assayed using synchrotron-basedμXRF 2D imaging.Cd and Ni were toxic to rice,reducing leaf and root biomass by 40%‒50%and inducing oxidative stress.However,their combined presence did not further exacerbate leaf growth reduction.Cd reduced root Ni accumulation by approximately 50%at equimolar concentrations,likely due to competitive inhibition at shared transport sites.Se promoted root growth in the presence of Ni and low Cd,suggesting an antioxidant role in mitigating metal-induced stress.However,high doses of Ni and Cd together significantly reduced Se accumulation(by 60%and 77%for Se^(4+)in roots and Se^(6+)in leaves,respectively)and caused severe oxidative stress in the presence of Se^(4+).The effectiveness of Se biofortification varied depending on the Se form:Se^(6+)was more effective at reducing Ni accumulation,while Se^(4+)effectively reduced Cd accumulation(by 45%‒75%)at low concentrations and Ni accumulation in the absence of Cd(by 50%).In conclusion,this study demonstrates that Se can mitigate Cd and Ni accumulation in rice.However,the co-presence of Cd and Ni may compromise Se enrichment in rice,highlighting the complexity of their interactions.
基金support from the National Natural Science Foundation of China(Grant No.32001995)the Major Science and Technology Project of Henan Province(Grant No.221100110400)+3 种基金the China Agriculture Research System of MOF and MARA(Grant No.CARS-26)the Special Engineering Science and Technology Innovation,CAAS(Grant No.CAAS-ASTIP-2024-ZFRI).Part of this research was funded under the TKI project:“Novel genetic and genomic tools for polyploid crops”(KV 1605-020BO 26.03009004,BO 50002022)and USDA's National Institute of Food and Agriculture(NIFA)Specialty Crop Research Initiative project“Tools for genomics assisted breeding in polyploids:Development of a community resource”(Grant No.2020-51181-32156/SCRI)received a scholarship from China Scholarship Council(Grant No.202303250034).
文摘Fruit quality traits play an important role in consumption of kiwiberry(Actinidia arguta).The genetic basis of fruit quality traits in this woody,perennial and dioecious fruit crop remains largely unknown.This study aimed to identify the underlying genetic basis of fruit quality traits in A.arguta,using a single nucleotide polymorphism(SNP)genetic linkage map previously developed in a tetraploid F1 population of‘Ruby-3’בKuiLv-M’.The F1 population was phenotyped over three years(2020–2022)for fruit quality traits,including skin color,flesh color,fruit weight,fruit diameter,total soluble solids,fruit longitudinal diameter and fruit shape index.A total of nine QTLs were detected for five traits,explaining 10%–32%of the trait variation.For fruit color,the support interval of a major QTL on LG9 contained an MYB transcription factor MYB110,which was previously demonstrated to control color regulation in kiwifruit,thus suggesting that the MYB110 is the candidate gene for fruit color in kiwiberry.The linked marker for fruit color was validated in an F1 population and 25 kiwiberry cultivars.In conclusion,the knowledge obtained through the QTL mapping is applicable to improve the efficiency and cost-effectiveness in kiwiberry breeding.
文摘Essential oils(EOs)derived from medicinal plants are gaining recognition as sustainable alternatives to synthetic fungicides in the management of plant pathogens.This study investigates the chemical composition,chromatographic profile,and antifungal of Mentha rotundifolia essential oil against Fusarium oxysporum f.sp.albedinis(Foa),the pathogen responsible for Bayoud disease in date palm.The oil was extracted through hydrodistillation and characterized using thin-layer chromatography(TLC)and gas chromatography–mass spectrometry(GC-MS),revealing multiple fractions corresponding to terpenoid constituents and 23 chemical constituents,predominantly oxygenated monoterpenes(68.51%),with piperitenone oxide as the major component(62.53%).The antifungal efficacy was evaluated against ten(10)isolates of F.o.a across seven(07)concentrations different concentrations.(0;0.25;0.5;0.75;1;1.25;1.5μL/mL).The results obtained show a progressive decrease in the diameters of the colonies of F.o.a isolates by increasing the doses of EOMR.The percentage of inhibition varies from 7.82 to 83.41%;However,the dose of 1.75μL/mL showed 100%inhibition for all F.o.a isolates tested.These outcomes demonstrate the potential of M.rotundifolia essential oil as a natural,environmentally friendly antifungal agent,supporting its application in sustainable management strategies for Bayoud disease in date palm.
