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Psoriasis treatment: Unconventional and non-standard modalities in the era of biologics 被引量:1
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作者 Vikram K Mahajan 《World Journal of Dermatology》 2016年第1期17-51,共35页
Psoriasis is a potentially debilitating inflammatory dermatosis affecting 0.2%-4.8% of the population worldwide causing a significant occupational, personal or psychosocial morbidity to these patients for life. The ba... Psoriasis is a potentially debilitating inflammatory dermatosis affecting 0.2%-4.8% of the population worldwide causing a significant occupational, personal or psychosocial morbidity to these patients for life. The basic aim of psoriasis therapy is to control the disease to maximum possible extent and improve the patient's quality of life. Management of triggers for flareups, lifestyle modifications, and dietary supplements are often recommended. Intermittent or rotational therapy with frequent alterations in treatment options is usually needed to reduce toxicity of anti-psoriatic drugs in the absence of safer alternatives. Currently, several biological agents categorized as either T-cell targeted(e.g., Alefacept, Efalizumab) or cytokine modulating(e.g., Adalimumab, Infliximab, Etanercept) are available for treating severe psoriasis. However, their high cost is often precluding for most patients. The usefulness of systemic(methotrexate, cyclosporine, acitretin or several other therapeutic agents) or topical(tar, anthralin, corticosteroids or calcipotriol ointments, phototherapy with or without psoralens) therapies has been well established for the management of psoriasis. The literature is also replete with benefits of less used non-standard and unconventional treatment modalities(hydroxycarbamide, azathioprine, leflunomide, mycophenolate mofetil, isotretinoin, fumarates, topical calcineurin inhibitors, peroxisome proliferator-activated receptors agonists, statins, sulfasalazine, pentoxifylline, colchicine, grenz ray therapy, excimer laser, climatotherapy and balneophototherapy, peritoneal dialysis, tonsillectomy, ichthyotherapy, etc.). These can be used alternatively to treat psoriasis patients who have mild/minimal lesions, are intolerant to conventional drugs, have developed side effects or achieved recommended cumulative dose, where comorbidities pose unusual therapeutic challenges, or may be as intermittent, rotational or combination treatment alternatives. 展开更多
关键词 Acetretin Azathioprine Balneophototherapy Calcineurin inhibitors CALCIPOTRIOL Calcium dobesilate Climatotherapy Colchicine Cyclosporine DAPSONE Excimer laser Fumarates Grenz ray therapy Hydroxycarbamide Ichthyotherapy ISOTRETINOIN Leflunamide Methotrexate MYCOPHENOLATE mofetil Pentoxifylline Peritoneal dialysis Phototherpy Plaque PSORIASIS Peroxisome proliferator-activated receptors agonists Statins SULFASALAZINE Tonsillectomy
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Exact Computer Modeling of Photovoltaic Sources with Lambert-W Explicit Solvers for Real-Time Emulation and Controller Verification
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作者 Abdulaziz Almalaq Ambe Harrison +2 位作者 Ibrahim Alsaleh Abdullah Alassaf Mashari Alangari 《Computer Modeling in Engineering & Sciences》 2026年第1期873-891,共19页
We present a computer-modeling framework for photovoltaic(PV)source emulation that preserves the exact single-diode physics while enabling iteration-free,real-time evaluation.We derive two closed-form explicit solvers... We present a computer-modeling framework for photovoltaic(PV)source emulation that preserves the exact single-diode physics while enabling iteration-free,real-time evaluation.We derive two closed-form explicit solvers based on the Lambert W function:a voltage-driven V-Lambert solver for high-fidelity I–V computation and a resistance-driven R-Lambert solver designed for seamless integration in a closed-loop PV emulator.Unlike Taylor-linearized explicit models,our proposed formulation retains the exponential nonlinearity of the PV equations.It employs a numerically stable analytical evaluation that eliminates the need for lookup tables and root-finding,all while maintaining limited computational costs and a small memory footprint.The R-Lambert model is integrated into a buck-converter emulator equipped with a discrete PI regulator,which generates current references directly from sensed operating points,thus supporting hardware-constrained implementation.Comprehensive numerical experiments conducted on six commercial modules from various technologies(mono,poly,and multicrystalline)demonstrate significant accuracy improvements under the IEC EN 50530 near-MPP criterion:the V-Lambert solver reduces the±10%Vmpp band error by up to 61 times compared to an explicit-model baseline.Dynamic simulations under varying irradiance,temperature,and load conditions achieve millisecond-scale settling with accurate trajectory tracking.Additionally,processor-in-the-loop experimental validation on an embedded microcontroller supports the simulation results.By unifying exact analytical modeling with embedded realization,this work advances computer modeling for PV emulation,MPPT benchmarking,and controller verification in integrated renewable energy systems. 展开更多
关键词 Photovoltaic emulators(PVE) explicit PV model(EPVM) IEC EN 50530 Lambert function maximum power point(MPP) PVE integration processor-in-the loop
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From amalgamation to post-orogenic Rodinian rifting:Decoded by the Neoproterozoic Shenshan Group,South China
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作者 Hong-shuai Wu Yu-zhi Zhang +5 位作者 Xue Yang Jian-wen Yang Meng-yuan Li Xiao-qing Yu Cheng Wang Cheng-shi Gan 《China Geology》 2026年第1期102-119,I0001-I0014,共32页
The Shenshan Group provides important geological information which is vital in unraveling the amalgamation and subsequent rifting processes of South China.While conventional studies have asserted its formation in a su... The Shenshan Group provides important geological information which is vital in unraveling the amalgamation and subsequent rifting processes of South China.While conventional studies have asserted its formation in a subduction setting,the distinct investigation reveals the necessity for reassessment.To address this,the authors employ integrated methods encompassing petrological,zircon U-Pb geochronological,Lu-Hf isotopic and geochemical methods for sedimentary rocks from the upper Shenshan subgroup and Banxi Group.The geochemical results indicate that they were formed through the recycling deposition of intermediate-acidic igneous source material and experienced moderate chemical weathering.Additionally,both sedimentary sequences exhibit characteristics consistent with those formed in an intracontinental extensional rift setting since ca.810 Ma.The provenance analysis indicates that the upper Shenshan subgroup primarily originates from the Yangtze Domain,while the Banxi Group from both the Yangtze and Cathaysia domains.Synthesizing with previous studies,the Shenshan Group should be subdivided into the lower and upper subgroups which represent distinct tectonic backgrounds.The lower subgroup is inferred to have formed in an Early Neoproterozoic fore-arc setting,akin to the Zhoutan group.The upper subgroup corresponds to the Banxi Group,representing the Middle Neoproterozoic postorogenic rift setting,responding to the breakup of Rodinia. 展开更多
关键词 South China plate Subdivision of the Shenshan Group The upper Shenshan Subgroup Sedimentary rock Intermediate-acidic igneous source material Post-orogenic rift setting MESO-NEOPROTEROZOIC Fore-arc environment Rodinian continental rifting Geological survey engineering
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Global Existence and Blow-up of Solutions for Fourth-order Parabolic Equation with p(x)-Laplacian and Variable Exponents
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作者 YANG Chunxiao YU Lifei DUAN Chenyan 《数学进展》 北大核心 2026年第1期221-239,共19页
In this paper,we consider the fourth-order parabolic equation with p(x)Laplacian and variable exponent source ut+∆^(2)u−div(|■u|^(p(x)−2■u))=|u|^(q(x))−1u.By applying potential well method,we obtain global existence... In this paper,we consider the fourth-order parabolic equation with p(x)Laplacian and variable exponent source ut+∆^(2)u−div(|■u|^(p(x)−2■u))=|u|^(q(x))−1u.By applying potential well method,we obtain global existence,asymptotic behavior and blow-up of solutions with initial energy J(u_(0))≤d.Moreover,we estimate the upper bound of the blow-up time for J(u_(0))≤0. 展开更多
关键词 fourth-order parabolic equation variable exponent source global existence asymptotic behavior BLOW-UP
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Optimal scheduling of active distribution networks based on multi-scenario fuzzy set based charging station resource prediction
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作者 Zhang Maosong Zhang Chunyu +3 位作者 Hao Shi Yang Jie Yang Lingxiao Wang Xiuqin 《High Technology Letters》 2026年第1期97-108,共12页
With the large-scale integration of new energy sources,various resources such as energy storage,electric vehicles(EVs),and photovoltaics(PV) have participated in the scheduling of active distribution networks(ADNs),po... With the large-scale integration of new energy sources,various resources such as energy storage,electric vehicles(EVs),and photovoltaics(PV) have participated in the scheduling of active distribution networks(ADNs),posing new challenges to the operation and scheduling of distribution networks.Aiming at the uncertainty of PV and EV,an optimal scheduling model for ADNs based on multi-scenario fuzzy set based charging station resource forecasting is constructed.To address the scheduling uncertainties caused by PV and load forecasting errors,a day-ahead optimal scheduling model based on conditional value at risk(CVaR) for cost assessment is established,with the optimization objectives of minimizing the operation cost of distribution networks and the risk cost caused by forecasting errors.An improved subtractive optimizer algorithm is proposed to solve the model and formulate day-ahead optimization schemes.Secondly,a forecasting model for dispatchable resources in charging stations is constructed based on event-based fuzzy set theory.On this basis,an intraday scheduling model is built to comprehensively utilize the dispatchable resources of charging stations to coordinate with the output of distributed power sources,achieving optimal scheduling with the goal of minimizing operation costs.Finally,an experimental scenario based on the IEEE-33 node system is designed for simulation verification.The comparison of optimal scheduling results shows that the proposed method can fully exploit the potential scheduling resources of charging stations,improving the operation stability of ADNs and the accommodution capacity of new energy. 展开更多
关键词 charging station resource prediction subtractive optimizer algorithm multi-scenario fuzzy set two-stage optimal scheduling distribution network cost optimization
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Local Characterizations of Results on the Normal Index of Subgroups in Finite Groups
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作者 Yubo LV Yangming LI Xiaoxia DONG 《Journal of Mathematical Research with Applications》 2026年第1期33-39,共7页
Let G be a finite group and H a subgroup of G.The normal index of H in G is defined as the order of K/H_(G),where K is a normal supplement of H in G such that|K|is minimal and H_(G)≤K■G.Let p be a prime which divide... Let G be a finite group and H a subgroup of G.The normal index of H in G is defined as the order of K/H_(G),where K is a normal supplement of H in G such that|K|is minimal and H_(G)≤K■G.Let p be a prime which divides the order of a group G.In this paper,some characterizations of G being p-solvable or p-supersolvable were obtained by analyzing the normal index of certain subgroups of G.These results can be viewed as local version of recent results in the literature. 展开更多
关键词 p-solvable group p-supersolvable group normal index maximal subgroup 2-maximal subgroup
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Orientation-and wavelength-dependent sperm motility in optical trapping
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作者 Juan Wang Jifu Lyu +8 位作者 Haoyu Pan Xinyu Fan Xiang Jiang Xuhui Bao Yi Wang Fengya Lu Zhiguo Zhang Zhensheng Zhong Jinhua Zhou 《Journal of Innovative Optical Health Sciences》 2026年第2期54-68,共15页
Optical tweezers technology has the characteristics of noncontact manipulation in three dimensions and steerable separation in solutions,and could be applied to obtain a separated sperm with high quality for intracyto... Optical tweezers technology has the characteristics of noncontact manipulation in three dimensions and steerable separation in solutions,and could be applied to obtain a separated sperm with high quality for intracytoplasmic sperm injection(ICSI).However,the effects of optical tweezers on sperm motility are still unclear.To elucidate the effects on sperm motility for optical tweezers,we systematically investigated the correlation between motility parameters and the parameters of optical tweezers(wavelength,power,trapping duration,and trapping orientation).Under three systems of optical tweezers with different laser wavelengths(1064,850,and 785 nm),the nine motility parameters of free swimming were mainly affected by trapping orientation(vertical/horizontal)and trapping duration.When 850 nm laser and 1064 nm laser are used,vertical trapping significantly reduces sperm free-swimming capability with prolonged exposure time,whereas horizontal trapping exhibits relatively minor interference on sperm motility.Notably,the 785 nm laser does not induce statistically significant changes in key parameters of sperm motility under any experimental conditions(trapping orientation and duration).For the rolling frequency of trapped sperm,horizontal trapping for three wavelengths has a negligible effect compared with vertical trapping,especially for the 785 nm laser.In conclusion,horizontal trapping can preserve sperm motility under low power(below 140mW at 1064 nm,below 100mW at 850nm,below 60mW at 785 nm)and short duration(below 4 min).This trapping duration is suffcient for the separation procedure of single live sperm in ICSI.This study provides critical parameter optimization guidelines for the safe application of optical tweezers technology in reproductive medicine. 展开更多
关键词 Optical tweezers SPERM wavelength trapping duration trapping orientation
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Adaptive implementation of multi-branch convolution with fusion coefficients based on reconfigurable array
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作者 Liu Dongyue Jiang Lin +2 位作者 Wang Mei Li Yuancheng Hao Juan 《High Technology Letters》 2026年第1期39-48,共10页
Reconfigurable array architecture has become an important hardware platform for edge-side deployment of convolutional neural networks due to their high parallelism and flexible programmability.However,traditional mult... Reconfigurable array architecture has become an important hardware platform for edge-side deployment of convolutional neural networks due to their high parallelism and flexible programmability.However,traditional multi-branch convolutional networks suffer from computational redundancy,high memory access overhead,and inefficient branch fusion.Therefore,this paper proposes an adaptive multi-branch convolutional module(AMBC)that integrates software-hardware co-optimization.During training,the learnable fusion coefficients are introduced to enable adaptive fusion of multi-scale features,while in the inference phase,the multiple branches and their normalization parameters are merged with the fusion coefficients into a single 3×3 convolutional kernel through operator fusion.On the SIREA-288 reconfigurable platform,compared with unoptimized multi-branch networks,the proposed AMBC reduces external memory accesses by 47.91%and inference latency by 47.20%,achieving a 1.90×speedup.This approach maximizes the utilization of the reconfigurable logic while minimizing both reconfiguration and data-movement overheads in edge inference. 展开更多
关键词 reconfigurable array processor structural re-parameterization model compression fusion coefficients edge-side inference acceleration hardware-software co-optimization
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Multi-strategy improved sand cat swarm optimization based on somersault pursuit and adaptive Lévy flight
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作者 Wu Jin Xiong Hao +1 位作者 Luo Wenxuan Hao Chengbin 《High Technology Letters》 2026年第1期30-38,共9页
To address the limitations of the sand cat swarm optimization(SCSO) algorithm which are slow convergence and low accuracy in complex problems,this study proposes an improved SCSO(ISCSO) algorithm that integrates multi... To address the limitations of the sand cat swarm optimization(SCSO) algorithm which are slow convergence and low accuracy in complex problems,this study proposes an improved SCSO(ISCSO) algorithm that integrates multiple enhancement strategies.Firstly,Kent chaotic mapping initializes the population for uniform distribution.Secondly,somersault foraging strategy is introduced during the search and attack phases,allowing the algorithm to escape local optima by intercepting evasive prey.Simultaneously,an adaptive Lévy flight strategy is incorporated into the attack phase to bolster global exploration.Finally,the vertical and horizontal crossover strategy is implemented to enhance population diversity.The performance of the proposed algorithm is evaluated using 16 benchmark test functions.The experimental results demonstrate that ISCSO significantly outperforms the original SCSO and shows notable advantages over other metaheuristic algorithms.Furthermore,application to a pressure vessel design problem verifies ISCSO's effectiveness in solving practical engineering optimization challenges. 展开更多
关键词 sand cat swarm optimization Kent chaotic mapping somersault pursuit adaptive Lévy flight vertical and horizontal crossover
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3D radiation-hydrodynamics simulations of octahedral spherical hohlraums
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作者 Rafael Ramis 《Matter and Radiation at Extremes》 2026年第2期74-84,共11页
Achieving uniform X-ray irradiation in indirect-drive inertial confinement fusion(ICF)is a key challenge for successful capsule implosion.Spherical hohlraums,particularly those with octahedral laser entrance holes(LEH... Achieving uniform X-ray irradiation in indirect-drive inertial confinement fusion(ICF)is a key challenge for successful capsule implosion.Spherical hohlraums,particularly those with octahedral laser entrance holes(LEHs),are an alternative to the cylindrical hohlraums currently considered for ICF at NIF(USA)and LMJ(France).These spherical hohlraums are advantageous in terms of irradiation uniformity on the fusion capsule because,owing to their octahedral symmetry,low-order asymmetries cancel out intrinsically.However,they may be less favorable from an energetic point of view,primarily owing to radiation losses through their multiple LEHs.The net balance of these advantages and disadvantages is difficult to determine,because,unlike cylindrical hohlraums,they require fully 3D modeling.To address this,a new version of the MULTI-3D simulation code has been developed.MULTI-3D is a 3D radiation-hydrodynamics code with arbitrary Langrangian-Eulerian(ALE)hydrodynamics,multigroup SN radiation transport,and ray-tracing laser deposition.Using this tool,several aspects of the behavior of spherical hohlraums have been analyzed,with special attention to phenomena inaccessible to 2D modeling.In these targets,laser beams strike the inner walls at very oblique angles,and the expansion of plasma significantly alters the locations where primary X rays are produced.Furthermore,the complex distribution of laser hot spots leads to mutual interactions,where plasma bubbles from one beam intersect the path of another.The laser-to-X-ray energy conversion efficiency has been analyzed as a function of key parameters.The symmetry on the capsule has also been evaluated,revealing nonuniformities of less than 1%. 展开更多
关键词 octahedral laser entrance holes lehs cylindrical hohlraums irradiation uniformity spherical hohlraums octahedral spherical hohlraums capsule implosion fusion capsule indirect drive inertial confinement fusion
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Star-shaped Block Copolymers of Poly-2-alkyl-5,6-dihydrooxazines:Synthesis,Conformational Characteristics,Thermoresponsiveness and Complexation with Curcumin
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作者 Tatyana U.Kirila Serafim V.Rodchenko +2 位作者 Nina D.Kozina Andrey V.Tenkovtsev Alexander P.Filippov 《Chinese Journal of Polymer Science》 2026年第2期423-436,I0012,共15页
Star-shaped six-arm polymers with hexaaza[2_(6)]orthoparacyclophane core and arms of block copolymers of poly-2-ethyl-5,6-dihydrooxazine with poly-2-isopropyl-5,6-dihydrooxazine were synthesized successfully using cat... Star-shaped six-arm polymers with hexaaza[2_(6)]orthoparacyclophane core and arms of block copolymers of poly-2-ethyl-5,6-dihydrooxazine with poly-2-isopropyl-5,6-dihydrooxazine were synthesized successfully using cationic ring-opening polymerization.The ratio of blocks,the order of their attachment to the core,and arm length were varied.Conformation of synthesized stars was determined by methods of molecular hydrodynamics and optics.It has been shown that star-shaped molecules were characterized by high intramolecular density,and the arm folding increased with their lengthening.The influence of the structure of block copolymers and their molar mass on the critical micelle concentration has been established.Complexes of synthesized star-shaped block copolymers with curcumin were obtained and the efficient binding of curcumin to polymer molecules was demonstrated.The behavior of the aqueous solutions of the prepared polymer stars and their complexes with curcumin was investigated by light scattering and turbidimetry methods.The influence of the structure and molar mass of star polymers on their thermoresponsiveness and the phase separation temperatures in aqueous solutions was analyzed.A slight increase in the phase separation temperature was found on passage from polymer solutions to solutions of polymer complexes with hydrophobic curcumin. 展开更多
关键词 Thermoresponsive star-shaped polymers Block copolymer of poly-2-alkyl-5 6-dihydrooxazine Aqueous solutions Complex of polymer with curcumin Phase separation
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Comparing of small and large optimal tapered cascades for supplying enriched uranium for fresh fuel production in the equilibrium cycle of a nuclear power reactor
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作者 S.L.Mirmohammadi J.Safdari A.A.Ghorbanpour Khamseh 《Nuclear Science and Techniques》 2026年第3期208-234,共27页
One of the main issues in designing optimum tapered cascades for uranium enrichment for annual fuel production in a power reactor is whether to employ large(fat)or small(thin)cascades.What will be the permissible and ... One of the main issues in designing optimum tapered cascades for uranium enrichment for annual fuel production in a power reactor is whether to employ large(fat)or small(thin)cascades.What will be the permissible and optimal ranges of the number of machines that can be used in a cascade?For the first time,the permissible and optimal ranges of the number of gas centrifuges that can be utilized in a cascade were investigated using two types of centrifuges,and the performance of small and large tapered cascades was discussed.The particle swarm optimization algorithm(PSO)has been used to optimize tapered cascades.The results show:(1)For the first centrifuge,41 cascades(91≤n≤4897)and for the second centrifuge,49 cascades(18≤n≤3839)with small and large sizes can be used in enrichment facilities,and the best cascade for them has 530(with 23 stages)and 39(with 7 stages)centrifuges,respectively.(2)For both centrifuges,when 600≤n(number of centrifuges=n),the large cascade performance changes are relatively insignificant.(3)For both types of gas centrifuges,the annual los s of separation power in enrichment facilities is approximately 1.25%-4.82%of the total separation work required. 展开更多
关键词 Small tapered cascade(thin) Large tapered cascade(fat) Enriched uranium fuel Power reactor PSO algorithm
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Evaluation of Strip-Processed Cotton Stalks as a Raw Material for Structural Panels
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作者 Aadarsha Lamichhane Arun Kuttoor Vasudevan +3 位作者 Ethan Dean Mostafa Mohammadabadi Kevin Ragon Ardeshir Adeli 《Journal of Renewable Materials》 2026年第1期37-52,共16页
This study explores a novel method for processing cotton stalks—an abundant agricultural byproduct—into long strips that serve as sustainable raw material for engineered bio-based panels.To evaluate the effect of ra... This study explores a novel method for processing cotton stalks—an abundant agricultural byproduct—into long strips that serve as sustainable raw material for engineered bio-based panels.To evaluate the effect of raw material morphology on panel’s performance,two types of cotton stalk-based panels were developed:one using long strips,maintaining fiber continuity,and the other using ground particles,representing conventional processing.A wood strand-based panel made from commercial southern yellow pine strands served as the control.All panels were bonded using phenol-formaldehyde resin and hot-pressed to a target thickness of 12.7 mm and density of 640 kg/m^(3).Their mechanical and physical properties were evaluated through internal bond,bending,thickness swelling,and water absorption tests.Both cotton stalk-based panels showed improved bonding performance compared to the control.The internal bond of the strip-based panel was nearly four times higher than that of the control,while the particlebased panel exceeded it by a factor of two.The strip-based panel showed approximately 15% lower bending stiffness than the wood strand-based panel,yet it surpassed it in load-carrying capacity by 5%.In contrast,the particleboard showed significantly lower bending performance than the strip-based and control panels,despite particle processing being a more conventional method.Both cotton stalk-based panels exhibited higher water absorption and thickness swelling than the wood strand panel.Overall,cotton stalk-based panels—particularly those using strip processing—show promisingmechanical properties,suggesting potential applications in sheathing,furniture,and interior paneling.However,improvements in dimensional stability are needed for broader use. 展开更多
关键词 Crop residues bio-based materials cotton stalk experimental testing bending performance internal bond water absorption
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miR-449a:A Novel Biomarker for Diagnosis,Prognosis,and Treatment Response in Locally Advanced Laryngeal Squamous Cell Carcinoma
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作者 Amal F.Gharib Ohud Alsalmi +5 位作者 Hayaa M.Alhuthali Afaf Alharthi Saud Ayed Alharthi Shaimaa A.Alharthi Rasha L.Etewa Wael H.Elsawy 《Oncology Research》 2026年第3期558-574,共17页
Background:Locally advanced laryngeal squamous cell carcinoma(LA-LSCC)presents clinical challenges due to the lack of reliable non-invasive biomarkers.This study aimed to evaluate miR-449a as a diagnostic and prognost... Background:Locally advanced laryngeal squamous cell carcinoma(LA-LSCC)presents clinical challenges due to the lack of reliable non-invasive biomarkers.This study aimed to evaluate miR-449a as a diagnostic and prognostic biomarker in LA-LSCC.Methods:miR-449a expression was analyzed in tumor tissues,adjacent normal tissues,and serum from 81 LA-LSCC patients and 50 controls using quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR).We assessed the diagnostic accuracy by Receiver Operating Characteristic curve(ROC curves),clinicopathological associations,survival outcomes(Kaplan-Meier),and treatment response dynamics.Results:miR-449a was significantly downregulated in LA-LSCC tissues(p<0.0001)and serum(p<0.0001),with a strong tissue-serum correlation(R^(2)=0.988).Tissue miR-449a demonstrated a diagnostic accuracy(Area Under the Curve,AUC=0.857),while serum showed moderate accuracy(AUC=0.734).High miR-449a expression correlated with favorable clinicopathological features and improved survival(median overall survival:67.82 vs.23.74 months;p=0.0012).Multivariate analysis confirmed miR-449a as an independent prognostic factor(p<0.001).miR-449a levels increased post-treatment,particularly in responders to chemotherapy/radiation(p<0.0001).Conclusion:miR-449a serves as a non-invasive biomarker for LA-LSCC diagnosis,prognosis,and treatment monitoring.Its dynamic expression highlights potential for risk stratification and therapy response prediction,warranting further validation in larger cohorts. 展开更多
关键词 Locally advanced laryngeal squamous cell carcinoma(LA-LSCC) microRNA-449a(miR-449a) BIOMARKER PROGNOSIS DIAGNOSIS treatment response serum biomarker CHEMORADIOTHERAPY organ preservation
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Explainable AI for predicting the strength of bio-cemented sands
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作者 Waleed El-Sekelly Muhammad Nouman Amjad Raja Tarek Abdoun 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第2期1552-1569,共18页
The biological stabilization of soil using microbially induced carbonate precipitation(MICP)employs ureolytic bacteria to precipitate calcium carbonate(CaCO3),which binds soil particles,enhancing strength,stiffness,an... The biological stabilization of soil using microbially induced carbonate precipitation(MICP)employs ureolytic bacteria to precipitate calcium carbonate(CaCO3),which binds soil particles,enhancing strength,stiffness,and erosion resistance.The unconfinedcompressive strength(UCS),a key measure of soil strength,is critical in geotechnical engineering as it directly reflectsthe mechanical stability of treated soils.This study integrates explainable artificialintelligence(XAI)with geotechnical insights to model the UCS of MICP-treated sands.Using 517 experimental data points and a combination of various input variables—including median grain size(D50),coefficientof uniformity(Cu),void ratio(e),urea concentration(Mu),calcium concentration(Mc),optical density(OD)of bacterial solution,pH,and total injection volume(Vt)—fivemachine learning(ML)models,including eXtreme gradient boosting(XGBoost),Light gradient boosting machine(LightGBM),random forest(RF),gene expression programming(GEP),and multivariate adaptive regression splines(MARS),were developed and optimized.The ensemble models(XGBoost,LightGBM,and RF)were optimized using the Chernobyl disaster optimizer(CDO),a recently developed metaheuristic algorithm.Of these,LightGBM-CDO achieved the highest accuracy for UCS prediction.XAI techniques like feature importance analysis(FIA),SHapley additive exPlanations(SHAP),and partial dependence plots(PDPs)were also used to investigate the complex non-linear relationships between the input and output variables.The results obtained have demonstrated that the XAI-driven models can enhance the predictive accuracy and interpretability of MICP processes,offering a sustainable pathway for optimizing geotechnical applications. 展开更多
关键词 Microbially induced carbonate precipitation(MICP) Bio-cementation Unconfined compressive strength(UCS) Explainable artificialintelligence(XAI) Optimization
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Well-posedness and exponential stability of a dynamic frictionless contact problem with normal compliance and infinite memory
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作者 Imane Ouakil Benyattou Benabderrahmane Yamna Boukhatem 《Applied Mathematics(A Journal of Chinese Universities)》 2026年第1期99-119,共21页
A model for dynamic frictionless contact between a viscoelastic body and foundation is considered.The viscoelastic constitutive law is assumed to be nonlinear and the contact is modelled with the normal compliance con... A model for dynamic frictionless contact between a viscoelastic body and foundation is considered.The viscoelastic constitutive law is assumed to be nonlinear and the contact is modelled with the normal compliance condition.We obtain the well-posedness using nonlinear semigroup theory arguments.Moreover,the exponential stability result of the solution is shown by using the energy method to produce a suitable Lyapunov function. 展开更多
关键词 dynamic process viscoelastic body normal compliance nonlinear semigroup theory exponential stability
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Feasibility of water vapor thermal therapy for treating lower urinary tract symptoms in men with localized prostate cancer on active surveillance:a case series
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作者 Mustufa Babar Farooz Babar +2 位作者 Noah Hawks-Ladds Justin Loloi Michael Ciatto 《The Canadian Journal of Urology》 2026年第1期193-199,共7页
Background:Prostate cancer is a common malignancy,with many men on active surveillance for localized,low-risk disease also experiencing lower urinary tract symptoms(LUTS)from benign prostatic hyperplasia(BPH).Water Va... Background:Prostate cancer is a common malignancy,with many men on active surveillance for localized,low-risk disease also experiencing lower urinary tract symptoms(LUTS)from benign prostatic hyperplasia(BPH).Water Vapor Thermal Therapy(WVTT)is a minimally invasive BPH treatment,but its safety and efficacy in this setting are unclear.Case Description:We report three men with localized PCa on active surveillance who underwent WVTT for LUTS.Conclusions:WVTT appears safe and potentially effective in treating LUTS,especially in those with lower-risk disease and smaller prostate volumes.Further research is needed to confirm safety,efficacy,and optimal patient selection. 展开更多
关键词 lower urinary tract symptoms benign prostatic hyperplasia prostatic neoplasms active surveillance case report
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Zirconium-and hafnium-based chalcogenide perovskites:From materials to devices and applications
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作者 Hicham Zalrhi Salma Daim +4 位作者 Mohammed Makha Nelson Yaw Dzade Abdelkader Outzourhit Mohammed Abd-lefdil Lahoucine Atourki 《Journal of Energy Chemistry》 2026年第3期448-472,共25页
Chalcogenide perovskites(CPs)based on zirconium(Zr)and hafnium(Hf)are becoming increasingly attractive as a new class of materials for next-generation solar cells.CPs with the ABX_(3) structure stand out due to their ... Chalcogenide perovskites(CPs)based on zirconium(Zr)and hafnium(Hf)are becoming increasingly attractive as a new class of materials for next-generation solar cells.CPs with the ABX_(3) structure stand out due to their attractive optical and electrical properties,such as efficient light absorption,direct bandgaps in the range of 1.1–2.1 eV,and remarkable defect tolerance,making them a compelling alternative to hybrid and double perovskites for solar energy conversion.Although theoretical studies have progressed rapidly,experimental verification still faces challenges such as the high synthesis temperatures required(>900℃),particularly in producing high-quality,phase-pure thin films and scalable solution-based processes.In this review,we aim to provide a comprehensive overview of the progress and remaining obstacles in advancing CP-based materials and devices.First,we describe the structure and composition as well as the different CPs in which the B site is occupied by Zr and Hf.Second,we summarize the methods used and the challenges that researchers face in producing an effective device.We highlight the main features that make CPs a preferred option for photovoltaic and other applications.Third,we look at the progress made in simulating solar cells that can achieve a power conversion efficiency(PCE)of over 30%using SCAPS-1D software.In the end,challenges and future research directions toward the development of CP materials and devices are provided.Overall,this review will serve as a valuable resource for researchers in selecting suitable strategies to achieve high-performance optoelectronic devices. 展开更多
关键词 Chalcogenide perovskites Lead-free perovskites Solar energy conversion Thin-film fabrication Photovoltaic materials Perovskite based solar cells
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Effectiveness of conventional municipal wastewater treatment plants in microplastics removal:Insights from multiple analytical techniques
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作者 Simone Cavazzoli Costanza Scopetani +9 位作者 David Chelazzi Tania Martellini Alessandra Cincinelli Emiliano Carretti Miriam Ascolese Riccardo Gori Karl Mair Werner Tirler Massimo Donegà Gianni Andreottola 《Journal of Environmental Sciences》 2026年第2期424-438,共15页
This study investigated microplastics(MPs)sized 10–5000μm across stages of a conventional municipal wastewater treatment plant using multiple analytical techniques.Samples were collected via pumping and filtration,t... This study investigated microplastics(MPs)sized 10–5000μm across stages of a conventional municipal wastewater treatment plant using multiple analytical techniques.Samples were collected via pumping and filtration,treated with the Fenton reaction for wet peroxidation,and separated by density separation.Analysis employed Focal Plane Array Micro-Fourier Transform Infrared Spectroscopy(FPA micro-FTIR),a widely used technique in MPs analysis,alongside the less common Laser Direct Infrared Spectroscopy(LDIR),providing complementary data on particle composition,shape,size,and colour.To enhance insights,spectroscopic methods were supplemented with Thermal Desorption Gas Chromatography-Mass Spectrometry(TD-GC/MS),calibrated for specific polymers,to quantify MPs by mass and assess removal efficiency.Wastewater treatment effectively reduced MPs.In influent samples,concentrations reached 72 MPs/L(FTIR),2117 MPs/L(LDIR),and 177μg/L(TD-GC/MS).Primary treatments removed 41%–55%,while the wastewater treatment plant effluent contained 1 MPs/L(FTIR),93 MPs/L(LDIR),and 2μg/L(TD-GC/MS),reflecting 96%–99%removal efficiency.Activated sludge showed concentrations of 123 MPs/L(FTIR),10,800 MPs/L(LDIR),and 0.3 mg/g dry weight(TD-GC/MS),underscoring its role in MPs capture.However,sludge dewatering released significant MPs into centrifuge rejected water:484 MPs/L(FTIR),23,000 MPs/L(LDIR),and 1100μg/L(TD-GC/MS).These results highlight the effectiveness of conventional treatments in MPs removal and the critical role of sludge in capturing these contaminants.However,sludge dewatering poses a risk of reintroducing MPs into the environment.Effective sludge management should prioritize nutrient recovery and biomass valorisation to mitigate these risks and minimise harmful environmental impacts. 展开更多
关键词 Emerging contaminant Plastic pollution Analytical method Spectroscopy SPECTROMETRY MPs in WWTPs
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Hyponormal Block Toeplitz Operators on the Weighted Bergman Space with Circulant Symbols
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作者 FU Guangyang ZHOU Jiang 《数学进展》 北大核心 2026年第1期183-191,共9页
In this paper,we present a necessary and sufficient condition for hyponormal block Toeplitz operators T on the vector-valued weighted Bergman space with symbolsΦ(z)=G^(*)(z)+F(z),where F(z)=∑^(N)_(i)=1 A_(i)z^(i)and... In this paper,we present a necessary and sufficient condition for hyponormal block Toeplitz operators T on the vector-valued weighted Bergman space with symbolsΦ(z)=G^(*)(z)+F(z),where F(z)=∑^(N)_(i)=1 A_(i)z^(i)and G(z)=∑^(N)_(i)=1 A_(−i)z^(i),A_(i)ae culants. 展开更多
关键词 block Toeplitz operator hyponormal weighted Bergman space CIRCULANT COMMUTATOR
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