To the Editor:Postoperative organ injuries and complications are the leading causes of perioperative morbidity and mortality.Although many retrospective studies have revealed the association between intraoperative hyp...To the Editor:Postoperative organ injuries and complications are the leading causes of perioperative morbidity and mortality.Although many retrospective studies have revealed the association between intraoperative hypotension and perioperative organ injury,[1]the results of prospective randomized trials with regard to tight blood pressure management and clinical outcomes were inconsistent.[2–4]Organ injury could be also provoked by surgery-induced stress.Dexmedetomidine has been validated to attenuate the over-expression of stress mediators;however,whether perioperative dexmedetomidine can improve clinical outcomes remains uncertain.[5,6]Therefore,this 2×2 factorial randomized trial was designed to investigate whether targeted blood pressure management with/without dexmedetomidine administration could minimize the occurrence of a composite of major organ injuries and complications within 30 days in moderateto-high risk patients after major non-cardiac surgery.展开更多
When patients having major surgery reach the post-anaesthesia care unit,families naturally assume that they have survived the most dangerous part of the perioperative experience.Their assumption is wrong.Mortality in ...When patients having major surgery reach the post-anaesthesia care unit,families naturally assume that they have survived the most dangerous part of the perioperative experience.Their assumption is wrong.Mortality in the 30 days after surgery is 140 times higher than intraoperative mortality.^([1,2])In fact,if the month after surgery were considered a disease,it would be the world’s third leading cause of death.^([3])展开更多
基金supported by grants from the National Key Research&Development Program of China(Nos.2023YFC2506900 and 2018YFC2001800)the National High Level Hospital Clinical Research Funding(Nos.2022CR74 and 2022CR78 of Peking University First Hos pital)Braun Anesthesia Scientific Research Fund(No.BBDF-2019-004).
文摘To the Editor:Postoperative organ injuries and complications are the leading causes of perioperative morbidity and mortality.Although many retrospective studies have revealed the association between intraoperative hypotension and perioperative organ injury,[1]the results of prospective randomized trials with regard to tight blood pressure management and clinical outcomes were inconsistent.[2–4]Organ injury could be also provoked by surgery-induced stress.Dexmedetomidine has been validated to attenuate the over-expression of stress mediators;however,whether perioperative dexmedetomidine can improve clinical outcomes remains uncertain.[5,6]Therefore,this 2×2 factorial randomized trial was designed to investigate whether targeted blood pressure management with/without dexmedetomidine administration could minimize the occurrence of a composite of major organ injuries and complications within 30 days in moderateto-high risk patients after major non-cardiac surgery.
文摘When patients having major surgery reach the post-anaesthesia care unit,families naturally assume that they have survived the most dangerous part of the perioperative experience.Their assumption is wrong.Mortality in the 30 days after surgery is 140 times higher than intraoperative mortality.^([1,2])In fact,if the month after surgery were considered a disease,it would be the world’s third leading cause of death.^([3])
