Neuropsychological impairment has long been established as a fundamental characteristic of depression,but a generally accepted, specific pattern of neuropsychological impairment has not been summarized. In this study,...Neuropsychological impairment has long been established as a fundamental characteristic of depression,but a generally accepted, specific pattern of neuropsychological impairment has not been summarized. In this study,we examined the classic neuropsychological paradigm of self-face recognition, to explore whether the self was impaired in major depressive disorder(MDD). Eighteen MDD patients and 20 healthy subjects were recruited to participate in this study. By using a face morphing technique, we measured the size of processing bias in MDD patients during different face discrimination tasks relative to controls. Results of analysis of variance(ANOVA) showed a significant main effect of Group(F(1, 36)= 7.388, P =0.01). Subsequent independent t-tests further revealed that self bias(t = 2.636, P = 0.012) and self-recognition bias(t = 2.190, P = 0.035) observed in self-famous task and self-stranger task respectively for patients were significantly greater than that for controls. Both self-processing and selfrecognition were impaired in patients with MDD, indicating that MDD individuals might exist level of self-abnormalities. These findings provide a new perspective for further study on the etiological and pathological mechanisms of MDD.展开更多
基金funded by the National Health and Medical Research Council of Australia,Targeted Call for Research 1046692supported by NHMRC Career Development Fellowship(APP1061998)+2 种基金supported by an NHMRC Fellowshipsupported by an NHMRC Early Career Fellowship(APP1035887)supported by an Early Career Fellowship from the Society of Mental Health Research
基金supported by Beijing EducationCommittee Funds(1102013501)
文摘Neuropsychological impairment has long been established as a fundamental characteristic of depression,but a generally accepted, specific pattern of neuropsychological impairment has not been summarized. In this study,we examined the classic neuropsychological paradigm of self-face recognition, to explore whether the self was impaired in major depressive disorder(MDD). Eighteen MDD patients and 20 healthy subjects were recruited to participate in this study. By using a face morphing technique, we measured the size of processing bias in MDD patients during different face discrimination tasks relative to controls. Results of analysis of variance(ANOVA) showed a significant main effect of Group(F(1, 36)= 7.388, P =0.01). Subsequent independent t-tests further revealed that self bias(t = 2.636, P = 0.012) and self-recognition bias(t = 2.190, P = 0.035) observed in self-famous task and self-stranger task respectively for patients were significantly greater than that for controls. Both self-processing and selfrecognition were impaired in patients with MDD, indicating that MDD individuals might exist level of self-abnormalities. These findings provide a new perspective for further study on the etiological and pathological mechanisms of MDD.
