To investigate the fracture propagation characteristics and failure mechanism of anti-dip rock slope induced by underground mining,the Jiguanling landslide in Wulong,Chongqing,China is taken as the prototype,and physi...To investigate the fracture propagation characteristics and failure mechanism of anti-dip rock slope induced by underground mining,the Jiguanling landslide in Wulong,Chongqing,China is taken as the prototype,and physical model test is utilized to study the fracture evolution process,deformation characteristics and failure mechanism of anti-dip rock slope.In this study,the digital image correlation(DIC)technique and pressure acquisition system are combined to analyze the displacement and stress field of rock slope during underground mining stages.The results show that the anti-dip rock slope experiences four stages during underground coal mining:tensile fracture propagation in upper toppling zone,shallow damage in the lower shear zone,coal seam roof caving,failure of the whole slope.There is a phenomenon of local tensile and compressive stress conversion in upper toppling zone after roof caving.The appearance of coal seam roof caving increases the compressive area and pressure of the shear zone,leading to the failure of the shear blocks at the front edge,and ultimately causing failure of the whole slope.Mining with retained coal pillar before shallow failure in the shear zone can effectively block the impact of lower mining on the upper toppling zone,achieve a 16%contraction in toppling zone,and improve the stability of the slope.The failure mode of slope can be summarized as shear–slip–toppling collapse failure.This paper improves the understanding on the failure mechanism of anti-dip rock slope caused by underground mining.展开更多
Background:Primary liver cancer poses a significant global health burden,with projections indicating a surpassing of one million cases by 2025.Cuproptosis,a copper-dependent mechanism of cell death,plays a crucial rol...Background:Primary liver cancer poses a significant global health burden,with projections indicating a surpassing of one million cases by 2025.Cuproptosis,a copper-dependent mechanism of cell death,plays a crucial role in the pathogenesis,progression,and prognosis of various cancers,including hepatocellular carcinoma(HCC).Purpose:This study aimed to develop a prognostic model for HCC based on cuproptosis-related genes,utilizing clinical data and gene expression profiles from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)databases.Materials and Methods:Clinical features and gene expression data of HCC patients were collected from publicly available databases.Patients from TCGA were randomly divided into training and testing sets,and Lasso Cox regression was applied to develop a predictive model using cuproptosis-related genes.Results:The analysis identified Copper Metabolism Domain Containing 1(COMMD1)as a potential prognostic marker for HCC,with deletion of this gene impacting disease progression.Cellular functional experiments validated the role of COMMD1 in HCC.Conclusions:COMMD1 emerges as a promising candidate for HCC treatment,with implications for prognosis prediction and therapeutic targeting.展开更多
Lignin is a natural biopolymer with a complex three-dimensional network, commercially obtained from wasteliquid of paper pulp and bioethanol production, and could be a candidate for preparation of environment-friendly...Lignin is a natural biopolymer with a complex three-dimensional network, commercially obtained from wasteliquid of paper pulp and bioethanol production, and could be a candidate for preparation of environment-friendlybio-based polyphenol material. In the present work, the demethylated wheat straw alkali lignin (D-Lig), preparedby demethylation of wheat straw alkali lignin (Lig) using an in-situ generated Lewis acid, was used to synthesizebio-based phenol formaldehyde resin adhesive (D-LPF) applied in plywood. Effects of synthetic process’s factors,including lignin substitution for phenol, NaOH concentration and molar ratio of formaldehyde to phenol, on thebonding strength and free formaldehyde content of D-LPF were investigated in detail, and the optimum syntheticprocess of D-LPF was obtained as following: Lignin substitution for phenol 60%, NaOH concentration 5.0% andmolar ratio of formaldehyde to phenol 2.0, and under the optimum reaction condition, the D-LPF presented lower free formaldehyde content (0.18%) and higher bonding strength (2.19 MPa), which was better than those ofcontaining-lignin phenol formaldehyde resin adhesive (LPF). Additionally, the curing behavior of the adhesivewas studied by differential scanning calorimetry (DSC) combined with gel time. It can be obtained that D-LPFresin adhesive had the shortest gel time, and fastest curing rate, compared with those of PF and L-PF resin adhesives. The curing kinetics data was fitted well by Kissinger model using non-isothermal DSC method, and theaverage activation energy value was 85.3 kJ/mol, slightly higher than that of commercial PF resin, while lowerthan that of LPF (90.2 kJ/mol). Finally, based on the analytical results of high temperature fourier transform infrared spectroscopy (FTIR), a possible curing mechanism of D-LPF was proposed.展开更多
Objective:To evaluate some agricultural waste extracts as insecticide and their effects on enzyme activities in liver and kidney of male mice.Methods:The insecticidal activity of five tested compounds(one crude extrac...Objective:To evaluate some agricultural waste extracts as insecticide and their effects on enzyme activities in liver and kidney of male mice.Methods:The insecticidal activity of five tested compounds(one crude extract and 4 waste compounds) was bioassay against the 3rd instars of the Culex pipiens(Cx.pipiens) larvae in the laboratory.The LC_(50) values of eucalyptol,apricot kernel.Rice bran,corn,black liquor and white liquor are 91.45.1166.1,1203.3.21449.65.4025.78 and 6343.18 ppm,respectively.Selection of the compounds for the subsequent studies was not only dependent on LC_(50) values but also on the persistence of these wastes products on large scale.Results:White and black liquor did not produce any gross effect at 200 mg/Kg body weight.No apparent toxic symptoms were observed in tested animals during the whole period of the experimenl which run out for 14 days.No statistically significance was observed in the enzyme choliuesterase activity,the activities of liver enzymes and kidney function in treated mice with black and while liquors.While,no and slighl inhibition was observed after the 2weeks ol treatment period with deltamethrin and lenilrothion reached to about 24%in plasma cholinesterase enzyme activity.Significantly increase in the activities ol liver enzymes and kidney function in treated mice with deltamethrin and fenitrothion.Conclusions:Black liquor can be used efficiently In control Cx.pipiens larvae under laboratory condition.Environmental problem caused by rice straw can be solved by converting the waste material to beneficial natural selective insecticide.展开更多
The disposable income per capita of rural residents in Tibet was 7471 yuan in 2014. There is a high gap with the national average disposable income per capita of rural residents( 10489 yuan). Thus,it is urgent to incr...The disposable income per capita of rural residents in Tibet was 7471 yuan in 2014. There is a high gap with the national average disposable income per capita of rural residents( 10489 yuan). Thus,it is urgent to increase income of farmers and herdsmen in Tibet. On the basis of literature in recent years,this paper analyzed methods for increasing income of farmers and herdsmen in Tibet,major factors restricting increase of their income,and approaches for increasing their income. It is expected to provide certain reference for further expanding ideas of increase of their income in the new period.展开更多
In recent years,as China's industrialization process and urban-rural integration strategy have continued to deepen,some industrial and domestic wastewater has been discharged directly into rivers without effective...In recent years,as China's industrialization process and urban-rural integration strategy have continued to deepen,some industrial and domestic wastewater has been discharged directly into rivers without effective treatment.This has resulted in the continuous accumulation and enrichment of pollutants in water bodies.This phenomenon results in a significant accumulation of heavy metals in the sediment of water bodies,which not only represents a significant threat to the ecological environment but also ultimately poses a risk to human health.The objective of this study is to provide a comprehensive review of the current status of heavy metal pollution in water sediment in China.In addition,this paper analyzes the advantages and limitations of existing techniques for the harmless treatment of heavy metal pollution and forecasts the development direction of this field.展开更多
We report here the synthesis and in vivo anticonvulsant/neurotoxicity activities of a series of compounds belonging to 2-aryl-4-arylidene-1-phenyl-1H-imidazol-5(4H)-one. The scaffold is based on the commonality of 5-m...We report here the synthesis and in vivo anticonvulsant/neurotoxicity activities of a series of compounds belonging to 2-aryl-4-arylidene-1-phenyl-1H-imidazol-5(4H)-one. The scaffold is based on the commonality of 5-membered lactam ring structures as successful anticonvulsant agents. The present compounds exhibited a range of anticonvulsant activity in pentylenetetrazole (PTZ)-induced seizure test. In particular, the protection was excellent by compounds bearing furylmethylidene on C4, possibly due to good pharmacokinetic properties. It was found that high lipophilicity and/or electron deficient aryl ring substitution at C4 compromised the anticonvulsant activities. For example, chloro analogues were found much less active than unsubstituted phenyl or furyl derivatives. Regarding side effects, active compounds exerted no observable neurotoxic effect at their therapeutic doses in Chimney test.展开更多
Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the an...Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying mechanisms.The results showed that naringin inhibited H_(2)O_(2)-induced decline in cell viability and decreased,the content of reactive oxygen species in cells.Meanwhile,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde content.Naringin also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem cells.Moreover,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of lysosomes.Furthermore,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS)pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.展开更多
Alginate blended with cellulose nanocrystals(CNC),cellulose nanofibers(CNF),and tri-carboxylate cellulose nanofibers(TPC-CNF)prepared and encapsulated in the form of microcapsules(bio-polymeric beads).The cellulosic n...Alginate blended with cellulose nanocrystals(CNC),cellulose nanofibers(CNF),and tri-carboxylate cellulose nanofibers(TPC-CNF)prepared and encapsulated in the form of microcapsules(bio-polymeric beads).The cellulosic nanomaterials that used in this study were investigated as nanomaterials for wastewater treatment applications.Batch experiments were performed to study the removal of copper,lead,magnesium,and iron from aqueous solutions by the prepared beads.The effects of the sorbent dosage and the modified polymers on the removing efficiency of the metal cations were examined.Atomic absorption was used to measure the metal ions concentrations.The modified bio-polymeric beads(Alg-CNF,Alg-CNC,and Alg-TPC-CNF)exhibited high-efficiency towards removing of the metal cations;Cu^(2+),Pb^(2+),Mg^(2+),and Fe^(2+).The Alg-TPC-CNF composite was exhibited excellent removing efficiency which around 95%for Pb,92%for Cu,43%for Fe and 54%for Mg.These outcomes affirm that the utilization of nanomaterials giving higher adsorption capacities contrasted with similar material in its micro or macrostructure form.展开更多
Structure-soil interface friction characteristics is of importance to investigate the interaction between engineering structures and soils,especially for offshore structures.The interface friction behavior between mar...Structure-soil interface friction characteristics is of importance to investigate the interaction between engineering structures and soils,especially for offshore structures.The interface friction behavior between marine clay and structural materials with different roughness was studied in this paper by using 3D optical scanning tests,a modified direct shear device and numerical simulation.Relationships between the surface roughness of structures,water content and interface friction angle were presented by model tests.The increase of water contents decreased the interface friction angles.For interfaces with different roughness,the interface friction angles will be smaller than that of the soil when the water content exceeds a certain value.The roughness of the interface and the water content of the soil are mutually coupled to influence the coefficient of friction(COF).This paper proposed a Finite Element Method(FEM)to simulate the interface direct shear tests of structures with different roughness.The surface models with different roughness are established based on the structure data obtained by 3D scanning.The Coupled Eulerian-Lagrangian(CEL)approach was employed to analyse soils sheared by irregular surfaces.The interface behavior for interfaces with different roughness under cyclic shear stresses was analyzed by FEM.展开更多
OBJECTIVE:To evaluate the antidiarrheal effect of jujube honey on experimentally castor oil-induced diarrhea in mice by using different testing models(diarrhea,enteropooling and gastrointestinal motility).METHODS:The ...OBJECTIVE:To evaluate the antidiarrheal effect of jujube honey on experimentally castor oil-induced diarrhea in mice by using different testing models(diarrhea,enteropooling and gastrointestinal motility).METHODS:The mice intragastric administration castor oil was post-treated after 30 min with jujube honey,diluted jujube honey and loperamide or vehicles in different experimental groups.The onset and number of wet defecation on the absorbent paper was recorded for each animal for 4 h.Plasma was examined for C-reactive protein(CRP)and nitric oxide(NO)for clinical inflammation evaluation.The oxidative stress was investigated by superoxide dismutase(SOD)and catalase levels.RESULTS:The diluted jujube honey exhibited an important antidiarrheal activity manifested by significant delay in onset of diarrhea(P<0.05),loss in number of wet stools(P<0.001),total number of stools(P<0.001)and total stool weight of fecal output(P<0.001)in 4 h in castor oil-induced diarrheal groups.The inhibition of intestinal transit of charcoal meal(P<0.01)is a most likely mechanism that may account for antidiarrheal effect of jujube honey.It also significantly increased SOD and catalase levels(P<0.001)and significantly decreased CRP and NO in plasma diarrheic mice(P<0.01).CONCLUSION:The results of this research reveal that the jujube honey contains pharmacologically active compounds with antidiarrheal properties.However,diluted honey is more effective in the treatment of diarrhea and imbalance of intestinal motility.In conclusion,these findings illustrated the antidiarrheal activity effect of jujube honey and which has the strongest evidence supporting its use in the treatment of diarrhea in traditional medicine.展开更多
Identification of ocean eddies from a large amount of ocean data provided by satellite measurements and numerical simulations is crucial,while the academia has invented many traditional physical methods with accurate ...Identification of ocean eddies from a large amount of ocean data provided by satellite measurements and numerical simulations is crucial,while the academia has invented many traditional physical methods with accurate detection capability,but their detection computational efficiency is low.In recent years,with the increasing application of deep learning in ocean feature detection,many deep learning-based eddy detection models have been developed for more effective eddy detection from ocean data.But it is difficult for them to precisely fit some physical features implicit in traditional methods,leading to inaccurate identification of ocean eddies.In this study,to address the low efficiency of traditional physical methods and the low detection accuracy of deep learning models,we propose a solution that combines the target detection model Faster Region with CNN feature(Faster R-CNN)with the traditional dynamic algorithm Angular Momentum Eddy Detection and Tracking Algorithm(AMEDA).We use Faster R-CNN to detect and generate bounding boxes for eddies,allowing AMEDA to detect the eddy center within these bounding boxes,thus reducing the complexity of center detection.To demonstrate the detection efficiency and accuracy of this model,this paper compares the experimental results with AMEDA and the deep learning-based eddy detection method eddyNet.The results show that the eddy detection results of this paper are more accurate than eddyNet and have higher execution efficiency than AMEDA.展开更多
Several modifications in CA-4 were reported in literature for the development of various tubulin inhibitors. In our study, twenty-two newly synthesized heterocyclic derivatives of Combretastatin A-4 (CA-4) have been t...Several modifications in CA-4 were reported in literature for the development of various tubulin inhibitors. In our study, twenty-two newly synthesized heterocyclic derivatives of Combretastatin A-4 (CA-4) have been tested for their cytotoxic effect on four different types of cells with malignant behavior using CA-4 as a positive control. Compounds 5b, 15 and 16 showed the foremost potent antiproliferative activities as compared to CA-4 with IC50 starting from 6.9 to 13.7 μM. Molecular docking was performed with the crystal structure of tubulin employing a potent tubulin inhibitor CA-4 as a parent molecule. Molecular study advised that 5b, 15, 16 and 17 are promising tubulin inhibitors.展开更多
Immunotherapy that specifically targets tumor cells is the preferred approach to induce tumor regression.Over the pastdecade,significant progress has been made in devising various methods to direct the immune system t...Immunotherapy that specifically targets tumor cells is the preferred approach to induce tumor regression.Over the pastdecade,significant progress has been made in devising various methods to direct the immune system to respond to tumorcells.The major hurdle for successful immunotherapy is to overcome immune tolerance in the tumor microenvironment.Recent clinical trials with dendritic cell-based vaccination[1,2]and CTLA4 blocking antibodies[3]have shown greatpromise,though complete cancer regression is not always achieved[4].Currently,alternative strategies potentially leadingto cancer eradication or regression in animal or clinical models are being enthusiastically pursued.In this issue of CellResearch,Wang et al.report a novel way to induce tumor immunity by the use of irradiated autologous T cells[5].展开更多
Individuals frequently generate emotion during the anticipation process and the anticipatory emotion has an important adaptive significance, especially the negative anticipative emotion. Many researches used conscious...Individuals frequently generate emotion during the anticipation process and the anticipatory emotion has an important adaptive significance, especially the negative anticipative emotion. Many researches used conscious emotion regulation strategy and successfully reduced negative anticipatory emotion. However, it is costly for our limited cognition. In the present study, we used sentence unscrambling tasks to prime unconscious emotion control goal and investigated its effect on anticipatory anxiety, including experience and physiological activity. The results showed that 1) relative to anticipating neutral images, participations’ anxiety experience and skin conductance level were higher when anticipating negative and unknown images;2) participants who had a unconscious emotion control goal primed achieved the same decrease in skin conductance as those explicitly instructed to reappraise, compared to a control group;3) heart rate was not affected by experiment condition and anticipation type. Together, these findings suggest that unconscious emotion regulation may provide an effective mean of regulating negative anticipatory emotion.展开更多
Recently, due to the growth of environmental pollution and the increase in the resistance of microorganisms to artificially create chemical drugs, there has been an urgent need for a radical change in the direction of...Recently, due to the growth of environmental pollution and the increase in the resistance of microorganisms to artificially create chemical drugs, there has been an urgent need for a radical change in the direction of the medical preparations development, for changing chemicals to naturally produced ones based on herbal natural remedies. Since homeopathy is a branch of medicine that includes not only herbal preparations, but also chemical ingredients, our newly developed patent—although it belongs to the field of homeopathy—is its offshoot aimed solely at maintaining the body’s strength without harming it, increasing the survival of the body in a polluted environment removing toxins from the body by strengthening adaptive immune mechanisms. Thus, thyme, cumin, oregano, licorice, and other natural resources of the earth, which are the basis of our patent, successfully fight cold and diseases of the upper respiratory tract. The article presents a methodology for the development of a new herbal preparation, its dosage, and use as the main ingredient in a treatment course in infectious diseases.展开更多
At present,there is a great demand for building materials in the market,and the market prospect of building materials is relatively considerable.Through studying the composition of river sediment and its resource util...At present,there is a great demand for building materials in the market,and the market prospect of building materials is relatively considerable.Through studying the composition of river sediment and its resource utilization in the field of building materials,this paper expounds the current domestic scholars research on river sediment in building materials,and summarizes the current problems and challenges,so as to provide a reference for the sustainable development of river sediment in the field of building materials.展开更多
基金supported by the National Natural Science Foundation of China(52474092 and 52074042).
文摘To investigate the fracture propagation characteristics and failure mechanism of anti-dip rock slope induced by underground mining,the Jiguanling landslide in Wulong,Chongqing,China is taken as the prototype,and physical model test is utilized to study the fracture evolution process,deformation characteristics and failure mechanism of anti-dip rock slope.In this study,the digital image correlation(DIC)technique and pressure acquisition system are combined to analyze the displacement and stress field of rock slope during underground mining stages.The results show that the anti-dip rock slope experiences four stages during underground coal mining:tensile fracture propagation in upper toppling zone,shallow damage in the lower shear zone,coal seam roof caving,failure of the whole slope.There is a phenomenon of local tensile and compressive stress conversion in upper toppling zone after roof caving.The appearance of coal seam roof caving increases the compressive area and pressure of the shear zone,leading to the failure of the shear blocks at the front edge,and ultimately causing failure of the whole slope.Mining with retained coal pillar before shallow failure in the shear zone can effectively block the impact of lower mining on the upper toppling zone,achieve a 16%contraction in toppling zone,and improve the stability of the slope.The failure mode of slope can be summarized as shear–slip–toppling collapse failure.This paper improves the understanding on the failure mechanism of anti-dip rock slope caused by underground mining.
文摘Background:Primary liver cancer poses a significant global health burden,with projections indicating a surpassing of one million cases by 2025.Cuproptosis,a copper-dependent mechanism of cell death,plays a crucial role in the pathogenesis,progression,and prognosis of various cancers,including hepatocellular carcinoma(HCC).Purpose:This study aimed to develop a prognostic model for HCC based on cuproptosis-related genes,utilizing clinical data and gene expression profiles from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)databases.Materials and Methods:Clinical features and gene expression data of HCC patients were collected from publicly available databases.Patients from TCGA were randomly divided into training and testing sets,and Lasso Cox regression was applied to develop a predictive model using cuproptosis-related genes.Results:The analysis identified Copper Metabolism Domain Containing 1(COMMD1)as a potential prognostic marker for HCC,with deletion of this gene impacting disease progression.Cellular functional experiments validated the role of COMMD1 in HCC.Conclusions:COMMD1 emerges as a promising candidate for HCC treatment,with implications for prognosis prediction and therapeutic targeting.
基金This work was supported by the National Natural Science Foundation of China(51473024)by University Science Research General Project of Jiangsu Province(16KJD430001)。
文摘Lignin is a natural biopolymer with a complex three-dimensional network, commercially obtained from wasteliquid of paper pulp and bioethanol production, and could be a candidate for preparation of environment-friendlybio-based polyphenol material. In the present work, the demethylated wheat straw alkali lignin (D-Lig), preparedby demethylation of wheat straw alkali lignin (Lig) using an in-situ generated Lewis acid, was used to synthesizebio-based phenol formaldehyde resin adhesive (D-LPF) applied in plywood. Effects of synthetic process’s factors,including lignin substitution for phenol, NaOH concentration and molar ratio of formaldehyde to phenol, on thebonding strength and free formaldehyde content of D-LPF were investigated in detail, and the optimum syntheticprocess of D-LPF was obtained as following: Lignin substitution for phenol 60%, NaOH concentration 5.0% andmolar ratio of formaldehyde to phenol 2.0, and under the optimum reaction condition, the D-LPF presented lower free formaldehyde content (0.18%) and higher bonding strength (2.19 MPa), which was better than those ofcontaining-lignin phenol formaldehyde resin adhesive (LPF). Additionally, the curing behavior of the adhesivewas studied by differential scanning calorimetry (DSC) combined with gel time. It can be obtained that D-LPFresin adhesive had the shortest gel time, and fastest curing rate, compared with those of PF and L-PF resin adhesives. The curing kinetics data was fitted well by Kissinger model using non-isothermal DSC method, and theaverage activation energy value was 85.3 kJ/mol, slightly higher than that of commercial PF resin, while lowerthan that of LPF (90.2 kJ/mol). Finally, based on the analytical results of high temperature fourier transform infrared spectroscopy (FTIR), a possible curing mechanism of D-LPF was proposed.
文摘Objective:To evaluate some agricultural waste extracts as insecticide and their effects on enzyme activities in liver and kidney of male mice.Methods:The insecticidal activity of five tested compounds(one crude extract and 4 waste compounds) was bioassay against the 3rd instars of the Culex pipiens(Cx.pipiens) larvae in the laboratory.The LC_(50) values of eucalyptol,apricot kernel.Rice bran,corn,black liquor and white liquor are 91.45.1166.1,1203.3.21449.65.4025.78 and 6343.18 ppm,respectively.Selection of the compounds for the subsequent studies was not only dependent on LC_(50) values but also on the persistence of these wastes products on large scale.Results:White and black liquor did not produce any gross effect at 200 mg/Kg body weight.No apparent toxic symptoms were observed in tested animals during the whole period of the experimenl which run out for 14 days.No statistically significance was observed in the enzyme choliuesterase activity,the activities of liver enzymes and kidney function in treated mice with black and while liquors.While,no and slighl inhibition was observed after the 2weeks ol treatment period with deltamethrin and lenilrothion reached to about 24%in plasma cholinesterase enzyme activity.Significantly increase in the activities ol liver enzymes and kidney function in treated mice with deltamethrin and fenitrothion.Conclusions:Black liquor can be used efficiently In control Cx.pipiens larvae under laboratory condition.Environmental problem caused by rice straw can be solved by converting the waste material to beneficial natural selective insecticide.
基金Supported by Tibet Project of Humanities and Social Science Foundation of Ministry of Education(12XZJC790002)Young Scholar Project of Humanities and Social Science Foundation of Ministry of Education(13YJCZH156)Special Project of Philosophy and Social Science of Tibet Autonomous Region(13BJY012)
文摘The disposable income per capita of rural residents in Tibet was 7471 yuan in 2014. There is a high gap with the national average disposable income per capita of rural residents( 10489 yuan). Thus,it is urgent to increase income of farmers and herdsmen in Tibet. On the basis of literature in recent years,this paper analyzed methods for increasing income of farmers and herdsmen in Tibet,major factors restricting increase of their income,and approaches for increasing their income. It is expected to provide certain reference for further expanding ideas of increase of their income in the new period.
基金Supported by Provincial Undergraduate Innovation and Entrepreneurship Training Program of Jiangxi Provincial Department of Education(S202310846007,S202310846004).
文摘In recent years,as China's industrialization process and urban-rural integration strategy have continued to deepen,some industrial and domestic wastewater has been discharged directly into rivers without effective treatment.This has resulted in the continuous accumulation and enrichment of pollutants in water bodies.This phenomenon results in a significant accumulation of heavy metals in the sediment of water bodies,which not only represents a significant threat to the ecological environment but also ultimately poses a risk to human health.The objective of this study is to provide a comprehensive review of the current status of heavy metal pollution in water sediment in China.In addition,this paper analyzes the advantages and limitations of existing techniques for the harmless treatment of heavy metal pollution and forecasts the development direction of this field.
文摘We report here the synthesis and in vivo anticonvulsant/neurotoxicity activities of a series of compounds belonging to 2-aryl-4-arylidene-1-phenyl-1H-imidazol-5(4H)-one. The scaffold is based on the commonality of 5-membered lactam ring structures as successful anticonvulsant agents. The present compounds exhibited a range of anticonvulsant activity in pentylenetetrazole (PTZ)-induced seizure test. In particular, the protection was excellent by compounds bearing furylmethylidene on C4, possibly due to good pharmacokinetic properties. It was found that high lipophilicity and/or electron deficient aryl ring substitution at C4 compromised the anticonvulsant activities. For example, chloro analogues were found much less active than unsubstituted phenyl or furyl derivatives. Regarding side effects, active compounds exerted no observable neurotoxic effect at their therapeutic doses in Chimney test.
基金supported by the open project of the Key Laboratory of Environmental Pollution Monitoring and Disease Control,Ministry of Education,Guizhou Medical University,China (GMU-2022-HJZ-06)。
文摘Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying mechanisms.The results showed that naringin inhibited H_(2)O_(2)-induced decline in cell viability and decreased,the content of reactive oxygen species in cells.Meanwhile,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde content.Naringin also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem cells.Moreover,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of lysosomes.Furthermore,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS)pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.
基金The authors acknowledge the Science and Technology Development Fund(STDF),Egypt for financial support of the research activities related to the projectProject ID 15203+1 种基金The authors also gratefully express their sincere gratitude to the“PHC-UTIQUE CMCU”(18G1132)the CMPTM(17TM22),as well as to the Tunisian Ministry of Higher Education for the financial support.
文摘Alginate blended with cellulose nanocrystals(CNC),cellulose nanofibers(CNF),and tri-carboxylate cellulose nanofibers(TPC-CNF)prepared and encapsulated in the form of microcapsules(bio-polymeric beads).The cellulosic nanomaterials that used in this study were investigated as nanomaterials for wastewater treatment applications.Batch experiments were performed to study the removal of copper,lead,magnesium,and iron from aqueous solutions by the prepared beads.The effects of the sorbent dosage and the modified polymers on the removing efficiency of the metal cations were examined.Atomic absorption was used to measure the metal ions concentrations.The modified bio-polymeric beads(Alg-CNF,Alg-CNC,and Alg-TPC-CNF)exhibited high-efficiency towards removing of the metal cations;Cu^(2+),Pb^(2+),Mg^(2+),and Fe^(2+).The Alg-TPC-CNF composite was exhibited excellent removing efficiency which around 95%for Pb,92%for Cu,43%for Fe and 54%for Mg.These outcomes affirm that the utilization of nanomaterials giving higher adsorption capacities contrasted with similar material in its micro or macrostructure form.
基金supported by a grant from the National Natural Science Foundations of China(No.52171282)supported by Taishan Scholars Program of Shandong Province,China(No.tsqn202306098)the Shandong Provincial Key Research and Development Plan,China(No.2021ZLGX04).
文摘Structure-soil interface friction characteristics is of importance to investigate the interaction between engineering structures and soils,especially for offshore structures.The interface friction behavior between marine clay and structural materials with different roughness was studied in this paper by using 3D optical scanning tests,a modified direct shear device and numerical simulation.Relationships between the surface roughness of structures,water content and interface friction angle were presented by model tests.The increase of water contents decreased the interface friction angles.For interfaces with different roughness,the interface friction angles will be smaller than that of the soil when the water content exceeds a certain value.The roughness of the interface and the water content of the soil are mutually coupled to influence the coefficient of friction(COF).This paper proposed a Finite Element Method(FEM)to simulate the interface direct shear tests of structures with different roughness.The surface models with different roughness are established based on the structure data obtained by 3D scanning.The Coupled Eulerian-Lagrangian(CEL)approach was employed to analyse soils sheared by irregular surfaces.The interface behavior for interfaces with different roughness under cyclic shear stresses was analyzed by FEM.
文摘OBJECTIVE:To evaluate the antidiarrheal effect of jujube honey on experimentally castor oil-induced diarrhea in mice by using different testing models(diarrhea,enteropooling and gastrointestinal motility).METHODS:The mice intragastric administration castor oil was post-treated after 30 min with jujube honey,diluted jujube honey and loperamide or vehicles in different experimental groups.The onset and number of wet defecation on the absorbent paper was recorded for each animal for 4 h.Plasma was examined for C-reactive protein(CRP)and nitric oxide(NO)for clinical inflammation evaluation.The oxidative stress was investigated by superoxide dismutase(SOD)and catalase levels.RESULTS:The diluted jujube honey exhibited an important antidiarrheal activity manifested by significant delay in onset of diarrhea(P<0.05),loss in number of wet stools(P<0.001),total number of stools(P<0.001)and total stool weight of fecal output(P<0.001)in 4 h in castor oil-induced diarrheal groups.The inhibition of intestinal transit of charcoal meal(P<0.01)is a most likely mechanism that may account for antidiarrheal effect of jujube honey.It also significantly increased SOD and catalase levels(P<0.001)and significantly decreased CRP and NO in plasma diarrheic mice(P<0.01).CONCLUSION:The results of this research reveal that the jujube honey contains pharmacologically active compounds with antidiarrheal properties.However,diluted honey is more effective in the treatment of diarrhea and imbalance of intestinal motility.In conclusion,these findings illustrated the antidiarrheal activity effect of jujube honey and which has the strongest evidence supporting its use in the treatment of diarrhea in traditional medicine.
基金the National Science Foundation of China(No.42175194)the National Natural Science Foundation of China(No.41976165)for funding this work.
文摘Identification of ocean eddies from a large amount of ocean data provided by satellite measurements and numerical simulations is crucial,while the academia has invented many traditional physical methods with accurate detection capability,but their detection computational efficiency is low.In recent years,with the increasing application of deep learning in ocean feature detection,many deep learning-based eddy detection models have been developed for more effective eddy detection from ocean data.But it is difficult for them to precisely fit some physical features implicit in traditional methods,leading to inaccurate identification of ocean eddies.In this study,to address the low efficiency of traditional physical methods and the low detection accuracy of deep learning models,we propose a solution that combines the target detection model Faster Region with CNN feature(Faster R-CNN)with the traditional dynamic algorithm Angular Momentum Eddy Detection and Tracking Algorithm(AMEDA).We use Faster R-CNN to detect and generate bounding boxes for eddies,allowing AMEDA to detect the eddy center within these bounding boxes,thus reducing the complexity of center detection.To demonstrate the detection efficiency and accuracy of this model,this paper compares the experimental results with AMEDA and the deep learning-based eddy detection method eddyNet.The results show that the eddy detection results of this paper are more accurate than eddyNet and have higher execution efficiency than AMEDA.
文摘Several modifications in CA-4 were reported in literature for the development of various tubulin inhibitors. In our study, twenty-two newly synthesized heterocyclic derivatives of Combretastatin A-4 (CA-4) have been tested for their cytotoxic effect on four different types of cells with malignant behavior using CA-4 as a positive control. Compounds 5b, 15 and 16 showed the foremost potent antiproliferative activities as compared to CA-4 with IC50 starting from 6.9 to 13.7 μM. Molecular docking was performed with the crystal structure of tubulin employing a potent tubulin inhibitor CA-4 as a parent molecule. Molecular study advised that 5b, 15, 16 and 17 are promising tubulin inhibitors.
文摘Immunotherapy that specifically targets tumor cells is the preferred approach to induce tumor regression.Over the pastdecade,significant progress has been made in devising various methods to direct the immune system to respond to tumorcells.The major hurdle for successful immunotherapy is to overcome immune tolerance in the tumor microenvironment.Recent clinical trials with dendritic cell-based vaccination[1,2]and CTLA4 blocking antibodies[3]have shown greatpromise,though complete cancer regression is not always achieved[4].Currently,alternative strategies potentially leadingto cancer eradication or regression in animal or clinical models are being enthusiastically pursued.In this issue of CellResearch,Wang et al.report a novel way to induce tumor immunity by the use of irradiated autologous T cells[5].
文摘Individuals frequently generate emotion during the anticipation process and the anticipatory emotion has an important adaptive significance, especially the negative anticipative emotion. Many researches used conscious emotion regulation strategy and successfully reduced negative anticipatory emotion. However, it is costly for our limited cognition. In the present study, we used sentence unscrambling tasks to prime unconscious emotion control goal and investigated its effect on anticipatory anxiety, including experience and physiological activity. The results showed that 1) relative to anticipating neutral images, participations’ anxiety experience and skin conductance level were higher when anticipating negative and unknown images;2) participants who had a unconscious emotion control goal primed achieved the same decrease in skin conductance as those explicitly instructed to reappraise, compared to a control group;3) heart rate was not affected by experiment condition and anticipation type. Together, these findings suggest that unconscious emotion regulation may provide an effective mean of regulating negative anticipatory emotion.
文摘Recently, due to the growth of environmental pollution and the increase in the resistance of microorganisms to artificially create chemical drugs, there has been an urgent need for a radical change in the direction of the medical preparations development, for changing chemicals to naturally produced ones based on herbal natural remedies. Since homeopathy is a branch of medicine that includes not only herbal preparations, but also chemical ingredients, our newly developed patent—although it belongs to the field of homeopathy—is its offshoot aimed solely at maintaining the body’s strength without harming it, increasing the survival of the body in a polluted environment removing toxins from the body by strengthening adaptive immune mechanisms. Thus, thyme, cumin, oregano, licorice, and other natural resources of the earth, which are the basis of our patent, successfully fight cold and diseases of the upper respiratory tract. The article presents a methodology for the development of a new herbal preparation, its dosage, and use as the main ingredient in a treatment course in infectious diseases.
基金Supported by Undergraduate Training Program for Innovation and Entrepreneurship of Jiangxi Provincial Department of Education(S202310846004&S202310846007).
文摘At present,there is a great demand for building materials in the market,and the market prospect of building materials is relatively considerable.Through studying the composition of river sediment and its resource utilization in the field of building materials,this paper expounds the current domestic scholars research on river sediment in building materials,and summarizes the current problems and challenges,so as to provide a reference for the sustainable development of river sediment in the field of building materials.
