AIM:To identify differences in clinical features between thyroid eye disease(TED)patients with and without strabismus.METHODS:This retrospective,single-center,consecutive case series study was conducted on TED patient...AIM:To identify differences in clinical features between thyroid eye disease(TED)patients with and without strabismus.METHODS:This retrospective,single-center,consecutive case series study was conducted on TED patients who were determined to be surgical candidates.The patients’cohort were divided into two groups based on the presence or absence of strabismus.Demographics and complete eye examinations were recorded and compared between the TED and TED with strabismus groups.RESULTS:A total of 76 patients with TED were enrolled,including 58 males(76.3%)with a mean age of 52.68±10.45y.The 55 patients(male:female=2:1)were found to have TED with strabismus,while the remaining 21 patients(male:female=4:1)had TED without strabismus.There was nearly a four times greater likelihood of lid retraction being associated with TED without strabismus(OR=4.1,P=0.018)and they showed higher prevalence of proptosis(95.2%)than the TED strabismus group(63.6%,P<0.001).In the TED-strabismus group,20%of patients had abnormal head posture(AHP),while none were identified in the TED group(P=0.029).Despite the higher incidence of vision-threatening complications such as dysthyroid optic neuropathy(19%vs 8.1%)and exposure keratopathy(4.8%vs 1.8%)in the TED group than in the TED-strabismus group,the difference did not reach statistical significance(P>0.05).The most common types of strabismus were hypotropia(36%)and esotropia(29%),respectively.CONCLUSION:Strabismus-associated TED is characterized by a lower prevalence of proptosis and lid retraction,but a higher incidence of compensatory AHP.Identifying these differences may aid in risk stratification and early intervention for TED patients,particularly those at risk for restrictive strabismus.展开更多
AIM： To evaluate the clinical utility of automated refraction（AR） and keratometry（KR） compared with subjective or manifest refraction（MR） after cataract or refractive lens exchange surgery with implantation of ...AIM： To evaluate the clinical utility of automated refraction（AR） and keratometry（KR） compared with subjective or manifest refraction（MR） after cataract or refractive lens exchange surgery with implantation of Lentis Mplus X（Oculentis GmbH） refractive multifocal intraocular lens（IOL）.METHODS： Eighty-six eyes implanted with the Lentis Mplus X multifocal IOL were included. MR was performed in all patients followed by three consecutive AR measurements using the Topcon KR-8000 autorefractor. Assessment of repeatability of consecutive AR before and after dilation with phenylephrine 10%, and comparison of the AR and KR with MR using vector analysis were performed at 3 mo follow-up.RESULTS： Analysis showed excellent repeatability of the AR measurements. Linear regression of AR versus MR showed good correlation for sphere and spherical equivalent, whereas the correlation for astigmatism was low. The mean difference AR-MR was-1.28±0.29 diopters（D） for sphere. Astigmatism showed better correlation between KR and MR. CONCLUSION： We suggest AR sphere plus 1.25 D and the KR cylinder as the starting point for MR in eyes with a Lentis Mplus X multifocal IOL. If AR measurements are equal to MR, decentration of the IOL should be suspected.展开更多
The changes in the iridocorneal angle structure during accommodation are assessed by means of anterior segment optical coherence tomography.Thirteen right eyes were included in the study.The device used for the measur...The changes in the iridocorneal angle structure during accommodation are assessed by means of anterior segment optical coherence tomography.Thirteen right eyes were included in the study.The device used for the measurement was the Visante？omni system.The stimuli were set up at different vergences（0.0 D,-1.5 D,and-3.0 D）.The angle opening distance 500 and 750,the trabecular iris space area 500 and 750,and the scleral spur angle parameters were assessed at the nasal and temporal regions.The results in the iridotrabecular angle comparing the three accommodative states of the eye did not yield any statistically significant difference at nasal or temporal angle sections.In light of our results and in the conditions of our study,the structures of the iridocorneal angle are not significantly changed with accommodation.展开更多
Background To evaluate the axial length acquisition success rates and agreement between various biometric parameters obtained with different biometers in dense cataracts.Methods Fifty-one eyes were measured using Ante...Background To evaluate the axial length acquisition success rates and agreement between various biometric parameters obtained with different biometers in dense cataracts.Methods Fifty-one eyes were measured using Anterion,Argos and IOL Master 700 swept-source optical coherence tomography(SS-OCT)biometers,a Pentacam AXL partial coherence interferometry(PCI)biometer,and an OcuScan RxP ultrasound biometer.We measured keratometry(K1,flattest keratometry and K2,steepest keratometry),white-to-white(WTW),anterior chamber depth(ACD),lens thickness(LT)and axial length.Cataracts were classified according to the Lens Opacities Classification System Ⅲ grading system,the dysfunctional lens index(DLI)and Pentacam nucleus staging(PNS)metrics.Percentage of acquisition success rate and a Bland-Altman analysis for the agreement between biometers were calculated.Results The mean LOCSⅢ score was 3.63±0.92,the mean DLI was 2.95±1.30,and the mean PNS was 2.36±1.20.The acquisition success rates for the Anterion,Argos,IOLMaster 700,Pentacam AXL and OcuScan RxP biometers were 94.12%,100%,98.04%,60.78% and 100%,respectively.There were significant differences in the success rates between biometers(P=O.014).There were statistically significant differences between biometers for all parameters evaluated(P<O.05).The range of the limit of agreement(LoA)for all comparisons of K1 and K2 were>1.00 D.The LoA for WTW ranged from 0.095 to 1.050 mm.The LoA for ACD and LT ranged from 0.307 to 0.114 mm and from 0.378 to 0.108 mm,respectively.The LoA for axial length ranged from 0.129 to 2.378 mm.Conclusions Among optical biometers,those based on SS-OcT technology are more successful at measuring axial length in eyes with dense cataracts.Trial Registration:The study was registered with the National Institutes of Health(clinical trial identifier NCT05239715,http://www.clinicaltrials.gov).展开更多
Background To evaluate the repeatability of a fully automated swept-source optical coherence tomography(SSOCT)and its agreement with an optical low coherence reflectometry(OLCR)for several biometric parameters.Methods...Background To evaluate the repeatability of a fully automated swept-source optical coherence tomography(SSOCT)and its agreement with an optical low coherence reflectometry(OLCR)for several biometric parameters.Methods In this study,74 eyes of 74 patients were measured using the Eyestar 900 SS-OCT and Lenstar LS 900 OLCR.Flat keratometry(K1)and steep keratometry(K2),central corneal thickness(CCT),anterior chamber depth(ACD),lens thickness(LT),and axial length(AL)were measured three times with each device.The repeatability was analyzed with the intrasubject standard deviation,coefficient of variability(CoV),and coefficient of repeatability(CoR)for each instrument.The agreement between the instruments was evaluated with Bland-Altman analysis.Results K1,K2 and CCT CoV values were<0.2%,<0.4%and<0.55%,respectively.Higher CoV values were found for ACD and LT ranging from 0.56%to 1.74%.The lowest CoV values were found for the AL measurements(0.03%and 0.06%for the Eyestar 900 and the Lenstar LS 900,respectively).AL measurements provided the highest repeatability,measured with both CoV and CoR values,and the CCT was the parameter with the lowest repeatability.The CCT and LT measurements were statistically significant between the two biometers(P<0.001).The interval of the limits of agreement was<0.6 D for K1 and K2,15.78μm for CCT,0.21 mm for ACD,0.34 mm for LT,and 0.08 mm for AL.Conclusions Both biometers provide repeatable measurements for the different parameters analyzed and can be used interchangeably.展开更多
文摘AIM:To identify differences in clinical features between thyroid eye disease(TED)patients with and without strabismus.METHODS:This retrospective,single-center,consecutive case series study was conducted on TED patients who were determined to be surgical candidates.The patients’cohort were divided into two groups based on the presence or absence of strabismus.Demographics and complete eye examinations were recorded and compared between the TED and TED with strabismus groups.RESULTS:A total of 76 patients with TED were enrolled,including 58 males(76.3%)with a mean age of 52.68±10.45y.The 55 patients(male:female=2:1)were found to have TED with strabismus,while the remaining 21 patients(male:female=4:1)had TED without strabismus.There was nearly a four times greater likelihood of lid retraction being associated with TED without strabismus(OR=4.1,P=0.018)and they showed higher prevalence of proptosis(95.2%)than the TED strabismus group(63.6%,P<0.001).In the TED-strabismus group,20%of patients had abnormal head posture(AHP),while none were identified in the TED group(P=0.029).Despite the higher incidence of vision-threatening complications such as dysthyroid optic neuropathy(19%vs 8.1%)and exposure keratopathy(4.8%vs 1.8%)in the TED group than in the TED-strabismus group,the difference did not reach statistical significance(P>0.05).The most common types of strabismus were hypotropia(36%)and esotropia(29%),respectively.CONCLUSION:Strabismus-associated TED is characterized by a lower prevalence of proptosis and lid retraction,but a higher incidence of compensatory AHP.Identifying these differences may aid in risk stratification and early intervention for TED patients,particularly those at risk for restrictive strabismus.
文摘AIM： To evaluate the clinical utility of automated refraction（AR） and keratometry（KR） compared with subjective or manifest refraction（MR） after cataract or refractive lens exchange surgery with implantation of Lentis Mplus X（Oculentis GmbH） refractive multifocal intraocular lens（IOL）.METHODS： Eighty-six eyes implanted with the Lentis Mplus X multifocal IOL were included. MR was performed in all patients followed by three consecutive AR measurements using the Topcon KR-8000 autorefractor. Assessment of repeatability of consecutive AR before and after dilation with phenylephrine 10%, and comparison of the AR and KR with MR using vector analysis were performed at 3 mo follow-up.RESULTS： Analysis showed excellent repeatability of the AR measurements. Linear regression of AR versus MR showed good correlation for sphere and spherical equivalent, whereas the correlation for astigmatism was low. The mean difference AR-MR was-1.28±0.29 diopters（D） for sphere. Astigmatism showed better correlation between KR and MR. CONCLUSION： We suggest AR sphere plus 1.25 D and the KR cylinder as the starting point for MR in eyes with a Lentis Mplus X multifocal IOL. If AR measurements are equal to MR, decentration of the IOL should be suspected.
基金Support by the Ministerio de Economiay Competitivad[Research project SAF2013-44510-R with ERDF(European Regional Development Funds)from European Union]Daniel Monsálvez-Romín has a "Formación de Profesorado Universitario" Grant(FPU13/05332,Ministerio de Educación,Cultura y Deporte)Antonio Deláguila-Carrasco has an"Atraccióde talent"research scholarship(Universitat de València UV-INV-PREDOC14-179135)
文摘The changes in the iridocorneal angle structure during accommodation are assessed by means of anterior segment optical coherence tomography.Thirteen right eyes were included in the study.The device used for the measurement was the Visante？omni system.The stimuli were set up at different vergences（0.0 D,-1.5 D,and-3.0 D）.The angle opening distance 500 and 750,the trabecular iris space area 500 and 750,and the scleral spur angle parameters were assessed at the nasal and temporal regions.The results in the iridotrabecular angle comparing the three accommodative states of the eye did not yield any statistically significant difference at nasal or temporal angle sections.In light of our results and in the conditions of our study,the structures of the iridocorneal angle are not significantly changed with accommodation.
基金supported by an investigator-initiated study grant from Alcon Laboratories(IIT#68386009).
文摘Background To evaluate the axial length acquisition success rates and agreement between various biometric parameters obtained with different biometers in dense cataracts.Methods Fifty-one eyes were measured using Anterion,Argos and IOL Master 700 swept-source optical coherence tomography(SS-OCT)biometers,a Pentacam AXL partial coherence interferometry(PCI)biometer,and an OcuScan RxP ultrasound biometer.We measured keratometry(K1,flattest keratometry and K2,steepest keratometry),white-to-white(WTW),anterior chamber depth(ACD),lens thickness(LT)and axial length.Cataracts were classified according to the Lens Opacities Classification System Ⅲ grading system,the dysfunctional lens index(DLI)and Pentacam nucleus staging(PNS)metrics.Percentage of acquisition success rate and a Bland-Altman analysis for the agreement between biometers were calculated.Results The mean LOCSⅢ score was 3.63±0.92,the mean DLI was 2.95±1.30,and the mean PNS was 2.36±1.20.The acquisition success rates for the Anterion,Argos,IOLMaster 700,Pentacam AXL and OcuScan RxP biometers were 94.12%,100%,98.04%,60.78% and 100%,respectively.There were significant differences in the success rates between biometers(P=O.014).There were statistically significant differences between biometers for all parameters evaluated(P<O.05).The range of the limit of agreement(LoA)for all comparisons of K1 and K2 were>1.00 D.The LoA for WTW ranged from 0.095 to 1.050 mm.The LoA for ACD and LT ranged from 0.307 to 0.114 mm and from 0.378 to 0.108 mm,respectively.The LoA for axial length ranged from 0.129 to 2.378 mm.Conclusions Among optical biometers,those based on SS-OcT technology are more successful at measuring axial length in eyes with dense cataracts.Trial Registration:The study was registered with the National Institutes of Health(clinical trial identifier NCT05239715,http://www.clinicaltrials.gov).
文摘Background To evaluate the repeatability of a fully automated swept-source optical coherence tomography(SSOCT)and its agreement with an optical low coherence reflectometry(OLCR)for several biometric parameters.Methods In this study,74 eyes of 74 patients were measured using the Eyestar 900 SS-OCT and Lenstar LS 900 OLCR.Flat keratometry(K1)and steep keratometry(K2),central corneal thickness(CCT),anterior chamber depth(ACD),lens thickness(LT),and axial length(AL)were measured three times with each device.The repeatability was analyzed with the intrasubject standard deviation,coefficient of variability(CoV),and coefficient of repeatability(CoR)for each instrument.The agreement between the instruments was evaluated with Bland-Altman analysis.Results K1,K2 and CCT CoV values were<0.2%,<0.4%and<0.55%,respectively.Higher CoV values were found for ACD and LT ranging from 0.56%to 1.74%.The lowest CoV values were found for the AL measurements(0.03%and 0.06%for the Eyestar 900 and the Lenstar LS 900,respectively).AL measurements provided the highest repeatability,measured with both CoV and CoR values,and the CCT was the parameter with the lowest repeatability.The CCT and LT measurements were statistically significant between the two biometers(P<0.001).The interval of the limits of agreement was<0.6 D for K1 and K2,15.78μm for CCT,0.21 mm for ACD,0.34 mm for LT,and 0.08 mm for AL.Conclusions Both biometers provide repeatable measurements for the different parameters analyzed and can be used interchangeably.
