To the Editor： The Chinese government is actively advocating medical reform, aiming at reducing medical costs, and improving service quality. As to ophthalmology, transition from traditional hospitalized surgery to a...To the Editor： The Chinese government is actively advocating medical reform, aiming at reducing medical costs, and improving service quality. As to ophthalmology, transition from traditional hospitalized surgery to a predominant outpatient mode could be a solution. Zhongshan Ophthalmic Center （ZOC） is one of the largest and leading ophthalmic centers in China,展开更多
AIM:To investigate the effects of shortening the duration of silicone oil tamponade on retinal structure and function in patients undergoing silicone oil removal(SOR)after surgery for primary rhegmatogenous retinal de...AIM:To investigate the effects of shortening the duration of silicone oil tamponade on retinal structure and function in patients undergoing silicone oil removal(SOR)after surgery for primary rhegmatogenous retinal detachment(RRD).METHODS:A total of 58 eligible patients were enrolled and randomly assigned to two groups based on tamponade duration:the short-term group(30-45d)and the conventional group(≥90d).Comprehensive evaluations were performed before and after SOR,including slitlamp examination,best-corrected visual acuity(BCVA)measurement,intraocular pressure(IOP)testing,optical coherence tomography(OCT),optical coherence tomography angiography(OCTA),microperimetry,electroretinography(ERG),and visual evoked potential(VEP)assessment.RESULTS:A total of 33 patients(23 males and 10 females;33 eyes)were enrolled in the short-term SO tamponade group with mean age of 52.45±9.35y,and 25 patients(15 males and 10 females;25 eyes)were enrolled in the conventional SO tamponade group with mean age of 50.80±12.06y.Compared with the conventional group,the short-term silicone oil tamponade group had a significantly lower incidence of silicone oil emulsification and cataract progression,with no significant difference in retinal reattachment success rate.Structurally,short-term tamponade was associated with increased thickness of the retinal ganglion cell layer(RGCL)in the nasal and superior macular regions and improved recovery of superficial retinal vascular density in these areas.Functionally,the shortterm group showed better BCVA and retinal sensitivity both before and 1mo after SOR;additionally,the P100 amplitude in VEP tests was significantly increased in this group.CONCLUSION:Shortening the duration of silicone oil tamponade effectively reduces damage to retinal structure and function without compromising the success rate of retinal reattachment in patients with primary RRD.展开更多
AIM:To comprehensively assess the relationship between asthma and myopia based on the National Health and Nutrition Examination Survey(NHANES)database combined with Mendelian randomization(MR).METHODS:Initially,20497 ...AIM:To comprehensively assess the relationship between asthma and myopia based on the National Health and Nutrition Examination Survey(NHANES)database combined with Mendelian randomization(MR).METHODS:Initially,20497 subjects from the complete questionnaire cycle in the NHANES database from 2005 to 2008 were included.By exclusion criteria,8460 subjects were screened with 1676 myopia samples and 6784 control samples.Subsequently,baseline characteristics,association analyses,risk stratification analyses,and receive operating characteristic curve(ROC)were used to investigate the associations between covariates and myopia.Then,the causal relationship was explored in depth by MR analysis,and was estimated the reliability by sensitivity analyses and directionality tests.RESULTS:Baseline characteristics illustrated a significant difference between myopia and controls for both asthma and covariates(excluding gender;P<0.05).The results in all three models indicated that asthma was strongly associated with myopia and the effect on myopia was not significantly confounded by other covariates[model 3:odd ratio(OR)=1.31;95%CI=1.07-1.62;P=0.0133].The risk stratification analysis again verified that asthma remained strongly associated with myopia and was a risk factor for myopia(P<0.05,OR>1).ROC proved that the model was accurate in its prediction[area under curve(AUC)=0.7].Subsequently,the causal relationship between them was statistically significant(P<0.05)according to the inverse variance weighted(IVW)method in MR.Scatterplot showed that asthma and myopia had significant positive causality and were not affected by confounders.Forest plot displayed an increasing risk of myopia on asthma(OR>1).The funnel plot demonstrated compliance with Mendel’s second law.Sensitivity analysis and directional analysis further confirmed the confidence of the MR analysis results and a unidirectional causal relationship between them.CONCLUSION:A significant association and causality between asthma and myopia is found through the NHANES database and MR analysis,which is important implications for public health policy development and clinical practice.展开更多
Dear Editor,Dorsal pontine lesions may cause a variety of complex neuro-ophthalmic deficits,including horizontal gaze palsy(HGP),internuclear ophthalmoplegia,one-and-ahalf syndrome,abducens nerve palsy,skew deviation,...Dear Editor,Dorsal pontine lesions may cause a variety of complex neuro-ophthalmic deficits,including horizontal gaze palsy(HGP),internuclear ophthalmoplegia,one-and-ahalf syndrome,abducens nerve palsy,skew deviation,or any combination of these.Here we present a rare case of an adult patient who developed multiple complicated clinical manifestations after surgical removal of a pontine cavernous hemangioma(PCH).Our case highlights a single pontine lesion may involve complicated neural pathways and result in complicated symptoms and signs,in which abducens nerve palsy or skew deviation is easily missed when combined with HGP.展开更多
AIM:To evaluate the agreement of axial length(AL),anterior chamber parameters,and total cornea power obtained by swept-source optical coherence tomography(SS-OCT)-based and Scheimpflug-based optical biometers in myopi...AIM:To evaluate the agreement of axial length(AL),anterior chamber parameters,and total cornea power obtained by swept-source optical coherence tomography(SS-OCT)-based and Scheimpflug-based optical biometers in myopic children.METHODS:AL,steep keratometry(K),flat K,posterior corneal keratometry(PK),total keratometry(TK),anterior chamber depth(ACD),horizontal corneal diameter(CD),and central corneal thickness(CCT)were obtained using IOL Master 700 and Pentacam AXL.The agreement between the devices was evaluated using intraclass correlation coefficients(ICC),Bland-Altman plots,and astigmatism vector analysis.RESULTS:Totally 175 myopic children(48.5%male)with a mean age of 10.29±2.14y were enrolled.The ICC and Bland-Altman plots indicated a satisfactory agreement for AL,ACD,and CCT.The mean difference in CD of-0.31±0.30 mm was considered clinically significant(>0.2 mm).Additionally,measurements of K and TK obtained from the IOL Master 700 showed good agreement.Nevertheless,there were clinically significant differences observed in PK,simulated keratometry(simK),total cornea power,and astigmatism(at least 10%of the cases with a difference of>10 degrees in meridian)between the two devices.CONCLUSION:The study findings demonstrate a significant difference in K,PK,astigmatism,and CD,indicating that the two optical biometers cannot be considered interchangeable.Therefore,it is recommended to utilize one kind device for follow-up examinations in myopic children.展开更多
AIM:To investigate the characteristics and associated factors of intraocular lens(IOL)tilt and decentration after transscleral suture-fixated IOL surgery in congenital ectopia lentis(CEL).METHODS:CEL patients undergoi...AIM:To investigate the characteristics and associated factors of intraocular lens(IOL)tilt and decentration after transscleral suture-fixated IOL surgery in congenital ectopia lentis(CEL).METHODS:CEL patients undergoing transscleral suture-fixated IOL surgery were divided into two groups based on implanted IOL type(three-piece IOL or one-piece IOL).The IOL tilt and decentration at 3-month and 1-year postoperative were measured.Multivariate regression analyses were performed to identify the associated factors of IOL tilt and decentration as well as longitudinal changes.RESULTS:The 61 CEL patients(mean age 9.07±5.05y)in three-piece IOL(M/F:14/7)group had a greater tilt than those with one-piece IOL(M/F:28/12)group both at 3-month postoperative(horizontal:P=0.024;vertical:P=0.048)and 1-year postoperative(horizontal:P=0.011;vertical:P=0.001).Three-piece IOL group had a greater longitudinal change between 3-month postoperative to 1-year postoperative in IOL tilt(horizontal:P=0.028;vertical:P=0.026)and a greater longitudinal change in horizontal IOL decentration than one-piece IOL group(P<0.05).The longer axial length(AL)was associated with the longitudinal changes in IOL tilt(P=0.039),while the three-piece IOL was associated with the longitudinal changes in horizontal IOL decentration 1-year postoperatively(P=0.011).CONCLUSION:IOL tilt is greater in the three-piece IOL group than that in the one-piece IOL group 1-year postoperatively.The three-piece IOL is associated with greater longitudinal changes of IOL decentration,while longer AL is associated with longitudinal changes of IOL tilt.For CEL patients,more stable IOL type should be selected and patients with longer AL warrant closer monitoring.展开更多
Synaptic plasticity is essential for maintaining neuronal function in the central nervous system and serves as a critical indicator of the effects of neurodegenerative disease.Glaucoma directly impairs retinal ganglio...Synaptic plasticity is essential for maintaining neuronal function in the central nervous system and serves as a critical indicator of the effects of neurodegenerative disease.Glaucoma directly impairs retinal ganglion cells and their axons,leading to axonal transport dysfuntion,subsequently causing secondary damage to anterior or posterior ends of the visual system.Accordingly,recent evidence indicates that glaucoma is a degenerative disease of the central nervous system that causes damage throughout the visual pathway.However,the effects of glaucoma on synaptic plasticity in the primary visual cortex remain unclear.In this study,we established a mouse model of unilateral chronic ocular hypertension by injecting magnetic microbeads into the anterior chamber of one eye.We found that,after 4 weeks of chronic ocular hypertension,the neuronal somas were smaller in the superior colliculus and lateral geniculate body regions of the brain contralateral to the affected eye.This was accompanied by glial cell activation and increased expression of inflammatory factors.After 8 weeks of ocular hypertension,we observed a reduction in the number of excitatory and inhibitory synapses,dendritic spines,and activation of glial cells in the primary visual cortex contralateral to the affected eye.These findings suggest that glaucoma not only directly damages the retina but also induces alterations in synapses and dendritic spines in the primary visual cortex,providing new insights into the pathogenesis of glaucoma.展开更多
Purpose:.To evaluate the effect of preoperative visits on patients′ psychology, physiology, and behavior during the perioperative period of eye surgery under local anesthesia, with the aim of enhancing patients′ coo...Purpose:.To evaluate the effect of preoperative visits on patients′ psychology, physiology, and behavior during the perioperative period of eye surgery under local anesthesia, with the aim of enhancing patients′ cooperation with the surgery and improving their degree of satisfaction.Methods:.A total of 240 patients scheduled to undergo eye surgery between August and October 2013 were randomly divided into an observation(n = 120) and a control(n = 120)group..Patients in the observation group attended preoperative visits with nurses and received conventional nursing care. The control group received only conventional nursing.Results:.The Zung self-rating anxiety scale(SAS) scores were significantly lower in patients from the observation group than in the control group(P<0.05). Surgeons operating on the observation group were more satisfied with their patients′ cooperation with the surgery than were surgeons operating on the controls(P<0.01). Patients in the observation group had a significantly higher degree of satisfaction in terms of work efficiency in the operating room(P<0.01).Conclusion:.Preoperative visits by patients scheduled to undergo eye surgery can effectively mitigate preoperative anxiety in those patients,.build up a positive attitude toward the upcoming surgery,.instruct the patients to coordinate with the surgery,.enhance surgical safety,.and improve the patients′degree of satisfaction regarding the nursing care in the operating room.展开更多
Purpose:Corneal topograph-guided laser subepithelial keratomileusis (LASEK) can effectively correct decentered ablation occurring post laser in situ keratomileusis (LASIK) and to enhance our understanding and diagnosi...Purpose:Corneal topograph-guided laser subepithelial keratomileusis (LASEK) can effectively correct decentered ablation occurring post laser in situ keratomileusis (LASIK) and to enhance our understanding and diagnosis of decentered ablation following LASIK. Methods:Previous studies in the relevant literature are reviewed, and a case report is provided. Results:A patient with high myopia undergoing LASIK in both eyes presented with distorted vision in the left eye, which interfered with the vision in the right eye and caused blurred vision in both eyes. The patient was unable to see objects with both eyes. After receiving corneal topography-guided LASEK,the signs of distorted vision in the left eye and bilateral blurred vision were significantly alleviated,and the patient could see objects with both eyes simultaneously. Conclusion: Clinical ophthalmologists should be aware of the occurrence of decentered ablation after LASIK. Corneal topography-guided LASEK is an efficacious tool for correcting decentered ablation.展开更多
AIM: To determine the incidence and risk factors of retinopathy of prematurity(ROP) and the sensitivity of current screening criteria in a tertiary eye center in Tehran, Iran. METHODS: In a cross-sectional observation...AIM: To determine the incidence and risk factors of retinopathy of prematurity(ROP) and the sensitivity of current screening criteria in a tertiary eye center in Tehran, Iran. METHODS: In a cross-sectional observational study, neonates weighing ≤2000 grams at birth or born <34 wk gestational age(GA) and all other infants at risk of ROP admitted to the neonatal intensive care unit(NICU) or referred to our ROP clinic were investigated. The incidence of ROP and severe ROP(i.e. patients needing treatment) were determined. The associations between risk factors and the development and severity of ROP were assessed. We also examined the sensitivity of the current national screening guideline in Iran. RESULTS: Among 207 infants, the incidence of ROP and severe ROP was 33.3% and 11.1%, respectively. Mean GA and birth weight(BW) were significantly lower in ROP vs non-ROP infants(29±2 wk vs 33±3 wk, P<0.001;1274±489 g vs 1916±550 g, P<0.001, respectively). Univariate analysis displayed significant association between ROP incidence and GA, BW, NICU admission period, blood transfusion, surfactant usage, sepsis, intraventricular hemorrhage and patent ductus arteriosus(P<0.05 for all). BW [relative risk(RR): 0.857(0.711-0.873), P<0.001], GA [RR: 0.788(0.711-0.873), P<0.001] and blood transfusion [RR: 1.888(0.995-3.583), P=0.052] were independent ROP risk factors. The sensitivity of country-specific screening guidelines was 95.7% and 100% for overall and severe ROP detection, respectively. CONCLUSION: ROP incidence is relatively high in Iran. Identifying ROP risk factors results in more accurate screening and reduces the risk of irreversible vision loss. The ROP screening criteria utilized in Iran are efficient at the present time.展开更多
Objective:To evaluate the effectiveness of music therapy on the anxiety level and physiological response of patients undergoing ophthalmic surgery.Methods:Relevant randomized controlled trials that compared the combin...Objective:To evaluate the effectiveness of music therapy on the anxiety level and physiological response of patients undergoing ophthalmic surgery.Methods:Relevant randomized controlled trials that compared the combined effect of music therapy for patients undergoing ophthalmic surgery were included.Four English databases and three Chinese databases were searched from inception to Jan.2022.Two reviewers independently performed data extraction and risk of bias assessments.The Cochrane Collaboration tool was used to assess the risk of bias.Meta-analysis was performed using Review Manager 5.3.The outcomes were overall anxiety,blood pressure,heart rate and pain.Results:A total of 11 trials with 1,469 participants were included in the meta-analysis.Compared to standard care,music therapy had a good effect on reducing the anxiety levels of patients undergoing ophthalmic surgery(P<0.05).The results also suggested that music therapy produced a significant improvement in blood pressure(P<0.05)and heart rate(P<0.05).The visual analogue scale(VAS)showed that music therapy significantly reduced pain compared to standard care(P<0.05).Conclusions:This meta-analysis provided evidence that music therapy has an obvious effect on relieving anxiety levels,while it is also more effective in alleviating pain and improving physiological responses than standard care alone.Our findings may provide accurate evidence-based guidance for the clinical implementation of music therapy.In the future,more high-quality studies are required for verifying these results.展开更多
Background:We investigated the procedures used by medical institutions in Guangdong Province for reprocessing ophthalmic surgical instruments and analyzed the problems identified in order to improve the quality of cle...Background:We investigated the procedures used by medical institutions in Guangdong Province for reprocessing ophthalmic surgical instruments and analyzed the problems identified in order to improve the quality of cleaning medical instruments and its management.Methods:The reprocessing of ophthalmic surgical instruments was investigated in 72 hospitals in Guangdong Province using a questionnaire designed for this purpose.Results:Ophthalmic surgical instruments underwent centralized reprocessing in the disinfection and supply centers in 50%of the 72 hospitals.Cataract phacoemulsification surgery was the main ophthalmic surgery performed in 94%of the 72 hospitals.The main reasons for using centralized reprocessing were an insufficient supply of ophthalmic surgical instruments,short turnaround times between surgeries,and the high cost of losing these precise and fragile instruments.Manual processing was the predominant method of reprocessing ophthalmic surgical instruments;enzyme detergents were used in 63.89%of the hospitals;and 48.61%of the hospitals used N-model small pressure-steam sterilizers for the ophthalmic surgical instruments.Conclusions:In order to improve the quality and management of the cleaning of medical instruments,and guarantee high-quality medical care,the following measures are recommended.Centralized management of ophthalmic surgical instruments should be based on the instruments’characteristics.Pay more attention to reprocessing site locations and staff training.Choose detergents based on manufacturers’instructions for use with specific instruments.Increase the number of available ophthalmic instruments in accordance with their demand and select appropriate small pressure-steam sterilizers.展开更多
Blindness prevention has been an important national policy in China.Previous strategies,such as deploying experienced cataract surgeons to rural areas and assisting in building local ophthalmology centers,had successf...Blindness prevention has been an important national policy in China.Previous strategies,such as deploying experienced cataract surgeons to rural areas and assisting in building local ophthalmology centers,had successfully decreased the prevalence of visual impairment and blindness.However,new challenges arise with the aging population and the shift of the disease spectrum towards age-related eye diseases and myopia.With the constant technological boom,digital healthcare innovations in ophthalmology could immensely enhance screening and diagnosing capabilities.Artificial intelligence(AI)and telemedicine have been proven valuable in clinical ophthalmology settings.Moreover,the integration of cutting-edge communication technology and AI in mobile clinics and remote surgeries is on the horizon,potentially revolutionizing blindness prevention and ophthalmic healthcare.The future of blindness prevention in China is poised to undergo significant transformation,driven by emerging challenges and new opportunities.展开更多
AIM： To investigate the spectrum and antibiotic susceptibility of bacteria isolated from patients with suspected corneal infections in Zhongshan Ophthalmic Center in South China over the past four years retrospective...AIM： To investigate the spectrum and antibiotic susceptibility of bacteria isolated from patients with suspected corneal infections in Zhongshan Ophthalmic Center in South China over the past four years retrospectively. METHODS： Totally 1943 corneal scrapes from patients with corneal infections from 2010 to 2013 were cultured and processed using standard microbiological procedures to identify bacterial isolates. Simultaneously, the bacterial isolates were tested for antibiotic susceptibility to 8 antibiotics （ceftazidime, cefuroxim, cefazolin, levofloxacin, ofloxacin, neomycin, tobramycin, chloramphenicol） using the Kirby-Bauer disc diffusion technique. RESULTS： Of the total 1943 scrapes, 397 （20.43%） were culture-positive, of which 294 （74.06%） were gram- positive （GP） and 103 （25.94%） were gram-negative （GN） bacteria. Of the GP organisms, the most prevalent genera were Staphylococcus spp. （56.17%, n=223）, Kocuria spp. （5.29%, n=21） and Micrococcus spp. （1.26%, n=5）. On the other hand, the most prevalent genera were Pseudomonas spp. （12.85%, n=51）, Burkholderia spp. （2.02%, n=8） and Acinetobacter spp. （1.51%, n =6） for the GN organisms. Among five antibiotics that have eye drop products, the resistant to neomycin of GP （7.82%, 95% Ch 4.72%-10.92%） and GN isolates （9.71%, 95% Ch 4.01%-15.41% ） was lowest, while the resistant to chloramphenicol was highest （GP： 34.35%, 95% Ch 28.92%-39.78%; GN： 60.19%, 95% Ch 50.74%-69.64%）. CONCLUSION： Staphylococcus spp. was the most common bacterial pathogens isolated from patients with corneal infections in this setting. High percentages of GP and GN bacteria were mostly susceptible to neomycin and highly resistant to chloramphenicol.展开更多
AIM:To report the clinical prognosis and pathological findings of accidental lens vacuolar changes in eyes with intraoperative exposure to a dispersive ophthalmic viscosurgical device(OVD).METHODS:Two patients who dev...AIM:To report the clinical prognosis and pathological findings of accidental lens vacuolar changes in eyes with intraoperative exposure to a dispersive ophthalmic viscosurgical device(OVD).METHODS:Two patients who developed transient lens vacuolar changes during uneventful persistent pupillary membrane(PPM)removal surgery were presented and followed up.This event was speculated to be associated with an intraoperative dispersive OVD DisCoVisc(hyaluronic acid 1.6%-chondroitin sulfate 4.0%)exposure.Then,to provide the pathological basis for our speculation,another four cataract patients were randomly exposed to different OVDs,and their anterior lens capsules were investigated with transmission electron microscopy(TEM).RESULTS:After months,the subcapsular vacuoles in both PPM cases were gradually disappeared without visual deterioration.For the cataract patients,similar lens changes were observed intraoperatively in those exposed to a dispersive DisCoVisc but not a cohesive OVD IVIZ(sodium hyaluronate gel 1.0%).In addition,marked ultrastructural changes,including chromatin condensation,extensive cytoplasmic vacuoles,and obvious intercellular space between lens epithelial cells in the anterior lens capsules of all eyes exposed to DisCoVisc,were observed by TEM.CONCLUSION:The lens vacuolar changes may be associated with a dispersive OVD exposure.Therefore,it is not preferable to use dispersive OVDs in patients with transparent lenses or without the intention of lens extraction.In addition,close follow-ups instead of immediate lens extraction are recommended for the occurrence of similar lens lesions.展开更多
AIM:To explore the factors influencing individuals’willingness to participate in ophthalmic clinical trials.METHODS:A questionnaire survey was conducted from January to April 2021 among patients and their family memb...AIM:To explore the factors influencing individuals’willingness to participate in ophthalmic clinical trials.METHODS:A questionnaire survey was conducted from January to April 2021 among patients and their family members at Zhongshan Ophthalmic Center,Sun Yat-sen University,in Guangzhou,China.The survey gathered data on respondents’willingness,demographic and socioeconomic profiles,as well as their reasons and concerns regarding engagement in clinical trials.RESULTS:Of the 1078 residents surveyed(mean age 31.2±13.1y;65.8%females)in Guangzhou,749(69.5%)expressed a willingness to participate in future ophthalmic clinical trials.Specific characteristics associated with greater willingness included a younger age,lower annual income,higher education,prior participation experience,previous ophthalmic treatment,and a better understanding of clinical trials.With the exception of age,these characteristics were significantly linked to a higher willingness.The primary barrier to participation,expressed by 64.8%of those willing and 54.4%of those unwilling,was“Uncertain efficacy”.In terms of motivations,the willing group ranked“Better therapeutic benefits”(35.0%),“Professional monitoring”(34.3%),and“Trust in healthcare professionals”(33.1%)as their top three reasons,whereas the unwilling participants indicated“Full comprehension of the protocol”(46.2%)as the key facilitator.CONCLUSION:This study reveals a substantial willingness to participate in ophthalmic clinical trials and demonstrates the predictive role of demographic and socioeconomic factors.Variations in motivators and concerns between willing and unwilling participants highlight the significance of tailored recruitment strategies.Importantly,the need for and trust in healthcare professionals stand out as powerful motivations,underscoring the importance of enhancing physician-patient relationships,adopting patient-centered communication approaches,and addressing individualized needs to improve accrual rates.展开更多
【正】Dear Sir,We hereby report two cases of methanol optic neuropathy with relapsed vision disturbance.Methanol intoxication appears after accidental or suicidal oral ingestion of industrial solvents or cleaning and ...【正】Dear Sir,We hereby report two cases of methanol optic neuropathy with relapsed vision disturbance.Methanol intoxication appears after accidental or suicidal oral ingestion of industrial solvents or cleaning and antifreeze liquids or occasionally is due to fraudulent adulteration of wine or other alcoholic beverages.Its ingestion can cause severe visual disturbances and the outcomes of visual disturbances vary diffusively.Some completely or partially recovered,and some suffered展开更多
Background:Using a randomized controlled trial(RCT),to assess the efficacy of the folded technique of self-adherent wrap to eyes after orbital tumour extirpation and compare it with the classic technique.Methods:A sin...Background:Using a randomized controlled trial(RCT),to assess the efficacy of the folded technique of self-adherent wrap to eyes after orbital tumour extirpation and compare it with the classic technique.Methods:A single-centre,prospective,randomized,controlled study was conducted among 128 patients who underwent orbital tumour extirpation in this study.The folded and classic techniques of applying self-adherent wraps were randomly allocated to patients(1:1).The primary endpoint was the interface pressure on the affected eye.Secondary efficacy endpoints were the interface pressure above and below the ear of the affected side,above the ear of the non-affected side,and discomfort scores.Postoperative complications were observed for 24 hours.Results:The interface pressure with the folded technique on the affected eye was neither inferior nor superior to the classic technique(1.33±0.07 vs.1.41±0.09 mmHg,P=0.480).Most importantly,the pressure at three other points outside of the affected eye,including above and below the ear of the affected side,and above the ear of the non-affected side,were significantly higher when using the classic technique than when using the folded technique(P=0.041,0.019,and 0.047,respectively).Discomfort scores were higher in the classic technique group than in the folded technique group(2.93±0.30 vs.1.52±0.19,P≤0.001).Conclusions:Findings demonstrated the advantages of using folded technique to apply self-adherent wrap for wounds after orbital tumour extirpation with lower interface pressure outside of the affected eye and patient discomfort scores,without influencing pressure on the affected eye comparing with the classic technique.展开更多
Background:This study aims to investigate the current status and influencing factors of evidence-based practice(EBP)with knowledge,attitude and practice(KAP)of ophthalmic nursing staffs in south China.Methods:Using a ...Background:This study aims to investigate the current status and influencing factors of evidence-based practice(EBP)with knowledge,attitude and practice(KAP)of ophthalmic nursing staffs in south China.Methods:Using a convenient sampling method,we selected 429 ophthalmic nursing staffs from 28 ophthalmology specialist hospitals or general hospitals in south China,and investigated their general information and implemented the evidence-based practice questionnaire(EBPQ).Results:The scores of EBP and KAP of ophthalmic nursing staffs in south China from high to low were as follows:practical attitude(4.85±1.07 points),practical behavior(4.42±1.14 points),practical knowledge and skills(4.30±0.65 points).The single factor analysis results showed that the first graduation degree,technical title,scientific research achievements,whether or not participate in EBP training,the frequency of reading literature at ordinary time,and whether or not participate in EBP project were the influencing factors of EBP level;the multi-factor analysis results showed that EBP attitude,EBP knowledge and skills,whether or not participate in EBP training were independent influencing factors of EBP.Conclusions:The ophthalmic nursing staffs in south China have a positive attitude towards EBP,however,their EBP knowledge,skills and behavioral capabilities need to be focused and improved.The ophthalmic nursing administrators should fully master the factors affecting the implementation of EBP,and take effective intervention measurement to improve the EBP abilities of ophthalmic nursing staffs,and promote the development of EBP in ophthalmology specialty.展开更多
This special edition of Annals of Eye Science comprehensively addresses many of principles and changes that have occurred over the past couple of decades.The fairly new concept of competency-based training represents ...This special edition of Annals of Eye Science comprehensively addresses many of principles and changes that have occurred over the past couple of decades.The fairly new concept of competency-based training represents a shift from the old paradigm of showing that training programs are capable of teaching to showing that trainees can actually do what is expected of them.“Competence”is not just the ability to do something,but to do it well.In other words,teaching doesn’t equal learning!We must maximize our teaching abilities in lecture,clinic and surgery to enhance every learning opportunity.In this issue,Palis(1)provides tips on improving lecture skills;Neufeld and associates(2)define principles of good surgical teaching.Mayorga(3),Yang and associates(4)both describe a relatively new concept called the flipped classroom that is designed to maximize the expertise of the teacher and enhance higher order cognitive learning in students.Each of these articles contains many valuable concepts that if employed,will enhance learning.展开更多
文摘To the Editor： The Chinese government is actively advocating medical reform, aiming at reducing medical costs, and improving service quality. As to ophthalmology, transition from traditional hospitalized surgery to a predominant outpatient mode could be a solution. Zhongshan Ophthalmic Center （ZOC） is one of the largest and leading ophthalmic centers in China,
基金Supported by the Key Science&Technology Project of Guangzhou(No.202103000045)the National Natural Science Foundation of China(No.82070972,No.82271093).
文摘AIM:To investigate the effects of shortening the duration of silicone oil tamponade on retinal structure and function in patients undergoing silicone oil removal(SOR)after surgery for primary rhegmatogenous retinal detachment(RRD).METHODS:A total of 58 eligible patients were enrolled and randomly assigned to two groups based on tamponade duration:the short-term group(30-45d)and the conventional group(≥90d).Comprehensive evaluations were performed before and after SOR,including slitlamp examination,best-corrected visual acuity(BCVA)measurement,intraocular pressure(IOP)testing,optical coherence tomography(OCT),optical coherence tomography angiography(OCTA),microperimetry,electroretinography(ERG),and visual evoked potential(VEP)assessment.RESULTS:A total of 33 patients(23 males and 10 females;33 eyes)were enrolled in the short-term SO tamponade group with mean age of 52.45±9.35y,and 25 patients(15 males and 10 females;25 eyes)were enrolled in the conventional SO tamponade group with mean age of 50.80±12.06y.Compared with the conventional group,the short-term silicone oil tamponade group had a significantly lower incidence of silicone oil emulsification and cataract progression,with no significant difference in retinal reattachment success rate.Structurally,short-term tamponade was associated with increased thickness of the retinal ganglion cell layer(RGCL)in the nasal and superior macular regions and improved recovery of superficial retinal vascular density in these areas.Functionally,the shortterm group showed better BCVA and retinal sensitivity both before and 1mo after SOR;additionally,the P100 amplitude in VEP tests was significantly increased in this group.CONCLUSION:Shortening the duration of silicone oil tamponade effectively reduces damage to retinal structure and function without compromising the success rate of retinal reattachment in patients with primary RRD.
基金Supported by the Hainan Provincial Natural Science Foundation of China(No.825RC898)Hainan Province Clinical Medical Center。
文摘AIM:To comprehensively assess the relationship between asthma and myopia based on the National Health and Nutrition Examination Survey(NHANES)database combined with Mendelian randomization(MR).METHODS:Initially,20497 subjects from the complete questionnaire cycle in the NHANES database from 2005 to 2008 were included.By exclusion criteria,8460 subjects were screened with 1676 myopia samples and 6784 control samples.Subsequently,baseline characteristics,association analyses,risk stratification analyses,and receive operating characteristic curve(ROC)were used to investigate the associations between covariates and myopia.Then,the causal relationship was explored in depth by MR analysis,and was estimated the reliability by sensitivity analyses and directionality tests.RESULTS:Baseline characteristics illustrated a significant difference between myopia and controls for both asthma and covariates(excluding gender;P<0.05).The results in all three models indicated that asthma was strongly associated with myopia and the effect on myopia was not significantly confounded by other covariates[model 3:odd ratio(OR)=1.31;95%CI=1.07-1.62;P=0.0133].The risk stratification analysis again verified that asthma remained strongly associated with myopia and was a risk factor for myopia(P<0.05,OR>1).ROC proved that the model was accurate in its prediction[area under curve(AUC)=0.7].Subsequently,the causal relationship between them was statistically significant(P<0.05)according to the inverse variance weighted(IVW)method in MR.Scatterplot showed that asthma and myopia had significant positive causality and were not affected by confounders.Forest plot displayed an increasing risk of myopia on asthma(OR>1).The funnel plot demonstrated compliance with Mendel’s second law.Sensitivity analysis and directional analysis further confirmed the confidence of the MR analysis results and a unidirectional causal relationship between them.CONCLUSION:A significant association and causality between asthma and myopia is found through the NHANES database and MR analysis,which is important implications for public health policy development and clinical practice.
文摘Dear Editor,Dorsal pontine lesions may cause a variety of complex neuro-ophthalmic deficits,including horizontal gaze palsy(HGP),internuclear ophthalmoplegia,one-and-ahalf syndrome,abducens nerve palsy,skew deviation,or any combination of these.Here we present a rare case of an adult patient who developed multiple complicated clinical manifestations after surgical removal of a pontine cavernous hemangioma(PCH).Our case highlights a single pontine lesion may involve complicated neural pathways and result in complicated symptoms and signs,in which abducens nerve palsy or skew deviation is easily missed when combined with HGP.
基金Supported by National Natural Science Foundation of Guangdong,China(No.2020A1515010829,No.2023A1515011652,No.2025A1515012389)Science and Technology Program of Guangzhou,China(No.2025A03J4033).
文摘AIM:To evaluate the agreement of axial length(AL),anterior chamber parameters,and total cornea power obtained by swept-source optical coherence tomography(SS-OCT)-based and Scheimpflug-based optical biometers in myopic children.METHODS:AL,steep keratometry(K),flat K,posterior corneal keratometry(PK),total keratometry(TK),anterior chamber depth(ACD),horizontal corneal diameter(CD),and central corneal thickness(CCT)were obtained using IOL Master 700 and Pentacam AXL.The agreement between the devices was evaluated using intraclass correlation coefficients(ICC),Bland-Altman plots,and astigmatism vector analysis.RESULTS:Totally 175 myopic children(48.5%male)with a mean age of 10.29±2.14y were enrolled.The ICC and Bland-Altman plots indicated a satisfactory agreement for AL,ACD,and CCT.The mean difference in CD of-0.31±0.30 mm was considered clinically significant(>0.2 mm).Additionally,measurements of K and TK obtained from the IOL Master 700 showed good agreement.Nevertheless,there were clinically significant differences observed in PK,simulated keratometry(simK),total cornea power,and astigmatism(at least 10%of the cases with a difference of>10 degrees in meridian)between the two devices.CONCLUSION:The study findings demonstrate a significant difference in K,PK,astigmatism,and CD,indicating that the two optical biometers cannot be considered interchangeable.Therefore,it is recommended to utilize one kind device for follow-up examinations in myopic children.
基金Supported by the National Natural Science Foundation of China(No.81900841)the Guangzhou Major Difficult and Rare Diseases Project(No.2024MDRD05)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(No.2021A1515011673No.2022A1515011181)the Guangzhou Basic Research Program,City&University(Institute)Joint Funding Project(No.SL2023A03J00514).
文摘AIM:To investigate the characteristics and associated factors of intraocular lens(IOL)tilt and decentration after transscleral suture-fixated IOL surgery in congenital ectopia lentis(CEL).METHODS:CEL patients undergoing transscleral suture-fixated IOL surgery were divided into two groups based on implanted IOL type(three-piece IOL or one-piece IOL).The IOL tilt and decentration at 3-month and 1-year postoperative were measured.Multivariate regression analyses were performed to identify the associated factors of IOL tilt and decentration as well as longitudinal changes.RESULTS:The 61 CEL patients(mean age 9.07±5.05y)in three-piece IOL(M/F:14/7)group had a greater tilt than those with one-piece IOL(M/F:28/12)group both at 3-month postoperative(horizontal:P=0.024;vertical:P=0.048)and 1-year postoperative(horizontal:P=0.011;vertical:P=0.001).Three-piece IOL group had a greater longitudinal change between 3-month postoperative to 1-year postoperative in IOL tilt(horizontal:P=0.028;vertical:P=0.026)and a greater longitudinal change in horizontal IOL decentration than one-piece IOL group(P<0.05).The longer axial length(AL)was associated with the longitudinal changes in IOL tilt(P=0.039),while the three-piece IOL was associated with the longitudinal changes in horizontal IOL decentration 1-year postoperatively(P=0.011).CONCLUSION:IOL tilt is greater in the three-piece IOL group than that in the one-piece IOL group 1-year postoperatively.The three-piece IOL is associated with greater longitudinal changes of IOL decentration,while longer AL is associated with longitudinal changes of IOL tilt.For CEL patients,more stable IOL type should be selected and patients with longer AL warrant closer monitoring.
基金supported by the National Natural Science Foundation of China,No.82271115(to MY).
文摘Synaptic plasticity is essential for maintaining neuronal function in the central nervous system and serves as a critical indicator of the effects of neurodegenerative disease.Glaucoma directly impairs retinal ganglion cells and their axons,leading to axonal transport dysfuntion,subsequently causing secondary damage to anterior or posterior ends of the visual system.Accordingly,recent evidence indicates that glaucoma is a degenerative disease of the central nervous system that causes damage throughout the visual pathway.However,the effects of glaucoma on synaptic plasticity in the primary visual cortex remain unclear.In this study,we established a mouse model of unilateral chronic ocular hypertension by injecting magnetic microbeads into the anterior chamber of one eye.We found that,after 4 weeks of chronic ocular hypertension,the neuronal somas were smaller in the superior colliculus and lateral geniculate body regions of the brain contralateral to the affected eye.This was accompanied by glial cell activation and increased expression of inflammatory factors.After 8 weeks of ocular hypertension,we observed a reduction in the number of excitatory and inhibitory synapses,dendritic spines,and activation of glial cells in the primary visual cortex contralateral to the affected eye.These findings suggest that glaucoma not only directly damages the retina but also induces alterations in synapses and dendritic spines in the primary visual cortex,providing new insights into the pathogenesis of glaucoma.
文摘Purpose:.To evaluate the effect of preoperative visits on patients′ psychology, physiology, and behavior during the perioperative period of eye surgery under local anesthesia, with the aim of enhancing patients′ cooperation with the surgery and improving their degree of satisfaction.Methods:.A total of 240 patients scheduled to undergo eye surgery between August and October 2013 were randomly divided into an observation(n = 120) and a control(n = 120)group..Patients in the observation group attended preoperative visits with nurses and received conventional nursing care. The control group received only conventional nursing.Results:.The Zung self-rating anxiety scale(SAS) scores were significantly lower in patients from the observation group than in the control group(P<0.05). Surgeons operating on the observation group were more satisfied with their patients′ cooperation with the surgery than were surgeons operating on the controls(P<0.01). Patients in the observation group had a significantly higher degree of satisfaction in terms of work efficiency in the operating room(P<0.01).Conclusion:.Preoperative visits by patients scheduled to undergo eye surgery can effectively mitigate preoperative anxiety in those patients,.build up a positive attitude toward the upcoming surgery,.instruct the patients to coordinate with the surgery,.enhance surgical safety,.and improve the patients′degree of satisfaction regarding the nursing care in the operating room.
文摘Purpose:Corneal topograph-guided laser subepithelial keratomileusis (LASEK) can effectively correct decentered ablation occurring post laser in situ keratomileusis (LASIK) and to enhance our understanding and diagnosis of decentered ablation following LASIK. Methods:Previous studies in the relevant literature are reviewed, and a case report is provided. Results:A patient with high myopia undergoing LASIK in both eyes presented with distorted vision in the left eye, which interfered with the vision in the right eye and caused blurred vision in both eyes. The patient was unable to see objects with both eyes. After receiving corneal topography-guided LASEK,the signs of distorted vision in the left eye and bilateral blurred vision were significantly alleviated,and the patient could see objects with both eyes simultaneously. Conclusion: Clinical ophthalmologists should be aware of the occurrence of decentered ablation after LASIK. Corneal topography-guided LASEK is an efficacious tool for correcting decentered ablation.
文摘AIM: To determine the incidence and risk factors of retinopathy of prematurity(ROP) and the sensitivity of current screening criteria in a tertiary eye center in Tehran, Iran. METHODS: In a cross-sectional observational study, neonates weighing ≤2000 grams at birth or born <34 wk gestational age(GA) and all other infants at risk of ROP admitted to the neonatal intensive care unit(NICU) or referred to our ROP clinic were investigated. The incidence of ROP and severe ROP(i.e. patients needing treatment) were determined. The associations between risk factors and the development and severity of ROP were assessed. We also examined the sensitivity of the current national screening guideline in Iran. RESULTS: Among 207 infants, the incidence of ROP and severe ROP was 33.3% and 11.1%, respectively. Mean GA and birth weight(BW) were significantly lower in ROP vs non-ROP infants(29±2 wk vs 33±3 wk, P<0.001;1274±489 g vs 1916±550 g, P<0.001, respectively). Univariate analysis displayed significant association between ROP incidence and GA, BW, NICU admission period, blood transfusion, surfactant usage, sepsis, intraventricular hemorrhage and patent ductus arteriosus(P<0.05 for all). BW [relative risk(RR): 0.857(0.711-0.873), P<0.001], GA [RR: 0.788(0.711-0.873), P<0.001] and blood transfusion [RR: 1.888(0.995-3.583), P=0.052] were independent ROP risk factors. The sensitivity of country-specific screening guidelines was 95.7% and 100% for overall and severe ROP detection, respectively. CONCLUSION: ROP incidence is relatively high in Iran. Identifying ROP risk factors results in more accurate screening and reduces the risk of irreversible vision loss. The ROP screening criteria utilized in Iran are efficient at the present time.
文摘Objective:To evaluate the effectiveness of music therapy on the anxiety level and physiological response of patients undergoing ophthalmic surgery.Methods:Relevant randomized controlled trials that compared the combined effect of music therapy for patients undergoing ophthalmic surgery were included.Four English databases and three Chinese databases were searched from inception to Jan.2022.Two reviewers independently performed data extraction and risk of bias assessments.The Cochrane Collaboration tool was used to assess the risk of bias.Meta-analysis was performed using Review Manager 5.3.The outcomes were overall anxiety,blood pressure,heart rate and pain.Results:A total of 11 trials with 1,469 participants were included in the meta-analysis.Compared to standard care,music therapy had a good effect on reducing the anxiety levels of patients undergoing ophthalmic surgery(P<0.05).The results also suggested that music therapy produced a significant improvement in blood pressure(P<0.05)and heart rate(P<0.05).The visual analogue scale(VAS)showed that music therapy significantly reduced pain compared to standard care(P<0.05).Conclusions:This meta-analysis provided evidence that music therapy has an obvious effect on relieving anxiety levels,while it is also more effective in alleviating pain and improving physiological responses than standard care alone.Our findings may provide accurate evidence-based guidance for the clinical implementation of music therapy.In the future,more high-quality studies are required for verifying these results.
文摘Background:We investigated the procedures used by medical institutions in Guangdong Province for reprocessing ophthalmic surgical instruments and analyzed the problems identified in order to improve the quality of cleaning medical instruments and its management.Methods:The reprocessing of ophthalmic surgical instruments was investigated in 72 hospitals in Guangdong Province using a questionnaire designed for this purpose.Results:Ophthalmic surgical instruments underwent centralized reprocessing in the disinfection and supply centers in 50%of the 72 hospitals.Cataract phacoemulsification surgery was the main ophthalmic surgery performed in 94%of the 72 hospitals.The main reasons for using centralized reprocessing were an insufficient supply of ophthalmic surgical instruments,short turnaround times between surgeries,and the high cost of losing these precise and fragile instruments.Manual processing was the predominant method of reprocessing ophthalmic surgical instruments;enzyme detergents were used in 63.89%of the hospitals;and 48.61%of the hospitals used N-model small pressure-steam sterilizers for the ophthalmic surgical instruments.Conclusions:In order to improve the quality and management of the cleaning of medical instruments,and guarantee high-quality medical care,the following measures are recommended.Centralized management of ophthalmic surgical instruments should be based on the instruments’characteristics.Pay more attention to reprocessing site locations and staff training.Choose detergents based on manufacturers’instructions for use with specific instruments.Increase the number of available ophthalmic instruments in accordance with their demand and select appropriate small pressure-steam sterilizers.
基金supported by the Science and Technology Program of Guangzhou(202201020337)the Science and Technology Planning Projects of Guangdong Province(2021B1111610006)+4 种基金the Science and Technology Program of Guangzhou(2024B03J1233)the National Natural Science Foundation of China(82171035)the High-level Science and Technology Journals Projects of Guangdong Province(2021B1212010003)the National Natural Science Foundation of China(82201237)the China Postdoctoral Science Foundation(2023T160751).
文摘Blindness prevention has been an important national policy in China.Previous strategies,such as deploying experienced cataract surgeons to rural areas and assisting in building local ophthalmology centers,had successfully decreased the prevalence of visual impairment and blindness.However,new challenges arise with the aging population and the shift of the disease spectrum towards age-related eye diseases and myopia.With the constant technological boom,digital healthcare innovations in ophthalmology could immensely enhance screening and diagnosing capabilities.Artificial intelligence(AI)and telemedicine have been proven valuable in clinical ophthalmology settings.Moreover,the integration of cutting-edge communication technology and AI in mobile clinics and remote surgeries is on the horizon,potentially revolutionizing blindness prevention and ophthalmic healthcare.The future of blindness prevention in China is poised to undergo significant transformation,driven by emerging challenges and new opportunities.
基金Supported in part by the Doctoral Program of Higher Education,Ministry of Education and the Ophthalmologic State Key Laboratory,Sun-Yat Sen University,China
文摘AIM： To investigate the spectrum and antibiotic susceptibility of bacteria isolated from patients with suspected corneal infections in Zhongshan Ophthalmic Center in South China over the past four years retrospectively. METHODS： Totally 1943 corneal scrapes from patients with corneal infections from 2010 to 2013 were cultured and processed using standard microbiological procedures to identify bacterial isolates. Simultaneously, the bacterial isolates were tested for antibiotic susceptibility to 8 antibiotics （ceftazidime, cefuroxim, cefazolin, levofloxacin, ofloxacin, neomycin, tobramycin, chloramphenicol） using the Kirby-Bauer disc diffusion technique. RESULTS： Of the total 1943 scrapes, 397 （20.43%） were culture-positive, of which 294 （74.06%） were gram- positive （GP） and 103 （25.94%） were gram-negative （GN） bacteria. Of the GP organisms, the most prevalent genera were Staphylococcus spp. （56.17%, n=223）, Kocuria spp. （5.29%, n=21） and Micrococcus spp. （1.26%, n=5）. On the other hand, the most prevalent genera were Pseudomonas spp. （12.85%, n=51）, Burkholderia spp. （2.02%, n=8） and Acinetobacter spp. （1.51%, n =6） for the GN organisms. Among five antibiotics that have eye drop products, the resistant to neomycin of GP （7.82%, 95% Ch 4.72%-10.92%） and GN isolates （9.71%, 95% Ch 4.01%-15.41% ） was lowest, while the resistant to chloramphenicol was highest （GP： 34.35%, 95% Ch 28.92%-39.78%; GN： 60.19%, 95% Ch 50.74%-69.64%）. CONCLUSION： Staphylococcus spp. was the most common bacterial pathogens isolated from patients with corneal infections in this setting. High percentages of GP and GN bacteria were mostly susceptible to neomycin and highly resistant to chloramphenicol.
基金Supported by the National Key R&D Program of China(No.2020YFC2008200)the National Natural Science Foundation of China(No.81970778,No.82271066,No.81970813)+1 种基金the Natural Science Foundation of Guangdong Province(No.2023A1515011198)Guangzhou Municipal Science and Technology Project(No.SL2022A03J00553).
文摘AIM:To report the clinical prognosis and pathological findings of accidental lens vacuolar changes in eyes with intraoperative exposure to a dispersive ophthalmic viscosurgical device(OVD).METHODS:Two patients who developed transient lens vacuolar changes during uneventful persistent pupillary membrane(PPM)removal surgery were presented and followed up.This event was speculated to be associated with an intraoperative dispersive OVD DisCoVisc(hyaluronic acid 1.6%-chondroitin sulfate 4.0%)exposure.Then,to provide the pathological basis for our speculation,another four cataract patients were randomly exposed to different OVDs,and their anterior lens capsules were investigated with transmission electron microscopy(TEM).RESULTS:After months,the subcapsular vacuoles in both PPM cases were gradually disappeared without visual deterioration.For the cataract patients,similar lens changes were observed intraoperatively in those exposed to a dispersive DisCoVisc but not a cohesive OVD IVIZ(sodium hyaluronate gel 1.0%).In addition,marked ultrastructural changes,including chromatin condensation,extensive cytoplasmic vacuoles,and obvious intercellular space between lens epithelial cells in the anterior lens capsules of all eyes exposed to DisCoVisc,were observed by TEM.CONCLUSION:The lens vacuolar changes may be associated with a dispersive OVD exposure.Therefore,it is not preferable to use dispersive OVDs in patients with transparent lenses or without the intention of lens extraction.In addition,close follow-ups instead of immediate lens extraction are recommended for the occurrence of similar lens lesions.
基金Supported by the Science and Technology Program of Guangzhou(No.201803010066)the High-level Hospital Construction Project,Zhongshan Ophthalmic Center,Sun Yat-sen University(No.303010202).
文摘AIM:To explore the factors influencing individuals’willingness to participate in ophthalmic clinical trials.METHODS:A questionnaire survey was conducted from January to April 2021 among patients and their family members at Zhongshan Ophthalmic Center,Sun Yat-sen University,in Guangzhou,China.The survey gathered data on respondents’willingness,demographic and socioeconomic profiles,as well as their reasons and concerns regarding engagement in clinical trials.RESULTS:Of the 1078 residents surveyed(mean age 31.2±13.1y;65.8%females)in Guangzhou,749(69.5%)expressed a willingness to participate in future ophthalmic clinical trials.Specific characteristics associated with greater willingness included a younger age,lower annual income,higher education,prior participation experience,previous ophthalmic treatment,and a better understanding of clinical trials.With the exception of age,these characteristics were significantly linked to a higher willingness.The primary barrier to participation,expressed by 64.8%of those willing and 54.4%of those unwilling,was“Uncertain efficacy”.In terms of motivations,the willing group ranked“Better therapeutic benefits”(35.0%),“Professional monitoring”(34.3%),and“Trust in healthcare professionals”(33.1%)as their top three reasons,whereas the unwilling participants indicated“Full comprehension of the protocol”(46.2%)as the key facilitator.CONCLUSION:This study reveals a substantial willingness to participate in ophthalmic clinical trials and demonstrates the predictive role of demographic and socioeconomic factors.Variations in motivators and concerns between willing and unwilling participants highlight the significance of tailored recruitment strategies.Importantly,the need for and trust in healthcare professionals stand out as powerful motivations,underscoring the importance of enhancing physician-patient relationships,adopting patient-centered communication approaches,and addressing individualized needs to improve accrual rates.
基金Supported by Natural Science Foundation of Guangdong ProvinceChina(S2012010008439)
文摘【正】Dear Sir,We hereby report two cases of methanol optic neuropathy with relapsed vision disturbance.Methanol intoxication appears after accidental or suicidal oral ingestion of industrial solvents or cleaning and antifreeze liquids or occasionally is due to fraudulent adulteration of wine or other alcoholic beverages.Its ingestion can cause severe visual disturbances and the outcomes of visual disturbances vary diffusively.Some completely or partially recovered,and some suffered
基金This work was supported by the National Natural Science Foundation of China(81700875,81870689,81670887)the Sun Yat-sen University Clinical Research 5010 Program,China(2014014).
文摘Background:Using a randomized controlled trial(RCT),to assess the efficacy of the folded technique of self-adherent wrap to eyes after orbital tumour extirpation and compare it with the classic technique.Methods:A single-centre,prospective,randomized,controlled study was conducted among 128 patients who underwent orbital tumour extirpation in this study.The folded and classic techniques of applying self-adherent wraps were randomly allocated to patients(1:1).The primary endpoint was the interface pressure on the affected eye.Secondary efficacy endpoints were the interface pressure above and below the ear of the affected side,above the ear of the non-affected side,and discomfort scores.Postoperative complications were observed for 24 hours.Results:The interface pressure with the folded technique on the affected eye was neither inferior nor superior to the classic technique(1.33±0.07 vs.1.41±0.09 mmHg,P=0.480).Most importantly,the pressure at three other points outside of the affected eye,including above and below the ear of the affected side,and above the ear of the non-affected side,were significantly higher when using the classic technique than when using the folded technique(P=0.041,0.019,and 0.047,respectively).Discomfort scores were higher in the classic technique group than in the folded technique group(2.93±0.30 vs.1.52±0.19,P≤0.001).Conclusions:Findings demonstrated the advantages of using folded technique to apply self-adherent wrap for wounds after orbital tumour extirpation with lower interface pressure outside of the affected eye and patient discomfort scores,without influencing pressure on the affected eye comparing with the classic technique.
基金The first author would like to thank The Teaching and Research Department of Sun Yat-sen Ophthalmology Center of Sun Yat-sen University for the funding support。
文摘Background:This study aims to investigate the current status and influencing factors of evidence-based practice(EBP)with knowledge,attitude and practice(KAP)of ophthalmic nursing staffs in south China.Methods:Using a convenient sampling method,we selected 429 ophthalmic nursing staffs from 28 ophthalmology specialist hospitals or general hospitals in south China,and investigated their general information and implemented the evidence-based practice questionnaire(EBPQ).Results:The scores of EBP and KAP of ophthalmic nursing staffs in south China from high to low were as follows:practical attitude(4.85±1.07 points),practical behavior(4.42±1.14 points),practical knowledge and skills(4.30±0.65 points).The single factor analysis results showed that the first graduation degree,technical title,scientific research achievements,whether or not participate in EBP training,the frequency of reading literature at ordinary time,and whether or not participate in EBP project were the influencing factors of EBP level;the multi-factor analysis results showed that EBP attitude,EBP knowledge and skills,whether or not participate in EBP training were independent influencing factors of EBP.Conclusions:The ophthalmic nursing staffs in south China have a positive attitude towards EBP,however,their EBP knowledge,skills and behavioral capabilities need to be focused and improved.The ophthalmic nursing administrators should fully master the factors affecting the implementation of EBP,and take effective intervention measurement to improve the EBP abilities of ophthalmic nursing staffs,and promote the development of EBP in ophthalmology specialty.
文摘This special edition of Annals of Eye Science comprehensively addresses many of principles and changes that have occurred over the past couple of decades.The fairly new concept of competency-based training represents a shift from the old paradigm of showing that training programs are capable of teaching to showing that trainees can actually do what is expected of them.“Competence”is not just the ability to do something,but to do it well.In other words,teaching doesn’t equal learning!We must maximize our teaching abilities in lecture,clinic and surgery to enhance every learning opportunity.In this issue,Palis(1)provides tips on improving lecture skills;Neufeld and associates(2)define principles of good surgical teaching.Mayorga(3),Yang and associates(4)both describe a relatively new concept called the flipped classroom that is designed to maximize the expertise of the teacher and enhance higher order cognitive learning in students.Each of these articles contains many valuable concepts that if employed,will enhance learning.
