The present research work attempted to delineate and characterize the reservoir facies from the Dawson Canyon Formation in the Penobscot field,Scotian Basin.An integrated study of instantaneous frequency,P-impedance,v...The present research work attempted to delineate and characterize the reservoir facies from the Dawson Canyon Formation in the Penobscot field,Scotian Basin.An integrated study of instantaneous frequency,P-impedance,volume of clay and neutron-porosity attributes,and structural framework was done to unravel the Late Cretaceous depositional system and reservoir facies distribution patterns within the study area.Fault strikes were found in the EW and NEE-SWW directions indicating the dominant course of tectonic activities during the Late Cretaceous period in the region.P-impedance was estimated using model-based seismic inversion.Petrophysical properties such as the neutron porosity(NPHI)and volume of clay(VCL)were estimated using the multilayer perceptron neural network with high accuracy.Comparatively,a combination of low instantaneous frequency(15-30 Hz),moderate to high impedance(7000-9500 gm/cc*m/s),low neutron porosity(27%-40%)and low volume of clay(40%-60%),suggests fair-to-good sandstone development in the Dawson Canyon Formation.After calibration with the welllog data,it is found that further lowering in these attribute responses signifies the clean sandstone facies possibly containing hydrocarbons.The present study suggests that the shale lithofacies dominates the Late Cretaceous deposition(Dawson Canyon Formation)in the Penobscot field,Scotian Basin.Major faults and overlying shale facies provide structural and stratigraphic seals and act as a suitable hydrocarbon entrapment mechanism in the Dawson Canyon Formation's reservoirs.The present research advocates the integrated analysis of multi-attributes estimated using different methods to minimize the risk involved in hydrocarbon exploration.展开更多
The Moyar-Bhavani Shear Zone(MBSZ)of the South Indian Granulite Terrain(SIGT),a complex continental block formed by the accretion of various crustal units during the Archaean to Neoproterozoic,bear evidences of
Ocular cells like,retinal pigment epithelium(RPE)is a highly specialized pigmented monolayer of post-mitotic cells,which is located in the posterior segment of the eye between neuro sensory retina and vascular choroid...Ocular cells like,retinal pigment epithelium(RPE)is a highly specialized pigmented monolayer of post-mitotic cells,which is located in the posterior segment of the eye between neuro sensory retina and vascular choroid.It functions as a selective barrier and nourishes retinal visual cells.As a result of high-level oxygen consumption of retinal cells,RPE cells are vulnerable to chronic oxidative stress and an increased level of reactive oxygen species(ROS)generated from mitochondria.These oxidative stress and ROS generation in retinal cells lead to RPE degeneration.Various sources including mtDNA damage could be an important factor of oxidative stress in RPE.Gene therapy and mitochondrial transfer studies are emerging fields in ocular disease research.For retinal degenerative diseases stem cell-based transplantation methods are developed from basic research to preclinical and clinical trials.Translational research contributions of gene and cell therapy would be a new strategy to prevent,treat and cure various ocular diseases.This review focuses on the effect of oxidative stress in ocular cell degeneration and recent translational researches on retinal degenerative diseases to cure blindness.展开更多
The challenges in the current energy consumption patterns and demand–supply gap are driving the need to develop commercially viable and sustainable alternative fuels that are eco-friendly and efficient.Given the exis...The challenges in the current energy consumption patterns and demand–supply gap are driving the need to develop commercially viable and sustainable alternative fuels that are eco-friendly and efficient.Given the existing alternatives,hydrogen is regarded as the ultimate carbon-less clean and green fuel with high energy density.Considerable efforts are being made to develop catalysts/photo-catalysts for the efficient production of hydrogen from abundantly available water resources via water-splitting process.In this review,the photocatalytic activity of tin oxide-based hybrid photocatalytic materials for increased hydrogen production has been studied.The existing bottlenecks and proposed solutions have also been discussed.展开更多
Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism.They have received extensive attention in bridging t...Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism.They have received extensive attention in bridging the gap between environmental exposures and disease development via their influence on gene expression.DNA methylation is the earliest discovered epigenetic alteration.In this review,we try to examine the role of DNA methylation and histone modification in Age related macular degeneration(AMD)and Diabetic Retinopathy(DR),its vascular complications and recent progress.Given the complex nature of AMD and DR,it is crucial to improve therapeutics which will greatly enhance the quality of life and reduce the burden for millions of patients living with these potentially blinding conditions.展开更多
文摘The present research work attempted to delineate and characterize the reservoir facies from the Dawson Canyon Formation in the Penobscot field,Scotian Basin.An integrated study of instantaneous frequency,P-impedance,volume of clay and neutron-porosity attributes,and structural framework was done to unravel the Late Cretaceous depositional system and reservoir facies distribution patterns within the study area.Fault strikes were found in the EW and NEE-SWW directions indicating the dominant course of tectonic activities during the Late Cretaceous period in the region.P-impedance was estimated using model-based seismic inversion.Petrophysical properties such as the neutron porosity(NPHI)and volume of clay(VCL)were estimated using the multilayer perceptron neural network with high accuracy.Comparatively,a combination of low instantaneous frequency(15-30 Hz),moderate to high impedance(7000-9500 gm/cc*m/s),low neutron porosity(27%-40%)and low volume of clay(40%-60%),suggests fair-to-good sandstone development in the Dawson Canyon Formation.After calibration with the welllog data,it is found that further lowering in these attribute responses signifies the clean sandstone facies possibly containing hydrocarbons.The present study suggests that the shale lithofacies dominates the Late Cretaceous deposition(Dawson Canyon Formation)in the Penobscot field,Scotian Basin.Major faults and overlying shale facies provide structural and stratigraphic seals and act as a suitable hydrocarbon entrapment mechanism in the Dawson Canyon Formation's reservoirs.The present research advocates the integrated analysis of multi-attributes estimated using different methods to minimize the risk involved in hydrocarbon exploration.
文摘The Moyar-Bhavani Shear Zone(MBSZ)of the South Indian Granulite Terrain(SIGT),a complex continental block formed by the accretion of various crustal units during the Archaean to Neoproterozoic,bear evidences of
基金The authors would like to thank the Science and Engi・neering Research Board(ECR/2018/000718)Indian Council of Medical Research(File No.2018-2786/CMB/Adhoc-BMS)and Countil for Scie ntific and In dustrial Research((Ref No.:27(0353)/19/EMR-ll),Government of India,New Delhi for providing necessary funding to complete this review article successfully.
文摘Ocular cells like,retinal pigment epithelium(RPE)is a highly specialized pigmented monolayer of post-mitotic cells,which is located in the posterior segment of the eye between neuro sensory retina and vascular choroid.It functions as a selective barrier and nourishes retinal visual cells.As a result of high-level oxygen consumption of retinal cells,RPE cells are vulnerable to chronic oxidative stress and an increased level of reactive oxygen species(ROS)generated from mitochondria.These oxidative stress and ROS generation in retinal cells lead to RPE degeneration.Various sources including mtDNA damage could be an important factor of oxidative stress in RPE.Gene therapy and mitochondrial transfer studies are emerging fields in ocular disease research.For retinal degenerative diseases stem cell-based transplantation methods are developed from basic research to preclinical and clinical trials.Translational research contributions of gene and cell therapy would be a new strategy to prevent,treat and cure various ocular diseases.This review focuses on the effect of oxidative stress in ocular cell degeneration and recent translational researches on retinal degenerative diseases to cure blindness.
文摘The challenges in the current energy consumption patterns and demand–supply gap are driving the need to develop commercially viable and sustainable alternative fuels that are eco-friendly and efficient.Given the existing alternatives,hydrogen is regarded as the ultimate carbon-less clean and green fuel with high energy density.Considerable efforts are being made to develop catalysts/photo-catalysts for the efficient production of hydrogen from abundantly available water resources via water-splitting process.In this review,the photocatalytic activity of tin oxide-based hybrid photocatalytic materials for increased hydrogen production has been studied.The existing bottlenecks and proposed solutions have also been discussed.
基金We thank Vision Research Foundation,Sankara Nethralaya,Chennai for supporting necessary facilities to carry out this review.
文摘Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism.They have received extensive attention in bridging the gap between environmental exposures and disease development via their influence on gene expression.DNA methylation is the earliest discovered epigenetic alteration.In this review,we try to examine the role of DNA methylation and histone modification in Age related macular degeneration(AMD)and Diabetic Retinopathy(DR),its vascular complications and recent progress.Given the complex nature of AMD and DR,it is crucial to improve therapeutics which will greatly enhance the quality of life and reduce the burden for millions of patients living with these potentially blinding conditions.
