Assessment of the relative distribution of myocardial flow with myocardial perfusion imaging （MPI） is meth- odologically limited to predict the presence or absence of flow-limited coronary artery disease （CAD）. Th...Assessment of the relative distribution of myocardial flow with myocardial perfusion imaging （MPI） is meth- odologically limited to predict the presence or absence of flow-limited coronary artery disease （CAD）. This limi- tation may often occur, when obstructive lesions involve multiple epicardial coronary arteries or disease-related disturbances of the coronary circulation coexist at the microvascular level. Non-invasive assessment of myocar- dial blood flow in absolute units with position emission tomography （PET） has been positioned as the solution to improve CAD diagnosis and prediction of patient outcomes associated with risks for cardiac events. This article reviews technical and clinical aspects of myocardial blood flow quantitation with PET and discusses the practical consideration of this approach toward worldwide clinical utilization.展开更多
The advantage of using plants in nanoparticles synthesis is that they are easily available, safe to handle and possess a broad variability of metabolites such as antioxidants, nucleotides and vitamins. The aim of this...The advantage of using plants in nanoparticles synthesis is that they are easily available, safe to handle and possess a broad variability of metabolites such as antioxidants, nucleotides and vitamins. The aim of this study was to investigate the effects of Green and Zimbro tea and also Green coconut water as a reducing and stabilizer agent in gold nanoparticle synthesis. The gold nanoparticles were characterized by UV-Vis absorption spectroscopy, X-ray diffraction (XRD), Dynamic light scattering (DLS) and Transmission electron microscopy (TEM) analysis. Their physical stability was determined using a UV-Vis spectrophotometer over several days during storage at room temperature. We observed that green chemical process to obtain gold nanoparticles did not require any external chemicals reagent for stabilization of nanoparticulate. Absorption measurements indicated that the plasmon resonance wavelength appears around 530 nm. X-ray diffracto-grams of gold nanoparticles evidenced the presence of Au-rich (fcc) phases. TEM analysis showed a homogeneous dispersion of nanoparticles and some agglomerates. Differences in size and shape of the nanoparticles were observed. Zeta potential of AuNPs synthetized in presence of Green tea was -33 mV indicating stability of the synthesized nanoparticles.展开更多
Currently,18F-FDG coincidence SPECT(Co-SPECT)/CT scan still serves as an important tool for diagnosis,staging,and evaluation of cancer treatment in developing countries.We implemented full physical corrections(FPC) to...Currently,18F-FDG coincidence SPECT(Co-SPECT)/CT scan still serves as an important tool for diagnosis,staging,and evaluation of cancer treatment in developing countries.We implemented full physical corrections(FPC) to Co-SPECT(quantitative Co-SPECT) to improve the image resolution and contrast along with the capability for image quantitation.FPC included attenuation,scatter,resolution recovery,and noise reduction.A standard NEMA phantom filled with 10:1 F-18 activity concentration ratio in spheres and background was utilized to evaluate image performance.Subsequently,15 patients with histologically confirmed thoracic carcinomas were included to undergo a 18 F-FDG Co-SPECT/CT scan followed by a 18 F-FDG PET/CT scan.Functional parameters as SUVmax,SUVmean,SULpeak,and MTV from both quantitative Co-SPECT and PET were analyzed.Image resolution of Co-SPECT for NEMA phantom was improved to reveal the smallest sphere from a diameter of 28 mm to 22 mm(17 mm for PET).The image contrast was enhanced from 1.7 to 6.32(6.69 for PET) with slightly degraded uniformity in background(3.1% vs.6.7%)(5.6% for PET).Patients’ SUVmax,SUVmean,SULpeak,and MTV measured from quantitative Co-SPECT were overall highly correlated with those from PET(r=0.82-0.88).Adjustment of the threshold of SUVmax and SUV to determine SUVmean and MTV did not further change the correlations with PET(r=0.81-0.88).Adding full physical corrections to Co-SPECT images can significantly improve image resolution and contrast to reveal smaller tumor lesions along with the capability to quantify functional parameters like PET/CT.展开更多
文摘Assessment of the relative distribution of myocardial flow with myocardial perfusion imaging （MPI） is meth- odologically limited to predict the presence or absence of flow-limited coronary artery disease （CAD）. This limi- tation may often occur, when obstructive lesions involve multiple epicardial coronary arteries or disease-related disturbances of the coronary circulation coexist at the microvascular level. Non-invasive assessment of myocar- dial blood flow in absolute units with position emission tomography （PET） has been positioned as the solution to improve CAD diagnosis and prediction of patient outcomes associated with risks for cardiac events. This article reviews technical and clinical aspects of myocardial blood flow quantitation with PET and discusses the practical consideration of this approach toward worldwide clinical utilization.
文摘The advantage of using plants in nanoparticles synthesis is that they are easily available, safe to handle and possess a broad variability of metabolites such as antioxidants, nucleotides and vitamins. The aim of this study was to investigate the effects of Green and Zimbro tea and also Green coconut water as a reducing and stabilizer agent in gold nanoparticle synthesis. The gold nanoparticles were characterized by UV-Vis absorption spectroscopy, X-ray diffraction (XRD), Dynamic light scattering (DLS) and Transmission electron microscopy (TEM) analysis. Their physical stability was determined using a UV-Vis spectrophotometer over several days during storage at room temperature. We observed that green chemical process to obtain gold nanoparticles did not require any external chemicals reagent for stabilization of nanoparticulate. Absorption measurements indicated that the plasmon resonance wavelength appears around 530 nm. X-ray diffracto-grams of gold nanoparticles evidenced the presence of Au-rich (fcc) phases. TEM analysis showed a homogeneous dispersion of nanoparticles and some agglomerates. Differences in size and shape of the nanoparticles were observed. Zeta potential of AuNPs synthetized in presence of Green tea was -33 mV indicating stability of the synthesized nanoparticles.
基金supported by the internal research grant from China-Japan Friendship Hospital,Beijing,China(Grant No.2016-1QN-9)。
文摘Currently,18F-FDG coincidence SPECT(Co-SPECT)/CT scan still serves as an important tool for diagnosis,staging,and evaluation of cancer treatment in developing countries.We implemented full physical corrections(FPC) to Co-SPECT(quantitative Co-SPECT) to improve the image resolution and contrast along with the capability for image quantitation.FPC included attenuation,scatter,resolution recovery,and noise reduction.A standard NEMA phantom filled with 10:1 F-18 activity concentration ratio in spheres and background was utilized to evaluate image performance.Subsequently,15 patients with histologically confirmed thoracic carcinomas were included to undergo a 18 F-FDG Co-SPECT/CT scan followed by a 18 F-FDG PET/CT scan.Functional parameters as SUVmax,SUVmean,SULpeak,and MTV from both quantitative Co-SPECT and PET were analyzed.Image resolution of Co-SPECT for NEMA phantom was improved to reveal the smallest sphere from a diameter of 28 mm to 22 mm(17 mm for PET).The image contrast was enhanced from 1.7 to 6.32(6.69 for PET) with slightly degraded uniformity in background(3.1% vs.6.7%)(5.6% for PET).Patients’ SUVmax,SUVmean,SULpeak,and MTV measured from quantitative Co-SPECT were overall highly correlated with those from PET(r=0.82-0.88).Adjustment of the threshold of SUVmax and SUV to determine SUVmean and MTV did not further change the correlations with PET(r=0.81-0.88).Adding full physical corrections to Co-SPECT images can significantly improve image resolution and contrast to reveal smaller tumor lesions along with the capability to quantify functional parameters like PET/CT.
