Background:Inflatable Penile Prosthesis(IPP)is the treatment for erectile dysfunction(ED)refractory to pharmacological therapies.Long-term data on factors associated with prosthesis survival remain unclear.This study ...Background:Inflatable Penile Prosthesis(IPP)is the treatment for erectile dysfunction(ED)refractory to pharmacological therapies.Long-term data on factors associated with prosthesis survival remain unclear.This study aimed to analyze the long-term survival of penile prostheses and identify risk factors associated with survival without reintervention.Methods:This is a retrospective,single-center study of patients who underwent IPP implantation between January 2014 and December 2022.Preoperative data related to the patient and the etiology of ED,as well as perioperative data,were collected.The primary outcome was survival without reintervention,defined as prosthesis revision or explantation due to mechanical dysfunction or infection.We conducted survival analyses without reintervention and searched for risk factors using a multivariate Cox model.Results:In total,33 out of 137 patients underwent reintervention(24.1%),including 24(17.5%)prosthesis revisions and 9(6.6%)had explantations.Median follow-up was 39 months with an interquartile range(IQR)of 9.00 to 62.00.Median survival without reintervention was 7 years.In univariate analysis,downsizing(p=0.046)was associated with reintervention.Smoking(p=0.003)and age(p=0.034)were associated with prosthesis explantation.The number of implantations(p=0.009)was associated with prosthesis revision.Multivariate analysis by the Cox model did not identify any independent predictive factors for reintervention.Conclusion:Smoking may play a role in infection post-IPP implantation.Primary implantations seem to be associated with better survival.Adjusting cylinder size,known as downsizing,is likely to be a proxy for the complexity of the procedure and thus linked to earlier reintervention.展开更多
目的分析2010—2023年非洲疟疾流行国家药浸蚊帐(insecticide-treated net,ITN)拥有情况,为我国更深入参与非洲疟疾治理提供参考。方法以2015年和2020年为时间节点,将2010—2023年分为基期(2010—2015年)、中期(2016—2019年)和终期(202...目的分析2010—2023年非洲疟疾流行国家药浸蚊帐(insecticide-treated net,ITN)拥有情况,为我国更深入参与非洲疟疾治理提供参考。方法以2015年和2020年为时间节点,将2010—2023年分为基期(2010—2015年)、中期(2016—2019年)和终期(2020—2023年)3个阶段,纳入11个在上述3个阶段均至少开展了1次人口与健康调查(Demographic and Health Survey,DHS)的非洲国家进行分析。从DHS数据库获取2010—2023年上述11个国家开展的33次调查中的ITN数据。计算上述国家ITN来源构成比,以及各阶段ITN人均拥有数、总体拥有率与每2人拥有率,分析ITN人均拥有数在城乡家庭之间和不同社会经济状况家庭之间的差异。结果在中期和终期,11个非洲国家来源于分发活动的ITN构成比分别为60.24%~94.01%、50.46%~85.04%。在基期、中期与终期,11个国家总体ITN人均拥有数的中位数(四分位数间距)分别为0.22(0.50)、0.33(0.50)和0.33(0.50),总体拥有率[95%可信区间(confidence interval,CI)]分别为59.77%(59.50%,60.05%)、70.32%(70.06%,70.57%)和69.21%(68.95%,69.47%),每2人拥有率(95%CI)分别为26.91%(26.66%,27.16%)、38.07%(37.80%,38.34%)和36.56%(36.29%,36.84%)。11个非洲国家中,有7个国家ITN人均拥有数在上述3个阶段呈先增长后下降的趋势(H=102.518~2327.440,P均<0.05;Z=-48.886~-4.653,P均<0.0167)。33项调查中,分别有31项调查显示城乡家庭间(Z=-26.719~-2.472,P均<0.05)、28项调查显示不同社会经济状况家庭间(Z=-27.316~-4.068,P均<0.001)ITN人均拥有数差异有统计学意义,其中20项调查显示乡村家庭ITN人均拥有数高于城市家庭,17项调查显示最贫穷家庭ITN人均拥有数高于最富有家庭。结论11个非洲国家ITN拥有情况存在较大差异,建议我国同非洲国家有针对性地开展ITN等疟疾防治项目,共建“人类卫生健康共同体”。展开更多
Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of waters.However,it still suffers from inefficient charge transfer...Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of waters.However,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current collectors.Herein,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport significantly.The effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal resistance.With the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current collectors.Meanwhile,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current collectors.Additionally,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.展开更多
BACKGROUND Parental presence in neonatal units(NUs)is essential for infant development and family well-being.A deeper understanding of the factors influencing parental presence is vital and will contribute to the deve...BACKGROUND Parental presence in neonatal units(NUs)is essential for infant development and family well-being.A deeper understanding of the factors influencing parental presence is vital and will contribute to the development of targeted interventions and policies that enhance parental engagement in neonatal care,thereby improving outcomes for infants and their families.AIM To identify and analyze primary factors influencing parental involvement in their child’s care in a neonatal intensive care unit(NICU).METHODS A literature search was conducted using the PubMed,MEDLINE,and Cochrane Library for systematic reviews databases,with the following search terms:“parental presence neonatology”,“couplet care”,“zero separation neonatal care”,“family integrated care”,“couplet care intervention”,“mother-child separation”,“parents newborn togetherness”,“mother-baby care”,“closeness and separation NICU”,“mother-infant interaction NICU”,“kangaroo care”,“dyad mother-infant”,and“newborn integrated care”.The database search for this literature review began on December 10,2024,with the final search conducted on April 10,2025.RESULTS The literature search yielded 281 articles,out of which 23 were selected for a detailed review.The factors associated with parental presence in NUs were grouped into five main categories:Parents’socio-demographic and cultural traits;the physical layout and care model of the NUs;the quality of parents’relationships with the healthcare staff;their active involvement in neonatal care;and the newborn’s health status.CONCLUSION The identification of factors that affect parental presence in NUs is critical for developing effective strategies aimed at encouraging increased parental involvement and ultimately improving neonatal and family outcomes.展开更多
Decision support systems(DSS)based on physically based numerical models are standard tools used by water services and utilities.However,few DSS based on holistic approaches combining distributed hydrological,hydraulic...Decision support systems(DSS)based on physically based numerical models are standard tools used by water services and utilities.However,few DSS based on holistic approaches combining distributed hydrological,hydraulic,and hydrogeological models are operationally exploited.This holistic approach was adopted for the development of the AquaVar DSS,used for water resource management in the French Mediterranean Var watershed.The year 2019 marked the initial use of the DSS in its operational environment.Over the next 5 years,multiple hydrological events allowed to test the performance of the DSS.The results show that the tool is capable of simulating peak flows associated with two extreme rainfall events(storms Alex and Aline).For a moderate flood,the real-time functionality was able to simulate forecast discharges 26 h before the flood peak,with a maximum local error of 30%.Finally,simulations for the drought period 2022-2023 highlighted the essential need for DSS to evolve in line with changing climatic conditions,which give rise to unprecedented hydrological processes.The lessons learned from these first 5 years of AquaVar use under operational conditions are synthesized,addressing various topics such as DSS modularity,evolution,data positioning,technology,and governance.展开更多
文摘Background:Inflatable Penile Prosthesis(IPP)is the treatment for erectile dysfunction(ED)refractory to pharmacological therapies.Long-term data on factors associated with prosthesis survival remain unclear.This study aimed to analyze the long-term survival of penile prostheses and identify risk factors associated with survival without reintervention.Methods:This is a retrospective,single-center study of patients who underwent IPP implantation between January 2014 and December 2022.Preoperative data related to the patient and the etiology of ED,as well as perioperative data,were collected.The primary outcome was survival without reintervention,defined as prosthesis revision or explantation due to mechanical dysfunction or infection.We conducted survival analyses without reintervention and searched for risk factors using a multivariate Cox model.Results:In total,33 out of 137 patients underwent reintervention(24.1%),including 24(17.5%)prosthesis revisions and 9(6.6%)had explantations.Median follow-up was 39 months with an interquartile range(IQR)of 9.00 to 62.00.Median survival without reintervention was 7 years.In univariate analysis,downsizing(p=0.046)was associated with reintervention.Smoking(p=0.003)and age(p=0.034)were associated with prosthesis explantation.The number of implantations(p=0.009)was associated with prosthesis revision.Multivariate analysis by the Cox model did not identify any independent predictive factors for reintervention.Conclusion:Smoking may play a role in infection post-IPP implantation.Primary implantations seem to be associated with better survival.Adjusting cylinder size,known as downsizing,is likely to be a proxy for the complexity of the procedure and thus linked to earlier reintervention.
文摘目的分析2010—2023年非洲疟疾流行国家药浸蚊帐(insecticide-treated net,ITN)拥有情况,为我国更深入参与非洲疟疾治理提供参考。方法以2015年和2020年为时间节点,将2010—2023年分为基期(2010—2015年)、中期(2016—2019年)和终期(2020—2023年)3个阶段,纳入11个在上述3个阶段均至少开展了1次人口与健康调查(Demographic and Health Survey,DHS)的非洲国家进行分析。从DHS数据库获取2010—2023年上述11个国家开展的33次调查中的ITN数据。计算上述国家ITN来源构成比,以及各阶段ITN人均拥有数、总体拥有率与每2人拥有率,分析ITN人均拥有数在城乡家庭之间和不同社会经济状况家庭之间的差异。结果在中期和终期,11个非洲国家来源于分发活动的ITN构成比分别为60.24%~94.01%、50.46%~85.04%。在基期、中期与终期,11个国家总体ITN人均拥有数的中位数(四分位数间距)分别为0.22(0.50)、0.33(0.50)和0.33(0.50),总体拥有率[95%可信区间(confidence interval,CI)]分别为59.77%(59.50%,60.05%)、70.32%(70.06%,70.57%)和69.21%(68.95%,69.47%),每2人拥有率(95%CI)分别为26.91%(26.66%,27.16%)、38.07%(37.80%,38.34%)和36.56%(36.29%,36.84%)。11个非洲国家中,有7个国家ITN人均拥有数在上述3个阶段呈先增长后下降的趋势(H=102.518~2327.440,P均<0.05;Z=-48.886~-4.653,P均<0.0167)。33项调查中,分别有31项调查显示城乡家庭间(Z=-26.719~-2.472,P均<0.05)、28项调查显示不同社会经济状况家庭间(Z=-27.316~-4.068,P均<0.001)ITN人均拥有数差异有统计学意义,其中20项调查显示乡村家庭ITN人均拥有数高于城市家庭,17项调查显示最贫穷家庭ITN人均拥有数高于最富有家庭。结论11个非洲国家ITN拥有情况存在较大差异,建议我国同非洲国家有针对性地开展ITN等疟疾防治项目,共建“人类卫生健康共同体”。
基金supported by the Shenzhen Science and Technology Program(JCYJ20230808105111022,JCYJ20220818095806013)Natural Science Foundation of Guangdong(2023A1515012267)+1 种基金the National Natural Science Foundation of China(22178223)the Royal Society/NSFC cost share program(IEC\NSFC\223372).
文摘Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of waters.However,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current collectors.Herein,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport significantly.The effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal resistance.With the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current collectors.Meanwhile,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current collectors.Additionally,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.
文摘BACKGROUND Parental presence in neonatal units(NUs)is essential for infant development and family well-being.A deeper understanding of the factors influencing parental presence is vital and will contribute to the development of targeted interventions and policies that enhance parental engagement in neonatal care,thereby improving outcomes for infants and their families.AIM To identify and analyze primary factors influencing parental involvement in their child’s care in a neonatal intensive care unit(NICU).METHODS A literature search was conducted using the PubMed,MEDLINE,and Cochrane Library for systematic reviews databases,with the following search terms:“parental presence neonatology”,“couplet care”,“zero separation neonatal care”,“family integrated care”,“couplet care intervention”,“mother-child separation”,“parents newborn togetherness”,“mother-baby care”,“closeness and separation NICU”,“mother-infant interaction NICU”,“kangaroo care”,“dyad mother-infant”,and“newborn integrated care”.The database search for this literature review began on December 10,2024,with the final search conducted on April 10,2025.RESULTS The literature search yielded 281 articles,out of which 23 were selected for a detailed review.The factors associated with parental presence in NUs were grouped into five main categories:Parents’socio-demographic and cultural traits;the physical layout and care model of the NUs;the quality of parents’relationships with the healthcare staff;their active involvement in neonatal care;and the newborn’s health status.CONCLUSION The identification of factors that affect parental presence in NUs is critical for developing effective strategies aimed at encouraging increased parental involvement and ultimately improving neonatal and family outcomes.
文摘Decision support systems(DSS)based on physically based numerical models are standard tools used by water services and utilities.However,few DSS based on holistic approaches combining distributed hydrological,hydraulic,and hydrogeological models are operationally exploited.This holistic approach was adopted for the development of the AquaVar DSS,used for water resource management in the French Mediterranean Var watershed.The year 2019 marked the initial use of the DSS in its operational environment.Over the next 5 years,multiple hydrological events allowed to test the performance of the DSS.The results show that the tool is capable of simulating peak flows associated with two extreme rainfall events(storms Alex and Aline).For a moderate flood,the real-time functionality was able to simulate forecast discharges 26 h before the flood peak,with a maximum local error of 30%.Finally,simulations for the drought period 2022-2023 highlighted the essential need for DSS to evolve in line with changing climatic conditions,which give rise to unprecedented hydrological processes.The lessons learned from these first 5 years of AquaVar use under operational conditions are synthesized,addressing various topics such as DSS modularity,evolution,data positioning,technology,and governance.
