This study developed a digital twin(DT)and structural health monitoring(SHM)system for a balanced cantilever bridge,utilizing advanced measurement techniques to enhance accuracy.Vibration and dynamic strain measuremen...This study developed a digital twin(DT)and structural health monitoring(SHM)system for a balanced cantilever bridge,utilizing advanced measurement techniques to enhance accuracy.Vibration and dynamic strain measurements were obtained using accelerometers and piezo-resistive strain gauges,capturing low-magnitude dynamic strains during operational vibrations.3D-LiDAR scanning and Ultrasonic Pulse Velocity(UPV)tests captured the bridge's as-is geometry and modulus of elasticity.The resulting detailed 3D point cloud model revealed the structure's true state and highlighted discrepancies between the as-designed and as-built conditions.Dynamic properties,including modal frequencies and shapes,were extracted from the strain and acceleration measurements,providing critical insights into the bridge's structural behavior.The neutral axis depth,indicating stress distribution and potential damage,was accurately determined.Good agreement between vibration measurement data and the as-is model results validated the reliability of the digital twin model.Dynamic strain patterns and neutral axis parameters showed strong correlation with model predictions,serving as sensitive indicators of local damage.The baseline digital twin model and measurement results establish a foundation for future bridge inspections and investigations.This study demonstrates the effectiveness of combining digital twin technology with field measurements for real-time monitoring and predictive maintenance,ensuring the sustainability and safety of the bridge infrastructure,thereby enhancing its overall resilience to operational and environmental stressors.展开更多
The conversion of sound vibration into electrical potential is a critical function performed by cochlear hair cells.Unlike the regenerative capacity found in various other cells throughout the body,cochlear sensory ce...The conversion of sound vibration into electrical potential is a critical function performed by cochlear hair cells.Unlike the regenerative capacity found in various other cells throughout the body,cochlear sensory cells lack the ability to regenerate once damaged.Furthermore,a decline in the quantity of these cells results in a deterioration of auditory function.Piezoelectric materials can generate electric charge in response to sound wave vibration,making them theoretically suitable for replacing hair cell function.This study explores an innovative approach using piezoelectric nanocomposite filaments,namely poly(vinylidene fluoride),poly(vinylidene fluoride)/barium titanate,and poly(vinylidene fluoride)/reduced graphene oxide,as self-powered acoustic sensors designed to function in place of cochlear hair cells.These flexible filaments demonstrate a unique ability to generate electricity in response to frequency sounds from 50 up to 1000 Hz at moderate sound pressure levels(60–95 dB),approaching the audible range with an overall acoustoelectric energy conversion efficiency of 3.25%.Serving as self-powered acoustic sensors,these flexible filaments hold promise for potential applications in cochlear implants,with a high sensitivity of 117.5 mV(Pa-cm^(2))^(-1).The cytocompatibility of these filaments was assessed through in vitro viability tests conducted on three cell lines,serving as a model for inner ear cells.展开更多
Polyphenol is an important secondary metabolite with unique physiological functions and biological activity.The polyphenols in different plants and biomass have different chemical structures,which needs various extrac...Polyphenol is an important secondary metabolite with unique physiological functions and biological activity.The polyphenols in different plants and biomass have different chemical structures,which needs various extraction methods to obtain them.Recently,plant polyphenols and their application research in food and medicine have become a research hotspot,which is mainly focused on preparation,purification,structural identification,and biological activity assays.Among these researches,extraction and separation are the key sections to investigate the structure and activity of polyphenol.Hence,this review summarized the recent extraction and separation techniques of polyphenol,including solvent extraction,supercritical fluid extraction,ultrasonic extraction,enzymatic extraction,resin adsorption extraction,and electric field method,etc.In addition,this review also reveals the current problems and proposes future extraction research of polyphenol.It is hoped that this review will provide a guide for the researchers who are actively committed to promoting progress in the field of polyphenolics.展开更多
AIM:To compare the efficacy and safety of tenofovir disoproxil fumarate(TDF)in Asian and non-Asian chronic hepatitis B(CHB)patients.METHODS:The efficacy and safety of the initial 48wk of treatment with TDF was compare...AIM:To compare the efficacy and safety of tenofovir disoproxil fumarate(TDF)in Asian and non-Asian chronic hepatitis B(CHB)patients.METHODS:The efficacy and safety of the initial 48wk of treatment with TDF was compared in a posthoc analysis of combined data from 217 Asians and299 non-Asians included in Studies 102 and 103and a post-approval,open-label trial(Study 123).Patient groups were compared according to baseline hepatitis B e antigen(HBe Ag)status and viral load.The main outcome measures included the proportion of patients who achieved a hepatitis B virus(HBV)DNA level<400 copies/m L at Week 48 of treatment.Secondary measures included:HBV DNA and alanine aminotransaminase(ALT)levels over time;proportion of patients with normal ALT levels;proportion of patients with HBe Ag loss/seroconversion and proportion of patients with hepatitis B surface antigen loss/seroconversion;changes in liver histology.Safety and tolerability were evaluated by the occurrence of adverse events(AEs),serious AEs,laboratory abnormalities,discontinuation of the study drug due to AEs,or death.The primary efficacy and safety analysis set included all patients who were randomly assigned to treatment and received at least one dose of study drug.RESULTS:At week 48,similar proportions of Asians and non-Asians reached HBV DNA<400 copies/m L(96%of Asian and 97%of non-Asian patients with HBe Ag-negative CHB and 83%of Asian and 79%of non-Asian patients with HBe Ag-positive CHB had HBV DNA)and normal ALT(78%of Asian and 81%of nonAsian patients with HBe Ag-negative CHB and 71%of Asian and 74%of non-Asian patients with HBe Agpositive CHB had normal ALT).On-treatment HBV DNA decline rates were similar between Asians and nonAsians regardless of baseline HBe Ag status and viralload.HBV DNA decline during the first four weeks was2.9 log10 copies/m L in HBe Ag-negative Asians and nonAsians,and in HBe Ag-positive non-Asians,and 3.1log10 copies/m L in HBe Ag-positive Asians.HBe Ag loss and seroconversion was achieved in 14%of Asians vs 26%and 24%,respectively,in non-Asians.Liver histology improved in 77.2%of Asians and 71.5%of non-Asians.No resistance to TDF developed.No renal safety signals were observed.CONCLUSION:TDF demonstrated similar viral suppression,normalization of ALT,improvements in liver fibrosis,and no detectable resistance in Asian and non-Asian patients regardless of baseline HBe Ag status.展开更多
Sodium-ion capacitors(SICs)have received increasing interest for grid stationary energy storage application due to their affordability,high power,and energy densities.The major challenge for SICs is to overcome the ki...Sodium-ion capacitors(SICs)have received increasing interest for grid stationary energy storage application due to their affordability,high power,and energy densities.The major challenge for SICs is to overcome the kinetics imbalance between faradaic anode and nonfaradaic cathode.To boost the Na+reaction kinetics,the present work demonstrated a high-rate MnS-based anode by embedding the MnS nanocrystals into the N,S-co-doped carbon matrix(MnS@NSC).Benefiting from the fast pseudocapacitive Na+storage behavior,the resulting composite exhibits extraordinary rate capability(205.6 mAh g−1 at 10 A g−1)and outstanding cycling stability without notable degradation after 2000 cycles.A prototype SIC was demonstrated using MnS@NSC anode and N-doped porous carbon(NC)cathode;the obtained hybrid SIC device can display a high energy density of 139.8 Wh kg−1 and high power density of 11,500 W kg−1,as well as excellent cyclability with 84.5%capacitance retention after 3000 cycles.The superior electrochemical performance is contributed to downsizing of MnS and encapsulation of conductive N,S-co-doped carbon matrix,which not only promote the Na+and electrons transport,but also buffer the volume variations and maintain the structure integrity during Na+insertion/extraction,enabling its comparable fast reaction kinetics and cyclability with NC cathode.展开更多
AIM:To evaluate the efficacy and tolerability of the fixed combination of bimatoprost 0.03%and timolol 0.5%(BTFC)in patients in Greece with primary open angle glaucoma(POAG)or ocular hypertension(OHT)whose previous th...AIM:To evaluate the efficacy and tolerability of the fixed combination of bimatoprost 0.03%and timolol 0.5%(BTFC)in patients in Greece with primary open angle glaucoma(POAG)or ocular hypertension(OHT)whose previous therapy provided insufficient lowering of intraocular pressure(IOP).·METHODS:A multicenter,prospective,open-label,non-interventional,observational study of the use of BTFC in clinical practice was conducted at 41 sites in Greece.The primary endpoint was the reduction in IOP from baseline at study end,approximately 12wk after initiation of BTFC therapy.·RESULTS:A total of 785 eligible patients were enrolled in the study and 97.6%completed the study.The mean±SD IOP reduction from baseline at 12wk after initiation of BTFC was 6.3±2.8 mm Hg(=764;〈0.001).In patients(=680)who replaced their previous IOP-lowering monotherapy(a single drug,or a fixed combination of 2drugs in a single ophthalmic drop)with once-daily BTFC,the mean±SD IOP reduction from baseline at 12wk was 6.2±2.8 mm Hg(〈0.001).IOP was reduced from baseline in 99.2%of patients,and 58.0%of patients reached or exceeded their target IOP.Substantial mean IOP reductions were observed regardless of the previous therapy.BTFC was well tolerated,with 96.0%of patients who completed the study rating the tolerability of BTFC as"good"or"very good."Adverse events were reported in 8.3%of patients;only 0.6%of patients discontinued the study due to adverse events.·C ONCLUSION:In clinical practice in Greece,BTFC is well tolerated and effectively lower the IOP in patients with POAG or OHT who requires additional IOP lowering on their previous therapy.展开更多
Amorphous Fe78-xRExSi4 Nb5 B12Cu1(RE=Gd,Dy) ribbons with different RE contents were prepared by melt spinning to investigate the effect of heavy rare earth(Gd,Dy) substitution on the hyperfine structure,magnetic prope...Amorphous Fe78-xRExSi4 Nb5 B12Cu1(RE=Gd,Dy) ribbons with different RE contents were prepared by melt spinning to investigate the effect of heavy rare earth(Gd,Dy) substitution on the hyperfine structure,magnetic properties and magnetocaloric effect.The Curie temperature of RE substituted alloys,hyperfine field and magnetic moments of Fe atoms initially increase up to 1 at% RE content and then decrease monotonously for increasing RE content up to 10 at%.The dependence of magnetic entropy change(-△SM) and refrigeration capacity(RC) of the alloys on RE contents displays the same tendency.The RCAREA values of the alloys substituted with 1 at% Gd and Dy are similar to those of recently reported Fe-based metallic glasses with enhanced RC values compared with those of Gd5 Ge1.9Si2 Fe0.1.Enhanced-△SM and RC values,negligible coercive force and hysteresis commonly make these Fe78-xREx-Si4 Nb5 B12Cu1 amorphous alloys as low-cost candidates for high-temperature magnetic refrigeration.展开更多
Water resources, although renewable, are limited and threatened by climate <span>change and anthropic activities. Assessment and forecasting of these resources</span> can provide valuable information for w...Water resources, although renewable, are limited and threatened by climate <span>change and anthropic activities. Assessment and forecasting of these resources</span> can provide valuable information for water resource planners. This study aims to quantify the surface water resources used for sugarcane production in sugar complexes of Ferkessedougou. This is based on the morphological characterization of the river Morrison and Lopkoho dams and on <span>extreme daily flow probability of occurrence estimation using frequency analysis</span> method. The bathymetric survey showed that the Morrison Dam im<span>poundment had a maximum depth of 11.98 m;a water capacity of 11,656,735.5</span> m<sup>3</sup>. For the Lokpoho dam, the reservoir had a maximum depth of 8.82 m, which corresponds to a water volume of 4,354,531.5 m<sup>3</sup>. Nevertheless, the water capacity of these reservoirs is greatly reduced by a large volume of sediment estimated at 1,013,058.96 m<sup>3</sup> for Morrison and 599,740 m<sup>3</sup> for Lokpoho. Statistical analysis of maximum daily flows shows that flows between 73.9 and 100 m<sup>3</sup>/s have the potential to occur every five years at the Route Korhogo Badikaha hydrometric station. The recurrence of the decennial (298 m<sup>3</sup>) and quinquenal (248 m<sup>3</sup>) flows shows the importance of the flood flows of the Bandama River. It also shows that the low water levels of the Bandama are very pronounced. The minimum flow that SUCAF-CI water managers should expect every five years is 1.36 m<sup>3</sup>/s and the ten-year low flow is 2.10 m<sup>3</sup>/s. These results are indicators of water scarcity risks and could guide decision making in the Ferkessedougou sugar complexes.展开更多
Satellite precipitation products are widely used in different domain, in area where there is a lack in observation. These have different spatio-temporal resolutions consequently resulting in different precipitation am...Satellite precipitation products are widely used in different domain, in area where there is a lack in observation. These have different spatio-temporal resolutions consequently resulting in different precipitation amounts depending on the product. The present study validates three satellite products, namely the Climate Hazard group Infrared Precipitation with Stations (CHIRPS), the Climate Research Unit (CRU) and the Global Precipitation Climatology Project (GPCP) over Bandama and Mono river basins for 1981-2005 and 1981-2016 respectively by comparing them to the observation precipitation of the basin. The available studies are focused on the regional scale but not on a watershed scale for hydrological studies. The analysis reveals that all the products are strongly correlated to each other as well as to the observed data at basin level. The Lamb coefficient test shows that most all the chosen basin namely Bandama and Mono presents the same climatic indices. All the products present the same variability and trend as the observation at basins scale. By comparing those products to observation, CHIRPS product following by GPCP give the lowest mean absolute error (MAE) at annual and seasonal time scales while CHIRPS is followed by CRU at monthly scale. Overall, all products overestimate the precipitation at Bandama basin while they underestimate it over Mono river basin. The comparison over 1981-2017 period of the total annual precipitation increasing southern ward (from Sahel to the coastal zone) for all the three studied products which varies from 300 mm to 2400 mm/year. All the three products are not significantly different from one another and they all highlight the same areas of hotspot rainfall in the region. The same conclusion is made at monthly and seasonal scales. Therefore, any of these products especially CHIRPS can be used for study in this region due to its lowest bias and MAE.展开更多
Smart molecules have attracted increasing attention due to their transformative role in creating the next generation of smart structures and devices.Smart bistable coordination complexes are a class of functional comp...Smart molecules have attracted increasing attention due to their transformative role in creating the next generation of smart structures and devices.Smart bistable coordination complexes are a class of functional complexes which have two stable states that can be reversibly switched in response to external stimuli.Such bistable molecules play a vital role in various applications,such as sensors,data storage,spintronics,smart windows,optical switches,information encryption and decryption,displays,actuators,etc.Herein,the recent research studies into the development of these smart bistable metal coordination complexes are reviewed.According to the different external stimuli,these smart bistable coordination systems have been classified and summarized,including light-responsive systems,thermally-responsive systems,electrically-responsive systems,mechanicallyresponsive systems,and some other cases.These systems are further subdivided according to the changes in signals(e.g.,color,fluorescence,spin state,crystalline phase)under external stimuli.The design principles of each type of smart bistable metal complexes as well as their broad and innovative applications are comprehensively described.Finally,the challenges and opportunities in this field are briefly analyzed and discussed.展开更多
The West African Monsoon (WAM) is characterized by strong decadal and multi-decadal variability and the impacts can be catastrophic for the local populations. One of the factors put forward to explain this variability...The West African Monsoon (WAM) is characterized by strong decadal and multi-decadal variability and the impacts can be catastrophic for the local populations. One of the factors put forward to explain this variability involves the role of atmospheric dynamics, linked in particular to the Saharan Heat Low (SHL). This article addresses this question by comparing the sets of preindustrial control and historical simulation data from climate models carried out in the framework of the CMIP5 project and observations data over the 20<sup>th</sup> century. Through multivariate statistical analyses, it was established that decadal modes of ocean variability and decadal variability of Saharan atmospheric dynamics significantly influence decadal variability of monsoon precipitation. These results also suggest the existence of external anthropogenic forcing, which is superimposed on the decadal natural variability inducing an intensification of the signal in the historical simulations compared to preindustrial control simulations. We have also shown that decadal rainfall variability in the Sahel, once the influence of oceanic modes has been eliminated, appears to be driven mainly by the activity of the Arabian Heat Low (AHL) in the central Sahel, and by the structure of the meridional temperature gradient over the inter-tropical Atlantic in the western Sahel.展开更多
A mini-hydrocyclone(MHC)is known for its higher separation efficiency,particularly for fine or ultra-fine particles.However,the exact mechanism for enhancing the separation efficiency of MHCs has not been fully elucid...A mini-hydrocyclone(MHC)is known for its higher separation efficiency,particularly for fine or ultra-fine particles.However,the exact mechanism for enhancing the separation efficiency of MHCs has not been fully elucidated.This literature review fills the existing gap by comprehensively reviewing characteristics of the flow field inside MHCs,metrics of separation performance,applicable research methods,influence of physical and operating parameters,and provides references for future design and applications.Among them,the metrics of separation performance include grade separation efficiency,total separation efficiency,cut size,pressure drop,separation sharpness,and the fish hook effect,etc.This is the first time to comprehensively review the differences between MHCs and conventional hydrocyclones(CHCs)based on the above characteristics and metrics and analyze the separation advantages of MHCs.The fluid in MHC exhibits larger centrifugal acceleration,poor symmetry of tangential velocity,higher proportion of the wall friction loss,more obvious amplitude of partial sway of the air core,and smaller ratio of the locus of zero vertical velocity height to the total length of MHC.Challenges and further work on MHCs are also discussed in terms of potential applications and needed improvements.展开更多
基金funded by the Thailand Science Research and Innovation Fund,Chulalongkorn University(BCG_FF_68_165_2100_027)The first author(Tidarut Jirawattanasomkul)also gratefully acknowledges support from the Grants for Development of New Faculty Staff,Ratchadaphiseksomphot Fund,Chulalongkorn University.The corresponding author(Supasit Srivaranun)acknowledges the Research and Innovation Funding from National Research Council of Thailand(No.N84A680208)+2 种基金the Research Grant from Faculty of Engineering,Kasetsart University(No.67/05/CE)The fourth author(Suched Likitlersuang)acknowledges Thailand Science Research and Innovation Fund Chulalongkorn University(DISF68210001)the National Research Council of Thailand(NRCT):Grant No.N42A670572.
文摘This study developed a digital twin(DT)and structural health monitoring(SHM)system for a balanced cantilever bridge,utilizing advanced measurement techniques to enhance accuracy.Vibration and dynamic strain measurements were obtained using accelerometers and piezo-resistive strain gauges,capturing low-magnitude dynamic strains during operational vibrations.3D-LiDAR scanning and Ultrasonic Pulse Velocity(UPV)tests captured the bridge's as-is geometry and modulus of elasticity.The resulting detailed 3D point cloud model revealed the structure's true state and highlighted discrepancies between the as-designed and as-built conditions.Dynamic properties,including modal frequencies and shapes,were extracted from the strain and acceleration measurements,providing critical insights into the bridge's structural behavior.The neutral axis depth,indicating stress distribution and potential damage,was accurately determined.Good agreement between vibration measurement data and the as-is model results validated the reliability of the digital twin model.Dynamic strain patterns and neutral axis parameters showed strong correlation with model predictions,serving as sensitive indicators of local damage.The baseline digital twin model and measurement results establish a foundation for future bridge inspections and investigations.This study demonstrates the effectiveness of combining digital twin technology with field measurements for real-time monitoring and predictive maintenance,ensuring the sustainability and safety of the bridge infrastructure,thereby enhancing its overall resilience to operational and environmental stressors.
基金financial support received from Deakin University through the Alfred Deakin Postdoctoral Research Fellowship(2022)partially funded by the European Union–Next-Generation EU via the Italian Ministry of University and Research(MUR),PRIN 2022 Program(PROMISE project,CUP 153D23004700006)+1 种基金support from the Australian National Fabrication Facility(ANFF)the ARC Research Hub for Future Fibres.
文摘The conversion of sound vibration into electrical potential is a critical function performed by cochlear hair cells.Unlike the regenerative capacity found in various other cells throughout the body,cochlear sensory cells lack the ability to regenerate once damaged.Furthermore,a decline in the quantity of these cells results in a deterioration of auditory function.Piezoelectric materials can generate electric charge in response to sound wave vibration,making them theoretically suitable for replacing hair cell function.This study explores an innovative approach using piezoelectric nanocomposite filaments,namely poly(vinylidene fluoride),poly(vinylidene fluoride)/barium titanate,and poly(vinylidene fluoride)/reduced graphene oxide,as self-powered acoustic sensors designed to function in place of cochlear hair cells.These flexible filaments demonstrate a unique ability to generate electricity in response to frequency sounds from 50 up to 1000 Hz at moderate sound pressure levels(60–95 dB),approaching the audible range with an overall acoustoelectric energy conversion efficiency of 3.25%.Serving as self-powered acoustic sensors,these flexible filaments hold promise for potential applications in cochlear implants,with a high sensitivity of 117.5 mV(Pa-cm^(2))^(-1).The cytocompatibility of these filaments was assessed through in vitro viability tests conducted on three cell lines,serving as a model for inner ear cells.
基金This work was sponsored by Natural Science Foundation of Jiangsu Province(BK20180772)National Natural Science Foundation of China(31800501)Qing Lan Project.
文摘Polyphenol is an important secondary metabolite with unique physiological functions and biological activity.The polyphenols in different plants and biomass have different chemical structures,which needs various extraction methods to obtain them.Recently,plant polyphenols and their application research in food and medicine have become a research hotspot,which is mainly focused on preparation,purification,structural identification,and biological activity assays.Among these researches,extraction and separation are the key sections to investigate the structure and activity of polyphenol.Hence,this review summarized the recent extraction and separation techniques of polyphenol,including solvent extraction,supercritical fluid extraction,ultrasonic extraction,enzymatic extraction,resin adsorption extraction,and electric field method,etc.In addition,this review also reveals the current problems and proposes future extraction research of polyphenol.It is hoped that this review will provide a guide for the researchers who are actively committed to promoting progress in the field of polyphenolics.
基金Supported by Gilead SciencesEditorial support was provided by Carol Lovegrove,associated with Elements Communications(Westerham,United Kingdom),and funded by Gilead Sciences
文摘AIM:To compare the efficacy and safety of tenofovir disoproxil fumarate(TDF)in Asian and non-Asian chronic hepatitis B(CHB)patients.METHODS:The efficacy and safety of the initial 48wk of treatment with TDF was compared in a posthoc analysis of combined data from 217 Asians and299 non-Asians included in Studies 102 and 103and a post-approval,open-label trial(Study 123).Patient groups were compared according to baseline hepatitis B e antigen(HBe Ag)status and viral load.The main outcome measures included the proportion of patients who achieved a hepatitis B virus(HBV)DNA level<400 copies/m L at Week 48 of treatment.Secondary measures included:HBV DNA and alanine aminotransaminase(ALT)levels over time;proportion of patients with normal ALT levels;proportion of patients with HBe Ag loss/seroconversion and proportion of patients with hepatitis B surface antigen loss/seroconversion;changes in liver histology.Safety and tolerability were evaluated by the occurrence of adverse events(AEs),serious AEs,laboratory abnormalities,discontinuation of the study drug due to AEs,or death.The primary efficacy and safety analysis set included all patients who were randomly assigned to treatment and received at least one dose of study drug.RESULTS:At week 48,similar proportions of Asians and non-Asians reached HBV DNA<400 copies/m L(96%of Asian and 97%of non-Asian patients with HBe Ag-negative CHB and 83%of Asian and 79%of non-Asian patients with HBe Ag-positive CHB had HBV DNA)and normal ALT(78%of Asian and 81%of nonAsian patients with HBe Ag-negative CHB and 71%of Asian and 74%of non-Asian patients with HBe Agpositive CHB had normal ALT).On-treatment HBV DNA decline rates were similar between Asians and nonAsians regardless of baseline HBe Ag status and viralload.HBV DNA decline during the first four weeks was2.9 log10 copies/m L in HBe Ag-negative Asians and nonAsians,and in HBe Ag-positive non-Asians,and 3.1log10 copies/m L in HBe Ag-positive Asians.HBe Ag loss and seroconversion was achieved in 14%of Asians vs 26%and 24%,respectively,in non-Asians.Liver histology improved in 77.2%of Asians and 71.5%of non-Asians.No resistance to TDF developed.No renal safety signals were observed.CONCLUSION:TDF demonstrated similar viral suppression,normalization of ALT,improvements in liver fibrosis,and no detectable resistance in Asian and non-Asian patients regardless of baseline HBe Ag status.
基金financially supported by the NRF Investigatorship (NRFI), Award No. NRF-NRFI2016-05the Campus for Research Excellent and Technological Enterprise (CREATE),National Research Foundation, Prime Minister’s Office, Singapore
文摘Sodium-ion capacitors(SICs)have received increasing interest for grid stationary energy storage application due to their affordability,high power,and energy densities.The major challenge for SICs is to overcome the kinetics imbalance between faradaic anode and nonfaradaic cathode.To boost the Na+reaction kinetics,the present work demonstrated a high-rate MnS-based anode by embedding the MnS nanocrystals into the N,S-co-doped carbon matrix(MnS@NSC).Benefiting from the fast pseudocapacitive Na+storage behavior,the resulting composite exhibits extraordinary rate capability(205.6 mAh g−1 at 10 A g−1)and outstanding cycling stability without notable degradation after 2000 cycles.A prototype SIC was demonstrated using MnS@NSC anode and N-doped porous carbon(NC)cathode;the obtained hybrid SIC device can display a high energy density of 139.8 Wh kg−1 and high power density of 11,500 W kg−1,as well as excellent cyclability with 84.5%capacitance retention after 3000 cycles.The superior electrochemical performance is contributed to downsizing of MnS and encapsulation of conductive N,S-co-doped carbon matrix,which not only promote the Na+and electrons transport,but also buffer the volume variations and maintain the structure integrity during Na+insertion/extraction,enabling its comparable fast reaction kinetics and cyclability with NC cathode.
文摘AIM:To evaluate the efficacy and tolerability of the fixed combination of bimatoprost 0.03%and timolol 0.5%(BTFC)in patients in Greece with primary open angle glaucoma(POAG)or ocular hypertension(OHT)whose previous therapy provided insufficient lowering of intraocular pressure(IOP).·METHODS:A multicenter,prospective,open-label,non-interventional,observational study of the use of BTFC in clinical practice was conducted at 41 sites in Greece.The primary endpoint was the reduction in IOP from baseline at study end,approximately 12wk after initiation of BTFC therapy.·RESULTS:A total of 785 eligible patients were enrolled in the study and 97.6%completed the study.The mean±SD IOP reduction from baseline at 12wk after initiation of BTFC was 6.3±2.8 mm Hg(=764;〈0.001).In patients(=680)who replaced their previous IOP-lowering monotherapy(a single drug,or a fixed combination of 2drugs in a single ophthalmic drop)with once-daily BTFC,the mean±SD IOP reduction from baseline at 12wk was 6.2±2.8 mm Hg(〈0.001).IOP was reduced from baseline in 99.2%of patients,and 58.0%of patients reached or exceeded their target IOP.Substantial mean IOP reductions were observed regardless of the previous therapy.BTFC was well tolerated,with 96.0%of patients who completed the study rating the tolerability of BTFC as"good"or"very good."Adverse events were reported in 8.3%of patients;only 0.6%of patients discontinued the study due to adverse events.·C ONCLUSION:In clinical practice in Greece,BTFC is well tolerated and effectively lower the IOP in patients with POAG or OHT who requires additional IOP lowering on their previous therapy.
基金Project supported by the National Natural Science Foundation of China(51874143,51801047)the Natural Science Foundation of Guangdong Province(2017A030313317)Natural Science Foundation of Zhejiang Province(LY20E010002)。
文摘Amorphous Fe78-xRExSi4 Nb5 B12Cu1(RE=Gd,Dy) ribbons with different RE contents were prepared by melt spinning to investigate the effect of heavy rare earth(Gd,Dy) substitution on the hyperfine structure,magnetic properties and magnetocaloric effect.The Curie temperature of RE substituted alloys,hyperfine field and magnetic moments of Fe atoms initially increase up to 1 at% RE content and then decrease monotonously for increasing RE content up to 10 at%.The dependence of magnetic entropy change(-△SM) and refrigeration capacity(RC) of the alloys on RE contents displays the same tendency.The RCAREA values of the alloys substituted with 1 at% Gd and Dy are similar to those of recently reported Fe-based metallic glasses with enhanced RC values compared with those of Gd5 Ge1.9Si2 Fe0.1.Enhanced-△SM and RC values,negligible coercive force and hysteresis commonly make these Fe78-xREx-Si4 Nb5 B12Cu1 amorphous alloys as low-cost candidates for high-temperature magnetic refrigeration.
文摘Water resources, although renewable, are limited and threatened by climate <span>change and anthropic activities. Assessment and forecasting of these resources</span> can provide valuable information for water resource planners. This study aims to quantify the surface water resources used for sugarcane production in sugar complexes of Ferkessedougou. This is based on the morphological characterization of the river Morrison and Lopkoho dams and on <span>extreme daily flow probability of occurrence estimation using frequency analysis</span> method. The bathymetric survey showed that the Morrison Dam im<span>poundment had a maximum depth of 11.98 m;a water capacity of 11,656,735.5</span> m<sup>3</sup>. For the Lokpoho dam, the reservoir had a maximum depth of 8.82 m, which corresponds to a water volume of 4,354,531.5 m<sup>3</sup>. Nevertheless, the water capacity of these reservoirs is greatly reduced by a large volume of sediment estimated at 1,013,058.96 m<sup>3</sup> for Morrison and 599,740 m<sup>3</sup> for Lokpoho. Statistical analysis of maximum daily flows shows that flows between 73.9 and 100 m<sup>3</sup>/s have the potential to occur every five years at the Route Korhogo Badikaha hydrometric station. The recurrence of the decennial (298 m<sup>3</sup>) and quinquenal (248 m<sup>3</sup>) flows shows the importance of the flood flows of the Bandama River. It also shows that the low water levels of the Bandama are very pronounced. The minimum flow that SUCAF-CI water managers should expect every five years is 1.36 m<sup>3</sup>/s and the ten-year low flow is 2.10 m<sup>3</sup>/s. These results are indicators of water scarcity risks and could guide decision making in the Ferkessedougou sugar complexes.
文摘Satellite precipitation products are widely used in different domain, in area where there is a lack in observation. These have different spatio-temporal resolutions consequently resulting in different precipitation amounts depending on the product. The present study validates three satellite products, namely the Climate Hazard group Infrared Precipitation with Stations (CHIRPS), the Climate Research Unit (CRU) and the Global Precipitation Climatology Project (GPCP) over Bandama and Mono river basins for 1981-2005 and 1981-2016 respectively by comparing them to the observation precipitation of the basin. The available studies are focused on the regional scale but not on a watershed scale for hydrological studies. The analysis reveals that all the products are strongly correlated to each other as well as to the observed data at basin level. The Lamb coefficient test shows that most all the chosen basin namely Bandama and Mono presents the same climatic indices. All the products present the same variability and trend as the observation at basins scale. By comparing those products to observation, CHIRPS product following by GPCP give the lowest mean absolute error (MAE) at annual and seasonal time scales while CHIRPS is followed by CRU at monthly scale. Overall, all products overestimate the precipitation at Bandama basin while they underestimate it over Mono river basin. The comparison over 1981-2017 period of the total annual precipitation increasing southern ward (from Sahel to the coastal zone) for all the three studied products which varies from 300 mm to 2400 mm/year. All the three products are not significantly different from one another and they all highlight the same areas of hotspot rainfall in the region. The same conclusion is made at monthly and seasonal scales. Therefore, any of these products especially CHIRPS can be used for study in this region due to its lowest bias and MAE.
基金supported by the National Natural Science Foundation of China(Grant Nos.22271139)the Fundamental Research Funds for the Central Universities(020514380294).
文摘Smart molecules have attracted increasing attention due to their transformative role in creating the next generation of smart structures and devices.Smart bistable coordination complexes are a class of functional complexes which have two stable states that can be reversibly switched in response to external stimuli.Such bistable molecules play a vital role in various applications,such as sensors,data storage,spintronics,smart windows,optical switches,information encryption and decryption,displays,actuators,etc.Herein,the recent research studies into the development of these smart bistable metal coordination complexes are reviewed.According to the different external stimuli,these smart bistable coordination systems have been classified and summarized,including light-responsive systems,thermally-responsive systems,electrically-responsive systems,mechanicallyresponsive systems,and some other cases.These systems are further subdivided according to the changes in signals(e.g.,color,fluorescence,spin state,crystalline phase)under external stimuli.The design principles of each type of smart bistable metal complexes as well as their broad and innovative applications are comprehensively described.Finally,the challenges and opportunities in this field are briefly analyzed and discussed.
文摘The West African Monsoon (WAM) is characterized by strong decadal and multi-decadal variability and the impacts can be catastrophic for the local populations. One of the factors put forward to explain this variability involves the role of atmospheric dynamics, linked in particular to the Saharan Heat Low (SHL). This article addresses this question by comparing the sets of preindustrial control and historical simulation data from climate models carried out in the framework of the CMIP5 project and observations data over the 20<sup>th</sup> century. Through multivariate statistical analyses, it was established that decadal modes of ocean variability and decadal variability of Saharan atmospheric dynamics significantly influence decadal variability of monsoon precipitation. These results also suggest the existence of external anthropogenic forcing, which is superimposed on the decadal natural variability inducing an intensification of the signal in the historical simulations compared to preindustrial control simulations. We have also shown that decadal rainfall variability in the Sahel, once the influence of oceanic modes has been eliminated, appears to be driven mainly by the activity of the Arabian Heat Low (AHL) in the central Sahel, and by the structure of the meridional temperature gradient over the inter-tropical Atlantic in the western Sahel.
基金supported by the China Scholarship Council(202408230140)the National Key Research and Development Project of China(2018YFE0196000)+5 种基金the Joint Funds of the National Natural Science Foundation of China(Key program)(U21A20104)Northeast Petroleum University National Fund Cultivation Project(2023-GPL-10)Guiding Science and Technology Plan Project in Daqing City(zd-2023-34)Talent Introduction and Research Initiation Project of Northeast Petroleum University(2022KQ13)the United States Department of Energy(CERC-WET Project 2.5)the Water-Energy Nexus(WEX)Center of the University of California,Irvine.
文摘A mini-hydrocyclone(MHC)is known for its higher separation efficiency,particularly for fine or ultra-fine particles.However,the exact mechanism for enhancing the separation efficiency of MHCs has not been fully elucidated.This literature review fills the existing gap by comprehensively reviewing characteristics of the flow field inside MHCs,metrics of separation performance,applicable research methods,influence of physical and operating parameters,and provides references for future design and applications.Among them,the metrics of separation performance include grade separation efficiency,total separation efficiency,cut size,pressure drop,separation sharpness,and the fish hook effect,etc.This is the first time to comprehensively review the differences between MHCs and conventional hydrocyclones(CHCs)based on the above characteristics and metrics and analyze the separation advantages of MHCs.The fluid in MHC exhibits larger centrifugal acceleration,poor symmetry of tangential velocity,higher proportion of the wall friction loss,more obvious amplitude of partial sway of the air core,and smaller ratio of the locus of zero vertical velocity height to the total length of MHC.Challenges and further work on MHCs are also discussed in terms of potential applications and needed improvements.
