The Hedgehog(HH)family includes Indian(IHH),Desert(DHH),and Sonic Hedgehog(SHH).Proteins of the HH family are distinguished by their function as morphogens,i.e.,molecules that regulate the pattern of tissue developmen...The Hedgehog(HH)family includes Indian(IHH),Desert(DHH),and Sonic Hedgehog(SHH).Proteins of the HH family are distinguished by their function as morphogens,i.e.,molecules that regulate the pattern of tissue development in accordance with concentration gradient.Data accumulated over the years clearly demonstrate that HH signaling is essential in myelination,particularly in the life cycle of the oligodendrocyte lineage.展开更多
基金Spanish government(PID2022-143110OB-IOO)Merck Foundation(20234599)grants(to FdeCS)Univesidad Camilo Jose Cela(CEIDI_VI_08_06_XI_EMYDEM)grant(to MMF)。
文摘The Hedgehog(HH)family includes Indian(IHH),Desert(DHH),and Sonic Hedgehog(SHH).Proteins of the HH family are distinguished by their function as morphogens,i.e.,molecules that regulate the pattern of tissue development in accordance with concentration gradient.Data accumulated over the years clearly demonstrate that HH signaling is essential in myelination,particularly in the life cycle of the oligodendrocyte lineage.
