Distribution networks face an increasing penetration of solar PV （photovoltaic） and small WTG （wind turbine generator） as well as other forms of micro-generation. To this scenario, one must add the dissemination o...Distribution networks face an increasing penetration of solar PV （photovoltaic） and small WTG （wind turbine generator） as well as other forms of micro-generation. To this scenario, one must add the dissemination of non-linear loads such as EV （electric vehicles）. There is something in common between those loads and sources： the extensive use of power electronic converters with commutated switches. These devices may be a source of medium-to-high frequency harmonic distortion and their impact on the local distribution grid must be carefully assessed in order to evaluate their negative impacts on the network, on the existing conventional loads and also on other active devices. In this paper, methodologies to characterize effects such as： harmonics, network unbalances, damaging power line resonance conditions, and over/under voltages are described and applied to a real local grid configuration.展开更多
Among the existing research on the treatment of disorders of consciousness(DOC),deep brain stimulation(DBS)offers a highly promising therapeutic approach.This comprehensive review documents the historical development ...Among the existing research on the treatment of disorders of consciousness(DOC),deep brain stimulation(DBS)offers a highly promising therapeutic approach.This comprehensive review documents the historical development of DBS and its role in the treatment of DOC,tracing its progression from an experimental therapy to a detailed modulation approach based on the mesocircuit model hypothesis.The mesocircuit model hypothesis suggests that DOC arises from disruptions in a critical network of brain regions,providing a framework for refining DBS targets.We also discuss the multimodal approaches for assessing patients with DOC,encompassing clinical behavioral scales,electrophysiological assessment,and neuroimaging techniques methods.During the evolution of DOC therapy,the segmentation of central nuclei,the recording of single-neurons,and the analysis of local field potentials have emerged as favorable technical factors that enhance the efficacy of DBS treatment.Advances in computational models have also facilitated a deeper exploration of the neural dynamics associated with DOC,linking neuron-level dynamics with macroscopic behavioral changes.Despite showing promising outcomes,challenges remain in patient selection,precise target localization,and the determination of optimal stimulation parameters.Future research should focus on conducting large-scale controlled studies to delve into the pathophysiological mechanisms of DOC.It is imperative to further elucidate the precise modulatory effects of DBS on thalamo-cortical and cortico-cortical functional connectivity networks.Ultimately,by optimizing neuromodulation strategies,we aim to substantially enhance therapeutic outcomes and greatly expedite the process of consciousness recovery in patients.展开更多
Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BC...Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BCIs,including their fundamental principles,technical advancements,and applications in specific domains.However,these reviews often focus on signal processing,hardware development,or limited applications such as motor rehabilitation or communication.This paper aims to offer a comprehensive review of recent electroencephalogram(EEG)-based BCI applications in the medical field across 8 critical areas,encompassing rehabilitation,daily communication,epilepsy,cerebral resuscitation,sleep,neurodegenerative diseases,anesthesiology,and emotion recognition.Moreover,the current challenges and future trends of BCIs were also discussed,including personal privacy and ethical concerns,network security vulnerabilities,safety issues,and biocompatibility.展开更多
One of the most challenging anthropogenic activities that have driven climate change off the edge is deforestation.Increased human populations have exerted a lot of pressure on natural forests due to the increased dem...One of the most challenging anthropogenic activities that have driven climate change off the edge is deforestation.Increased human populations have exerted a lot of pressure on natural forests due to the increased demand of resources—one of which is paper.An example of this effect is the increased usage of mobile phone scratch cards made out of paper that most of the population in Africa use to top-up展开更多
Semantic Web Services is an emerging technology that promises to enable dynamic, execution-time discovery, composition, and invocation of Web Services. Semantic matchmaking plays a vital role in the automated and dyna...Semantic Web Services is an emerging technology that promises to enable dynamic, execution-time discovery, composition, and invocation of Web Services. Semantic matchmaking plays a vital role in the automated and dynamic discovery process of Semantic Web Services and consists in measuring the semantic distance between a requested service and an advertised one. In this paper, an innovative approach to effectively compute the semantic distance between Ontology Web Language for Services （OWL-S） annotated services is proposed. First, an edge-based method for measuring the semantic distance between Web Ontology Language （OWL） concepts is presented. Then, a comparison of the proposed measure and the one presented in a recent related work is made in order to show that our method is more efficient and fine-grained. Finally, some equations to compute semantic matchmaking of service capabilities, which are expressed in terms of inputs and outputs, are presented.展开更多
The low-energy electronic states and energy gaps of carbon nanocones in an electric field are studied using a single-?-band tight-binding model. The analysis considers five perfect carbon nanocones with disclination a...The low-energy electronic states and energy gaps of carbon nanocones in an electric field are studied using a single-?-band tight-binding model. The analysis considers five perfect carbon nanocones with disclination angles of 60°, 120°, 180°, 240° and 300°, respectively. The numerical results reveal that the low-energy electronic states and energy gaps of a carbon nanocones are highly sensitive to its geometric shape(i.e. the disclination angle and height), and to the direction and magnitude of an electric field. The electric field causes a strong modulation of the state energies and energy gaps of the nanocones, changes their Fermi levels, and induces zero-gap transitions. The energy-gap modulation effect becomes particularly pronounced at higher strength of the applied electric field, and is strongly related to the geometric structure of the nanocone.展开更多
Enhancer RNAs(eRNAs),a subclass of non-coding RNAs transcribed from enhancer regions,have emerged as critical regulators of gene expression;however,their functional roles in prostate cancer remain largely unexplored.I...Enhancer RNAs(eRNAs),a subclass of non-coding RNAs transcribed from enhancer regions,have emerged as critical regulators of gene expression;however,their functional roles in prostate cancer remain largely unexplored.In this study,we performed integrated chromatin accessibility and transcriptomic analyses using ATAC-seq and RNA-seq on twenty pairs of prostate cancer and matched benign tissues.By incorporating chromatin immunoprecipitation sequencing data,we identified a subset of differentially expressed eRNAs significantly associated with genes involved in prostate development and oncogenic signaling pathways.Among these,lactotransferrin-eRNA(LTFe)was markedly downregulated in prostate cancer tissues,with functional analyses revealing its tumor-suppressive role.Mechanistically,LTFe promotes the transcription of its target gene,lactotransferrin(LTF),by interacting with heterogeneous nuclear ribonucleoprotein F(HNRNPF)and facilitating enhancer-promoter chromatin interactions.Furthermore,we demonstrate that the LTFe-LTF axis facilitates ferroptosis by modulating iron transport.Notably,androgen receptor(AR)signaling disrupts LTFe-associated chromatin looping,leading to ferroptosis resistance.Therapeutically,co-administration of the AR inhibitor enzalutamide and the ferroptosis inducer RSL3 significantly suppressed tumor growth,offering a promising strategy for castrationresistant prostate cancer.Collectively,this study provides novel insights into the mechanistic role of eRNAs in prostate cancer,highlighting the LTFe-LTF axis as a critical epigenetic regulator and potential therapeutic target for improved treatment outcomes.展开更多
Recently,wireless communication capacity has been witnessing unprecedented growth.Benefits from the optoelectronic components with large bandwidth,photonics-assisted terahertz(THz)communication links have been extensi...Recently,wireless communication capacity has been witnessing unprecedented growth.Benefits from the optoelectronic components with large bandwidth,photonics-assisted terahertz(THz)communication links have been extensively developed to accommodate the upcoming wireless transmission with a high data rate.However,limited by the available signalto-noise ratio and THz component bandwidth,single-lane transmission of beyond 100 Gbit/s data rate using a single pair of THz transceivers is still very challenging.In this study,a multicarrier THz photonic wireless communication link in the 300 GHz band is proposed and experimentally demonstrated.Enabled by subcarrier multiplexing,spectrally efficient modulation format,well-tailored digital signal processing routine,and broadband THz transceivers,a line rate of 72 Gbit/s over a wireless distance of 30 m is successfully demonstrated,resulting in a total net transmission capacity of up to 202.5 Gbit/s.The single-lane transmission of beyond 200 Gbit/s overall data rate with a single pair of transceivers at 300 GHz is considered a significant step toward a viable photonics-assisted solution for the next-generation information and communication technology (ICT) infrastructure.展开更多
Terahertz(THz)communications are vulnerable to eavesdropping due to their scattering and diffraction properties,which limits their practical deployment.We propose a photonic THz chaos encryption and synchronization sc...Terahertz(THz)communications are vulnerable to eavesdropping due to their scattering and diffraction properties,which limits their practical deployment.We propose a photonic THz chaos encryption and synchronization scheme to secure THz communications.We experimentally demonstrate the generation,encryption,and wireless transmission of a 5 Gbit∕s non-return-to-zero signal at 120 GHz using flexible photonic THz chaos.In addition,we achieve high-quality chaos synchronization with a neural network,attaining a correlation coefficient of up to 90.6%.This scheme offers a viable solution for secure THz communications,showing significant potential for enhancing wireless communication privacy.展开更多
Cross-frequency coupling(CFC)reflects(nonlinear)interactions between signals of different frequencies.Evidence from both patient and healthy participant studies suggests that CFC plays an essential role in neuronal co...Cross-frequency coupling(CFC)reflects(nonlinear)interactions between signals of different frequencies.Evidence from both patient and healthy participant studies suggests that CFC plays an essential role in neuronal computation,interregional interaction,and disease pathophysiology.The present review discusses methodological advances and challenges in the computation of CFC with particular emphasis on potential solutions to spurious coupling,inferring intrinsic rhythms in a targeted frequency band,and causal interferences.We specifically focus on the literature exploring CFC in the context of cognition/memory tasks,sleep,and neurological disorders,such as Alzheimer's disease,epilepsy,and Parkinson's disease.Furthermore,we highlight the implication of CFC in the context and for the optimization of invasive and noninvasive neuromodulation and rehabilitation.Mainly,CFC could support advancing the understanding of the neurophysiology of cognition and motor control,serve as a biomarker for disease symptoms,and leverage the optimization of therapeutic interventions,e.g.,closed-loop brain stimulation.Despite the evident advantages of CFC as an investigative and translational tool in neuroscience,further methodological improvements are required to facilitate practical and correct use in cyborg and bionic systems in the field.展开更多
Epigenetic readers frequently affect gene regulation,correlate with disease prognosis,and hold significant potential as therapeutic targets for cancer.Zinc finger MYND-type containing 11(ZMYND11)is notably recognized ...Epigenetic readers frequently affect gene regulation,correlate with disease prognosis,and hold significant potential as therapeutic targets for cancer.Zinc finger MYND-type containing 11(ZMYND11)is notably recognized for reading the epigenetic marker H3.3K36me3;however,its broader functions and mechanisms of action in cancer remain underexplored.Here,we report that ZMYND11 downregulation is prevalent across various cancers and profoundly correlates with poorer outcomes in prostate cancer patients.Depletion of ZMYND11 promotes tumor cell growth,migration,and invasion in vitro,as well as tumor formation and metastasis in vivo.Mechanistically,we discover that ZMYND11 exhibits tumor suppressive roles by recognizing arginine-194-methylated HNRNPA1 dependent on its MYND domain,thereby retaining HNRNPA1 in the nucleus and preventing the formation of stress granules in the cytoplasm.Furthermore,ZMYND11 counteracts the HNRNPA1-driven increase in the PKM2/PKM1 ratio,thus mitigating the aggressive tumor phenotype promoted by PKM2.Remarkably,ZMYND11 recognition of HNRNPA1 can be disrupted by pharmaceutical inhibition of the arginine methyltransferase PRMT5.Tumors with low ZMYND11 expression show sensitivity to PRMT5 inhibitors.Taken together,our findings uncover a previously unexplored noncanonical role of ZMYND11 as a nonhistone methylation reader and underscore the critical importance of arginine methylation in the ZMYND11-HNRNPA1 interaction for restraining tumor progression,thereby proposing novel therapeutic targets and potential biomarkers for cancer treatment.展开更多
文摘Distribution networks face an increasing penetration of solar PV （photovoltaic） and small WTG （wind turbine generator） as well as other forms of micro-generation. To this scenario, one must add the dissemination of non-linear loads such as EV （electric vehicles）. There is something in common between those loads and sources： the extensive use of power electronic converters with commutated switches. These devices may be a source of medium-to-high frequency harmonic distortion and their impact on the local distribution grid must be carefully assessed in order to evaluate their negative impacts on the network, on the existing conventional loads and also on other active devices. In this paper, methodologies to characterize effects such as： harmonics, network unbalances, damaging power line resonance conditions, and over/under voltages are described and applied to a real local grid configuration.
基金supported by the Science and Technology Innovation 2030(2022ZD0205300)the International(Hong Kong,Macao,and Taiwan)Science and Technology Cooperation Project(Z221100002722014)+5 种基金the 2022 Open Project of Key Laboratory and Engineering Technology Research of the Ministry of Civil Affairs(2022GKZS0003)the Chinese Institute for Brain Research Youth Scholar Program(2022-NKX-XM-02)the Natural Science Foundation of Beijing municipality(7232049)the General Program of National Natural Science Foundation of China(82371197)the FundRef Organization name of Guarantors of Brain(HMR04170)the Royal Society(IES\R3\213123).
文摘Among the existing research on the treatment of disorders of consciousness(DOC),deep brain stimulation(DBS)offers a highly promising therapeutic approach.This comprehensive review documents the historical development of DBS and its role in the treatment of DOC,tracing its progression from an experimental therapy to a detailed modulation approach based on the mesocircuit model hypothesis.The mesocircuit model hypothesis suggests that DOC arises from disruptions in a critical network of brain regions,providing a framework for refining DBS targets.We also discuss the multimodal approaches for assessing patients with DOC,encompassing clinical behavioral scales,electrophysiological assessment,and neuroimaging techniques methods.During the evolution of DOC therapy,the segmentation of central nuclei,the recording of single-neurons,and the analysis of local field potentials have emerged as favorable technical factors that enhance the efficacy of DBS treatment.Advances in computational models have also facilitated a deeper exploration of the neural dynamics associated with DOC,linking neuron-level dynamics with macroscopic behavioral changes.Despite showing promising outcomes,challenges remain in patient selection,precise target localization,and the determination of optimal stimulation parameters.Future research should focus on conducting large-scale controlled studies to delve into the pathophysiological mechanisms of DOC.It is imperative to further elucidate the precise modulatory effects of DBS on thalamo-cortical and cortico-cortical functional connectivity networks.Ultimately,by optimizing neuromodulation strategies,we aim to substantially enhance therapeutic outcomes and greatly expedite the process of consciousness recovery in patients.
基金supported by the National Key R&D Program of China(2021YFF1200602)the National Science Fund for Excellent Overseas Scholars(0401260011)+3 种基金the National Defense Science and Technology Innovation Fund of Chinese Academy of Sciences(c02022088)the Tianjin Science and Technology Program(20JCZDJC00810)the National Natural Science Foundation of China(82202798)the Shanghai Sailing Program(22YF1404200).
文摘Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BCIs,including their fundamental principles,technical advancements,and applications in specific domains.However,these reviews often focus on signal processing,hardware development,or limited applications such as motor rehabilitation or communication.This paper aims to offer a comprehensive review of recent electroencephalogram(EEG)-based BCI applications in the medical field across 8 critical areas,encompassing rehabilitation,daily communication,epilepsy,cerebral resuscitation,sleep,neurodegenerative diseases,anesthesiology,and emotion recognition.Moreover,the current challenges and future trends of BCIs were also discussed,including personal privacy and ethical concerns,network security vulnerabilities,safety issues,and biocompatibility.
文摘One of the most challenging anthropogenic activities that have driven climate change off the edge is deforestation.Increased human populations have exerted a lot of pressure on natural forests due to the increased demand of resources—one of which is paper.An example of this effect is the increased usage of mobile phone scratch cards made out of paper that most of the population in Africa use to top-up
文摘Semantic Web Services is an emerging technology that promises to enable dynamic, execution-time discovery, composition, and invocation of Web Services. Semantic matchmaking plays a vital role in the automated and dynamic discovery process of Semantic Web Services and consists in measuring the semantic distance between a requested service and an advertised one. In this paper, an innovative approach to effectively compute the semantic distance between Ontology Web Language for Services （OWL-S） annotated services is proposed. First, an edge-based method for measuring the semantic distance between Web Ontology Language （OWL） concepts is presented. Then, a comparison of the proposed measure and the one presented in a recent related work is made in order to show that our method is more efficient and fine-grained. Finally, some equations to compute semantic matchmaking of service capabilities, which are expressed in terms of inputs and outputs, are presented.
基金supported in part by the National Science Council of Taiwan under Grant Nos.NSC 96-2221-E-492-007-MY3 and NSC 98-2221-E-006-131-MY3National Center for Theoretical Science(NCTS)in Taiwan
文摘The low-energy electronic states and energy gaps of carbon nanocones in an electric field are studied using a single-?-band tight-binding model. The analysis considers five perfect carbon nanocones with disclination angles of 60°, 120°, 180°, 240° and 300°, respectively. The numerical results reveal that the low-energy electronic states and energy gaps of a carbon nanocones are highly sensitive to its geometric shape(i.e. the disclination angle and height), and to the direction and magnitude of an electric field. The electric field causes a strong modulation of the state energies and energy gaps of the nanocones, changes their Fermi levels, and induces zero-gap transitions. The energy-gap modulation effect becomes particularly pronounced at higher strength of the applied electric field, and is strongly related to the geometric structure of the nanocone.
基金supported by the National Natural Science Foundation of China(Nos.82373333,82173068)to Z.Wang,and Nos.82073082,82311530050 to G.-H.Wei+2 种基金the Hubei Natural Science Foundation Innovation Development Joint Fund Key Project(2024AFD420 to Z.Wang)the National Key Research and Development Program of China(2022YFC2703600 to G.-H.Wei)Z.X.Wang was supported by the National Natural Science Foundation of China(82203416)。
文摘Enhancer RNAs(eRNAs),a subclass of non-coding RNAs transcribed from enhancer regions,have emerged as critical regulators of gene expression;however,their functional roles in prostate cancer remain largely unexplored.In this study,we performed integrated chromatin accessibility and transcriptomic analyses using ATAC-seq and RNA-seq on twenty pairs of prostate cancer and matched benign tissues.By incorporating chromatin immunoprecipitation sequencing data,we identified a subset of differentially expressed eRNAs significantly associated with genes involved in prostate development and oncogenic signaling pathways.Among these,lactotransferrin-eRNA(LTFe)was markedly downregulated in prostate cancer tissues,with functional analyses revealing its tumor-suppressive role.Mechanistically,LTFe promotes the transcription of its target gene,lactotransferrin(LTF),by interacting with heterogeneous nuclear ribonucleoprotein F(HNRNPF)and facilitating enhancer-promoter chromatin interactions.Furthermore,we demonstrate that the LTFe-LTF axis facilitates ferroptosis by modulating iron transport.Notably,androgen receptor(AR)signaling disrupts LTFe-associated chromatin looping,leading to ferroptosis resistance.Therapeutically,co-administration of the AR inhibitor enzalutamide and the ferroptosis inducer RSL3 significantly suppressed tumor growth,offering a promising strategy for castrationresistant prostate cancer.Collectively,this study provides novel insights into the mechanistic role of eRNAs in prostate cancer,highlighting the LTFe-LTF axis as a critical epigenetic regulator and potential therapeutic target for improved treatment outcomes.
基金supported by the National Key Research and Development Program of China(Nos.2020YFB1805700,2018YFB1801503,and 2021YFB2800805)the National Natural Science Foundation of China(No.62101483)+1 种基金the Natural Science Foundation of Zhejiang Province(No.LQ21F010015)the Zhejiang Lab(No.2020LC0AD01)。
文摘Recently,wireless communication capacity has been witnessing unprecedented growth.Benefits from the optoelectronic components with large bandwidth,photonics-assisted terahertz(THz)communication links have been extensively developed to accommodate the upcoming wireless transmission with a high data rate.However,limited by the available signalto-noise ratio and THz component bandwidth,single-lane transmission of beyond 100 Gbit/s data rate using a single pair of THz transceivers is still very challenging.In this study,a multicarrier THz photonic wireless communication link in the 300 GHz band is proposed and experimentally demonstrated.Enabled by subcarrier multiplexing,spectrally efficient modulation format,well-tailored digital signal processing routine,and broadband THz transceivers,a line rate of 72 Gbit/s over a wireless distance of 30 m is successfully demonstrated,resulting in a total net transmission capacity of up to 202.5 Gbit/s.The single-lane transmission of beyond 200 Gbit/s overall data rate with a single pair of transceivers at 300 GHz is considered a significant step toward a viable photonics-assisted solution for the next-generation information and communication technology (ICT) infrastructure.
基金supported by the National Key R&D Program of China(Grant No.2020YFB1805700)the National Natural Science Foundation of China(Grant No.62471433)+2 种基金the LZP FLPP project‘MIR FAST’lzp-2023-1-0503the Swedish Research Council(VR)projects 2019-05197 and 2022-04798the strategic innovation program Smarter Electronic Systems-a joint venture by Vinnova,Formas and the Swedish Energy Agency A-FRONTAHUL project(2023-00659).
文摘Terahertz(THz)communications are vulnerable to eavesdropping due to their scattering and diffraction properties,which limits their practical deployment.We propose a photonic THz chaos encryption and synchronization scheme to secure THz communications.We experimentally demonstrate the generation,encryption,and wireless transmission of a 5 Gbit∕s non-return-to-zero signal at 120 GHz using flexible photonic THz chaos.In addition,we achieve high-quality chaos synchronization with a neural network,attaining a correlation coefficient of up to 90.6%.This scheme offers a viable solution for secure THz communications,showing significant potential for enhancing wireless communication privacy.
基金supported by the National Natural Science Foundation of China(Nos.62171028 and 62001026)the BIT National High-level Fellow Research Fund Pro gram(No.3050012222022)+2 种基金the MRC Clinician Scientist Fellowship(No.MR/W024810/1)the Swiss National Science Foundation(No.PZ00P3_202166)the National Science and Technology Council(Nos.110-2221-E-008-093,111-2221-E-008-015-MY3,111-2221-E008-103-MY3,and 111-2218-E-008-009).
文摘Cross-frequency coupling(CFC)reflects(nonlinear)interactions between signals of different frequencies.Evidence from both patient and healthy participant studies suggests that CFC plays an essential role in neuronal computation,interregional interaction,and disease pathophysiology.The present review discusses methodological advances and challenges in the computation of CFC with particular emphasis on potential solutions to spurious coupling,inferring intrinsic rhythms in a targeted frequency band,and causal interferences.We specifically focus on the literature exploring CFC in the context of cognition/memory tasks,sleep,and neurological disorders,such as Alzheimer's disease,epilepsy,and Parkinson's disease.Furthermore,we highlight the implication of CFC in the context and for the optimization of invasive and noninvasive neuromodulation and rehabilitation.Mainly,CFC could support advancing the understanding of the neurophysiology of cognition and motor control,serve as a biomarker for disease symptoms,and leverage the optimization of therapeutic interventions,e.g.,closed-loop brain stimulation.Despite the evident advantages of CFC as an investigative and translational tool in neuroscience,further methodological improvements are required to facilitate practical and correct use in cyborg and bionic systems in the field.
基金National Key Research and Development Program of China(2022YFC2703600)National Natural Science Foundation of China(82073082,82311530050,81772948,81972617)+1 种基金Shanghai Interactional Collaborative Project(23410713300)Key Research and Development Program of Anhui Province(2022i01020023)。
文摘Epigenetic readers frequently affect gene regulation,correlate with disease prognosis,and hold significant potential as therapeutic targets for cancer.Zinc finger MYND-type containing 11(ZMYND11)is notably recognized for reading the epigenetic marker H3.3K36me3;however,its broader functions and mechanisms of action in cancer remain underexplored.Here,we report that ZMYND11 downregulation is prevalent across various cancers and profoundly correlates with poorer outcomes in prostate cancer patients.Depletion of ZMYND11 promotes tumor cell growth,migration,and invasion in vitro,as well as tumor formation and metastasis in vivo.Mechanistically,we discover that ZMYND11 exhibits tumor suppressive roles by recognizing arginine-194-methylated HNRNPA1 dependent on its MYND domain,thereby retaining HNRNPA1 in the nucleus and preventing the formation of stress granules in the cytoplasm.Furthermore,ZMYND11 counteracts the HNRNPA1-driven increase in the PKM2/PKM1 ratio,thus mitigating the aggressive tumor phenotype promoted by PKM2.Remarkably,ZMYND11 recognition of HNRNPA1 can be disrupted by pharmaceutical inhibition of the arginine methyltransferase PRMT5.Tumors with low ZMYND11 expression show sensitivity to PRMT5 inhibitors.Taken together,our findings uncover a previously unexplored noncanonical role of ZMYND11 as a nonhistone methylation reader and underscore the critical importance of arginine methylation in the ZMYND11-HNRNPA1 interaction for restraining tumor progression,thereby proposing novel therapeutic targets and potential biomarkers for cancer treatment.
