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Automatic Classification of Superimposed Modulations for 5G MIMO Two-Way Cognitive Relay Networks 被引量:1
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作者 Haithem Ben Chikha Ahmad Almadhor 《Computers, Materials & Continua》 SCIE EI 2022年第1期1799-1814,共16页
To promote reliable and secure communications in the cognitive radio network,the automatic modulation classification algorithms have been mainly proposed to estimate a single modulation.In this paper,we address the cl... To promote reliable and secure communications in the cognitive radio network,the automatic modulation classification algorithms have been mainly proposed to estimate a single modulation.In this paper,we address the classification of superimposed modulations dedicated to 5G multipleinput multiple-output(MIMO)two-way cognitive relay network in realistic channels modeled with Nakagami-m distribution.Our purpose consists of classifying pairs of users modulations from superimposed signals.To achieve this goal,we apply the higher-order statistics in conjunction with the Multi-BoostAB classifier.We use several efficiency metrics including the true positive(TP)rate,false positive(FP)rate,precision,recall,F-Measure and receiver operating characteristic(ROC)area in order to evaluate the performance of the proposed algorithm in terms of correct superimposed modulations classification.Computer simulations prove that our proposal allows obtaining a good probability of classification for ten superimposed modulations at a low signal-to-noise ratio,including the worst case(i.e.,m=0.5),where the fading distribution follows a one-sided Gaussian distribution.We also carry out a comparative study between our proposal usingMultiBoostAB classifier with the decision tree(J48)classifier.Simulation results show that the performance of MultiBoostAB on the superimposed modulations classifications outperforms the one of J48 classifier.In addition,we study the impact of the symbols number,path loss exponent and relay position on the performance of the proposed automatic classification superimposed modulations in terms of probability of correct classification. 展开更多
关键词 Automatic classification MIMO two-way cognitive relay network Nakagami-m channels superimposed modulations 5G
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Joint Allocation of Computing and Connectivity Resources in Survivable Inter-Datacenter Elastic Optical Networks
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作者 Yang Tao Li Yang Chen Xue 《China Communications》 SCIE CSCD 2024年第8期172-181,共10页
Inter-datacenter elastic optical networks(EON)need to provide the service for the requests of cloud computing that require not only connectivity and computing resources but also network survivability.In this paper,to ... Inter-datacenter elastic optical networks(EON)need to provide the service for the requests of cloud computing that require not only connectivity and computing resources but also network survivability.In this paper,to realize joint allocation of computing and connectivity resources in survivable inter-datacenter EONs,a survivable routing,modulation level,spectrum,and computing resource allocation algorithm(SRMLSCRA)algorithm and three datacenter selection strategies,i.e.Computing Resource First(CRF),Shortest Path First(SPF)and Random Destination(RD),are proposed for different scenarios.Unicast and manycast are applied to the communication of computing requests,and the routing strategies are calculated respectively.Simulation results show that SRMLCRA-CRF can serve the largest amount of protected computing tasks,and the requested calculation blocking probability is reduced by 29.2%,28.3%and 30.5%compared with SRMLSCRA-SPF,SRMLSCRA-RD and the benchmark EPS-RMSA algorithms respectively.Therefore,it is more applicable to the networks with huge calculations.Besides,SRMLSCRA-SPF consumes the least spectrum,thereby exhibiting its suitability for scenarios where the amount of calculation is small and communication resources are scarce.The results demonstrate that the proposed methods realize the joint allocation of computing and connectivity resources,and could provide efficient protection for services under single-link failure and occupy less spectrum. 展开更多
关键词 computing and connectivity interdatacenter networks joint resource allocation service protection
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Analysis of Different Call Admission Control Strategies and Its Impact on the Performance of LTE-Advanced Networks
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作者 Mahammad A. Safwat Hesham M. El-Badawy +1 位作者 Ahmad Yehya Hosni El-Motaafy 《Communications and Network》 2014年第2期137-154,共18页
The call admission control (CAC) optimizes the use of allocated channels against offered traffic maintaining the required quality of service (QoS). Provisioning QoS to user at cell-edge is a challenge where there is l... The call admission control (CAC) optimizes the use of allocated channels against offered traffic maintaining the required quality of service (QoS). Provisioning QoS to user at cell-edge is a challenge where there is limitation in cell resources due to inter-cell interference (ICI). Soft Frequency Reuse is ICI mitigation scheme that controls the distribution of resources between users. In this paper, the Impact of four CAC schemes (Cutoff Priority scheme (CP), Uniform Fractional Guard Channel (UFGC), Limited Fractional Guard Channel (LFGC), New Call Bounding (NCB) scheme) at cell-edge have investigated using queuing analysis in a comparative manner. The comparison is based on two criteria. The first criterion guarantees a particular level of service to already admitted users while trying to optimize the revenue obtained. The second criterion determines the minimum of number of radio resources that provides hard constraints in both of blocking and dropping probabilities. The four schemes are compared at different scenarios of new and handover call arrival rates. 展开更多
关键词 CALL ADMISSION Control SOFT Frequency REUSE QOS
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Enhancement of MTC Performance in LTE Networks by Maximizing Random Access Procedure Throughput
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作者 Ibraheem M. Fayed Eman S. El-Din 《Journal of Electrical Engineering》 2018年第1期40-45,共6页
A fundamental requirement for any cellular system is the possibility for the device to request a connection setup, commonly referred to as random access procedure. In LTE (long term evolution) networks, the distribu... A fundamental requirement for any cellular system is the possibility for the device to request a connection setup, commonly referred to as random access procedure. In LTE (long term evolution) networks, the distribution of a limited number of radio resources among H2H (Human-to-Human) users and increasing number of MTC (Machine-Type-Communication) devices in M2M (Machine-to-Machine) communications is one of the main problems. An analytical model is conducted to compute the throughput for message 1 and message 2. This is done using a Markov chain model for the four messages signaling flow with buffering for message 4. This model is used in LTE 3GPP (Third-Generation Partnership Project) random access. The network performance will be enhanced by determining a dedicated arrival rate corresponding to maximum throughput of message 2 that will assist the network planner to optimize the network performance. In this paper, a deduced arrival rate less than 3.333 requests/ms will maximize network throughput. 展开更多
关键词 MTC (machine type communication) M2M LTE network random access procedure.
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Performance Assessment for LTE-Advanced Networks with Uniform Fractional Guard Channel over Soft Frequency Reuse Scheme
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作者 Mahammad A. Safwat Hesham M. El-Badawy +1 位作者 Ahmad Yehya Hosni El-Motaafy 《Wireless Engineering and Technology》 2013年第4期161-170,共10页
Dropping probability of handoff calls and blocking probability of new calls are two important Quality of Service (QoS) measures for LTE-Advanced networks. Applying QoS for Cell edge users in soft frequency reuse schem... Dropping probability of handoff calls and blocking probability of new calls are two important Quality of Service (QoS) measures for LTE-Advanced networks. Applying QoS for Cell edge users in soft frequency reuse scheme in LTE system is a challenge as they already suffer from limited resources. Assigning some resources for handover calls may enhance dropping probability but this is in price of degradation in the blocking probability for new calls in cell-edge. Uniform Fractional Guard Channel (UFGC) is a call admission policy that provides QoS without reserving resources for handover calls. In this paper, the performance of Soft Frequency Reuse (SFR) in presence of Uniform Fractional Guard Channel (UFGC) will be investigated using queuing analysis. The mathematical model and performance metrics will be deduced in this assessment. The impact of UFGC will be evaluated in edge and core part separately. Then the optimal value for the parameter of UFGC will be obtained to minimize the blocking probability of new calls with the constraint on the upper bound on the dropping probability of handoff calls. 展开更多
关键词 Soft Frequency REUSE QUEUING UNIFORM FRACTIONAL GUARD Channel
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Bridging 2D and 3D Object Detection:Advances in Occlusion Handling through Depth Estimation
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作者 Zainab Ouardirhi Mostapha Zbakh Sidi Ahmed Mahmoudi 《Computer Modeling in Engineering & Sciences》 2025年第6期2509-2571,共63页
Object detection in occluded environments remains a core challenge in computer vision(CV),especially in domains such as autonomous driving and robotics.While Convolutional Neural Network(CNN)-based twodimensional(2D)a... Object detection in occluded environments remains a core challenge in computer vision(CV),especially in domains such as autonomous driving and robotics.While Convolutional Neural Network(CNN)-based twodimensional(2D)and three-dimensional(3D)object detection methods havemade significant progress,they often fall short under severe occlusion due to depth ambiguities in 2D imagery and the high cost and deployment limitations of 3D sensors such as Light Detection and Ranging(LiDAR).This paper presents a comparative review of recent 2D and 3D detection models,focusing on their occlusion-handling capabilities and the impact of sensor modalities such as stereo vision,Time-of-Flight(ToF)cameras,and LiDAR.In this context,we introduce FuDensityNet,our multimodal occlusion-aware detection framework that combines Red-Green-Blue(RGB)images and LiDAR data to enhance detection performance.As a forward-looking direction,we propose a monocular depth-estimation extension to FuDensityNet,aimed at replacing expensive 3D sensors with a more scalable CNN-based pipeline.Although this enhancement is not experimentally evaluated in this manuscript,we describe its conceptual design and potential for future implementation. 展开更多
关键词 Object detection occlusion handling multimodal fusion MONOCULAR 3D sensors depth estimation
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Ultrashort-Term Power Prediction of Distributed Photovoltaic Based on Variational Mode Decomposition and Channel Attention Mechanism
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作者 Zhebin Sun Wei Wang +6 位作者 Mingxuan Du Tao Liang Yang Liu Hailong Fan Cuiping Li Xingxu Zhu Junhui Li 《Energy Engineering》 2025年第6期2155-2175,共21页
Responding to the stochasticity and uncertainty in the power height of distributed photovoltaic power generation.This paper presents a distributed photovoltaic ultra-short-term power forecasting method based on Variat... Responding to the stochasticity and uncertainty in the power height of distributed photovoltaic power generation.This paper presents a distributed photovoltaic ultra-short-term power forecasting method based on Variational Mode Decomposition(VMD)and Channel Attention Mechanism.First,Pearson’s correlation coefficient was utilized to filter out the meteorological factors that had a high impact on historical power.Second,the distributed PV power data were decomposed into a relatively smooth power series with different fluctuation patterns using variational modal decomposition(VMD).Finally,the reconstructed distributed PV power as well as other features are input into the combined CNN-SENet-BiLSTM model.In this model,the convolutional neural network(CNN)and channel attention mechanism dynamically adjust the weights while capturing the spatial features of the input data to improve the discriminative ability of key features.The extracted data is then fed into the bidirectional long short-term memory network(BiLSTM)to capture the time-series features,and the final output is the prediction result.The verification is conducted using a dataset from a distributed photovoltaic power station in the Northwest region of China.The results show that compared with other prediction methods,the method proposed in this paper has a higher prediction accuracy,which helps to improve the proportion of distributed PV access to the grid,and can guarantee the safe and stable operation of the power grid. 展开更多
关键词 Distributed photovoltaic power channel attention mechanism convolutional neural network bidirectional long short-term memory network
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ONTDAS: An Optimized Noise-Based Traffic Data Augmentation System for Generalizability Improvement of Traffic Classifiers
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作者 Rongwei Yu Jie Yin +2 位作者 Jingyi Xiang Qiyun Shao Lina Wang 《Computers, Materials & Continua》 2025年第7期365-391,共27页
With the emergence of new attack techniques,traffic classifiers usually fail to maintain the expected performance in real-world network environments.In order to have sufficient generalizability to deal with unknown ma... With the emergence of new attack techniques,traffic classifiers usually fail to maintain the expected performance in real-world network environments.In order to have sufficient generalizability to deal with unknown malicious samples,they require a large number of new samples for retraining.Considering the cost of data collection and labeling,data augmentation is an ideal solution.We propose an optimized noise-based traffic data augmentation system,ONTDAS.The system uses a gradient-based searching algorithm and an improved Bayesian optimizer to obtain optimized noise.The noise is injected into the original samples for data augmentation.Then,an improved bagging algorithm is used to integrate all the base traffic classifiers trained on noised datasets.The experiments verify ONTDAS on 6 types of base classifiers and 4 publicly available datasets respectively.The results show that ONTDAS can effectively enhance the traffic classifiers’performance and significantly improve their generalizability on unknown malicious samples.The system can also alleviate dataset imbalance.Moreover,the performance of ONTDAS is significantly superior to the existing data augmentation methods mentioned. 展开更多
关键词 Unknown malicious traffic classification data augmentation optimized noise generalizability improvement ensemble learning
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Wavelength- and structure-insensitive on-chip mode manipulation based on the Thouless pumping mechanism
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作者 Yingdi Pan Lu Sun +8 位作者 Jingchi Li Qiyao Sun Pan Hu Songyue Liu Qi Lu Xiong Ni Xintao He Jianwen Dong Yikai Su 《Advanced Photonics Nexus》 2025年第3期131-140,共10页
Coupled-waveguide devices are essential in photonic integrated circuits for coupling,polarization handling,and mode manipulation.However,the performance of these devices usually suffers from high wavelength and struct... Coupled-waveguide devices are essential in photonic integrated circuits for coupling,polarization handling,and mode manipulation.However,the performance of these devices usually suffers from high wavelength and structure sensitivity,which makes it challenging to realize broadband and reliable on-chip optical functions.Recently,topological pumping of edge states has emerged as a promising solution for implementing robust optical couplings.In this paper,we propose and experimentally demonstrate broadband on-chip mode manipulation with very large fabrication tolerance based on the Rice–Mele modeled silicon waveguide arrays.The Thouless pumping mechanism is employed in the design to implement broadband and robust mode conversion and multiplexing.The experimental results prove that various mode-order conversions with low insertion losses and intermodal crosstalk can be achieved over a broad bandwidth of 80 nm ranging from 1500 to 1580 nm.Thanks to such a topological design,the device has a remarkable fabrication tolerance of±70 nm for the structural deviations in waveguide width and gap distance,which is,to the best of our knowledge,the highest among the coupled-waveguide mode-handling devices reported so far.As a proof-of-concept experiment,we cascade the topological mode-order converters to form a four-channel mode-division multiplexer and demonstrate the transmission of a 200-Gb/s 16-quadrature amplitude modulation signal for each mode channel,with the bit error rates below the 7%forward error correction threshold of 3.8×10^(-3).We reveal the possibility of developing new classes of broadband and fabrication-tolerant coupled-waveguide devices with topological photonic approaches,which may find applications in many fields,including optical interconnects,quantum communications,and optical computing. 展开更多
关键词 topological photonics Thouless pumping coupled-waveguide device on-chip mode manipulation
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Direct detection with an optimal transfer function:toward the electrical spectral efficiency of coherent homodyne detection
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作者 Xingfeng Li Jingchi Li +5 位作者 Xiong Ni Hudi Liu Qunbi Zhuge Haoshuo Chen William Shieh Yikai Su 《Opto-Electronic Science》 2025年第2期1-15,共15页
Complex-valued double-sideband direct detection(DD)can reconstruct the optical field and achieve a high electrical spectral efficiency(ESE)comparable to that of a coherent homodyne receiver,and DD does not require a c... Complex-valued double-sideband direct detection(DD)can reconstruct the optical field and achieve a high electrical spectral efficiency(ESE)comparable to that of a coherent homodyne receiver,and DD does not require a costly local oscillator laser.However,a fundamental question remains if there is an optimal DD receiver structure with the simplest design to approach the performance of the coherent homodyne detection.This study derives the optimal DD receiver structure with an optimal transfer function to recover a quadrature amplitude modulation(QAM)signal with a near-zero guard band at the central frequency of the signal.We derive the theoretical ESE limit for various detection schemes by invoking Shannon’s formula.Our proposed scheme is closest to coherent homodyne detection in terms of the theoretical ESE limit.By leveraging a WaveShaper to construct the optimal transfer function,we conduct a proof-of-concept experiment to transmit a net 228.85-Gb/s 64-QAM signal over an 80-km single-mode fiber with a net ESE of 8.76 b/s/Hz.To the best of our knowledge,this study reports the highest net ESE per polarization per wavelength for DD transmission beyond 40-km single-mode fiber.For a comprehensive metric,denoted as 2ESE×Reach,we achieve the highest 2ESE×Reach per polarization per wavelength for DD transmission. 展开更多
关键词 optical communication direct detection optical field recovery electrical spectral efficiency
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An EfficientNet integrated ResNet deep network and explainable AI for breast lesion classification from ultrasound images
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作者 Kiran Jabeen Muhammad Attique Khan +4 位作者 Ameer Hamza Hussain Mobarak Albarakati Shrooq Alsenan Usman Tariq Isaac Ofori 《CAAI Transactions on Intelligence Technology》 2025年第3期842-857,共16页
Breast cancer is one of the major causes of deaths in women.However,the early diagnosis is important for screening and control the mortality rate.Thus for the diagnosis of breast cancer at the early stage,a computer-a... Breast cancer is one of the major causes of deaths in women.However,the early diagnosis is important for screening and control the mortality rate.Thus for the diagnosis of breast cancer at the early stage,a computer-aided diagnosis system is highly required.Ultrasound is an important examination technique for breast cancer diagnosis due to its low cost.Recently,many learning-based techniques have been introduced to classify breast cancer using breast ultrasound imaging dataset(BUSI)datasets;however,the manual handling is not an easy process and time consuming.The authors propose an EfficientNet-integrated ResNet deep network and XAI-based framework for accurately classifying breast cancer(malignant and benign).In the initial step,data augmentation is performed to increase the number of training samples.For this purpose,three-pixel flip mathematical equations are introduced:horizontal,vertical,and 90°.Later,two pretrained deep learning models were employed,skipped some layers,and fine-tuned.Both fine-tuned models are later trained using a deep transfer learning process and extracted features from the deeper layer.Explainable artificial intelligence-based analysed the performance of trained models.After that,a new feature selection technique is proposed based on the cuckoo search algorithm called cuckoo search controlled standard error mean.This technique selects the best features and fuses using a new parallel zeropadding maximum correlated coefficient features.In the end,the selection algorithm is applied again to the fused feature vector and classified using machine learning algorithms.The experimental process of the proposed framework is conducted on a publicly available BUSI and obtained 98.4%and 98%accuracy in two different experiments.Comparing the proposed framework is also conducted with recent techniques and shows improved accuracy.In addition,the proposed framework was executed less than the original deep learning models. 展开更多
关键词 augmentation breast cancer CLASSIFICATION deep learning OPTIMIZATION ultrasound images
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Role of physical exercise, vagal nerve stimulation, and vagotomy in inflammatory bowel disease
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作者 Alda Cassia Alves da Silva Juliana Soares Severo +9 位作者 Brenda Lois Barros dos Santos Heron Silva Soares Jorddam Almondes Martins Rodrigo Soares Pereira Lima Kalinne Kelly Lima Gadelha Francisco Leonardo Torres-Leal Paulo Correia-de-Sá Pedro Jorge Caldas Magalhães Armênio Aguiar Santos Moisés Tolentino Bento da Silva 《World Journal of Gastroenterology》 2025年第38期6-25,共20页
Inflammatory bowel disease(IBD),comprising Crohn’s disease and ulcerative colitis,represents the two predominant clinical entities within this spectrum of gastrointestinal disorders.Current evidence indicates that th... Inflammatory bowel disease(IBD),comprising Crohn’s disease and ulcerative colitis,represents the two predominant clinical entities within this spectrum of gastrointestinal disorders.Current evidence indicates that the etiology of IBD is multifactorial,involving a complex interplay between host genetic susceptibility and environmental determinants.In recent years,non-pharmacological strategies such as physical exercise and vagus nerve stimulation have gained increasing attention as adjunctive therapeutic approaches.Vagus nerve stimulation has emerged as a promising therapeutic modality,particularly in conditions characterized by autonomic dysfunction and diminished vagal tone.Conversely,vagotomy,by disrupting vagal control,abolishes parasympathetic reflexes and may potentiate inflammatory responses and exacerbate IBD symptomatology under stress conditions.Physical exercise has likewise been investigated as a non-pharmacological intervention in Crohn’s disease and ulcerative colitis.Although the precise mechanisms remain to be fully elucidated,accumulating evidence suggests that skeletal muscle contractions promote the secretion of myokines,with recognized anti-inflammatory properties.These myokines act on the intestinal microenvironment,conferring protection against malignant transformation and modulating the composition and function of the gut microbiota.In this review,we critically examine the interplay between physical exercise,vagus nerve stimulation,and vagotomy in the pathophysiology and management of IBD,with particular emphasis on their immunomodulatory and therapeutic potential. 展开更多
关键词 Physical exercise Vagus nerve stimulation Subdiaphragmatic vagotomy Inflammatory bowel disease Crohn’s disease Ulcerative colitis
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Computing Power Network:The Architecture of Convergence of Computing and Networking towards 6G Requirement 被引量:54
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作者 Xiongyan Tang Chang Cao +4 位作者 Youxiang Wang Shuai Zhang Ying Liu Mingxuan Li Tao He 《China Communications》 SCIE CSCD 2021年第2期175-185,共11页
In 6G era,service forms in which computing power acts as the core will be ubiquitous in the network.At the same time,the collaboration among edge computing,cloud computing and network is needed to support edge computi... In 6G era,service forms in which computing power acts as the core will be ubiquitous in the network.At the same time,the collaboration among edge computing,cloud computing and network is needed to support edge computing service with strong demand for computing power,so as to realize the optimization of resource utilization.Based on this,the article discusses the research background,key techniques and main application scenarios of computing power network.Through the demonstration,it can be concluded that the technical solution of computing power network can effectively meet the multi-level deployment and flexible scheduling needs of the future 6G business for computing,storage and network,and adapt to the integration needs of computing power and network in various scenarios,such as user oriented,government enterprise oriented,computing power open and so on. 展开更多
关键词 6G edge computing cloud computing convergence of cloud and network computing power network
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Recent advances of heterogeneously integrated Ⅲ–Ⅴ laser on Si 被引量:8
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作者 Xuhan Guo An He Yikai Su 《Journal of Semiconductors》 EI CAS CSCD 2019年第10期54-64,共11页
Due to the indirect bandgap nature,the widely used silicon CMOS is very inefficient at light emitting.The integration of silicon lasers is deemed as the‘Mount Everest’for the full take-up of Si photonics.The major c... Due to the indirect bandgap nature,the widely used silicon CMOS is very inefficient at light emitting.The integration of silicon lasers is deemed as the‘Mount Everest’for the full take-up of Si photonics.The major challenge has been the materials dissimilarity caused impaired device performance.We present a brief overview of the recent advances of integratedⅢ-Ⅴlaser on Si.We will then focus on the heterogeneous direct/adhesive bonding enabling methods and associated light coupling structures.A selected review of recent representative novel heterogeneously integrated Si lasers for emerging applications like spectroscopy,sensing,metrology and microwave photonics will be presented,including DFB laser array,ultra-dense comb lasers and nanolasers.Finally,the challenges and opportunities of heterogeneous integration approach are discussed. 展开更多
关键词 HETEROGENEOUS INTEGRATION LASERS silicon PHOTONICS INTEGRATED CIRCUITS
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Diffusion-weighted imaging of pancreatic cancer 被引量:14
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作者 Riccardo De Robertis Paolo Tinazzi Martini +4 位作者 Emanuele Demozzi Flavia Dal Corso Claudio Bassi Paolo Pederzoli Mirko D'Onofrio 《World Journal of Radiology》 CAS 2015年第10期319-328,共10页
Magnetic resonance imaging(MRI) is a reliable and accurate imaging method for the evaluation of patients with pancreatic ductal adenocarcinoma(PDAC). Diffusion-weighted imaging(DWI) is a relatively recent technologica... Magnetic resonance imaging(MRI) is a reliable and accurate imaging method for the evaluation of patients with pancreatic ductal adenocarcinoma(PDAC). Diffusion-weighted imaging(DWI) is a relatively recent technological improvement that expanded MRI capabilities, having brought functional aspects into conventional morphologic MRI evaluation. DWI can depict the random diffusion of water molecules within tissues(the so-called Brownian motions). Modifications of water diffusion induced by different factors acting on the extracellular and intracellular spaces, as increased cell density, edema, fibrosis, or altered functionality of cell membranes, can be detected using this MR sequence. The intravoxel incoherent motion(IVIM) model is an advanced DWI technique that consent a separate quantitative evaluation of all the microscopic random motions that contribute to DWI, which are essentially represented by molecular diffusion and blood microcirculation(perfusion). Technological improvements have made possible the routine use of DWI during abdominal MRI study. Several authors have reported that the addition of DWI sequence can be of value for the evaluation of patients with PDAC, especially improving the staging; nevertheless, it is still unclear whether and how DWI could be helpful for identification, characterization, prognostic stratification and follow-up during treatment. The aim of this paper is to review up-to-date literature data regarding the applications of DWI and IVIM to PDACs. 展开更多
关键词 PANCREAS PANCREATIC NEOPLASMS PANCREATIC DUCTAL CA
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Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies 被引量:98
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作者 Qiang Guo Yuxiang Wang +3 位作者 Dan Xu Johannes Nossent Nathan J.Pavlos Jiake Xu 《Bone Research》 CAS CSCD 2018年第2期107-120,共14页
Rheumatoid arthritis(RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A... Rheumatoid arthritis(RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific stages:(i) triggering,(ii) maturation,(iii) targeting, and(iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern pharmacologic therapies(including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs) remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drugs are urgently required. This review discusses recent advances of our understanding of RA pathogenesis, disease modifying drugs, and provides perspectives on next generation therapeutics for RA. 展开更多
关键词 RA pathological mechanisms modern pharmacologic therapies
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Multi-channel 28-GHz millimeter-wave signal generation on a silicon photonic chip with automated polarization control 被引量:2
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作者 Ruiyuan Cao Yu He +4 位作者 Qingming Zhu Jingchi Li Shaohua An Yong Zhang Yikai Su 《Journal of Semiconductors》 EI CAS CSCD 2019年第5期33-39,共7页
We propose and experimentally demonstrate an integrated silicon photonic scheme to generate multi-channel millimeter-wave(MMW) signals for 5 G multi-user applications. The fabricated silicon photonic chip has a footpr... We propose and experimentally demonstrate an integrated silicon photonic scheme to generate multi-channel millimeter-wave(MMW) signals for 5 G multi-user applications. The fabricated silicon photonic chip has a footprint of 1.1 × 2.1 mm^2 and integrates 7 independent channels each having on-chip polarization control and heterodyne mixing functions. 7 channels of4-Gb/s QPSK baseband signals are delivered via a 2-km multi-core fiber(MCF) and coupled into the chip with a local oscillator(LO) light. The polarization state of each signal light is automatically adjusted and aligned with that of the LO light, and then 7 channels of 28-GHz MMW carrying 4-Gb/s QPSK signals are generated by optical heterodyne beating. Automated polarizationcontrol function of each channel is also demonstrated with ~7-ms tuning time and ~27-dB extinction ratio. 展开更多
关键词 MULTI-CHANNEL millimeter-wave(MMW) generation SILICON PHOTONIC integrated circuits SILICON polarization control(SPC)
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Sub-femtometer-resolution absolute spectroscopy with sweeping electro-optic combs 被引量:5
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作者 Bingxin Xu Xinyu Fan +1 位作者 Shuai Wang Zuyuan He 《Opto-Electronic Advances》 SCIE EI CAS 2022年第12期35-43,共9页
Optical frequency comb with evenly spaced lines over a broad bandwidth has revolutionized the fields of optical metrology and spectroscopy.Here,we propose a fast interleaved dual-comb spectroscopy with sub-femtometer-... Optical frequency comb with evenly spaced lines over a broad bandwidth has revolutionized the fields of optical metrology and spectroscopy.Here,we propose a fast interleaved dual-comb spectroscopy with sub-femtometer-resolution and absolute frequency,in which two electro-optic frequency combs are swept.Electrically-modulated stabilized laser enables ultrahigh resolution of 0.16 fm(or 20 k Hz in optical frequency)and single-shot measurement in 90 ms.Total 20 million points are recorded spanning 3.2 nm(or 400 GHz)bandwidth,corresponding to a spectral sampling rate of 2.5×10^(8)points/s under Nyquist-limitation.Besides,considering the trade-off between the measurement time and spectral resolution,a fast single-shot measurement is also realized in 1.6 ms with 8 fm(or 1 MHz)resolution.We demonstrate the 25-averaged result with 30.6 d B spectral measurement signal-to-noise ratio(SNR)by reducing the filter bandwidth in demodulation.The results show great prospect for precise measurement with flexibly fast refresh time,high spectral resolution,and high SNR. 展开更多
关键词 dual-comb spectroscopy optical frequency comb interferometry
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Network Intrusion Traffic Detection Based on Feature Extraction 被引量:3
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作者 Xuecheng Yu Yan Huang +2 位作者 Yu Zhang Mingyang Song Zhenhong Jia 《Computers, Materials & Continua》 SCIE EI 2024年第1期473-492,共20页
With the increasing dimensionality of network traffic,extracting effective traffic features and improving the identification accuracy of different intrusion traffic have become critical in intrusion detection systems(... With the increasing dimensionality of network traffic,extracting effective traffic features and improving the identification accuracy of different intrusion traffic have become critical in intrusion detection systems(IDS).However,both unsupervised and semisupervised anomalous traffic detection methods suffer from the drawback of ignoring potential correlations between features,resulting in an analysis that is not an optimal set.Therefore,in order to extract more representative traffic features as well as to improve the accuracy of traffic identification,this paper proposes a feature dimensionality reduction method combining principal component analysis and Hotelling’s T^(2) and a multilayer convolutional bidirectional long short-term memory(MSC_BiLSTM)classifier model for network traffic intrusion detection.This method reduces the parameters and redundancy of the model by feature extraction and extracts the dependent features between the data by a bidirectional long short-term memory(BiLSTM)network,which fully considers the influence between the before and after features.The network traffic is first characteristically downscaled by principal component analysis(PCA),and then the downscaled principal components are used as input to Hotelling’s T^(2) to compare the differences between groups.For datasets with outliers,Hotelling’s T^(2) can help identify the groups where the outliers are located and quantitatively measure the extent of the outliers.Finally,a multilayer convolutional neural network and a BiLSTM network are used to extract the spatial and temporal features of network traffic data.The empirical consequences exhibit that the suggested approach in this manuscript attains superior outcomes in precision,recall and F1-score juxtaposed with the prevailing techniques.The results show that the intrusion detection accuracy,precision,and F1-score of the proposed MSC_BiLSTM model for the CIC-IDS 2017 dataset are 98.71%,95.97%,and 90.22%. 展开更多
关键词 Network intrusion traffic detection PCA Hotelling’s T^(2) BiLSTM
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Bidirectional optical amplifier for time transfer using bidirectional WDM transmission 被引量:6
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作者 DING Xuan WU Gui-ling +1 位作者 ZUO Fa-xing CHEN Jian-ping 《Optoelectronics Letters》 EI 2019年第6期401-405,共5页
In this letter, we propose a bidirectional optical amplification scheme for fiber-optic time transfer based on bidirectional wavelength-division multiplexing(WDM) transmission. The proposed scheme employs single unidi... In this letter, we propose a bidirectional optical amplification scheme for fiber-optic time transfer based on bidirectional wavelength-division multiplexing(WDM) transmission. The proposed scheme employs single unidirectional erbiumdoped fiber amplifier(Uni-EDFA) for commercial optical networks to implement bidirectional optical amplification. Since including isolators, the effect of backscattering due to the accumulated amplification can be efficiently suppressed by the proposed amplifier. The proposed scheme is validated over different length fiber links in laboratory. Experimental results show that the proposed amplifier can support fiber-optic time transfer over several thousands of kilometers with an additional bidirectional delay difference fluctuation at picosecond magnitude. 展开更多
关键词 AMPLIFIER FIBER OPTICAL
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