Diving medicine is one of the branches of military medicine,and plays an important role in naval development.This review introduces the progress of researches on undersea and hyperbaric physiology and medicine in the ...Diving medicine is one of the branches of military medicine,and plays an important role in naval development.This review introduces the progress of researches on undersea and hyperbaric physiology and medicine in the past few years in China.The article describes our research achievement in conventional diving and its medical support,researches on saturation diving and its medical support,submarine escape and its medical support,effects of hyperbaric environments and fast buoyancy ascent on immunological and cardiological functions.Diving disorders(including decompression sickness and oxygen toxicity) are also introduced.展开更多
Shaped charge has been widely used for penetrating concrete.However,due to the obvious difference between the propagation of shock waves and explosion products in water and air,the theory governing the formation of sh...Shaped charge has been widely used for penetrating concrete.However,due to the obvious difference between the propagation of shock waves and explosion products in water and air,the theory governing the formation of shaped charge jets in water as well as the underwater penetration effect of concrete need to be studied.In this paper,we introduced a modified forming theory of an underwater hemispherical shaped charge,and investigated the behavior of jet formation and concrete penetration in both air and water experimentally and numerically.The results show that the modified jet forming theory predicts the jet velocity of the hemispherical liner with an error of less than 10%.The underwater jets exhibit at least 3%faster and 11%longer than those in air.Concrete shows different failure modes after penetration in air and water.The depth of penetration deepens at least 18.75%after underwater penetration,accompanied by deeper crater with 65%smaller radius.Moreover,cracks throughout the entire target are formed,whereas cracks exist only near the penetration hole in air.This comprehensive study provides guidance for optimizing the structure of shaped charge and improves the understanding of the permeability effect of concrete in water.展开更多
This study designs four types of liquid-filled cylindrical shell structures to investigate their protection characteristics against explosive shock waves and high-speed fragments.Bare charge and charge-driven prefabri...This study designs four types of liquid-filled cylindrical shell structures to investigate their protection characteristics against explosive shock waves and high-speed fragments.Bare charge and charge-driven prefabricated fragments are employed to examine the damage under blast shock waves and combined blast and fragments loading on various liquid-filled cylindrical shell structures.The test results are compared to numerical calculations and theoretical analysis for the structure's deformation,the liquid medium's movement,and the pressure waves'propagation characteristics under different liquid-filling methods.The results showed that the filling method influences the blast protection and the struc-ture's energy absorption performance.The external filling method reduces the structural deformation,and the internal filling method increases the damage effect.The gapped internal filling method improves the structure's energy absorption efficiency.The pressure wave loading on the liquid-filled cylindrical shell structure differs depending on filling methods.Explosive shock waves and high-speed fragments show a damage enhancement effect on the liquid-filled cylindrical shell structure,depending on the thickness of the internal liquid container layer.The specific impulse on the inner surface of the cylindrical shell positively correlates to the radial deformation of the cylindrical shell structure,and the external liquid layer limits the radial structural deformation.展开更多
The current global cybersecurity landscape, characterized by the increasing scale and sophistication of cyberattacks, underscores the importance of integrating Cyber Threat Intelligence (CTI) into Land Administration ...The current global cybersecurity landscape, characterized by the increasing scale and sophistication of cyberattacks, underscores the importance of integrating Cyber Threat Intelligence (CTI) into Land Administration Systems (LAS). LAS services involve requests and responses concerning public and private cadastral data, including credentials of parties, ownership, and spatial parcels. This study explores the integration of CTI in LAS to enhance cyber resilience, focusing on the unique vulnerabilities of LAS, such as sensitive data management and interconnection with other critical systems related to spatial data uses and changes. The approach employs a case study of a typical country-specific LAS to analyse structured vulnerabilities and their attributes to determine the degree of vulnerability of LAS through a quantitative inductive approach. The analysis results indicate significant improvements in identifying and mitigating potential threats through CTI integration, thus enhancing cyber resilience. These findings are crucial for policymakers and practitioners to develop robust cybersecurity strategies for LAS.展开更多
The impact safety of explosive charges has been focused in these decades. The fragment impact is widely used to evaluate the response of explosive charges. In our work, the explosive detonation driving technique was u...The impact safety of explosive charges has been focused in these decades. The fragment impact is widely used to evaluate the response of explosive charges. In our work, the explosive detonation driving technique was used to generate a high velocity fragment with large mass. When the fragment masses are10 g, 16 g, 25 g, and 50 g, the highest velocity of fragments can reach 2400 m/s, 2100 m/s, 1900 m/s, and1400 m/s, respectively. The high velocity fragment with large mass was used to evaluate the safety of two kinds of CL-20 based explosive charges. The effects of the fragment mass and velocity were analyzed.Especially, the reaction extent was obtained based on visible phenomenon. The CL-20-based explosive charge containing Al had a higher safety level than that without Al. It was because Al had good ductility,and further improved the mechanical property of the material. Also, the numerical simulation was conducted to understand the reaction characteristics of the CL-20-based explosive charge. The results showed that as the fragment mass and velocity increased, the reaction became more violent.展开更多
This brief presents a cryogenic voltage reference circuit designed to operate effectively across a wide temperature range from 30 to 300 K.A key feature of the proposed design is utilizing a current subtraction techni...This brief presents a cryogenic voltage reference circuit designed to operate effectively across a wide temperature range from 30 to 300 K.A key feature of the proposed design is utilizing a current subtraction technique for temperature compensation of the reference current,avoiding the deployment of bipolar transistors to reduce area and power consumption.Implemented with a 0.18-μm CMOS process,the circuit achieves a temperature coefficient(TC)of 67.5 ppm/K,which was not achieved in previous works.The design can also attain a power supply rejection(PSR)of 58 d B at 10 k Hz.Meanwhile,the average reference voltage is 1.2 V within a 1.6%3σ-accuracy spread.Additionally,the design is characterized by a minimal power dissipation of 1μW at 30 K and a compact chip area of 0.0035 mm~2.展开更多
Coral reef limestone at different depositional depths and facies differ remarkably on the textural and mineralogical characteristics,owing to the complex sedimentary diagenesis.To explore the effects of pore structure...Coral reef limestone at different depositional depths and facies differ remarkably on the textural and mineralogical characteristics,owing to the complex sedimentary diagenesis.To explore the effects of pore structure and mineral composition associated with diagenetic variation on the mechanical behavior of reef limestone,a series of quasi-static and dynamic compression tests along with microscopic examinations were performed on the reef limestone at shallow and deep burial depths.It is revealed that the shallow reef limestone(SRL)is classified as a porous aragonite-type carbonate rock with high porosity(55.3±3.2)%and pore connectivity.In comparison,the deep reef limestone(DRL)is mainly composed of dense calcite-type calcium carbonate with low porosity(4.9±1.6)%and pore connectivity.The DRL strengthened and stiffened by the tight grain framework consistently displays much higher values of the dynamic compressive strength,elastic modulus,brittleness index,and specific energy absorption than those of the SRL.The gap between two types of limestone further increases with an increase in strain rate.It appears that the failure pattern of SRL is dominated by the inherent defects like weak bonding interfaces and growth lines,revealed by the intricate fracturing network and mixed failure.Likewise,although the preexisting megapores in DRL may affect the crack propagation on pore tips to a certain distance,it hardly alters the axial splitting failure of DRL under impacts.The stress wave propagation and attenuation in SRL is primarily controlled by the reflection and diffusion caused by plenty mesopores,as well as an energy dissipation in layer-wise pore collapse and adjacent grain crushing,while the stress wave in DRL is highly hinged on the insulation and diffraction induced by the isolated megapores.This process is accompanied by the energy dissipation behavior of inelastic deformation resulted from the pore-emanated microcracking.展开更多
Background: Cimetidine, an antagonist of histamine type II receptors, has shown protective effects against γ-rays or neutrons. However, there have been no reports on the effects of cimetidine against neutrons combine...Background: Cimetidine, an antagonist of histamine type II receptors, has shown protective effects against γ-rays or neutrons. However, there have been no reports on the effects of cimetidine against neutrons combined with γ-rays. This study was carried out to evaluate the protective effects of cimetidine on rats exposed to long-term, low-dose-rate neutron and γ-ray combined irradiation(n-γ LDR).Methods: Fifty male Sprague-Dawley(SD) rats were randomly divided into 5 groups: the normal control group, radiation model group, 20mg/(kg·d) cimetidine group, 80mg/(kg·d) cimetidine group and 160mg/(kg·d) cimetidine group(10 rats per group). Except for the normal control group, 40 rats were simultaneously exposed to fission neutrons(^(252)Cf, 0.085 m Gy/h) for 22 h every day and γ-rays(^(60)Co, 0.097Gy/h) for 1.03 h once every three days, and the cimetidine groups were administered intragastrically with cimetidine at doses of 20, 80 and 160mg/kg each day. Peripheral blood WBC of the rats was counted the day following exposure to γ-rays. The rats were anesthetized and sacrificed on the day following exposure to ^(252)Cf for 28 days. The spleen, thymus, testicle, liver and intestinal tract indexes were evaluated. The DNA content of bone marrow cells and concanavalin A(Con A)-induced lymphocyte proliferation were measured. The frequency of micronuclei in polychromatic erythrocytes(f MNPCEs), superoxide dismutase(SOD), malondialdehyde(MDA), and glutathione peroxidase(GSH-Px) in the serum and liver tissues were detected.Results: The peripheral blood WBC in the cimetidine groups was increased significantly on the 8th day and the 26 th day compared with those in the radiation model group. The spleen, thymus and testicle indexes of the cimetidine groups were higher than those of the radiation model group. The DNA content of bone marrow cells and lymphocyte proliferation in the cimetidine groups were increased significantly, and fMNPCE was reduced 1.41-1.77 fold in cimetidine treated groups. The activities of SOD and GSH-Px in the cimetidine groups were increased significantly, and the content of MDA in the cimetidine groups was decreased significantly.Conclusions: The results suggested that cimetidine alleviated damage induced by long-term, low-dose-rate neutron and γ combined irradiation via antioxidation and immunomodulation. Cimetidine might be useful as a potent radioprotector for radiotherapy patients as well as for occupational exposure workers.展开更多
A better understanding of the relationship between the structure and functions of urban and suburban spaces is one of the avenues of research still open for geographical information science.The research presented in t...A better understanding of the relationship between the structure and functions of urban and suburban spaces is one of the avenues of research still open for geographical information science.The research presented in this paper develops several graph-based metrics whose objective is to characterize some local and global structural properties that reflect the way the overall building layout can be cross-related to the one of the road layout.Such structural properties are modeled as an aggregation of parcels,buildings,and road networks.We introduce several computational measures(Ratio Minimum Distance,Minimum Ratio Minimum Distance,and Metric Compactness)that respectively evaluate the capability for a given road to be connected with the whole road network.These measures reveal emerging sub-network structures and point out differences between less-connective and moreconnective parts of the network.Based on these local and global properties derived from the topological and graph-based representation,and on building density metrics,this paper proposes an analysis of road and building layouts at different levels of granularity.The metrics developed are applied to a case study in which the derived properties reveal coherent as well as incoherent neighborhoods that illustrate the potential of the approach and the way buildings and roads can be relatively connected in a given urban environment.Overall,and by integrating the parcels and buildings layouts,this approach complements other previous and related works that mainly retain the configurational structure of the urban network as well as morphological studies whose focus is generally limited to the analysis of the building layout.展开更多
Background:Exercise induces blood flow redistribution among tissues,leading to splanchnic hypoperfusion.Intestinal epithelial cells are positioned between the anaerobic lumen and the highly metabolic lamina propria wi...Background:Exercise induces blood flow redistribution among tissues,leading to splanchnic hypoperfusion.Intestinal epithelial cells are positioned between the anaerobic lumen and the highly metabolic lamina propria with an oxygen gradient.Hypoxia-inducible factor(HIF)-la is pivotal in the transcriptional response to the oxygen flux.Methods:In this study,the pimonidazole hydrochloride staining was applied to observe the tissue hypoxia in different organs,which might be affected by the blood flow redistribution.The HIF-la luciferase reporter ROSA26 oxygen-dependent degradation domain(ODD)-Luc/^+mouse model(ODD domain-Luc;female,n=3-6/group) was used to detect the HIF-la expression in the intestine.We used 3 swimming models:moderate exercise for 30 min,heavy-intensity exercise bearing 5% bodyweight for 1.5 h,and long-time exercise for 3 h.Results:We found that 1 session of swimming at different intensities could induce tissue hypoxia redistribution in the small intestine,colon,liver and kidney,but not in the spleen,heart,and skeletal muscle.Our data showed that exercise exacerbated the extent of physiological hypoxia in the small intestine.Next,using ODD-Luc mice,we found that moderate exercise increased the in vivo HIF-1α level in the small intestine.The postexercise HIF-1α level was gradually decreased in a time-dependent manner.Interestingly,the redistribution of tissue hypoxia and the increase of HIF-la expression were not related to the exercise intensity and duration.Conclusion:This study provided evidence that the small intestine is the primary target organ for exercise-induced tissue hypoxia and HIF-la redistribution,suggesting that HIF-1α may be a potential target for the regulation of gastrointestinal functions after exercise.展开更多
Background: Wounded personnel who work at sea often encounter a plethora of difficulties. The most important of these difficulties is seawater immersion. Common medical dressings have little effect when the affected a...Background: Wounded personnel who work at sea often encounter a plethora of difficulties. The most important of these difficulties is seawater immersion. Common medical dressings have little effect when the affected area is immersed in seawater, and only rarely dressings have been reported for the treatment of seawater-immersed wounds. The objective of this study is to develop a new dressing which should be suitable to prevent the wound from seawater immersion and to promote the wound healing.Methods: Shark skin collagen(SSC) was purified via ethanol de-sugaring and de-pigmentation and adjusted for p H. A shark skin collagen sponge(SSCS) was prepared by freeze-drying. SSCS was attached to an anti-seawater immersion polyurethane(PU) film(SSCS+PU) to compose a new dressing. The biochemical properties of SSC and physicochemical properties of SSCS were assessed by standard methods. The effects of SSCS and SSCS+PU on the healing of seawaterimmersed wounds were studied using a seawater immersion rat model. For the detection of SSCS effects on seawaterimmersed wounds, 12 SD rats, with four wounds created in each rat, were divided into four groups: the 3 rd day group, 5 th day group, 7 th day group and 12 th day group. In each group, six wounds were treated with SSCS, three wounds treated with chitosan served as the positive control, and three wounds treated with gauze served as the negative control. For the detection of the SSCS+PU effects on seawater-immersed wounds, 36 SD rats were divided into three groups: the gauze(GZ)+PU group, chitosan(CS)+PU group and SSCS+PU group, with 12 rats in each group, and two wounds in each rat. The wound sizes were measured to calculate the healing rate, and histomorphology and the immunohistochemistry of the CD31 and TGF-β expression levels in the wounded tissues were measured by standard methods.Results: The results of Ultraviolet-visible(UV-vis) spectrum, Fourier-transform infrared(FTIR) spectrum, circular dichroism(CD) spectra, sodium dodecyl sulfate polyacrylamide gel electrophoresis(SDS-PAGE), and amino acid composition analyses of SSC demonstrated that SSC is type I collagen. SSCS had a homogeneous porous structure of approximately 200μm, porosity rate of 83.57%±2.64%, water vapor transmission ratio(WVTR) of 4500 g/m2, tensile strength of 1.79±0.41 N/mm, and elongation at break of 4.52%±0.01%. SSCS had significant beneficial effects on seawater-immersed wound healing. On the 3 rd day, the healing rates in the GZ negative control, CS positive control and SSCS rats were 13.94%±5.50%, 29.40%±1.10% and 47.24%±8.40%, respectively. SSCS also enhanced TGF-in the initial stage of the healing period. The SSCS+PU dressing effectively protected woundsβ and CD31 expression from seawater immersion for at least 4 h, and accelerated re-epithelialization, vascularization and granulation formation of seawater-immersed wounds in the earlier stages of wound healing, and as well as significantly promoted wound healing. The SSCS+PU dressing also enhanced expression of TGF-n and gauze dressings.β and CD31. The effects of SSCS and SSCS+PU were superior to those of both the chitosaConclusion: SSCS has significant positive effects on the promotion of seawater-immersed wound healing, and a SSCS+PU dressing effectively prevents seawater immersion, and significantly promotes seawater-immersed wound healing.展开更多
A biodegradable nerve regeneration conduit has been developed by the regular braided technique on a spindle-braiding machine. The geometry property indexes of braided nerve conduit consist of pitch, density, wall thic...A biodegradable nerve regeneration conduit has been developed by the regular braided technique on a spindle-braiding machine. The geometry property indexes of braided nerve conduit consist of pitch, density, wall thickness and porosity etc. In this article, the influences of the braiding parameters i.e. the linear density of yarn, gear ratio and spindle number of the braiding machine on these geometry property indexes of nerve conduit were discussed from which the optimal braiding parameters were obtained.展开更多
An ocean-acoustic joint model is developed for research of acoustic propagation uncertainty in internal wave environments.The internal waves are numerically produced by tidal forcing over a continental slope using an ...An ocean-acoustic joint model is developed for research of acoustic propagation uncertainty in internal wave environments.The internal waves are numerically produced by tidal forcing over a continental slope using an ocean model.Three parameters(i.e.,internal wave,source depth,and water depth)contribute to the dynamic waveguide environments,and result in stochastic sound fields.The sensitivity of the transmission loss(TL)to environment parameters,statistical characteristics of the TL variation,and the associated physical mechanisms are investigated by the Sobol sensitivity analysis method,the Monte Carlo sampling,and the coupled normal mode theory,respectively.The results show that the TL is most sensitive to the source depth in the near field,resulted from the initial amplitudes of higher-order modes;while in middle and far fields,the internal waves are responsible for more than 80%of the total acoustic propagation contribution.In addition,the standard deviation of the TL in the near field and the shallow layer is smaller than those in the middle and far fields and the deep layer.展开更多
This study observed the immune response induced by a HSP65 DNA vaccine fused with UbGR against Mycobacterium tuberculosis. BALB/c mice were inoculated with HSP65 DNA vaccine, UbGR-fused HSP65 DNA vaccine (Ub-GR-HSP65)...This study observed the immune response induced by a HSP65 DNA vaccine fused with UbGR against Mycobacterium tuberculosis. BALB/c mice were inoculated with HSP65 DNA vaccine, UbGR-fused HSP65 DNA vaccine (Ub-GR-HSP65) and blank vector respectively. HSP65 DNA vaccine elicited a Thl-polarized immune response. The Thl-type cytokine (IFN-γ) and proliferative T cell responses from spleen were improved significantly in UbGR-HSP65 group, compared with those in HSP65 DNA vaccine group. Furthermore, this fusion DNA vaccine also led to an increased ratio of IgG2ato IgGl and the cytotoxicity of T cells. IFN-γ intracellular staining of splenocytes indicated that UbGR-HSP65 fusion DNA vaccine could activate CD4+ and CD8+ T cells, with much higher CD8+ T cells. Thus, this study demonstrated that the UbGR fusion could improve HSP65-specific cellular immune responses, which is helpful to protect against TB infection.展开更多
Aim: Diabetes mellitus is a metabolic disorder leading to hyperglycemia and exhibiting altered fat and protein metabolism. Diabetes altered cellular microenvironment caused myriad untoward effects. Periodontitis is ch...Aim: Diabetes mellitus is a metabolic disorder leading to hyperglycemia and exhibiting altered fat and protein metabolism. Diabetes altered cellular microenvironment caused myriad untoward effects. Periodontitis is chronic inflammatory disease. Diabetes and periodontitis had higher prevalence in populations. The objective studied the relationship between diabetes and periodontitis associated with cell apoptosis and the influence of diabetes enhanced inflammation on apoptosis and periodontitis. Methods: This paper studied and analyzed the papers which published in the worldwide associated with the influence of diabetes enhanced inflammation on cell apoptosis and periodontitis, and reviewed the probably mechanism associated with apoptosis. Results: Diabetes induced hyperglycemia enhanced inflammation related to cell apoptosis. Periodontitis had a higher morbidity on diabetes patients. Periodontal intervention may be benefit to controlling the diabetes. The bidirectional efficiency happened between diabetes and periodontitis. Anti-apoptotic and anti-inflammation option can improve the therapeutic effects on diabetes and periodontitis. The finding included following several aspects. 1) Advanced glycation end products enhanced inflammatory response;2) Hyperglycemia induced cell apoptosis;3) inflammatory cytokines caused cell apoptosis;4) Mutuality between cell apoptosis and periodontitis;5) Diabetes induce periodontitis and bone loss;6) Periodontitis induced insulin resistance. 7) TNFα induce prostaglandins elicited cell apoptosis;8) periodontal therapies had effects on diabetes. Conclusion: Diabetes can enhance inflamemation leading to apoptosis and periodontitis. Effective periodontal therapy and control glucose may produce better effects on diabetes or periodontitis. Further research required to investigate the bidirectional mechanism between diabetes and periodontitis.展开更多
The acoustic properties of seafloor sediment are essential parameters in the exploration of marine resources,ocean scientific research and ocean engineering.Seafloor sediment samples were collected at the southern U-b...The acoustic properties of seafloor sediment are essential parameters in the exploration of marine resources,ocean scientific research and ocean engineering.Seafloor sediment samples were collected at the southern U-boundary of the South China Sea(SCS),and the acoustic and physical properties were measured in the laboratory.The correlation between physical and sound speed ratio(SSR)was discussed,and SSR-physical property empirical regressions in the Sunda Shelf were established for the first time.Compared with the northern continental shelf of SCS,the Sunda Shelf are mainly silty and sand sediment,and the SSR ranges from 0.9949 to 1.0944,which has higher SSR than the northern continental shelf,implies that the Sunda Shelf is a high SSR area.Since the same kind of sediment has different physical properties,the single physical parameter of sediment cannot fully represent the acoustic properties of sediment,therefore,the multiple parameter prediction model should develop in the future to improve the prediction precision.展开更多
Based on nuclear power plant(NPP) best-estimate transient analysis with RELAP5 / MOD3 code,the reactor point kinetics model in RELAP5 / MOD3 code is replaced by the two-group,3-D space and time dependent neutron kinet...Based on nuclear power plant(NPP) best-estimate transient analysis with RELAP5 / MOD3 code,the reactor point kinetics model in RELAP5 / MOD3 code is replaced by the two-group,3-D space and time dependent neutron kinetic model,and two-fluid model is replaced by drift flux model.A coupled three-dimensional physics and thermal-hydrodynamics model is used to develop its corresponding computing code,thus simulating natural circulation of single-phase flow for the PWR.In this paper,we report the forward and reverse flow distribution in the inverted U-tubes of the steam generator(SG) under some typical operating conditions in the natural circulation case, and analyze the influence of main coolant pump resistance on the forward and reverse flow distribution.The calculation results show that,the pressure drop between SG inlet and outlet plenum decreases,and the SG inlet and outlet mass flow decrease with an increased main coolant pump resistance,but net mass flux of reverse flow in inverted U-tubes,and the ratio of mass flow in all reverse flow tubes to that of main coolant pipeline increase, meanwhile,the secondary steam load is invariable in this process.展开更多
Aiming at the practical application of Unmanned Underwater Vehicle(UUV)in underwater combat,this paper proposes a battlefield ambush scene with UUV considering ocean current.Firstly,by establishing these mathematical ...Aiming at the practical application of Unmanned Underwater Vehicle(UUV)in underwater combat,this paper proposes a battlefield ambush scene with UUV considering ocean current.Firstly,by establishing these mathematical models of ocean current environment,target movement,and sonar detection,the probability calculation methods of single UUV searching target and multiple UUV cooperatively searching target are given respectively.Then,based on the Hybrid Quantum-behaved Particle Swarm Optimization(HQPSO)algorithm,the path with the highest target search probability is found.Finally,through simulation calculations,the influence of different UUV parameters and target parameters on the target search probability is analyzed,and the minimum number of UUVs that need to be deployed to complete the ambush task is demonstrated,and the optimal search path scheme is obtained.The method proposed in this paper provides a theoretical basis for the practical application of UUV in the future combat.展开更多
文摘Diving medicine is one of the branches of military medicine,and plays an important role in naval development.This review introduces the progress of researches on undersea and hyperbaric physiology and medicine in the past few years in China.The article describes our research achievement in conventional diving and its medical support,researches on saturation diving and its medical support,submarine escape and its medical support,effects of hyperbaric environments and fast buoyancy ascent on immunological and cardiological functions.Diving disorders(including decompression sickness and oxygen toxicity) are also introduced.
基金supported by the National Science Foundation of China(Grant Nos.12372361,12102427,12372335 and 12102202)the Fundamental Research Funds for the Central Universities(Grant No.30923010908)Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.KYCX23_0520).
文摘Shaped charge has been widely used for penetrating concrete.However,due to the obvious difference between the propagation of shock waves and explosion products in water and air,the theory governing the formation of shaped charge jets in water as well as the underwater penetration effect of concrete need to be studied.In this paper,we introduced a modified forming theory of an underwater hemispherical shaped charge,and investigated the behavior of jet formation and concrete penetration in both air and water experimentally and numerically.The results show that the modified jet forming theory predicts the jet velocity of the hemispherical liner with an error of less than 10%.The underwater jets exhibit at least 3%faster and 11%longer than those in air.Concrete shows different failure modes after penetration in air and water.The depth of penetration deepens at least 18.75%after underwater penetration,accompanied by deeper crater with 65%smaller radius.Moreover,cracks throughout the entire target are formed,whereas cracks exist only near the penetration hole in air.This comprehensive study provides guidance for optimizing the structure of shaped charge and improves the understanding of the permeability effect of concrete in water.
基金the National Natural Science Foundation of China(Grant Nos.52371342,52271338,52101378 and 51979277)。
文摘This study designs four types of liquid-filled cylindrical shell structures to investigate their protection characteristics against explosive shock waves and high-speed fragments.Bare charge and charge-driven prefabricated fragments are employed to examine the damage under blast shock waves and combined blast and fragments loading on various liquid-filled cylindrical shell structures.The test results are compared to numerical calculations and theoretical analysis for the structure's deformation,the liquid medium's movement,and the pressure waves'propagation characteristics under different liquid-filling methods.The results showed that the filling method influences the blast protection and the struc-ture's energy absorption performance.The external filling method reduces the structural deformation,and the internal filling method increases the damage effect.The gapped internal filling method improves the structure's energy absorption efficiency.The pressure wave loading on the liquid-filled cylindrical shell structure differs depending on filling methods.Explosive shock waves and high-speed fragments show a damage enhancement effect on the liquid-filled cylindrical shell structure,depending on the thickness of the internal liquid container layer.The specific impulse on the inner surface of the cylindrical shell positively correlates to the radial deformation of the cylindrical shell structure,and the external liquid layer limits the radial structural deformation.
文摘The current global cybersecurity landscape, characterized by the increasing scale and sophistication of cyberattacks, underscores the importance of integrating Cyber Threat Intelligence (CTI) into Land Administration Systems (LAS). LAS services involve requests and responses concerning public and private cadastral data, including credentials of parties, ownership, and spatial parcels. This study explores the integration of CTI in LAS to enhance cyber resilience, focusing on the unique vulnerabilities of LAS, such as sensitive data management and interconnection with other critical systems related to spatial data uses and changes. The approach employs a case study of a typical country-specific LAS to analyse structured vulnerabilities and their attributes to determine the degree of vulnerability of LAS through a quantitative inductive approach. The analysis results indicate significant improvements in identifying and mitigating potential threats through CTI integration, thus enhancing cyber resilience. These findings are crucial for policymakers and practitioners to develop robust cybersecurity strategies for LAS.
文摘The impact safety of explosive charges has been focused in these decades. The fragment impact is widely used to evaluate the response of explosive charges. In our work, the explosive detonation driving technique was used to generate a high velocity fragment with large mass. When the fragment masses are10 g, 16 g, 25 g, and 50 g, the highest velocity of fragments can reach 2400 m/s, 2100 m/s, 1900 m/s, and1400 m/s, respectively. The high velocity fragment with large mass was used to evaluate the safety of two kinds of CL-20 based explosive charges. The effects of the fragment mass and velocity were analyzed.Especially, the reaction extent was obtained based on visible phenomenon. The CL-20-based explosive charge containing Al had a higher safety level than that without Al. It was because Al had good ductility,and further improved the mechanical property of the material. Also, the numerical simulation was conducted to understand the reaction characteristics of the CL-20-based explosive charge. The results showed that as the fragment mass and velocity increased, the reaction became more violent.
基金supported in part by the National Key Research and Development Program of China(2021YFA0715503)。
文摘This brief presents a cryogenic voltage reference circuit designed to operate effectively across a wide temperature range from 30 to 300 K.A key feature of the proposed design is utilizing a current subtraction technique for temperature compensation of the reference current,avoiding the deployment of bipolar transistors to reduce area and power consumption.Implemented with a 0.18-μm CMOS process,the circuit achieves a temperature coefficient(TC)of 67.5 ppm/K,which was not achieved in previous works.The design can also attain a power supply rejection(PSR)of 58 d B at 10 k Hz.Meanwhile,the average reference voltage is 1.2 V within a 1.6%3σ-accuracy spread.Additionally,the design is characterized by a minimal power dissipation of 1μW at 30 K and a compact chip area of 0.0035 mm~2.
基金supported by the National Natural Science Foundation for Excellent Young Scholars of China(No.52222110)the Natural Science Foundation of Jiangsu Province(No.BK20211230).
文摘Coral reef limestone at different depositional depths and facies differ remarkably on the textural and mineralogical characteristics,owing to the complex sedimentary diagenesis.To explore the effects of pore structure and mineral composition associated with diagenetic variation on the mechanical behavior of reef limestone,a series of quasi-static and dynamic compression tests along with microscopic examinations were performed on the reef limestone at shallow and deep burial depths.It is revealed that the shallow reef limestone(SRL)is classified as a porous aragonite-type carbonate rock with high porosity(55.3±3.2)%and pore connectivity.In comparison,the deep reef limestone(DRL)is mainly composed of dense calcite-type calcium carbonate with low porosity(4.9±1.6)%and pore connectivity.The DRL strengthened and stiffened by the tight grain framework consistently displays much higher values of the dynamic compressive strength,elastic modulus,brittleness index,and specific energy absorption than those of the SRL.The gap between two types of limestone further increases with an increase in strain rate.It appears that the failure pattern of SRL is dominated by the inherent defects like weak bonding interfaces and growth lines,revealed by the intricate fracturing network and mixed failure.Likewise,although the preexisting megapores in DRL may affect the crack propagation on pore tips to a certain distance,it hardly alters the axial splitting failure of DRL under impacts.The stress wave propagation and attenuation in SRL is primarily controlled by the reflection and diffusion caused by plenty mesopores,as well as an energy dissipation in layer-wise pore collapse and adjacent grain crushing,while the stress wave in DRL is highly hinged on the insulation and diffraction induced by the isolated megapores.This process is accompanied by the energy dissipation behavior of inelastic deformation resulted from the pore-emanated microcracking.
基金supported by the Research Fund of National Science and Technology Major Project of China(No.2014ZX09J14103-07B)
文摘Background: Cimetidine, an antagonist of histamine type II receptors, has shown protective effects against γ-rays or neutrons. However, there have been no reports on the effects of cimetidine against neutrons combined with γ-rays. This study was carried out to evaluate the protective effects of cimetidine on rats exposed to long-term, low-dose-rate neutron and γ-ray combined irradiation(n-γ LDR).Methods: Fifty male Sprague-Dawley(SD) rats were randomly divided into 5 groups: the normal control group, radiation model group, 20mg/(kg·d) cimetidine group, 80mg/(kg·d) cimetidine group and 160mg/(kg·d) cimetidine group(10 rats per group). Except for the normal control group, 40 rats were simultaneously exposed to fission neutrons(^(252)Cf, 0.085 m Gy/h) for 22 h every day and γ-rays(^(60)Co, 0.097Gy/h) for 1.03 h once every three days, and the cimetidine groups were administered intragastrically with cimetidine at doses of 20, 80 and 160mg/kg each day. Peripheral blood WBC of the rats was counted the day following exposure to γ-rays. The rats were anesthetized and sacrificed on the day following exposure to ^(252)Cf for 28 days. The spleen, thymus, testicle, liver and intestinal tract indexes were evaluated. The DNA content of bone marrow cells and concanavalin A(Con A)-induced lymphocyte proliferation were measured. The frequency of micronuclei in polychromatic erythrocytes(f MNPCEs), superoxide dismutase(SOD), malondialdehyde(MDA), and glutathione peroxidase(GSH-Px) in the serum and liver tissues were detected.Results: The peripheral blood WBC in the cimetidine groups was increased significantly on the 8th day and the 26 th day compared with those in the radiation model group. The spleen, thymus and testicle indexes of the cimetidine groups were higher than those of the radiation model group. The DNA content of bone marrow cells and lymphocyte proliferation in the cimetidine groups were increased significantly, and fMNPCE was reduced 1.41-1.77 fold in cimetidine treated groups. The activities of SOD and GSH-Px in the cimetidine groups were increased significantly, and the content of MDA in the cimetidine groups was decreased significantly.Conclusions: The results suggested that cimetidine alleviated damage induced by long-term, low-dose-rate neutron and γ combined irradiation via antioxidation and immunomodulation. Cimetidine might be useful as a potent radioprotector for radiotherapy patients as well as for occupational exposure workers.
文摘A better understanding of the relationship between the structure and functions of urban and suburban spaces is one of the avenues of research still open for geographical information science.The research presented in this paper develops several graph-based metrics whose objective is to characterize some local and global structural properties that reflect the way the overall building layout can be cross-related to the one of the road layout.Such structural properties are modeled as an aggregation of parcels,buildings,and road networks.We introduce several computational measures(Ratio Minimum Distance,Minimum Ratio Minimum Distance,and Metric Compactness)that respectively evaluate the capability for a given road to be connected with the whole road network.These measures reveal emerging sub-network structures and point out differences between less-connective and moreconnective parts of the network.Based on these local and global properties derived from the topological and graph-based representation,and on building density metrics,this paper proposes an analysis of road and building layouts at different levels of granularity.The metrics developed are applied to a case study in which the derived properties reveal coherent as well as incoherent neighborhoods that illustrate the potential of the approach and the way buildings and roads can be relatively connected in a given urban environment.Overall,and by integrating the parcels and buildings layouts,this approach complements other previous and related works that mainly retain the configurational structure of the urban network as well as morphological studies whose focus is generally limited to the analysis of the building layout.
基金supported by National Natural Science Foundation of China (Grant number:31471135,31701040, and 31801003)Shanghai Sailing Program (Grant number: 17YF1418000)Shanghai Municipal Education Commission (Grant number:Chenguang Program 16CG57)
文摘Background:Exercise induces blood flow redistribution among tissues,leading to splanchnic hypoperfusion.Intestinal epithelial cells are positioned between the anaerobic lumen and the highly metabolic lamina propria with an oxygen gradient.Hypoxia-inducible factor(HIF)-la is pivotal in the transcriptional response to the oxygen flux.Methods:In this study,the pimonidazole hydrochloride staining was applied to observe the tissue hypoxia in different organs,which might be affected by the blood flow redistribution.The HIF-la luciferase reporter ROSA26 oxygen-dependent degradation domain(ODD)-Luc/^+mouse model(ODD domain-Luc;female,n=3-6/group) was used to detect the HIF-la expression in the intestine.We used 3 swimming models:moderate exercise for 30 min,heavy-intensity exercise bearing 5% bodyweight for 1.5 h,and long-time exercise for 3 h.Results:We found that 1 session of swimming at different intensities could induce tissue hypoxia redistribution in the small intestine,colon,liver and kidney,but not in the spleen,heart,and skeletal muscle.Our data showed that exercise exacerbated the extent of physiological hypoxia in the small intestine.Next,using ODD-Luc mice,we found that moderate exercise increased the in vivo HIF-1α level in the small intestine.The postexercise HIF-1α level was gradually decreased in a time-dependent manner.Interestingly,the redistribution of tissue hypoxia and the increase of HIF-la expression were not related to the exercise intensity and duration.Conclusion:This study provided evidence that the small intestine is the primary target organ for exercise-induced tissue hypoxia and HIF-la redistribution,suggesting that HIF-1α may be a potential target for the regulation of gastrointestinal functions after exercise.
基金supported by a Major Project of the Ministry of National Science and Technology of China(Grant No.2014ZX09J14103-09C).
文摘Background: Wounded personnel who work at sea often encounter a plethora of difficulties. The most important of these difficulties is seawater immersion. Common medical dressings have little effect when the affected area is immersed in seawater, and only rarely dressings have been reported for the treatment of seawater-immersed wounds. The objective of this study is to develop a new dressing which should be suitable to prevent the wound from seawater immersion and to promote the wound healing.Methods: Shark skin collagen(SSC) was purified via ethanol de-sugaring and de-pigmentation and adjusted for p H. A shark skin collagen sponge(SSCS) was prepared by freeze-drying. SSCS was attached to an anti-seawater immersion polyurethane(PU) film(SSCS+PU) to compose a new dressing. The biochemical properties of SSC and physicochemical properties of SSCS were assessed by standard methods. The effects of SSCS and SSCS+PU on the healing of seawaterimmersed wounds were studied using a seawater immersion rat model. For the detection of SSCS effects on seawaterimmersed wounds, 12 SD rats, with four wounds created in each rat, were divided into four groups: the 3 rd day group, 5 th day group, 7 th day group and 12 th day group. In each group, six wounds were treated with SSCS, three wounds treated with chitosan served as the positive control, and three wounds treated with gauze served as the negative control. For the detection of the SSCS+PU effects on seawater-immersed wounds, 36 SD rats were divided into three groups: the gauze(GZ)+PU group, chitosan(CS)+PU group and SSCS+PU group, with 12 rats in each group, and two wounds in each rat. The wound sizes were measured to calculate the healing rate, and histomorphology and the immunohistochemistry of the CD31 and TGF-β expression levels in the wounded tissues were measured by standard methods.Results: The results of Ultraviolet-visible(UV-vis) spectrum, Fourier-transform infrared(FTIR) spectrum, circular dichroism(CD) spectra, sodium dodecyl sulfate polyacrylamide gel electrophoresis(SDS-PAGE), and amino acid composition analyses of SSC demonstrated that SSC is type I collagen. SSCS had a homogeneous porous structure of approximately 200μm, porosity rate of 83.57%±2.64%, water vapor transmission ratio(WVTR) of 4500 g/m2, tensile strength of 1.79±0.41 N/mm, and elongation at break of 4.52%±0.01%. SSCS had significant beneficial effects on seawater-immersed wound healing. On the 3 rd day, the healing rates in the GZ negative control, CS positive control and SSCS rats were 13.94%±5.50%, 29.40%±1.10% and 47.24%±8.40%, respectively. SSCS also enhanced TGF-in the initial stage of the healing period. The SSCS+PU dressing effectively protected woundsβ and CD31 expression from seawater immersion for at least 4 h, and accelerated re-epithelialization, vascularization and granulation formation of seawater-immersed wounds in the earlier stages of wound healing, and as well as significantly promoted wound healing. The SSCS+PU dressing also enhanced expression of TGF-n and gauze dressings.β and CD31. The effects of SSCS and SSCS+PU were superior to those of both the chitosaConclusion: SSCS has significant positive effects on the promotion of seawater-immersed wound healing, and a SSCS+PU dressing effectively prevents seawater immersion, and significantly promotes seawater-immersed wound healing.
文摘A biodegradable nerve regeneration conduit has been developed by the regular braided technique on a spindle-braiding machine. The geometry property indexes of braided nerve conduit consist of pitch, density, wall thickness and porosity etc. In this article, the influences of the braiding parameters i.e. the linear density of yarn, gear ratio and spindle number of the braiding machine on these geometry property indexes of nerve conduit were discussed from which the optimal braiding parameters were obtained.
基金the National Key Research and Development Program of China(Grant No.2020YFA0607900)the National Natural Science Foundation of China(Grant Nos.42176019 and 11874061)the Youth Innovation Promotion Association CAS(Grant No.2021023).
文摘An ocean-acoustic joint model is developed for research of acoustic propagation uncertainty in internal wave environments.The internal waves are numerically produced by tidal forcing over a continental slope using an ocean model.Three parameters(i.e.,internal wave,source depth,and water depth)contribute to the dynamic waveguide environments,and result in stochastic sound fields.The sensitivity of the transmission loss(TL)to environment parameters,statistical characteristics of the TL variation,and the associated physical mechanisms are investigated by the Sobol sensitivity analysis method,the Monte Carlo sampling,and the coupled normal mode theory,respectively.The results show that the TL is most sensitive to the source depth in the near field,resulted from the initial amplitudes of higher-order modes;while in middle and far fields,the internal waves are responsible for more than 80%of the total acoustic propagation contribution.In addition,the standard deviation of the TL in the near field and the shallow layer is smaller than those in the middle and far fields and the deep layer.
文摘This study observed the immune response induced by a HSP65 DNA vaccine fused with UbGR against Mycobacterium tuberculosis. BALB/c mice were inoculated with HSP65 DNA vaccine, UbGR-fused HSP65 DNA vaccine (Ub-GR-HSP65) and blank vector respectively. HSP65 DNA vaccine elicited a Thl-polarized immune response. The Thl-type cytokine (IFN-γ) and proliferative T cell responses from spleen were improved significantly in UbGR-HSP65 group, compared with those in HSP65 DNA vaccine group. Furthermore, this fusion DNA vaccine also led to an increased ratio of IgG2ato IgGl and the cytotoxicity of T cells. IFN-γ intracellular staining of splenocytes indicated that UbGR-HSP65 fusion DNA vaccine could activate CD4+ and CD8+ T cells, with much higher CD8+ T cells. Thus, this study demonstrated that the UbGR fusion could improve HSP65-specific cellular immune responses, which is helpful to protect against TB infection.
文摘Aim: Diabetes mellitus is a metabolic disorder leading to hyperglycemia and exhibiting altered fat and protein metabolism. Diabetes altered cellular microenvironment caused myriad untoward effects. Periodontitis is chronic inflammatory disease. Diabetes and periodontitis had higher prevalence in populations. The objective studied the relationship between diabetes and periodontitis associated with cell apoptosis and the influence of diabetes enhanced inflammation on apoptosis and periodontitis. Methods: This paper studied and analyzed the papers which published in the worldwide associated with the influence of diabetes enhanced inflammation on cell apoptosis and periodontitis, and reviewed the probably mechanism associated with apoptosis. Results: Diabetes induced hyperglycemia enhanced inflammation related to cell apoptosis. Periodontitis had a higher morbidity on diabetes patients. Periodontal intervention may be benefit to controlling the diabetes. The bidirectional efficiency happened between diabetes and periodontitis. Anti-apoptotic and anti-inflammation option can improve the therapeutic effects on diabetes and periodontitis. The finding included following several aspects. 1) Advanced glycation end products enhanced inflammatory response;2) Hyperglycemia induced cell apoptosis;3) inflammatory cytokines caused cell apoptosis;4) Mutuality between cell apoptosis and periodontitis;5) Diabetes induce periodontitis and bone loss;6) Periodontitis induced insulin resistance. 7) TNFα induce prostaglandins elicited cell apoptosis;8) periodontal therapies had effects on diabetes. Conclusion: Diabetes can enhance inflamemation leading to apoptosis and periodontitis. Effective periodontal therapy and control glucose may produce better effects on diabetes or periodontitis. Further research required to investigate the bidirectional mechanism between diabetes and periodontitis.
基金Supported by the Guangdong Special Support Key Team Program(No.2019BT02H594)the National Key R&D Program of China(No.2021YFF0501202)+5 种基金the Youth Innovation Promotion Association CASthe National Natural Science Foundation of China(Nos.41706045,42176191,41773039,U22A2012)the Rising Star Foundation of the Integrated Research Center for Islands and Reefs Sciences,CAS(No.ZDRW-XH-2021-2-03)the CAS Key Laboratory of Science and Technology on Operational Oceanography Open Project Funding(No.OOST2021-01)the Guangdong Natural Science Foundation(No.2017A030313237)the State Key Laboratory of Acoustics,Chinese Academy of Sciences(Nos.SKLA202007,SKLA202106)。
文摘The acoustic properties of seafloor sediment are essential parameters in the exploration of marine resources,ocean scientific research and ocean engineering.Seafloor sediment samples were collected at the southern U-boundary of the South China Sea(SCS),and the acoustic and physical properties were measured in the laboratory.The correlation between physical and sound speed ratio(SSR)was discussed,and SSR-physical property empirical regressions in the Sunda Shelf were established for the first time.Compared with the northern continental shelf of SCS,the Sunda Shelf are mainly silty and sand sediment,and the SSR ranges from 0.9949 to 1.0944,which has higher SSR than the northern continental shelf,implies that the Sunda Shelf is a high SSR area.Since the same kind of sediment has different physical properties,the single physical parameter of sediment cannot fully represent the acoustic properties of sediment,therefore,the multiple parameter prediction model should develop in the future to improve the prediction precision.
文摘Based on nuclear power plant(NPP) best-estimate transient analysis with RELAP5 / MOD3 code,the reactor point kinetics model in RELAP5 / MOD3 code is replaced by the two-group,3-D space and time dependent neutron kinetic model,and two-fluid model is replaced by drift flux model.A coupled three-dimensional physics and thermal-hydrodynamics model is used to develop its corresponding computing code,thus simulating natural circulation of single-phase flow for the PWR.In this paper,we report the forward and reverse flow distribution in the inverted U-tubes of the steam generator(SG) under some typical operating conditions in the natural circulation case, and analyze the influence of main coolant pump resistance on the forward and reverse flow distribution.The calculation results show that,the pressure drop between SG inlet and outlet plenum decreases,and the SG inlet and outlet mass flow decrease with an increased main coolant pump resistance,but net mass flux of reverse flow in inverted U-tubes,and the ratio of mass flow in all reverse flow tubes to that of main coolant pipeline increase, meanwhile,the secondary steam load is invariable in this process.
文摘Aiming at the practical application of Unmanned Underwater Vehicle(UUV)in underwater combat,this paper proposes a battlefield ambush scene with UUV considering ocean current.Firstly,by establishing these mathematical models of ocean current environment,target movement,and sonar detection,the probability calculation methods of single UUV searching target and multiple UUV cooperatively searching target are given respectively.Then,based on the Hybrid Quantum-behaved Particle Swarm Optimization(HQPSO)algorithm,the path with the highest target search probability is found.Finally,through simulation calculations,the influence of different UUV parameters and target parameters on the target search probability is analyzed,and the minimum number of UUVs that need to be deployed to complete the ambush task is demonstrated,and the optimal search path scheme is obtained.The method proposed in this paper provides a theoretical basis for the practical application of UUV in the future combat.
