A comparison of ^99mTc-CQDO and ^99mTc-CQDO-MeB has been made for biodistribution and pharmacokinetics,^99mTc-CQDO and its adducts of methaneboronic acid^99mTc-CQDO-MeB were prepared by the reduction of Na ^99mTcO4 wi...A comparison of ^99mTc-CQDO and ^99mTc-CQDO-MeB has been made for biodistribution and pharmacokinetics,^99mTc-CQDO and its adducts of methaneboronic acid^99mTc-CQDO-MeB were prepared by the reduction of Na ^99mTcO4 with SnCl2.2H2O in aqueous solution,Radiochemical purity of ^99mTc-CQDO and ^99mTc-CQDO-MeB determined by TLC were over 95% after extraction.Biodistributions of ^99mTc-CQDO and ^99mTc-CQDOMeB in mice demonstrated that both of them could be easily absorbed by myocardium,and the peak uptake of each were 10.83±2.2% ID/g and 11.84±1.69%ID/g,respectively.^99mTc-CQDO showed rapid clearance from myocardial tissue while ^99mTc-CQDO-MeB had long retention in heart muscle.The myocardial uptake of ^99mTc-CQDO was only 5.88±1.66%/g at 10min and the uptake of ^99mTc-CQDO-MeB was 7.42±0.17%ID/g at 60min.The elimination of each from blood has a biexponential pattern.the first T1/2 is 1.38 and 1.5min,pespectively.The partition coefficient of ^99mTc-CQDO and ^99mTc-CQDO-MeB were 20 and 25 at pH 7.40,respectively.展开更多
文摘A comparison of ^99mTc-CQDO and ^99mTc-CQDO-MeB has been made for biodistribution and pharmacokinetics,^99mTc-CQDO and its adducts of methaneboronic acid^99mTc-CQDO-MeB were prepared by the reduction of Na ^99mTcO4 with SnCl2.2H2O in aqueous solution,Radiochemical purity of ^99mTc-CQDO and ^99mTc-CQDO-MeB determined by TLC were over 95% after extraction.Biodistributions of ^99mTc-CQDO and ^99mTc-CQDOMeB in mice demonstrated that both of them could be easily absorbed by myocardium,and the peak uptake of each were 10.83±2.2% ID/g and 11.84±1.69%ID/g,respectively.^99mTc-CQDO showed rapid clearance from myocardial tissue while ^99mTc-CQDO-MeB had long retention in heart muscle.The myocardial uptake of ^99mTc-CQDO was only 5.88±1.66%/g at 10min and the uptake of ^99mTc-CQDO-MeB was 7.42±0.17%ID/g at 60min.The elimination of each from blood has a biexponential pattern.the first T1/2 is 1.38 and 1.5min,pespectively.The partition coefficient of ^99mTc-CQDO and ^99mTc-CQDO-MeB were 20 and 25 at pH 7.40,respectively.
