The brain is a high-energy demanding organ,consuming around 20%of the metabolic energy generated.To fulfill this demand,cerebral blood flow(CBF)supplies oxygen and glucose continuously through the intricate network of...The brain is a high-energy demanding organ,consuming around 20%of the metabolic energy generated.To fulfill this demand,cerebral blood flow(CBF)supplies oxygen and glucose continuously through the intricate network of cerebral blood vessels.Although for many years brain activity and blood flow were conceived as independent processes,MRI-based functional brain imaging demonstrated that there is a coupling between them.展开更多
Due to the large amounts of pesticides commonly used and their impact on health, prompt and accurate pesticide analysis is important. This review gives an overview of recent advances and new trends in biosensors for p...Due to the large amounts of pesticides commonly used and their impact on health, prompt and accurate pesticide analysis is important. This review gives an overview of recent advances and new trends in biosensors for pesticide detection. Optical, electrochemical and piezoelectric biosensors have been reported based on the detection method. In this review biosensors have been classified according to the immobilized biorecognition element: enzymes, cells, antibodies and, more rarely, DNA. The use of tailor-designed biomolecules, such as aptamers and molecularly imprinted polymers, is reviewed. Artificial Neural Networks, that allow the analysis of pesticide mixtures are also presented. Recent advances in the field of nanomaterials merit special mention. The incorporation of nanomaterials provides highly sensitive sensing devices allowing the efficient detection of pesticides.展开更多
基金funded by the Ministry of Science,Innovation and Universities(MICIU)through the project NEUR-ON-A-CHIP(RTI2018-097038-B-C21 and RTI2018-097038-B-C22)(to MM,AL)the project UNIBBB(PDC2022-133918-C21)(to MM,AL)+4 种基金supported by Networking Biomedical Research Center(CIBER),Spain(to MM,AL)CIBER is an initiative funded by the VI National R&D&i Plan 2008–2011,Iniciativa Ingenio 2010,Consolider Program,CIBER Actions,and the Instituto de Salud Carlos III,with the support of the European Regional Development Fundfunded by the CERCA Programby the Commission for Universities and Research of the Department of Innovation,Universities,and Enterprise of the Generalitat de Catalunya(2017 SGR 1079)(to MM,AL)support from the program for predoctoral contracts for the training of doctors of the State Training Subprogram for the Promotion of Talent and its Employability in R+D+I(PRE2019-088286)by the Ministry of Science,Innovation and Universities(MICIU)。
文摘The brain is a high-energy demanding organ,consuming around 20%of the metabolic energy generated.To fulfill this demand,cerebral blood flow(CBF)supplies oxygen and glucose continuously through the intricate network of cerebral blood vessels.Although for many years brain activity and blood flow were conceived as independent processes,MRI-based functional brain imaging demonstrated that there is a coupling between them.
文摘Due to the large amounts of pesticides commonly used and their impact on health, prompt and accurate pesticide analysis is important. This review gives an overview of recent advances and new trends in biosensors for pesticide detection. Optical, electrochemical and piezoelectric biosensors have been reported based on the detection method. In this review biosensors have been classified according to the immobilized biorecognition element: enzymes, cells, antibodies and, more rarely, DNA. The use of tailor-designed biomolecules, such as aptamers and molecularly imprinted polymers, is reviewed. Artificial Neural Networks, that allow the analysis of pesticide mixtures are also presented. Recent advances in the field of nanomaterials merit special mention. The incorporation of nanomaterials provides highly sensitive sensing devices allowing the efficient detection of pesticides.
