Objectives To elucidate the re-lationship of plasma interleukin -6 (IL-6) to themetabolic measures associated with insulin resistance(IR) due to adiposity. Methods For a cross-sectionalstudy, eighty normotensive men w...Objectives To elucidate the re-lationship of plasma interleukin -6 (IL-6) to themetabolic measures associated with insulin resistance(IR) due to adiposity. Methods For a cross-sectionalstudy, eighty normotensive men with and without obe-sity were enrolled consecutively in our health exami-nation center. Fasting blood glucose (FBG), fastingplasma immunoreactive insulin (FIRI), HOMA -R(Homeostasis Model Assessment Insulin ResistanceIndex), plasma lipids (cholesterol, triglyceride, highdensity lipoprotein cholesterol), cortisol, dehy-droepiandrosterone-sulfate (DHEA - S), interleukin -6and C-reactive protein(CRP) were measured. ResultsPlasma levels of FIRI, triglyceride (TG), DHEA-S,CRP and HOMA -R were significantly higher inobese group with BMI over 25 than non-obese group,whereas HDL -C was significantly lower in obesegroup. BMI was positively correlated with FIRI, TG,hsCRP and HOMA-R, whereas negatively with HDL-C. BMI was positively correlated with plasma DHEA-S levels but not with cortisol. Plasma levels of IL-6were positively correlated with FIRI, TG, CRP andHOMA-R but in a multiple regression analysis withIL-6, only HOMA-R and TG remained explainablevariables. Conclusions Each of commonly used mea-sures of inflammatory reaction, CRP and IL-6, showeda significantly positive correlation with either FIRI orHOMA-R, suggesting associations between subclinicalinflammation and obesity as the risk of type 2 dia-betes mellitus.展开更多
文摘Objectives To elucidate the re-lationship of plasma interleukin -6 (IL-6) to themetabolic measures associated with insulin resistance(IR) due to adiposity. Methods For a cross-sectionalstudy, eighty normotensive men with and without obe-sity were enrolled consecutively in our health exami-nation center. Fasting blood glucose (FBG), fastingplasma immunoreactive insulin (FIRI), HOMA -R(Homeostasis Model Assessment Insulin ResistanceIndex), plasma lipids (cholesterol, triglyceride, highdensity lipoprotein cholesterol), cortisol, dehy-droepiandrosterone-sulfate (DHEA - S), interleukin -6and C-reactive protein(CRP) were measured. ResultsPlasma levels of FIRI, triglyceride (TG), DHEA-S,CRP and HOMA -R were significantly higher inobese group with BMI over 25 than non-obese group,whereas HDL -C was significantly lower in obesegroup. BMI was positively correlated with FIRI, TG,hsCRP and HOMA-R, whereas negatively with HDL-C. BMI was positively correlated with plasma DHEA-S levels but not with cortisol. Plasma levels of IL-6were positively correlated with FIRI, TG, CRP andHOMA-R but in a multiple regression analysis withIL-6, only HOMA-R and TG remained explainablevariables. Conclusions Each of commonly used mea-sures of inflammatory reaction, CRP and IL-6, showeda significantly positive correlation with either FIRI orHOMA-R, suggesting associations between subclinicalinflammation and obesity as the risk of type 2 dia-betes mellitus.
