BACKGROUND Neonatal screening(NS)is a public health policy to identify genetic pathologies such as cystic fibrosis(CF),sickle cell disease,and other diseases.Sickle cell disea-se is the comprehensive term for a group ...BACKGROUND Neonatal screening(NS)is a public health policy to identify genetic pathologies such as cystic fibrosis(CF),sickle cell disease,and other diseases.Sickle cell disea-se is the comprehensive term for a group of hemoglobinopathies characterized by the presence of hemoglobin S.CF is an autosomal recessive multisystemic disease with pathophysiology involving deleterious mutations in the transmembrane re-gulatory gene that encodes a protein that regulates the activity of chloride and sodium channels in the cell surface epithelium.NS is crucial for early diagnosis and management,which ensures a better quality of life.AIM To report a case of the coexistence of sickle cell anemia(SCA)and CF and perform an integrative literature review.METHODS This is an observational study and a review of the literature focusing on two rare genetic pathologies identified simultaneously in NS from the perspective of a clinical case.The authors identified only 5 cases of SCA associated with CF.No clinical trials or review articles were identified considering the rarity of the coexistence of these two pathologies.RESULTS Herein,the authors reported the case of a girl who after undergoing NS on day 8 of life was diagnosed with SCA with an alteration in the dosage of immunoreactive trypsin.The diagnosis of CF was confirmed by the Coulometry Sweat Test.The rarity of the co-occurrence of these two severe genetic pathologies(CF and SCA)is a challenge for medical science.CONCLUSION This study adds to the few case reports present in the literature that highlight the identification of two severe diseases via NS.展开更多
Psoriasis is a prevalent inflammatory disease that shares chronic inflammation pathways with the pathophysiology of metabolic syndrome(MetS),type-2 diabetes mellitus and atherosclerosis.A high prevalence of steatosis ...Psoriasis is a prevalent inflammatory disease that shares chronic inflammation pathways with the pathophysiology of metabolic syndrome(MetS),type-2 diabetes mellitus and atherosclerosis.A high prevalence of steatosis and advanced liver fibrosis has been described in psoriasis.The influence of MetS and its compounds,patatin-like phospholipase domain containing 3 and transmembrane 6 superfamily member 2 gene polymorphisms and the cumulative dose of methotrexate(MTX)in the progression of steatotic disease are still under debate.A suitable new classification for psoriasis-related liver disease,under the umbrella of steatotic liver disease(SLD),might be evaluated due to the potential impact of MTX on liver steatosis.Considering the interplay between the MetS,steatosis and MTX,a new definition for this complex disease might be discussed since it is not entirely addressed under the umbrella of SLD and metabolic-dysfunction associated SLD.Hence,shortly,a discussion could be raised on the feasible term“Met-Drug SLD”,metabolic and drug-induced SLD,which comprises both metabolic dysfunction and drug-related SLD.This review aims to report the best evidence to accurately classify liver disease in psoriasis,considering the new definition of SLD,allowing appropriate management once it is carefully defined.展开更多
The machining process remains relevant for manufacturing high-quality and high-precision parts,which can be found in industries such as aerospace and aeronautical,with many produced by turning,drilling,and milling pro...The machining process remains relevant for manufacturing high-quality and high-precision parts,which can be found in industries such as aerospace and aeronautical,with many produced by turning,drilling,and milling processes.Monitoring and analyzing tool wear during these processes is crucial to assess the tool’s life and optimize the tool’s performance under study;as such,standards detail procedures to measure and assess tool wear for various tools.Measuring wear in machining tools can be time-consuming,as the process is usually manual,requiring human interaction and judgment.In the present work,an automated offline flank wear measurement algorithm was developed in Python.The algorithm measures the flank wear of coated end-mills and slot drills from Scanning Electron Microscopy(SEM)images,according to the ISO 8688 standard,following the same wear measurement procedure.SEM images acquired with different magnifications and tools with varying machining parameters were analyzed using the developed algorithm.The flank wear measurements were then compared to the manually obtained,achieving relative errors for the most common magnifications of around 2.5%.Higher magnifications were also tested,yielding a maximum relative error of 13.4%.The algorithm can measure batches of images quickly on an ordinary personal computer,analyzing and measuring a 10-image batch in around 30 s,a process that would require around 30 min when performed manually by a skilled operator.Therefore,it can be a reliable alternative to measuring flank wear on many tools from SEM images,with the possibility of being adjusted for other wear measurements on different kinds of tools and different image types,for example,on images obtained by optical microscopy.展开更多
文摘BACKGROUND Neonatal screening(NS)is a public health policy to identify genetic pathologies such as cystic fibrosis(CF),sickle cell disease,and other diseases.Sickle cell disea-se is the comprehensive term for a group of hemoglobinopathies characterized by the presence of hemoglobin S.CF is an autosomal recessive multisystemic disease with pathophysiology involving deleterious mutations in the transmembrane re-gulatory gene that encodes a protein that regulates the activity of chloride and sodium channels in the cell surface epithelium.NS is crucial for early diagnosis and management,which ensures a better quality of life.AIM To report a case of the coexistence of sickle cell anemia(SCA)and CF and perform an integrative literature review.METHODS This is an observational study and a review of the literature focusing on two rare genetic pathologies identified simultaneously in NS from the perspective of a clinical case.The authors identified only 5 cases of SCA associated with CF.No clinical trials or review articles were identified considering the rarity of the coexistence of these two pathologies.RESULTS Herein,the authors reported the case of a girl who after undergoing NS on day 8 of life was diagnosed with SCA with an alteration in the dosage of immunoreactive trypsin.The diagnosis of CF was confirmed by the Coulometry Sweat Test.The rarity of the co-occurrence of these two severe genetic pathologies(CF and SCA)is a challenge for medical science.CONCLUSION This study adds to the few case reports present in the literature that highlight the identification of two severe diseases via NS.
文摘Psoriasis is a prevalent inflammatory disease that shares chronic inflammation pathways with the pathophysiology of metabolic syndrome(MetS),type-2 diabetes mellitus and atherosclerosis.A high prevalence of steatosis and advanced liver fibrosis has been described in psoriasis.The influence of MetS and its compounds,patatin-like phospholipase domain containing 3 and transmembrane 6 superfamily member 2 gene polymorphisms and the cumulative dose of methotrexate(MTX)in the progression of steatotic disease are still under debate.A suitable new classification for psoriasis-related liver disease,under the umbrella of steatotic liver disease(SLD),might be evaluated due to the potential impact of MTX on liver steatosis.Considering the interplay between the MetS,steatosis and MTX,a new definition for this complex disease might be discussed since it is not entirely addressed under the umbrella of SLD and metabolic-dysfunction associated SLD.Hence,shortly,a discussion could be raised on the feasible term“Met-Drug SLD”,metabolic and drug-induced SLD,which comprises both metabolic dysfunction and drug-related SLD.This review aims to report the best evidence to accurately classify liver disease in psoriasis,considering the new definition of SLD,allowing appropriate management once it is carefully defined.
文摘The machining process remains relevant for manufacturing high-quality and high-precision parts,which can be found in industries such as aerospace and aeronautical,with many produced by turning,drilling,and milling processes.Monitoring and analyzing tool wear during these processes is crucial to assess the tool’s life and optimize the tool’s performance under study;as such,standards detail procedures to measure and assess tool wear for various tools.Measuring wear in machining tools can be time-consuming,as the process is usually manual,requiring human interaction and judgment.In the present work,an automated offline flank wear measurement algorithm was developed in Python.The algorithm measures the flank wear of coated end-mills and slot drills from Scanning Electron Microscopy(SEM)images,according to the ISO 8688 standard,following the same wear measurement procedure.SEM images acquired with different magnifications and tools with varying machining parameters were analyzed using the developed algorithm.The flank wear measurements were then compared to the manually obtained,achieving relative errors for the most common magnifications of around 2.5%.Higher magnifications were also tested,yielding a maximum relative error of 13.4%.The algorithm can measure batches of images quickly on an ordinary personal computer,analyzing and measuring a 10-image batch in around 30 s,a process that would require around 30 min when performed manually by a skilled operator.Therefore,it can be a reliable alternative to measuring flank wear on many tools from SEM images,with the possibility of being adjusted for other wear measurements on different kinds of tools and different image types,for example,on images obtained by optical microscopy.
