Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al.,2019).Following the primary impact,the spinal cord under...Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al.,2019).Following the primary impact,the spinal cord undergoes a cascade of secondary injury mechanisms that are driven by disruption of the blood-spinal cord ba rrier,vascula r inju ry,glial reactivity,neu roinfla mmation,oxidative stress,lipid peroxidation,and glutamate excitotoxicity that culminate in neuronal and oligodendroglial cell death,demyelination,and axonal damage(Alizadeh et al.,2019).To achieve a meaningful functional recovery after SCI,regeneration of new neurons and oligodendrocytes and their successful growth and integration within the neural network are critical steps for reconstructing the damaged spinal cord tissue (Fischer et al.,2020).展开更多
Objective To explore the effects of acupuncture in comparison with sham acupuncture on cognitive functions in patients with relapsing-remitting multiple sclerosis(RRMS).Methods In this randomized controlled trial,31 R...Objective To explore the effects of acupuncture in comparison with sham acupuncture on cognitive functions in patients with relapsing-remitting multiple sclerosis(RRMS).Methods In this randomized controlled trial,31 RRMS patients in the acupuncture group were treated with traditional Chinese acupuncture based on the treatment principle of calming the mind,reinforcing qi and blood,and 31 patients in the control group were treated with sham acupuncture(shallow needling at non-acupuncture points)twice a week for 12 weeks.The primary outcome was the Brief International Cognitive Assessment for Multiple Sclerosis(BICAMS)score,which was evaluated by a psychologist at baseline and after 12 weeks of treatment.The secondary outcomes were the Symptom Checklist 90-Revised(SCL-90-R),Pittsburgh Sleep Quality Index(PSQI),and Fatigue Severity Scale(FSS)scores.The participants were provided with contact information from the researchers with constant access to report any adverse symptoms.Results In total,62 participants were enrolled and allocated to the acupuncture group(31 cases)or control group(31 cases).After 12 weeks of acupuncture treatment,BICAMS including Symbol Digit Modalities Test(SDMT),California Verbal Learning Test-2(CVLT-2)and delayed CVLT-2 scores were significantly improved in comparison with the control group(P<0.01).However,the changes in the Brief Visuospatial Memory Test-Revised(BVMT-R)and delayed BVMT-R scores related to visual/spatial memory did not differ significantly between the two groups(both P>0.05).The FSS,PSQI,and SCL-90-R scores were significantly reduced after 12-week treatment in the acupuncture group compared to the control group(P<0.05 or P<0.01).No life-threatening adverse events occurred throughout the study.Conclusions Twelve weeks of acupuncture treatment was effective in improving immediate and short-term auditory/verbal memory,attention and processing speed;reducing fatigue and decreasing sleep latency and the use of sleeping medications;alleviating depression,somatization,obsessive-compulsive and paranoid disorders in patients with RRMS.展开更多
基金funding support from the Canadian Institutes of Health Researchsupported by a Doctoral Studentship from the Wings for Life Foundation。
文摘Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al.,2019).Following the primary impact,the spinal cord undergoes a cascade of secondary injury mechanisms that are driven by disruption of the blood-spinal cord ba rrier,vascula r inju ry,glial reactivity,neu roinfla mmation,oxidative stress,lipid peroxidation,and glutamate excitotoxicity that culminate in neuronal and oligodendroglial cell death,demyelination,and axonal damage(Alizadeh et al.,2019).To achieve a meaningful functional recovery after SCI,regeneration of new neurons and oligodendrocytes and their successful growth and integration within the neural network are critical steps for reconstructing the damaged spinal cord tissue (Fischer et al.,2020).
文摘Objective To explore the effects of acupuncture in comparison with sham acupuncture on cognitive functions in patients with relapsing-remitting multiple sclerosis(RRMS).Methods In this randomized controlled trial,31 RRMS patients in the acupuncture group were treated with traditional Chinese acupuncture based on the treatment principle of calming the mind,reinforcing qi and blood,and 31 patients in the control group were treated with sham acupuncture(shallow needling at non-acupuncture points)twice a week for 12 weeks.The primary outcome was the Brief International Cognitive Assessment for Multiple Sclerosis(BICAMS)score,which was evaluated by a psychologist at baseline and after 12 weeks of treatment.The secondary outcomes were the Symptom Checklist 90-Revised(SCL-90-R),Pittsburgh Sleep Quality Index(PSQI),and Fatigue Severity Scale(FSS)scores.The participants were provided with contact information from the researchers with constant access to report any adverse symptoms.Results In total,62 participants were enrolled and allocated to the acupuncture group(31 cases)or control group(31 cases).After 12 weeks of acupuncture treatment,BICAMS including Symbol Digit Modalities Test(SDMT),California Verbal Learning Test-2(CVLT-2)and delayed CVLT-2 scores were significantly improved in comparison with the control group(P<0.01).However,the changes in the Brief Visuospatial Memory Test-Revised(BVMT-R)and delayed BVMT-R scores related to visual/spatial memory did not differ significantly between the two groups(both P>0.05).The FSS,PSQI,and SCL-90-R scores were significantly reduced after 12-week treatment in the acupuncture group compared to the control group(P<0.05 or P<0.01).No life-threatening adverse events occurred throughout the study.Conclusions Twelve weeks of acupuncture treatment was effective in improving immediate and short-term auditory/verbal memory,attention and processing speed;reducing fatigue and decreasing sleep latency and the use of sleeping medications;alleviating depression,somatization,obsessive-compulsive and paranoid disorders in patients with RRMS.
