Parkinson's disease(PD) is one of the most common neurodegenerative diseases,affecting individuals especially over 60 years of age.In the next three decades,more than 12 million people will suffer from PD worldwid...Parkinson's disease(PD) is one of the most common neurodegenerative diseases,affecting individuals especially over 60 years of age.In the next three decades,more than 12 million people will suffer from PD worldwide(Rocca,2018).The characteristic symptoms of PD begin as a movement disorder including bradykinesia,resting tremor,rigidity,and postural instability.展开更多
Introduction:Parkinson’s disease(PD)is the most common neurodegenerative movement disorder.The pathological hallmark is the progressive loss of dopaminergic neurons of the substantia nigra pars compacta,which is acco...Introduction:Parkinson’s disease(PD)is the most common neurodegenerative movement disorder.The pathological hallmark is the progressive loss of dopaminergic neurons of the substantia nigra pars compacta,which is accompanied by widespread alterations in the structu re and function of distributed brain networks.Togethe r,these processes cause a variety of motor symptoms such as bradykinesia,rigidity,tremor,gait disorders,or difficulties in fine motor control(Bange et al.,2022).展开更多
Approximately one-third of the 50 million patients with epilepsy worldwide are resistant to pharmacological treatments and may require aggressive interventions,such as surgery.However,many patients do not benefit from...Approximately one-third of the 50 million patients with epilepsy worldwide are resistant to pharmacological treatments and may require aggressive interventions,such as surgery.However,many patients do not benefit from surgery due to anatomical challenges or multifocal epileptogenic origins.Deep brain stimulation(DBS)is a promising alternative for these patients.DBS modulates neurotransmitter activity to prevent seizure propagation and has already been approved for the treatment of Parkinson’s disease and essential tremors.Although the anterior nucleus of the thalamus is the only DBS target approved for drug resistant epilepsy in Europe and Canada,the centromedian nucleus(CM)has emerged as a promising target,particularly for generalized and frontal lobe seizures.The CM is challenging to target because of its small size and complex connections,and it cannot be easily visualized using conventional imaging.This study focused on advanced methods for CM identification,including specialized magnetic resonance imaging sequences,intraoperative neurophysiological recordings,and diffusion tensor imaging tractography.These techniques are crucial for precise DBS targeting and for improving seizure control in affected patients.Our findings indicate that combining these advanced imaging and neurophysiological methods enhances the accuracy of DBS,potentially expanding its therapeutic applications in epilepsy.By opti mizing CM-DBS electrode placement,these approaches can improve clinical outcomes in drug resistant epilepsy,making them vital for effective treatment strategies.展开更多
Translational experimental approaches that help us better trace Parkinson’s disease(PD)pathophysiological mechanisms leading to new therapeutic targets are urgently needed.In this article,we review recent experimenta...Translational experimental approaches that help us better trace Parkinson’s disease(PD)pathophysiological mechanisms leading to new therapeutic targets are urgently needed.In this article,we review recent experimental and clinical studies addressing abnormal neuronal activity and pathological network oscillations,as well as their underlying mechanisms and modulation.Our aim is to enhance our knowledge about the progression of Parkinson's disease pathology and the timing of its symptom’s manifestation.Here,we present mechanistic insights relevant for the generation of aberrant oscillatory activity within the cortico-basal ganglia circuits.We summarize recent achievements extrapolated from available PD animal models,discuss their advantages and limitations,debate on their differential applicability,and suggest approaches for transferring knowledge on disease pathology into future research and clinical applications.展开更多
基金supported by the German Research Foundation (DFG):SFB-TR-128 (to SG,MM),MU 4354/1-1(to MM)the Boehringer Ingelheim Fonds BIF-03 (to SG,MM)。
文摘Parkinson's disease(PD) is one of the most common neurodegenerative diseases,affecting individuals especially over 60 years of age.In the next three decades,more than 12 million people will suffer from PD worldwide(Rocca,2018).The characteristic symptoms of PD begin as a movement disorder including bradykinesia,resting tremor,rigidity,and postural instability.
文摘Introduction:Parkinson’s disease(PD)is the most common neurodegenerative movement disorder.The pathological hallmark is the progressive loss of dopaminergic neurons of the substantia nigra pars compacta,which is accompanied by widespread alterations in the structu re and function of distributed brain networks.Togethe r,these processes cause a variety of motor symptoms such as bradykinesia,rigidity,tremor,gait disorders,or difficulties in fine motor control(Bange et al.,2022).
文摘Approximately one-third of the 50 million patients with epilepsy worldwide are resistant to pharmacological treatments and may require aggressive interventions,such as surgery.However,many patients do not benefit from surgery due to anatomical challenges or multifocal epileptogenic origins.Deep brain stimulation(DBS)is a promising alternative for these patients.DBS modulates neurotransmitter activity to prevent seizure propagation and has already been approved for the treatment of Parkinson’s disease and essential tremors.Although the anterior nucleus of the thalamus is the only DBS target approved for drug resistant epilepsy in Europe and Canada,the centromedian nucleus(CM)has emerged as a promising target,particularly for generalized and frontal lobe seizures.The CM is challenging to target because of its small size and complex connections,and it cannot be easily visualized using conventional imaging.This study focused on advanced methods for CM identification,including specialized magnetic resonance imaging sequences,intraoperative neurophysiological recordings,and diffusion tensor imaging tractography.These techniques are crucial for precise DBS targeting and for improving seizure control in affected patients.Our findings indicate that combining these advanced imaging and neurophysiological methods enhances the accuracy of DBS,potentially expanding its therapeutic applications in epilepsy.By opti mizing CM-DBS electrode placement,these approaches can improve clinical outcomes in drug resistant epilepsy,making them vital for effective treatment strategies.
文摘Translational experimental approaches that help us better trace Parkinson’s disease(PD)pathophysiological mechanisms leading to new therapeutic targets are urgently needed.In this article,we review recent experimental and clinical studies addressing abnormal neuronal activity and pathological network oscillations,as well as their underlying mechanisms and modulation.Our aim is to enhance our knowledge about the progression of Parkinson's disease pathology and the timing of its symptom’s manifestation.Here,we present mechanistic insights relevant for the generation of aberrant oscillatory activity within the cortico-basal ganglia circuits.We summarize recent achievements extrapolated from available PD animal models,discuss their advantages and limitations,debate on their differential applicability,and suggest approaches for transferring knowledge on disease pathology into future research and clinical applications.
