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Movement analysis in the diagnosis and management of Parkinson’s disease 被引量:1
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作者 Johannes Burtscher Nicolas Bourdillon +5 位作者 Jules MJanssen Daalen Aurélien Patoz Julien FBally Martin Kopp Davide Malatesta Bastiaan RBloem 《Neural Regeneration Research》 SCIE CAS 2025年第2期485-486,共2页
Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-mo... Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall phenotype.Clinically,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses inexorably.New biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024). 展开更多
关键词 DIAGNOSIS CLINICAL eventually
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Modifying the progression of Parkinson's disease through movement interventions:multimodal quantification of underlying mechanisms
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作者 Manuel Bange Damian Marc Herz +2 位作者 Dumitru Ciolac Gabriel Gonzalez-Escamilla Sergiu Groppa 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第8期1651-1652,共2页
Introduction:Parkinson’s disease(PD)is the most common neurodegenerative movement disorder.The pathological hallmark is the progressive loss of dopaminergic neurons of the substantia nigra pars compacta,which is acco... Introduction:Parkinson’s disease(PD)is the most common neurodegenerative movement disorder.The pathological hallmark is the progressive loss of dopaminergic neurons of the substantia nigra pars compacta,which is accompanied by widespread alterations in the structu re and function of distributed brain networks.Togethe r,these processes cause a variety of motor symptoms such as bradykinesia,rigidity,tremor,gait disorders,or difficulties in fine motor control(Bange et al.,2022). 展开更多
关键词 alterations MOVEMENT
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Linking 24-h Movement Behavior Guidelines to Cognitive Difficulties,Internalizing and Externalizing Problems in Preterm Youth 被引量:1
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作者 Zhihui Cheng Ailikute Aikeremu +6 位作者 Yanping Gao Zhihao Zhang Anthony G.Delli Paoli Paolo Marcello Cunha Alyx Taylor Fabian Herold Liye Zou 《International Journal of Mental Health Promotion》 2024年第8期651-662,共12页
Background:Given the heightened risk of developmental challenges associated with preterm birth,it is crucial to explore interventions that may ameliorate potential adverse outcomes.This study aimed to examine whether ... Background:Given the heightened risk of developmental challenges associated with preterm birth,it is crucial to explore interventions that may ameliorate potential adverse outcomes.This study aimed to examine whether meeting the 24-h movement behavior(24-HMB)guidelines,which include recommendations on physical activity(PA),screen time(ST),and sleep(SL),is related to indicators of cognitive difficulties,internalizing problems(e.g.,depression and anxiety),and externalizing problems(e.g.,difficulties in making friends and arguing)in a sample of preterm youth(children and adolescents born preterm).Methods:In this cross-sectional study,data from 3410 preterm youth(aged 6 to 17 years)were included for data analyses.Multivariable logistic regression was used to investigate associations between meeting the 24-HMB guidelines and the above-mentioned health outcomes,while controlling for sociodemographic and health-related factors.Results:The prevalence of meeting 24-HMB guidelines varied across independent and integrated components of the 24-HMB guidelines.Meeting the ST guideline alone(p<0.05)and integrated guidelines(i.e.,ST+SL and ST+SL+PA)were associated with fewer cognitive difficulties and reduced internalizing and externalizing problems(p<0.05).Specifically,meeting the SL guideline alone and integrated guidelines(i.e.,SL+ST)were associated with lower odds of depression and anxiety(p<0.01).Additionally,meeting independent,and integrated(PA and/or ST)guidelines were associated with less pronounced difficulties in making friends and arguing(p<0.05).Meeting 24-HMB guidelines in an isolated and integrated manner are linked to better cognitive performance and fewer internalizing and externalizing problems in preterm youth.Conclusion:Results suggest that advocating for the implementation of the 24-HMB guidelines may reduce cognitive challenges and behavioral issues,which is of high relevance for improving public health.Future longitudinal studies in preterm youth should investigate how modifying specific 24-HMB behaviors,especially ST,influence cognitive difficulties,internalizing and externalizing problems in this vulnerable population. 展开更多
关键词 Cognitive difficulties externalizing problems internalizing problems physical activity preterm youth
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Crustal movement in Chinese mainland observed from 1998 to 1999 被引量:3
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作者 顾国华 牛红叶 +4 位作者 郑贵明 许永江 孟国杰 孙世英 方颖 《Acta Seismologica Sinica(English Edition)》 EI CSCD 2000年第6期599-606,717,共9页
In this paper, GPS observations during 1998 to 1999 at fiducial stations in the Crustal Movement Observation Network of China (CMONOC) and GPS observation data processing with Bernese Software are briefly introduced. ... In this paper, GPS observations during 1998 to 1999 at fiducial stations in the Crustal Movement Observation Network of China (CMONOC) and GPS observation data processing with Bernese Software are briefly introduced. The processed results of crustal movement in the network during the period from early September 1998 to early July 1999, including the displacements at each fiducial station and strains in different part of the network, are discussed in detail. During the above mentioned period of observations, the eastern part of China was relatively stable. In contrast, the southwest part of China moved northwards about 17 mm with a dominant compression in NNE; the northwestern part of China moved northwestwards about 11 mm; and the Yunnan area moved southwards about 14 mm. The North-South seismic belt in the middle part of China is a belt of strong shear deformation. The maximum principal strain in the network is 2.9×10-8. The observation result shows that the northward push by the Indian Plate has still played the dominant role in the crystal movement in China. 展开更多
关键词 crustal movement GPS fiducial station DISPLACEMENT str?
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Return to Sports after Lower Extremity Injuries:Assessment of Movement Quality 被引量:1
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作者 Christiane Wilke Lucie Pfeiffer Ingo Frobose 《Health》 2017年第10期1416-1426,共11页
Numerous high performance athletes experience further damage or recurrent injuries even after successful rehabilitation. This is often caused by an insufficient movement quality, which has been very rarely assessed by... Numerous high performance athletes experience further damage or recurrent injuries even after successful rehabilitation. This is often caused by an insufficient movement quality, which has been very rarely assessed by test protocols which determine the point of reintegration into high performance sports (Return-to-Play, RTP). In order to assess the movement quality both objective and subjective test protocols exist. Objective methods like 3D-movement analysis are viewed as international gold standard, but are not the most practicable solutions for daily training routine. This study aims at reviewing the available literature on reliability and validity of existing subjective test protocols. Further their use within high-performance sports is evaluated. Up to now subjective methods fail to match sufficient validity. However some practical approaches for assessment of movement quality after injury are known. Based on selected criteria first recommendations for the use of different subjective screening test methods are given. In summary further research focusing on the validity of subjective tests is needed. The subjective testing methods should be used in combination with additional tests (e.g. strength testing) in order to identify other risk factors. Recurrent pre-injury screenings on movement quality should be carried out to enhance injury prevention. 展开更多
关键词 Lower Extremity INJURY Movement Quality Subjective Assessment
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Associations between meeting 24-hour movement guidelines and quality of life among children and adolescents with autism spectrum disorder 被引量:4
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作者 Chuidan Kong Aiguo Chen +9 位作者 Sebastian Ludyga Fabian Herold Sean Healy Mengxian Zhao Alyx Taylor Notger G.Muller Arthur F.Kramer Sitong Chen Mark S.Tremblay Liye Zou 《Journal of Sport and Health Science》 SCIE CSCD 2023年第1期73-86,共14页
Background:The Canadian 24-hour movement behavior(24-HMB)guidelines suggest that a limited amount of screen time use,an adequate level of physical activity(PA),and sufficient sleep duration are beneficial for ensuring... Background:The Canadian 24-hour movement behavior(24-HMB)guidelines suggest that a limited amount of screen time use,an adequate level of physical activity(PA),and sufficient sleep duration are beneficial for ensuring and optimizing the health and quality of life(QoL)of children and adolescents.However,this topic has yet to be examined for children and adolescents with autism spectrum disorder(ASD)specifically.The aim of this cross-sectional observational study was to examine the associations between meeting 24-HMB guidelines and several QoLrelated indicators among a national sample of American children and adolescents with ASD.Methods:Data were taken from the 2020 U.S.National Survey of Children’s Health dataset.Participants(n=956)aged 617 years and currently diagnosed with ASD were included.The exposure of interest was adherence to the 24-HMB guidelines.Outcomes were QoL indicators,including learning interest/curiosity,repeating grades,adaptive ability,victimization by bullying,and behavioral problems.Categorical variables were described with unweighted sample counts and weighted percentages.Age,sex,race,preterm birth status,medication,behavioral treatment,household poverty level,and the educational level of the primary caregivers were included as covariates.Odds ratio(OR)and 95%confidence interval(95%CI)were used to present the strength of association between adherence to 24-HMB guidelines and QoL-related indicators.Results:Overall,452 participants(45.34%)met 1 of the 3 recommendations,216(22.65%)met 2 recommendations,whereas only 39 participants(5.04%)met all 3 recommendations.Compared with meeting none of the recommendations,meeting both sleep duration and PA recommendations(OR=3.92,95%CI:1.639.48,p<0.001)or all 3 recommendations(OR=2.11,95%CI:1.034.35,p=0.04)was associated with higher odds of showing learning interest/curiosity.Meeting both screen time and PA recommendations(OR=0.15,95%CI:0.040.61,p<0.05)or both sleep duration and PA recommendations(OR=0.24,95%CI:0.070.87,p<0.05)was associated with lower odds of repeating any grades.With respect to adaptive ability,participants who met only the PA recommendation of the 24-HMB were less likely to have difficulties dressing or bathing(OR=0.11,95%CI:0.020.66,p<0.05)than those who did not.For participants who met all 3 recommendations(OR=0.38,95%CI:0.150.99,p=0.05),the odds of being victimized by bullying was lower.Participants who adhered to both sleep duration and PA recommendations were less likely to present with severe behavioral problems(OR=0.17,95%CI:0.040.71,p<0.05)than those who did not meet those guidelines.Conclusion:Significant associations were found between adhering to 24-HMB guidelines and selected QoL indicators.These findings highlight the importance of maintaining a healthy lifestyle as a key factor in promoting and preserving the QoL of children with ASD. 展开更多
关键词 24-hour movement guidelines Autism spectrum disorder Physical activity Quality of life
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Hip External Rotator Strength and Compensatory Movement in Three Different Positions 被引量:1
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作者 Sun-Hee Ahn Ui-Jae Hwang +3 位作者 Sung-Hoon Jung Hyun-A Kim Jun-Hee Kim Oh-Yun Kwon 《Health》 2018年第1期132-144,共13页
Measuring intrinsic hip external rotator strength (ER) without compensatory pelvic motion and activation of the sartorius is important for preventing or rehabilitating lower extremity injuries. However, the optimal me... Measuring intrinsic hip external rotator strength (ER) without compensatory pelvic motion and activation of the sartorius is important for preventing or rehabilitating lower extremity injuries. However, the optimal method for measuring intrinsic hip ER muscle strength while minimizing compensatory pelvic motions and activation of the sartorius is unclear. The purpose of this study is to compare measurements of hip ER strength, compensatory pelvic motion, and sartorius activation in the sitting, prone, and sidelying positions. Thirty-one healthy subjects (16 males and 15 females) were recruited for this study. Hip ER strength, pelvic kinematics, and sartorius muscle activation were measured during maximal isometric contraction of the hip ER in the sitting, prone, and sidelying positions. Hip ER strength was measured using a load-cell-type strength-measurement sensor. Pelvic kinematics was measured using an electromagnetic motion-tracking sensor. Electromyography was used to measure sartorius muscle activity. Data were analyzed using one-way repeated-measures analysis of variance. The result showed that hip ER strength and sartorius muscle activation were significantly lower in the sidelying compared with the sitting and prone positions (p < 0.01). Pelvic anteroposterior tilting was significantly greater in the sitting compared with the prone and sidelying positions (p < 0.01). Pelvic rotation differed significantly among positions (p < 0.01). Pelvic lateral tilting was significantly greater in the prone compared with the sitting position (p < 0.017). Compensatory pelvic motion and sartorius muscle activation were lower when hip ER strength measurements were made in the sidelying position. Therefore, the sidelying position is effective for measuring selective intrinsic hip ER strength. 展开更多
关键词 COMPENSATORY PELVIC Motion HIP EXTERNAL ROTATOR Measurement Position SARTORIUS
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四川盐边县下坝子遗址2018—2019年发掘简报
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作者 金国林(文/摄影) 滕杰臣 +7 位作者 赵勇涛 张鸿春 王军 安然 曾令玲(绘图) 涂希林(绘图) 王逸轩(绘图) 金宜宝(绘图) 《四川文物》 北大核心 2025年第4期4-26,共23页
下坝子遗址位于四川省攀枝花市盐边县红格镇金河村坝子组,地处金沙江左岸一级阶地上。为配合乌东德水电站建设工程,四川省文物考古研究院等单位于2018—2019年对该遗址进行了考古发掘,发现了新石器时代、汉至唐宋、明清时期遗存。其中... 下坝子遗址位于四川省攀枝花市盐边县红格镇金河村坝子组,地处金沙江左岸一级阶地上。为配合乌东德水电站建设工程,四川省文物考古研究院等单位于2018—2019年对该遗址进行了考古发掘,发现了新石器时代、汉至唐宋、明清时期遗存。其中新石器时代灰坑6个、沟2条,出土石斧、锛、凿、镞及陶罐、钵、盆等,文化面貌与安宁河谷及滇西相似。汉—唐宋遗存有墓葬1座、灰坑12个、沟9条,出土陶罐、拍、网坠,铁钩、耳环,银簪以及骨器等。明清时期遗存较为丰富,有房址、墓葬、蓄水池、灰坑、沟等,出土有瓷瓶、碗、铜铃铛、石砚、钱币等。此次发掘填补了该区域史前文化空白,对于研究川、滇族群迁徙及文化互动和交流有着较重要的意义。 展开更多
关键词 下坝子遗址 新石器时代 汉—唐宋 明清时期
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基于语音特征的帕金森病与多系统萎缩帕金森型的早期鉴别诊断
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作者 马凌燕 曹杰 +2 位作者 陈仲略 任康 冯涛 《中国康复理论与实践》 北大核心 2025年第10期1227-1233,共7页
目的基于语音信号分析和人工智能相结合的无创方法,实现帕金森病与多系统萎缩帕金森型(MSA-P)早期自动化鉴别诊断。方法2023年7月至2025年2月,于首都医科大学附属北京天坛医院运动障碍性疾病科招募病程<5年的MSA-P患者48例、帕金森... 目的基于语音信号分析和人工智能相结合的无创方法,实现帕金森病与多系统萎缩帕金森型(MSA-P)早期自动化鉴别诊断。方法2023年7月至2025年2月,于首都医科大学附属北京天坛医院运动障碍性疾病科招募病程<5年的MSA-P患者48例、帕金森病患者76例。设计11种语音任务范式,提取语音信号的声门、发声、构音、韵律、音系特征,以及基于表征学习提取的深度特征,通过数据驱动的方法筛选出最具鉴别力的特征,构建多种机器学习模型,实现对帕金森病与MSA-P患者的分类识别,选择鉴别效能最强的诊断模型。结果逻辑回归模型表现最佳。对病程<2年的早期患者,帕金森病与MSA-P间的分类准确率92.5%,精确率95.9%,召回率92.2%。在所有病程<5年的患者中,逻辑回归模型准确率89.1%,精确率91.6%,召回率92.4%。即使使用单一语音范式提取的特征进行分析,诊断准确率也可达77.7%。结论语音信号在帕金森病与MSA-P的早期鉴别诊断中具有重要的应用潜力。 展开更多
关键词 帕金森病 多系统萎缩 语音分析 机器学习 鉴别诊断 早期诊断
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α-倒捻子素改善大鼠软骨细胞的凋亡和炎症反应的作用机制
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作者 孟晓源 安梦宇 +1 位作者 王志刚 马乐 《局解手术学杂志》 2025年第9期759-764,共6页
目的探索α-倒捻子素(α-MG)对脂多糖(LPS)诱导的体外大鼠软骨细胞骨关节炎(OA)和巨噬细胞M1型极化的影响。方法用LPS诱导大鼠软骨细胞体外OA模型。将大鼠软骨细胞和巨噬细胞分为对照组(正常培养)、LPS组(使用1μg/mL LPS刺激24 h)、LPS... 目的探索α-倒捻子素(α-MG)对脂多糖(LPS)诱导的体外大鼠软骨细胞骨关节炎(OA)和巨噬细胞M1型极化的影响。方法用LPS诱导大鼠软骨细胞体外OA模型。将大鼠软骨细胞和巨噬细胞分为对照组(正常培养)、LPS组(使用1μg/mL LPS刺激24 h)、LPS+α-MG组(使用40μmol/Lα-MG联合1μg/mL LPS刺激细胞24 h)、LPS+α-MG+si-NC组(使用70μg/mL si-NC转染并联合40μmol/Lα-MG及1μg/mL LPS共同刺激细胞24 h)、LPS+α-MG+si-BDNF组(使用70μg/mL si-BDNF转染并联合40μmol/Lα-MG及1μg/mL LPS共同刺激细胞24 h)。CCK-8法检测各组软骨细胞和巨噬细胞增殖活性,流式细胞术检测软骨细胞的凋亡和巨噬细胞极化。ELISA法检测各组软骨细胞中白细胞介素(IL)-1β、IL-6、肿瘤坏死因子(TNF)-α水平。Western blot检测软骨细胞和巨噬细胞中BDNF、PI3K、Akt表达。结果在软骨细胞中,与对照组比较,LPS组的细胞增殖率降低,细胞凋亡率增加,BDNF、PI3K、Akt蛋白表达下调,而IL-1β、IL-6、TNF-α水平上调(P<0.05);与LPS组比较,LPS+α-MG组细胞增殖率增加,细胞凋亡率降低,BDNF、PI3K、Akt蛋白表达上调,而IL-1β、IL-6、TNF-α水平下调(P<0.05);与LPS+α-MG+si-NC组比较,LPS+α-MG+si-BDNF组细胞增殖率降低,细胞凋亡率增加,BDNF、PI3K、Akt蛋白表达下调,而IL-1β、IL-6、TNF-α水平均升高(P<0.05)。在巨噬细胞中,与对照组比较,LPS组细胞增殖率降低,M1型细胞比例增加,而BDNF、PI3K、Akt蛋白表达下调(P<0.05);与LPS组比较,LPS+α-MG组细胞增殖率增加,M1型细胞比例降低,而BDNF、PI3K、Akt蛋白表达上调(P<0.05);与LPS+α-MG+si-NC组比较,LPS+α-MG+si-BDNF组细胞增殖率降低,M1型细胞比例增加,而BDNF、PI3K、Akt蛋白表达水平下调(P<0.05)。结论α-MG通过激活BDNF/PI3K/Akt信号通路抑制巨噬细胞M1型极化,改善大鼠软骨细胞的凋亡和炎症。 展开更多
关键词 α-倒捻子素 BDNF/PI3K/Akt信号通路 巨噬细胞极化 软骨细胞 凋亡 炎症反应
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多巴胺能及抗胆碱能药物对帕金森病震颤的疗效比较及药物反应的影响因素分析
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作者 曹双双 崔雨沙 +1 位作者 苏东宁 冯涛 《神经损伤与功能重建》 2025年第10期564-568,595,共6页
目的:比较多巴胺能及抗胆碱能药物对帕金森病震颤的疗效,分析影响药物反应性的相关因素。方法:前瞻性纳入2021年12月至2024年3月在北京天坛医院就诊的帕金森病震颤患者141例,分别于连续2日清晨空腹状态下行复方左旋多巴及苯海索冲击试... 目的:比较多巴胺能及抗胆碱能药物对帕金森病震颤的疗效,分析影响药物反应性的相关因素。方法:前瞻性纳入2021年12月至2024年3月在北京天坛医院就诊的帕金森病震颤患者141例,分别于连续2日清晨空腹状态下行复方左旋多巴及苯海索冲击试验。通过统一帕金森病评定量表第Ⅲ部分(UPDRS-Ⅲ)和Fahn-Tolosa-Marin震颤评定量表(TRS)评估PD静止性、姿势性、意向性和动作性震颤,通过肌电图震颤分析评估不同情境下震颤功率。比较复方左旋多巴及苯海索对PD震颤量表评分的改善率及震颤功率的改善值。采用单因素及多重线性回归分析静止性震颤药物反应的相关因素。结果:对PD静止性(UPDRS-Ⅲ:P=0.003;TRS:P=0.007)、姿势性(TRS:P<0.001)、意向性(TRS:P=0.002)和动作性震颤(TRS:P<0.001)评分改善率,复方左旋多巴均高于苯海索;对静止、静止+任务、姿势以及持物状态下震颤功率改善值,复方左旋多巴均大于苯海索(P<0.05)。多重线性回归分析显示,PD静止性震颤患者对复方左旋多巴的反应与强直迟缓(β=0.215,P=0.033)、焦虑(β=0.211,P=0.015)评分正相关;PD静止性震颤伴有异动症时对复方左旋多巴反应好(β=0.300,P=0.001),对苯海索反应差(β=-0.357,P<0.001);PD动作性震颤评分越高,静止性震颤对复方左旋多巴(β=-0.276,P=0.007)和苯海索(β=-0.195,P=0.024)反应均差。结论:帕金森病震颤治疗应优先选择多巴胺能药物,尤其是强直迟缓明显、伴有焦虑及异动症的患者。若静止性震颤患者对多巴胺能药物反应差,同时伴有明显的动作性震颤,添加抗胆碱能药物的获益较小。 展开更多
关键词 帕金森病 震颤 多巴胺能 抗胆碱能 药物反应
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股骨头置换与髓内钉置入治疗股骨转子间骨折的疗效及对血清血栓素A2、肿瘤坏死因子-α和神经元特异性烯醇化酶影响
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作者 刘天泽 许建 《生物医学工程与临床》 2025年第4期505-510,共6页
目的 比较股骨头置换与髓内钉置入治疗股骨转子间骨折(IFF)的临床疗效,以及对血清血栓素A2(TXA2)、肿瘤坏死因子-α(TNF-α)和神经元特异性烯醇化酶(NSE)的影响。方法 采用回顾性方法,选择2022年5月至2024年5月在新疆维吾尔自治区人民... 目的 比较股骨头置换与髓内钉置入治疗股骨转子间骨折(IFF)的临床疗效,以及对血清血栓素A2(TXA2)、肿瘤坏死因子-α(TNF-α)和神经元特异性烯醇化酶(NSE)的影响。方法 采用回顾性方法,选择2022年5月至2024年5月在新疆维吾尔自治区人民医院诊断为IFF患者178例,其中男性102例,女性76例;年龄64~76岁,平均年龄69.5岁;身体质量指数22.5~26.9 kg/m^(2),平均身体质量指数25.4 kg/m^(2);骨折部位左93例,右85例;Evans分型Ⅲ68例,Ⅳ64例,Ⅴ46例;骨质疏松104例;住院时间7~15 d,平均住院时间10.5 d。根据治疗方式不同分为双极长柄人工股骨头置换(观察组)84例和股骨近端防旋髓内钉(PFNA)置入(对照组)94例。比较两组治疗前后髋关节Harris评分,评估优良率;术后和随访6个月并发症发生率,凝血功能[包括活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和D-二聚体]、TXA2、TNF-α和NSE水平。结果 两组随访6个月Harris评分均显著提高,且观察组明显高于对照组[(89.9±3.5)分vs(85.6±3.3)分],优良率增加[95.2%(80/84) vs 86.2%(81/94)](P<0.05)。两组并发症发生率比较,差异无统计学意义(P > 0.05)。两组术后1个月APTT、FIB、D-二聚体、TXA2、TNF-α和NSE水平较治疗前增加,但观察组仍低于对照组[(35.5±6.3) s vs(40.2±6.9) s、(5.6±1.5) g/L vs(6.2±1.6) g/L、(3.5±0.4) mg/L vs(4.3±0.5) mg/L、(165.5±32.3) ng/L vs(198.9±35.6) ng/L、(16.9±3.5) mg/L vs(19.8±3.7) mg/L、(11.3±2.6) ng/mL vs(14.5±2.3) ng/mL](P<0.05)。结论 股骨头置换和PFNA均是临床治疗IFF的常用术式,股骨头置换的总体疗效似乎更佳,尤其对凝血功能、TXA2、TNF-α和NSE水平的干扰较小。 展开更多
关键词 股骨转子间骨折 股骨头置换 股骨近端防旋髓内钉 血栓素A2 肿瘤坏死因子-Α 神经元特异性烯醇化酶
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椎间孔镜微创术对腰椎间盘突出症患者血清疼痛物质及氧化应激水平的影响
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作者 刘天泽 许建 《颈腰痛杂志》 2025年第5期865-869,共5页
目的 探讨经皮椎间孔镜(PELD)微创技术对腰椎间盘突出症(LDH)患者血清β-内啡肽、P物质及氧化应激水平的影响。方法 回顾性分析2022年5月至2024年5月新疆维吾尔自治区人民医院诊断单节段LDH的145例患者的临床资料,均接受PELD椎间盘切除... 目的 探讨经皮椎间孔镜(PELD)微创技术对腰椎间盘突出症(LDH)患者血清β-内啡肽、P物质及氧化应激水平的影响。方法 回顾性分析2022年5月至2024年5月新疆维吾尔自治区人民医院诊断单节段LDH的145例患者的临床资料,均接受PELD椎间盘切除术,术后至少随访6个月。根据术后6个月Oswestry功能障碍指数(ODI)评分将其分为有效组114例和无效组31例。比较两组术前、术后1个月、3个月和6个月的视觉模拟评分法(VAS)评分、血清β-内啡肽、P物质、过氧化物岐化酶(SOD)及丙二醛(MDA)水平。Pearson相关分析血清β-内啡肽、P物质、SOD、MDA与ODI评分间的相关性。多元Logistic回归分析与接受PELD微创术LDH患者预后相关的危险因素。结果 有效组术后3个月和6个月的ODI评分明显高于无效组,术后1个月、3个月和6个月的VAS评分、血清β-内啡肽、P物质及MDA水平明显低于无效组,SOD高于无效组(P<0.05)。两组手术时间、术中出血量和术后并发症比较差异无统计学意义(P>0.05)。Pearson相关分析显示,两组LDH患者血清β-内啡肽(r=0.753,P=0.033)、P物质(r=0.831,P=0.020)、SOD(r=0.727,P=0.037)、MDA(r=0.669,P=0.044)与ODI评分均呈正相关。血清β-内啡肽(OR=2.339,P=0.047)、SOD(OR=2.745,P=0.045)、MDA(OR=2.926,P=0.032)为接受PELD微创术LDH患者预后的危险因素,而PELD微创术式(OR=0.253,P=0.014)为预后的保护性因素。结论 PELD治疗LDH总体安全、有效,可减轻疼痛,降低氧化应激反应。 展开更多
关键词 经皮椎间孔镜 腰椎间盘突出症 疼痛 Β-内啡肽 P物质 氧化应激
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国家学生体质健康标准测试数据审核:异常检测算法优选与实证探索
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作者 高峰 董东 刘俊成 《体育科学研究》 2025年第2期59-70,78,共13页
异常检测技术可辅助审核员快速筛查数据集中的潜在异常,但不同算法存在适用场景的局限性。以大学生国家学生体质健康标准测试(NSPFS)数据集为实证研究对象,从算法优选与可视化的角度探究单变量和多变量异常检测方法的适用性。基于6个基... 异常检测技术可辅助审核员快速筛查数据集中的潜在异常,但不同算法存在适用场景的局限性。以大学生国家学生体质健康标准测试(NSPFS)数据集为实证研究对象,从算法优选与可视化的角度探究单变量和多变量异常检测方法的适用性。基于6个基准数据集,采用元学习推荐工具和接受者操作特性曲线下面积完成算法优选。结果显示:1.5IQR单变量检测可辅助审核员发现单项异常审核线索;IForest算法适用于大规模NSPFS数据中异常点识别;学校异常评分排序和分组散点矩阵图可为无监督IForest筛查结果提供可视化解释。可见,IForest与1.5IQR相结合的异常检测可辅助审核员快速筛查NSPFS数据中的异常个体和高风险学校,为基于计算机辅助技术的交互式NSPFS数据审核框架的构建提供实证支撑。 展开更多
关键词 国家学生体质健康标准测试 数据审核 异常检测 隔离森林 算法优选 可视化
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英国工党的政策主张、选举表现与执政前景探赜——基于2024年英国大选的分析
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作者 李华锋 刘聪睿 《聊城大学学报(社会科学版)》 2025年第1期17-25,共9页
在2024年英国大选中,斯塔默领导下的工党围绕英国经济社会现实,在承继工党传统政策主张的同时,对经济、社会、外交等政策作出了一系列迎合中间选民的变革。在此基础上,得益于保守党执政期间的负面表现及英国选举制度和钟摆效应的催化,... 在2024年英国大选中,斯塔默领导下的工党围绕英国经济社会现实,在承继工党传统政策主张的同时,对经济、社会、外交等政策作出了一系列迎合中间选民的变革。在此基础上,得益于保守党执政期间的负面表现及英国选举制度和钟摆效应的催化,工党以历史性胜利,时隔多年再度走到执政前台,赢得较为自如的执政环境。如何处理棘手的英国经济社会问题、能否保持工党内部的团结以及保守党等其他政党的发展状况是工党执政面临的现实挑战。 展开更多
关键词 英国工党 英国大选 政策主张 选举表现 执政前景
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Practical recommendations on stretching exercise:A Delphi consensus statement of international research experts
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作者 Konstantin Warneke Ewan Thomas +17 位作者 Anthony J.Blazevich José Afonso David G.Behm Paulo H.Marchetti Gabriel S.Trajano Masatoshi Nakamura Francisco Ayala Stefano Longo Nicolas Babault Sandro R.Freitas Pablo B.Costa Andreas Konrad Antoine Nordez Arnold Nelson Astrid Zech Anthony D.Kay Olyvia Dontit Jan Wilke 《Journal of Sport and Health Science》 2025年第5期110-123,共14页
Background:Stretching has wide appeal,but there seems to exist some mismatch between its purported applications and what the evidence shows.There is compelling evidence for some stretching applications,but for others,... Background:Stretching has wide appeal,but there seems to exist some mismatch between its purported applications and what the evidence shows.There is compelling evidence for some stretching applications,but for others,the evidence seems heterogeneous or unsupportive.The discrepancies even affect some systematic reviews,possibly due to heterogeneous eligibility criteria and search strategies.This consensus paper seeks to unify the divergent findings on stretching and its implications for both athletic performance and clinical practices by delivering evidence-based recommendations.Methods:A panel of 20 experts with a blend of practical experience and scholarly knowledge was assembled.The panel meticulously reviewed existing systematic reviews,defined key terminologies(e.g.,consensus definitions for different stretching modes),and crafted guidelines using a Delphi consensus approach(minimum required agreement:80%).The analysis focused on 8 topics,including stretching's acute and chronic(long-term)effects on range of motion,strength performance,muscle hypertrophy,stiffness,injury prevention,muscle recovery,posture correction,and cardiovascular health.Results:There was consensus that chronic and acute stretching(a)improves range of motion(although alternatives exist)and(b)reduces muscle stiffness(which may not always be desirable);the panel also agreed that chronic stretching(c)may promote vascular health,but more research is warranted.In contrast,consensus was found that stretch training does not(a)contribute substantively to muscle growth,(b)serve as an allencompassing injury prevention strategy,(c)improve posture,or(d)acutely enhance post-exercise recovery.Conclusion:These recommendations provide guidance for athletes and practitioners,highlighting research gaps that should be addressed to more comprehensively understand the full scope of stretching effects. 展开更多
关键词 Range of motion Strength Movement preparation Recovery Evidence-based practice STRETCH
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吡拉西坦联合银杏叶片治疗缺血性脑卒中后认知障碍的疗效及患者血清炎症因子、Lp-PLA2水平变化 被引量:1
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作者 王燕 路文革 +2 位作者 孔羽 王红丽 汪晶晶 《临床研究》 2025年第4期123-126,共4页
目的研究吡拉西坦联合银杏叶片治疗缺血性脑卒中后认知障碍疗效及患者血清炎症因子、脂蛋白相关磷脂酶A2(Lp-PLA2)水平的变化。方法选择2021年2月至2023年2月在商丘市第一人民医院治疗的脑卒中后认知障碍患者84例,采用随机数字表法分为... 目的研究吡拉西坦联合银杏叶片治疗缺血性脑卒中后认知障碍疗效及患者血清炎症因子、脂蛋白相关磷脂酶A2(Lp-PLA2)水平的变化。方法选择2021年2月至2023年2月在商丘市第一人民医院治疗的脑卒中后认知障碍患者84例,采用随机数字表法分为对照组(吡拉西坦)和观察组(吡拉西坦联合银杏叶片)各42例,对比两组美国国立卫生研究院卒中量表(NIHSS)、简易智力状态检查量表(MMSE)、改良Barthel指数(MBI)评分,大脑前、中、后动脉血流速度,及血清白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、脂蛋白相关磷脂酶A2(Lp-PLA2)、5-羟色胺(5-HT)、多巴胺(DA)、去甲肾上腺素(NE)、丙二醛(MDA)、晚期氧化蛋白产物(AOPP)、超氧化物歧化酶(SOD)水平。结果治疗后,两组NIHSS评分及血清IL-6、hs-CRP、TNF-α、Lp-PLA2、MDA、AOPP水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05);MMSE、MBI评分,大脑前、中、后动脉血流速度,以及血清5-HT、DA、NE、SOD水平均升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论吡拉西坦联合银杏叶片治疗缺血性脑卒中后认知障碍可改善神经功能,提高认知能力和日常生活活动能力,减轻炎症反应和氧化应激状态。 展开更多
关键词 吡拉西坦 银杏叶片 缺血性脑卒中 认知障碍 血清炎症因子 LP-PLA2
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血清血管生成素样蛋白4、过氧化物酶体增殖物激活受体γ表达水平与急性缺血性脑卒中预后的关系 被引量:1
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作者 刘丽鸽 闫秋月 +2 位作者 艾婧怡 焦如东 李猛 《安徽医药》 2025年第2期324-328,共5页
目的探究血清血管生成素样蛋白4(Angptl4)、过氧化物酶体增殖物激活受体γ(PPARγ)表达水平与急性缺血性脑卒中预后的关系。方法选取2020年2月至2022年6月沧州市中心医院收治的急性缺血性脑卒中病人100例作为观察组,依据美国国立卫生研... 目的探究血清血管生成素样蛋白4(Angptl4)、过氧化物酶体增殖物激活受体γ(PPARγ)表达水平与急性缺血性脑卒中预后的关系。方法选取2020年2月至2022年6月沧州市中心医院收治的急性缺血性脑卒中病人100例作为观察组,依据美国国立卫生研究院卒中量表(NIHSS)评分评估病情严重程度,分为轻症组(n=33,NIHSS评分<6分)、中症组(n=39,6分≤NIHSS评分<14分)、重症组(n=28,NIHSS评分≥14分);根据治疗90 d后改良Rankin量表(mRs)评分评估预后,分为预后良好组(n=68,0~2分)、预后不良组(n=32,≥3分);另选取同期健康志愿者100例作为对照组。酶联免疫吸附试验(ELISA)检测血清Angptl4、PPARγ表达水平,并进行组间比较;多因素logistic回归分析急性缺血性脑卒中病人预后的影响因素;受试者操作特征曲线(ROC曲线)分析血清Angptl4、PPARγ对预后的评估价值。结果观察组血清Angptl4[(14.16±3.28)μg/L比(11.52±2.36)μg/L]、PPARγ[(38.54±9.63)ng/L比(26.68±7.48)ng/L]表达水平高于对照组(P<0.05);重症组血清Angptl4、PPARγ表达水平高于轻症组和中症组,且中症组高于轻症组(P<0.05);预后不良组年龄、Angptl4、PPARγ、高血压比例、糖尿病比例、入院时NIHSS评分均明显高于预后良好组(P<0.05);血清Angptl4、PPARγ、NIHSS评分为急性缺血性脑卒中病人预后的影响因素(P<0.05);血清Angptl4、PPARγ二者联合评估急性缺血性脑卒中病人预后的曲线下面积(AUC)为0.98。结论血清Angptl4、PPARγ表达水平较高的急性缺血性脑卒中病人病情较严重,预后较差,血清Angptl4、PPARγ为急性缺血性脑卒中病人预后影响因素,能较好地评估病人预后情况。 展开更多
关键词 卒中 脑梗死 血管生成素样蛋白4 过氧化物酶体增殖物激活受体Γ 预后
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视觉、本体感觉干扰下单腿站立姿势控制与踝跖屈肌力稳定性的相关性
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作者 王冲 武梦旖 +2 位作者 王朋飞 邢泽宇 霍洪峰 《医用生物力学》 北大核心 2025年第5期1193-1199,共7页
目的探究单腿站立姿势控制与踝跖屈肌力稳定性的相关性,为提升人体姿势控制能力提供新的理论依据。方法随机选取20名健康男性大学生作为实验对象。采用iBalance平衡测试仪与训练系统测试单腿站立的足底压力中心(center of pressure,COP... 目的探究单腿站立姿势控制与踝跖屈肌力稳定性的相关性,为提升人体姿势控制能力提供新的理论依据。方法随机选取20名健康男性大学生作为实验对象。采用iBalance平衡测试仪与训练系统测试单腿站立的足底压力中心(center of pressure,COP)轨迹数据;采用CON-TREX MJ多关节等速测试与训练系统测试踝跖屈肌收缩期间的力矩振幅数据。采用单因素重复测量方差分析组间踝跖屈肌力矩振幅的标准偏差数据;采用Pearson相关系数进行相关性研究。结果踝跖屈肌执行的肌力稳定任务强度越大,力矩振幅的标准偏差越大;无干扰单腿站立下,C90面积与10%踝跖屈肌最大任意收缩(maximum voluntary contraction,MVC)力矩振幅的变异系数(coefficient of variation,CV)(r=0.761,P<0.05)呈正相关。干扰视觉单腿站立下,C90面积与30%踝跖屈肌MVC力矩振幅CV(r=0.632,P<0.05)呈正相关。干扰本体感觉单腿站立下,C90面积与20%踝跖屈肌MVC力矩振幅CV(r=0.583,P<0.05)呈正相关。结论随着踝跖屈肌执行的肌力稳定任务难度加大,肌力稳定性降低;踝跖屈肌力稳定性与单腿站立姿势控制能力存在正相关关系。相较于无干扰情况,在视觉、本体感觉干扰下,额外的信息传入减少或受到干扰,人体维持身体平衡的难度加大,踝跖屈肌需要更高发力模式下的肌力稳定性来参与人体单腿站立的姿势控制。 展开更多
关键词 肌力稳定性 踝跖屈肌 单腿站立 姿势控制 视觉 本体感觉
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