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Factors associated with cervical cancer screening in a safety net population
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作者 Meredith A Heberer Ian K Komenaka +7 位作者 Jesse N Nodora Chiu-Hsieh Hsu Sonal G Gandhi Lauren E Welch Marcia E Bouton Paula Aristizabal Barry D Weiss Maria Elena Martinez 《World Journal of Clinical Oncology》 CAS 2016年第5期406-413,共8页
AIM To identify factors associated with Papanicolaou-smear(Pap-smear)cervical cancer screening rates in a safety net population.METHODS From January 2012 to May 2013,the use of Pap-smear was determined for all patient... AIM To identify factors associated with Papanicolaou-smear(Pap-smear)cervical cancer screening rates in a safety net population.METHODS From January 2012 to May 2013,the use of Pap-smear was determined for all patients seen at the breast clinic in a safety net hospital.Health literacy assessment was performed using the validated Newest Vital Sign.The records of patients were reviewed to determine if they had undergone Pap-smears for cervical cancer screening.Sociodemographic information was collected included age,education,monthly income,race/ethnicity,employment,insurance status,and primary care provider of the patient.Logistic regression analysis was then performed to determine factors associated with utilization of Papsmears.Crude and adjusted odds ratios derived from multivariate logistic regression models were calculated as well as the associated 95%CIs and P-values.RESULTS Overall,39%had Pap-smears in the prior 15 mo,1377 consecutive women were seen during the study period and their records were reviewed.Significantly more patients with adequate health literacy underwent Papsmears as compared to those with limited health literacy(59%vs 34%,P<0.0001).In multivariate analysis,patients with adequate health literacy,younger patients,and those with later age of first live birth were more likely to undergo Pap-smears.Patients whose primary care providers were gynecologists were also significantly more likely to have Pap-smears compared to other specialties(P<0.0001).Patients younger than 21 years or older than 65 years underwent screening less frequently(11%and 11%,respectively)than those 21-64 years(41%,P<0.0001).Race,ethnicity,language,and insurance status were not associated with Pap-smear screening rates.CONCLUSION Patient health literacy and primary care physician were associated with Pap-smear utilization.Development of interventions to target low health literacy populations could improve cervical cancer screening. 展开更多
关键词 CERVICAL cancer Health LITERACY PREVENTION SCREENING Pap-smear
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Nat Methods:利用CRISPR-Cas9组合筛选发现癌症弱点 被引量:1
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作者 John Paul Shen, Ana Bojorquez-Gomez, Katherine Licon, Kristin Klepper, Daniel Pekin, Alex N Beckett, Kyle Salinas Sanchez, Jason F Kreisberg, Trey Ideker John Paul Shen, Trey Ideker, Prashant Mali +8 位作者 John Paul Shen, Dongxin Zhao, Dan Du, Assen Roguev, Jason F Kreisberg, Nevan Krogan, Lei Qi, Trey Ideker, Prashant Mali Dongxin Zhao, Chih-Chung Kuo, Prashant Mali Roman Sasik, Amanda Birmingham, Aaron N Chang, Trey Ideker Jens Luebeck, Alex Thomas Alex Thomas, Chih-Chung Kuo, Nathan E Lewis Dan Du Assen Roguev, Nevan Krogan Nathan E Lewis Lei Qi 《现代生物医学进展》 CAS 2017年第17期I0001-I0001,共1页
导致癌症的基因突变也会削弱癌细胞,从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性(synthetic lethality)”,这是因为这些药物仅对发生突变的(或者说合成的)细胞是致命性的。在... 导致癌症的基因突变也会削弱癌细胞,从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性(synthetic lethality)”,这是因为这些药物仅对发生突变的(或者说合成的)细胞是致命性的。在一项新的研究中。来自美国加州大学圣地亚哥分校、加州大学旧金山分校、斯坦福大学和癌细胞图谱项目(Cancer Cell Map Initiative)的研究人员开发出一种新的方法来寻找合成致死性的基因组合。 展开更多
关键词 组合筛选 癌症 美国加州大学 利用 基因突变 斯坦福大学 癌细胞 正常细胞
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