Background:Epidemiological studies showed that higher plasma urate was associated with lower risk for Parkinson’s disease(PD)and slower disease progression.Recent genome-wide association studies(GWAS)consistently sho...Background:Epidemiological studies showed that higher plasma urate was associated with lower risk for Parkinson’s disease(PD)and slower disease progression.Recent genome-wide association studies(GWAS)consistently showed that several single nucleotide polymorphisms(SNPs)in the solute carrier family 2 member 9 gene(SLC2A9)were associated with plasma urate concentration and the risk of gout.Methods:We conducted a case–control study to examine twelve tag SNPs of the SLC2A9 gene in relation to PD among 788 cases and 911 controls of European ancestry.Odds ratios(OR)and 95%confidence intervals(CI)were derived from logistic regression models,adjusting for age,sex,smoking and caffeine consumption.Results:These SNPs were all in linkage disequilibrium(R^(2)>0.7).None of them were associated with PD risk.Among women,however,there was a suggestion that the presence of the minor allele of one SNP(rs7442295)was related to a small increase in PD risk[OR(95%CI)=1.48(1.01-2.16)].Conclusion:This study provides little support for genetic variations of SLC2A9 and PD risk.展开更多
基金This study was supported by the intramural research program of the NIH,the National Institute of Environmental Health Sciences(Z01-ES-101986)NIH extramural grant to Dr.Huang(NS06722).
文摘Background:Epidemiological studies showed that higher plasma urate was associated with lower risk for Parkinson’s disease(PD)and slower disease progression.Recent genome-wide association studies(GWAS)consistently showed that several single nucleotide polymorphisms(SNPs)in the solute carrier family 2 member 9 gene(SLC2A9)were associated with plasma urate concentration and the risk of gout.Methods:We conducted a case–control study to examine twelve tag SNPs of the SLC2A9 gene in relation to PD among 788 cases and 911 controls of European ancestry.Odds ratios(OR)and 95%confidence intervals(CI)were derived from logistic regression models,adjusting for age,sex,smoking and caffeine consumption.Results:These SNPs were all in linkage disequilibrium(R^(2)>0.7).None of them were associated with PD risk.Among women,however,there was a suggestion that the presence of the minor allele of one SNP(rs7442295)was related to a small increase in PD risk[OR(95%CI)=1.48(1.01-2.16)].Conclusion:This study provides little support for genetic variations of SLC2A9 and PD risk.
