This study investigates the structural,electronic,vibrational,and mechanical properties of cubic InTe using density functional theory and density functional perturbation theory.The results reveal the metallic characte...This study investigates the structural,electronic,vibrational,and mechanical properties of cubic InTe using density functional theory and density functional perturbation theory.The results reveal the metallic character of cubic InTe,as indicated by its electronic structure and density of states.The dynamic stability of the material is confirmed by phonon dispersion analysis,with no imaginary frequencies observed.The Debye temperature(172.276 K)and melting temperature(1092.832 K)suggest excellent thermal resistance.A shear modulus of 18.20 GPa,Poisson’s ratio of 0.343,and Pugh’s ratio([Math Processing Error])of 2.87 support mechanical stability and indicate ductility.Isotropic dielectric properties,with Born effective charges of−3.768 for both In and Te atoms,highlight potential ferroelectric applications.These findings emphasize InTe’s suitability for electronic and construction applications.展开更多
Introduction: Despite advances in obstetrics and pediatrics over the past 20 years, premature birth remains an unpredictable event that can have a devastating impact on parenthood. This study aimed to a...Introduction: Despite advances in obstetrics and pediatrics over the past 20 years, premature birth remains an unpredictable event that can have a devastating impact on parenthood. This study aimed to analyze the psycho-affective experiences of fathers of premature newborns. Methods: This was a descriptive cross-sectional study, carried out in the department of neonatology and neonatal intensive care unit of the CHU Mohamed VI in OUJDA, over 6 months from March 2022 to August 2022. It focused on 30 fathers of premature newborns hospitalized in our department. Results: The majority of fathers described a state of fear and stress, and attributed their negative experience to the unexpected nature of the premature birth. At the first meeting, half the fathers had a positive image of their newborn’s physical appearance, while 22% of fathers reported feeling uncomfortable about their newborn’s low weight. Most fathers reported that they appreciated the welcome they received, the skill with which they cared for their newborn, and the availability of the pediatrician to provide information on their child’s state of health. Two fathers enjoyed skin-to-skin contact with their newborns. None of the fathers met a psychologist. When they returned home, half the fathers had a positive outlook, marked by happiness at being able to fully invest in their role as fathers, the other half reported being torn between the desire to see their child integrated into the family cocoon and the fear of not being able to manage delicate situations properly without a medical team. Conclusion: Bringing a premature baby into the world can be a difficult experience, leading to the development of even minor psychological distress in some fathers, and hence the need for specific psychological care.展开更多
Introduction: Even though lumbar puncture (LP) represents an important tool in the diagnosis of certain neurological diseases, this procedure is little practiced by our students. We aimed to evaluate the attitudes and...Introduction: Even though lumbar puncture (LP) represents an important tool in the diagnosis of certain neurological diseases, this procedure is little practiced by our students. We aimed to evaluate the attitudes and practices of students, interns, and residents about LP, and to assess their feelings about how this procedure is taught. Materials and Methods: We conducted a cross-sectional study of 160 participants, using an anonymous questionnaire, to evaluate the attitudes and practices of students, interns and residents in the pediatrics department concerning lumbar puncture. Results: Half of the participants had never performed LP, usually because of the risk involved or lack of confidence, while 20% had performed it more than 4 times. None of the participants had learned to perform the procedure through simulation sessions, while (42%) had learned it under the supervision of a senior physician and had not been able to perform it successfully the first time. Most participants inform the patient about the procedure before performing it. Only 44% of participants acknowledged that LP can be performed under local anesthetic. The sitting position (60%) was by far the most commonly used. Most LPs were performed for diagnostic purposes. Most participants stated that the pediatric ward and the pediatric emergency department are among the departments that perform LP most frequently, and that they would be interested in taking part in simulated lumbar puncture sessions in children in the future. Conclusion: The results of our study show that LP is perceived by students as a risky procedure that is difficult to perform. Teachers should reconsider how this technical procedure is taught, by integrating simulation on mannequins into student training.展开更多
Congenital hernia of the diaphragmatic dome (CHDD) is an embryonic malformation in which all or part of the diaphragmatic dome fails to develop properly. In the majority of cases (80% to 90%), this malformation affect...Congenital hernia of the diaphragmatic dome (CHDD) is an embryonic malformation in which all or part of the diaphragmatic dome fails to develop properly. In the majority of cases (80% to 90%), this malformation affects the left posterolateral part of the diaphragm, while in 10% to 15% of cases it affects the right. Bilateral cases are extremely rare, accounting for less than 1% of cases. This malformation is estimated to occur at a frequency of around 1 in 3500 births, with a male predominance. The diaphragmatic defect causes the abdominal organs to rise into the thoracic cavity during critical phases of lung development. These anomalies result in bilateral pulmonary hypoplasia, a reduced number of pulmonary vessels, and pulmonary arterial hypertension (PAH). The combination of these anatomical and functional anomalies, in varying degrees, explains the wide variability of symptoms at birth. Diagnosis is usually made prenatally by ultrasound, which enables severe forms of the disease to be detected and appropriate management initiated. The prognosis remains generally grave, with a neonatal mortality rate of between 30% and 60% depending on the study, and around half of all children will have long-term sequelae.展开更多
This letter to the editor highlights adding the diagnostic utility of immunoglobulin G4(IgG4)measurements and its potential role in IgG4-related spinal pachymeningitis(IgG4-RSP)pathogenesis to the case reported by Cha...This letter to the editor highlights adding the diagnostic utility of immunoglobulin G4(IgG4)measurements and its potential role in IgG4-related spinal pachymeningitis(IgG4-RSP)pathogenesis to the case reported by Chae TS et al,which focused on IgG4-RSP diagnosis based on magnetic resonance imaging findings and increased plasma IgG4 concentrations.A comprehensive understanding of both IgG4 serological and cerebrospinal fluid biomarkers is essential for managing this complex condition.展开更多
This editorial critically analyses the recent article by Jung et al,which investigates the utility of 4-hour serum amylase and lipase as early blood markers for postendoscopic retrograde cholangiopancreatography(ERCP)...This editorial critically analyses the recent article by Jung et al,which investigates the utility of 4-hour serum amylase and lipase as early blood markers for postendoscopic retrograde cholangiopancreatography(ERCP)acute pancreatitis prediction.Although these enzymes are valuable for the early diagnosis of post-ERCP pancreatitis,they lack specificity for disease etiology and provide limited insight into the molecular mechanisms underlying disease progression.Several cytokines,notably interleukin(IL)-6,tumor necrosis factor-alpha,and IL-8,are increased in post-ERCP pancreatitis and may serve as potential predictors for disease severity.The incorporation of these biomarkers in early enzymatic biomarkers and established prognostic scoring systems could further enhance their accuracy and allow for earlier,more effective management of patients with post-ERCP pancreatitis.展开更多
This study focuses on numerically investigating thermal behavior within a differentially heated cavity filled with nanofluid with and without obstacles.Numerical comparison with previous studies proves the consistency...This study focuses on numerically investigating thermal behavior within a differentially heated cavity filled with nanofluid with and without obstacles.Numerical comparison with previous studies proves the consistency and efficacy of the lattice Boltzmann method associated with a single relaxation time and its possibility of studying the nanofluid and heat transfer with high accuracy.Key parameters,including nanoparticle type and concentration,Rayleigh number,fluid basis,and obstacle position and dimension,were examined to identify optimal conditions for enhancing heat transfer quality.Principal findings indicated that increasing the Rayleigh number boosts buoyancy forces and alters vortex structure,improving the heat transfer efficiency across all nanofluid configu-rations.Moreover,nanoparticles with higher thermal conductivity,particularly Cu nanoparticles,exhibit slight improvements in heat transfer quality compared to Al2O3 nanoparticles,while higher nanoparticle concentrations generally lead to enhanced heat transfer effectiveness.Water-Cu nanofluids also demonstrate superior heat transfer performance over ethylene glycol-Cu nanofluids.Furthermore,the presence of obstacles at cavity extremities hampers overall heat transfer,whereas those positioned centrally augment heat exchange rates.This research offers valuable insights into optimizing convective heat transfer in nanofluid-filled cavities crucial for various engineering applications.展开更多
Centaurium erythraea Rafn(“Gosset El Haya”)has long been prized in North African folk medicine,yet Moroccan chemobiological data remain scarce.Ethanol extracts of northern Moroccan aerial parts were profiled by high...Centaurium erythraea Rafn(“Gosset El Haya”)has long been prized in North African folk medicine,yet Moroccan chemobiological data remain scarce.Ethanol extracts of northern Moroccan aerial parts were profiled by high-performance liquid chromatography(HPLC)and found rich in phenolics,dominated by 4-hydroxybenzoic acid(57.8%)and naringin(10.3%).The extract exhibited strong antioxidant power in the 2,2-diphenyl-1-picrylhydrazyl(DPPH)radical-scavenging assay,with a half-maximal inhibitory concentration(IC_(50))of≈74μg mL^(−1),and a total antioxidant capacity(TAC)of≈201μg mL^(−1)and selective antimicrobial activity,sharply inhibiting Aspergillus niger,Penicillium digitatum,and Rhodotorula glutinis while sparing Staphylococcus aureus.In-silico absorption,distribution,metabolism,excretion,and toxicity(ADMET)profiling predicted good oral bioavailability for low-molecular-weight acids and aglycones,lowtoxicity across all metabolites,but absorption liabilities for bulky glycosides.Molecular docking against A.niger esterase(1UKC),C.glabrata lanosterol 14-α-demethylase CYP51(5JLC),and P.digitatum ethyleneforming oxidoreductase(9EIR)corroborated bioassays:rutin and naringin bound more tightly than fluconazole(ΔG≈−9.1 to−10.0 kcal mol^(−1)),whereas quercetin and catechin offered balanced affinity pharmacokinetic profiles.Robust radical scavenging,targeted antifungal potency,and favorable in-silico pharmacokinetics thus position Moroccan C.erythraea as a promising,though standardization-dependent,source of nutraceutical,medicinal,and food-preservation agents.These results support the valorisation of Centaurium erythraea as a promising source for health promotion and green technology applications through its antioxidant,antimicrobial,and drug-like properties.展开更多
Malignant diseases in both children and adults are a worldwide public health priority with a high socioeconomic burden.Ectonucleoside triphosphate diphosphohydrolase 6(ENTPD6)molecule exhibits divergent expression pat...Malignant diseases in both children and adults are a worldwide public health priority with a high socioeconomic burden.Ectonucleoside triphosphate diphosphohydrolase 6(ENTPD6)molecule exhibits divergent expression patterns across different cancers.Its increased expression in some tumors may allow them to escape anti-tumor immune responses,potentially by inducing an immunosuppressive tumor microenvironment and favoring a poorer prognosis.Conversely,in vivo,a mutated ENTPD6 gene may induce effective cytotoxic T cell responses,thereby reducing liver tumor size.Additionally,low expression of ENTPD6 has been related to chemotherapy resistance,whereas specific ENTPD6-derived neoepitopes may potentially enhance the efficacy of immunotherapy.This paper analyses the dual roles and clinical utility of ENTPD6 in cancer.展开更多
Intradialytic hypotension(IDH)is a prevalent and critical complication of haemodialysis associated with significant morbidity,mortality,and reduced quality of life in end-stage renal disease patients.IDH results from ...Intradialytic hypotension(IDH)is a prevalent and critical complication of haemodialysis associated with significant morbidity,mortality,and reduced quality of life in end-stage renal disease patients.IDH results from multifactorial interactions,including excessive ultrafiltration rates(UFR),rapid osmotic shifts,impaired vascular resistance,and comorbidities such as diabetes and cardiovascular disease.It triggers hypovolemic stress,leading to myocardial stunning,cerebral ischemia,and organ dysfunction.Non-modifiable risk factors,including age and preexisting conditions,exacerbate susceptibility,while modifiable elements such as high interdialytic weight gain and improper dialysis prescriptions worsen outcomes.In this review,we aim to conduct an in-depth analysis of IDH,exploring its clinical relevance,underlying mechanisms,risk factors,and management approaches.Additionally,we advocate for a standardised definition and propose a strategic framework to guide future research efforts.Effective management requires individualised approaches,including optimised UFR,cooled dialysate,and nutritional adjustments,alongside emerging technologies like bio-impedance spectroscopy and artificial intelligence for real-time risk prediction.A multidisciplinary team approach,incorporating nephrologists,nurses,and dietitians,is essential for holistic patient care.Future research and technological advancements hold promise for mitigating IDH’s clinical and systemic impact,ultimately improving patient outcomes and survival.展开更多
Essential thrombocythemia is classified as a chronic myeloproliferative disorder characterized by the overproduction of platelets stemming from a megakaryocytic clone. The diagnosis primarily relies on bone marrow bio...Essential thrombocythemia is classified as a chronic myeloproliferative disorder characterized by the overproduction of platelets stemming from a megakaryocytic clone. The diagnosis primarily relies on bone marrow biopsy findings and the detection of the JAK2 V617F mutation, after the exclusion of secondary thrombocytosis due to conditions such as inflammation, hemolysis, infection, and iron deficiency. On the other hand, Ulcerative colitis represents an inflammatory disorder of the colon. The diagnosis of ulcerative colitis is established through clinical assessment, endoscopic examination, and histological criteria, without a discernible alternative etiology. The concomitant occurrence of these two conditions is infrequent. We present the case of an 85-year-old patient with a history of essential thrombocythemia who exhibited gastrointestinal symptoms characterized by alternating episodes of diarrhea and constipation. A subsequent colonoscopy accompanied by a biopsy revealed histological features consistent with ulcerative colitis. The patient was administered cytoreductive therapy in combination with mesalazine, resulting in favorable outcomes. Current literature addressing this association is limited, indicating the need for further investigative studies to elucidate the causal relationships between these two pathologies and to achieve improved therapeutic management strategies.展开更多
In light of the growing urgency to address environmental degradation and improve carbon sequestration strategies,this study rigorously investigates the potential of Cistus ladaniferus as a viable feedstock for biochar...In light of the growing urgency to address environmental degradation and improve carbon sequestration strategies,this study rigorously investigates the potential of Cistus ladaniferus as a viable feedstock for biochar and activated carbon production.The influence of pyrolysis temperature,heating rate and particle size on biochar yield was systematically examined.The results demonstrate that increasing pyrolysis temperature and heating rate significantly reduces biochar yield,while particle size plays a crucial role in thermal degradation and biochar retention.To evaluate the structural and chemical properties of the materials,various characterization techniques were employed,including Fourier-transform infrared spectroscopy(FTIR),scanning electron microscopy(SEM),and energy-dispersive X-ray analysis(EDXA).FTIR identified key functional groups,while SEM and EDXA provided valuable insights into the morphology and elemental composition of the materials.Activated carbons exhibited enhanced porosity and carbon content compared to their biochar counterparts,achieving specific surface areas of up to 1210 m^(2) g^(-1) for acidactivated shells(AC-Sha).The Brunauer-Emmett-Teller(BET)method confirmed the mesoporous characteristics of these materials,with AC-Sa displaying a surface area of 678.74 m^(2) g^(-1) and an average pore size of 2.73 nm.Elemental analysis revealed that activated carbons possessed a higher carbon content(96.40 wt.%for AC-Sha)and lower oxygen content(2.37 wt.%),highlighting their suitability for applications in adsorption and catalysis.These findings underscore the significant impact of activation processes on the stability and adsorption capabilities of Cistus-derived biochars and activated carbons,paving the way for future research and practical applications in pollution control,carbon sequestration,and bioenergy.展开更多
Objective:To evaluate the effectiveness of two doses of coenzyme Q10(CoQ10)on semen parameters,sperm DNA damage,and the partner pregnancy rate in men with idiopathic oligoasthenozoospermia.Methods:250 patients with id...Objective:To evaluate the effectiveness of two doses of coenzyme Q10(CoQ10)on semen parameters,sperm DNA damage,and the partner pregnancy rate in men with idiopathic oligoasthenozoospermia.Methods:250 patients with idiopathic oligoasthenozoospermia were examined.The first group(n=125)received 100 mg/day of CoQ10 and the second group(n=125)received 200 mg/day of CoQ10 orally for 6 months.Semen parameters,DNA fragmentation index(DFI)and the partner pregnancy rate were analyzed at baseline and after 6 months of treatment.Results:Comparing with baseline data,treatment with CoQ10(100 mg/day or 200 mg/day)resulted in a significant increase in sperm concentration(both P<0.001),a significant improvement in progressive motility and total motile sperm count(P=0.05,P=0.001,respectively).The mean DFI was significantly improved after treatment with CoQ10 at 100 mg/day and at 200 mg/day,after 6 months of treatment(P<0.01).Moreover,CoQ10 significantly improved the partner pregnancy rate.A strongest correlation was found between seminal fluid parameters and DFI(P<0.001).Conclusions:CoQ10 is effective in improving semen parameters,DFI and on the partner pregnancy rate after 6 months with CoQ10 at two doses,with a greater improvement shown in men who took 200 mg/day than in those who took 100 mg/day.展开更多
Background:Primary renal myoepithelial carcinoma is an exceptionally rare malignancy with limited data on optimal treatment,particularly in metastatic settings.Case Description:In 2020,Shenoy reported a dramatic respo...Background:Primary renal myoepithelial carcinoma is an exceptionally rare malignancy with limited data on optimal treatment,particularly in metastatic settings.Case Description:In 2020,Shenoy reported a dramatic response in a case of metastatic myoepithelial carcinoma with Ewing sarcoma breakpoint region 1-POU class 5 homeobox 1(EWSR1-POU5F1)fusion arising from the left kidney using the Ewing Sarcoma vincristine,doxorubicin,cyclophosphamide/ifosfamide,etoposide(VDC/IE)chemotherapy regimen.Ten months post-treatment,the patient showed~90%reduced disease burden on imaging.Subsequent treatment included consolidation vincristine,cyclophosphamide/ifosfamide,etoposide(VC/IE)chemotherapy,surgical resection of the remnant tumor,and follow-up imaging.Conclusion:The patient has been disease-free for 44 months off treatment and 5 years post-treatment initiation.To our knowledge,this is the first report of long-term disease-free survival in metastatic primary renal myoepithelial carcinoma.We also review the literature on this rare disease.展开更多
The Mekkam inlier is located 50 km southeast of the town of Taourirt,in northeastern Morocco.It offers a great opportunity for the study of Variscan magmatism in Morocco.This inlier is punctuated by small magmatic bod...The Mekkam inlier is located 50 km southeast of the town of Taourirt,in northeastern Morocco.It offers a great opportunity for the study of Variscan magmatism in Morocco.This inlier is punctuated by small magmatic bodies which we will characterize through a petrographic and geochemical study to situate this inlier in its geotectonic context.The petrographic study revealed the existence of three trends:acidic,intermediate,and basic,which are represented by facies ranging from granites to basanites,including andesites,rhyolites,trachytes,dacites,quartz microdiorites,Aplite and microgranites.All these facies have a mineralogical assemblage dominated by quartz,plagioclase,oligoclase,potassium feldspar,pyroxene,and biotite;the most abundant accessory minerals are zircon and apatite.Green hornblende is found in microdiorites and dacites.The geochemical analysis,conducted through the examination of major elements,trace elements,and rare earth elements,has uncovered the presence of two distinct magmatic series:a calc-alkaline series of the island arc type or active continental margin,and another alkaline series of syn-collision.Based on this combined data,we propose that the Mekkam sector represents a magmatic arc developed within a compressional tectonic regime located above a subduction zone,which was later followed by an intracontinental collision phase.展开更多
Juniperus oxycedrus(J.oxycedrus)is a traditional culinary spice and medicinal herb with a longstanding history of ethnopharmacological applications across diverse cultures.While prior research has explored the biologi...Juniperus oxycedrus(J.oxycedrus)is a traditional culinary spice and medicinal herb with a longstanding history of ethnopharmacological applications across diverse cultures.While prior research has explored the biological activities and phytochemical constituents of extracts derived from its leaves and seed cones,the present study systematically investigates their mineral and phenolic profiles alongside their multifunctional bioactive potential.Inductively coupled plasma-atomic emission spectroscopy(ICP-AES)analysis revealed a substantial abundance of essential macro-and microelements.Reversed-phase high-performance liquid chromatography(RP-HPLC)further identified high concentrations of phenolic acids(e.g.,p-coumaric acid)and flavonoids(e.g.,rutin and quercetin).The extracts exhibited potent radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl(DPPH),robust antioxidant capacity against hydrogen peroxide,and significant inhibition of xanthine oxidase(XO)activity.Notably,both extracts demonstrated marked antibacterial efficacy.In silico molecular docking studies suggested that the antimicrobial activity may stem from the phenolic constituents,which exhibited favorable binding affinities to the active site of bacterial target proteins.These findings underscore J.oxycedrus as a promising reservoir of bioactive natural compounds,warranting further exploration for therapeutic and nutraceutical applications.展开更多
Objective: To evaluate the in vitro antioxidant power of cactus pear seed oil [Opuntia ficusincida L. MILL.(CPSO)] and its protective effect against chemically induced diabetes mellitus in mice. Methods: The in vitro ...Objective: To evaluate the in vitro antioxidant power of cactus pear seed oil [Opuntia ficusincida L. MILL.(CPSO)] and its protective effect against chemically induced diabetes mellitus in mice. Methods: The in vitro antioxidant effect of CPSO was evaluated using 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging assay. The preventive effect was conducted on Swiss albino mice treated with CPSO(2 m L/kg, per os), before and after a single intraperitoneal alloxan administration(100 mg/kg). Survival rate, body weight and fasting blood glucose were measured and histopathological analysis of pancreas was performed to evaluate alloxaninduced tissue injuries. Results: CPSO exhibited an antioxidant effect in DPPH scavenging assay. Moreover, the administration of CPSO(2 m L/kg) significantly attenuated alloxaninduced death and hyperglycemia(P<0.001) in treated mice. Morphometric study of pancreas revealed that CPSO significantly protected islets of langerhans against alloxan induced-tissue alterations. Conclusions: Based on theses results, CPSO can prevent alloxan-induced-diabetes by quenching free radicals produced by alloxan and inhibiting tissue injuries in pancreatic β-cells.展开更多
Landsat 8 Oli,ASTER,and Sentinel 2A satellite images processing was used to map geological formations,lineaments and hydrothermal alteration minerals in the Aouli inlier,as a case study to illustrate the application o...Landsat 8 Oli,ASTER,and Sentinel 2A satellite images processing was used to map geological formations,lineaments and hydrothermal alteration minerals in the Aouli inlier,as a case study to illustrate the application of digital images processing and Geographic Information System(GIS)in geological mapping and mining prospecting.Principal Component Analysis(PCA)applied to the Landsat images allowed good lithological discrimination and contributed to the updating of available geological maps.The Automatic lineament extraction from Sentinel images revealed the main tectonic structures affecting Aouli inlier.The ratio bands(b5+b7)/b6 and the false color composite(b4/b6,b2/b1,b3/b2)allowed the hydrothermal alteration minerals mapping from Aster images.Combined with available geological data and field observations,the satellite derived data were integrated and analyzed in a GIS software to establish mining prospecting guides.The results showed that the anomaly zones are intimately linked to NNE-SSW and NW-SE oriented faults and to highly fractured areas developing argillic and Fe rich alterations.Verified via field survey,this approach was successfully applied to the Aouli inlier to rapidly target potential areas to be explored in the tactical phase.This provides a model for future prospecting efforts for similar mineral deposits in other areas.展开更多
In this paper,natural heat convection inside square and equilateral triangular cavities was studied using a meshless method based on collocation local radial basis function(RBF).The nanofluids used were Cu-water or Al...In this paper,natural heat convection inside square and equilateral triangular cavities was studied using a meshless method based on collocation local radial basis function(RBF).The nanofluids used were Cu-water or Al_(2)O_(3)-water mixture with nanoparticle volume fractions range of 0≤φ≤0.2.A system of continuity,momentum,and energy partial differential equations was used in modeling the flow and temperature behavior of the fluids.Partial derivatives in the governing equations were approximated using the RBF method.The artificial compressibility model was implemented to overcome the pressure velocity coupling problem that occurs in such equations.Themain goal of this work was to present a simple and efficient method to deal with complex geometries for a variety of problem conditions.To assess the accuracy of the proposed method,several test cases of natural convection in square and triangular cavities were selected.For Rayleigh numbers ranging from 103 to 105,a validation test of natural convection of Cu-water in a square cavity was used.The numerical investigation was then extended to Rayleigh number 106,as well as Al_(2)O_(3)-water nanofluid with a volume fraction range of 0≤φ≤0.2.In a second investigation,the same nanofluids were used in a triangular cavitywith varying volume fractions to test the proposed meshless approach on non-rectangular geometries.The numerical results appear to be in agreement with those from earlier investigations.Furthermore,the suggested meshless method was found to be stable and accurate,demonstrating that it may be a viable alternative for solving natural heat transfer equations of nanofluids in enclosures with irregular geometries.展开更多
The formation of inorganic-organic hybrids(IOH)on the metallic substrates would play a decisive role in improving their structural and functional features.In this work,the growth of organic coating(OC)consisting of co...The formation of inorganic-organic hybrids(IOH)on the metallic substrates would play a decisive role in improving their structural and functional features.In this work,the growth of organic coating(OC)consisting of coumarin-3-carboxylic acid(3-CCA)and albumin(ALB)on the inorganic layer(IC),produced by plasma electrolysis of AZ31 Mg alloy,led to enabling organically synergistic reactions on the porous inorganic surface,forming a flake-like structure sealing the structural defects of IC.Synergistic actions between OC and IC endow the flake-like structures with chemical protection and photocatalytic performance.Upon contact with a corrosive solution,the IOH layer possesses stable morphologies that delay the corrosive degradation of the whole structure.The electrochemical stability of the sample produced by immersion IC in the organic solution for 10 h(IOH2 sample)was superior to the other samples as it had the lowest corrosion current density(1.69×10^(−10)A·cm^(−2))and the highest top layer resistance(1.2×10^(7)Ω·cm^(2)).Moreover,the IOH layer can photodegrade the organic pollutants in model wastewater,where the highest photocatalytic efficiency of 99.47%was found in the IOH2 sample.Furthermore,computational calculations were performed to assess the relative activity of different parts of the ALB and 3-CCA structures,which provide helpful information into the formation mechanism of the IOH materials.展开更多
文摘This study investigates the structural,electronic,vibrational,and mechanical properties of cubic InTe using density functional theory and density functional perturbation theory.The results reveal the metallic character of cubic InTe,as indicated by its electronic structure and density of states.The dynamic stability of the material is confirmed by phonon dispersion analysis,with no imaginary frequencies observed.The Debye temperature(172.276 K)and melting temperature(1092.832 K)suggest excellent thermal resistance.A shear modulus of 18.20 GPa,Poisson’s ratio of 0.343,and Pugh’s ratio([Math Processing Error])of 2.87 support mechanical stability and indicate ductility.Isotropic dielectric properties,with Born effective charges of−3.768 for both In and Te atoms,highlight potential ferroelectric applications.These findings emphasize InTe’s suitability for electronic and construction applications.
文摘Introduction: Despite advances in obstetrics and pediatrics over the past 20 years, premature birth remains an unpredictable event that can have a devastating impact on parenthood. This study aimed to analyze the psycho-affective experiences of fathers of premature newborns. Methods: This was a descriptive cross-sectional study, carried out in the department of neonatology and neonatal intensive care unit of the CHU Mohamed VI in OUJDA, over 6 months from March 2022 to August 2022. It focused on 30 fathers of premature newborns hospitalized in our department. Results: The majority of fathers described a state of fear and stress, and attributed their negative experience to the unexpected nature of the premature birth. At the first meeting, half the fathers had a positive image of their newborn’s physical appearance, while 22% of fathers reported feeling uncomfortable about their newborn’s low weight. Most fathers reported that they appreciated the welcome they received, the skill with which they cared for their newborn, and the availability of the pediatrician to provide information on their child’s state of health. Two fathers enjoyed skin-to-skin contact with their newborns. None of the fathers met a psychologist. When they returned home, half the fathers had a positive outlook, marked by happiness at being able to fully invest in their role as fathers, the other half reported being torn between the desire to see their child integrated into the family cocoon and the fear of not being able to manage delicate situations properly without a medical team. Conclusion: Bringing a premature baby into the world can be a difficult experience, leading to the development of even minor psychological distress in some fathers, and hence the need for specific psychological care.
文摘Introduction: Even though lumbar puncture (LP) represents an important tool in the diagnosis of certain neurological diseases, this procedure is little practiced by our students. We aimed to evaluate the attitudes and practices of students, interns, and residents about LP, and to assess their feelings about how this procedure is taught. Materials and Methods: We conducted a cross-sectional study of 160 participants, using an anonymous questionnaire, to evaluate the attitudes and practices of students, interns and residents in the pediatrics department concerning lumbar puncture. Results: Half of the participants had never performed LP, usually because of the risk involved or lack of confidence, while 20% had performed it more than 4 times. None of the participants had learned to perform the procedure through simulation sessions, while (42%) had learned it under the supervision of a senior physician and had not been able to perform it successfully the first time. Most participants inform the patient about the procedure before performing it. Only 44% of participants acknowledged that LP can be performed under local anesthetic. The sitting position (60%) was by far the most commonly used. Most LPs were performed for diagnostic purposes. Most participants stated that the pediatric ward and the pediatric emergency department are among the departments that perform LP most frequently, and that they would be interested in taking part in simulated lumbar puncture sessions in children in the future. Conclusion: The results of our study show that LP is perceived by students as a risky procedure that is difficult to perform. Teachers should reconsider how this technical procedure is taught, by integrating simulation on mannequins into student training.
文摘Congenital hernia of the diaphragmatic dome (CHDD) is an embryonic malformation in which all or part of the diaphragmatic dome fails to develop properly. In the majority of cases (80% to 90%), this malformation affects the left posterolateral part of the diaphragm, while in 10% to 15% of cases it affects the right. Bilateral cases are extremely rare, accounting for less than 1% of cases. This malformation is estimated to occur at a frequency of around 1 in 3500 births, with a male predominance. The diaphragmatic defect causes the abdominal organs to rise into the thoracic cavity during critical phases of lung development. These anomalies result in bilateral pulmonary hypoplasia, a reduced number of pulmonary vessels, and pulmonary arterial hypertension (PAH). The combination of these anatomical and functional anomalies, in varying degrees, explains the wide variability of symptoms at birth. Diagnosis is usually made prenatally by ultrasound, which enables severe forms of the disease to be detected and appropriate management initiated. The prognosis remains generally grave, with a neonatal mortality rate of between 30% and 60% depending on the study, and around half of all children will have long-term sequelae.
文摘This letter to the editor highlights adding the diagnostic utility of immunoglobulin G4(IgG4)measurements and its potential role in IgG4-related spinal pachymeningitis(IgG4-RSP)pathogenesis to the case reported by Chae TS et al,which focused on IgG4-RSP diagnosis based on magnetic resonance imaging findings and increased plasma IgG4 concentrations.A comprehensive understanding of both IgG4 serological and cerebrospinal fluid biomarkers is essential for managing this complex condition.
文摘This editorial critically analyses the recent article by Jung et al,which investigates the utility of 4-hour serum amylase and lipase as early blood markers for postendoscopic retrograde cholangiopancreatography(ERCP)acute pancreatitis prediction.Although these enzymes are valuable for the early diagnosis of post-ERCP pancreatitis,they lack specificity for disease etiology and provide limited insight into the molecular mechanisms underlying disease progression.Several cytokines,notably interleukin(IL)-6,tumor necrosis factor-alpha,and IL-8,are increased in post-ERCP pancreatitis and may serve as potential predictors for disease severity.The incorporation of these biomarkers in early enzymatic biomarkers and established prognostic scoring systems could further enhance their accuracy and allow for earlier,more effective management of patients with post-ERCP pancreatitis.
文摘This study focuses on numerically investigating thermal behavior within a differentially heated cavity filled with nanofluid with and without obstacles.Numerical comparison with previous studies proves the consistency and efficacy of the lattice Boltzmann method associated with a single relaxation time and its possibility of studying the nanofluid and heat transfer with high accuracy.Key parameters,including nanoparticle type and concentration,Rayleigh number,fluid basis,and obstacle position and dimension,were examined to identify optimal conditions for enhancing heat transfer quality.Principal findings indicated that increasing the Rayleigh number boosts buoyancy forces and alters vortex structure,improving the heat transfer efficiency across all nanofluid configu-rations.Moreover,nanoparticles with higher thermal conductivity,particularly Cu nanoparticles,exhibit slight improvements in heat transfer quality compared to Al2O3 nanoparticles,while higher nanoparticle concentrations generally lead to enhanced heat transfer effectiveness.Water-Cu nanofluids also demonstrate superior heat transfer performance over ethylene glycol-Cu nanofluids.Furthermore,the presence of obstacles at cavity extremities hampers overall heat transfer,whereas those positioned centrally augment heat exchange rates.This research offers valuable insights into optimizing convective heat transfer in nanofluid-filled cavities crucial for various engineering applications.
文摘Centaurium erythraea Rafn(“Gosset El Haya”)has long been prized in North African folk medicine,yet Moroccan chemobiological data remain scarce.Ethanol extracts of northern Moroccan aerial parts were profiled by high-performance liquid chromatography(HPLC)and found rich in phenolics,dominated by 4-hydroxybenzoic acid(57.8%)and naringin(10.3%).The extract exhibited strong antioxidant power in the 2,2-diphenyl-1-picrylhydrazyl(DPPH)radical-scavenging assay,with a half-maximal inhibitory concentration(IC_(50))of≈74μg mL^(−1),and a total antioxidant capacity(TAC)of≈201μg mL^(−1)and selective antimicrobial activity,sharply inhibiting Aspergillus niger,Penicillium digitatum,and Rhodotorula glutinis while sparing Staphylococcus aureus.In-silico absorption,distribution,metabolism,excretion,and toxicity(ADMET)profiling predicted good oral bioavailability for low-molecular-weight acids and aglycones,lowtoxicity across all metabolites,but absorption liabilities for bulky glycosides.Molecular docking against A.niger esterase(1UKC),C.glabrata lanosterol 14-α-demethylase CYP51(5JLC),and P.digitatum ethyleneforming oxidoreductase(9EIR)corroborated bioassays:rutin and naringin bound more tightly than fluconazole(ΔG≈−9.1 to−10.0 kcal mol^(−1)),whereas quercetin and catechin offered balanced affinity pharmacokinetic profiles.Robust radical scavenging,targeted antifungal potency,and favorable in-silico pharmacokinetics thus position Moroccan C.erythraea as a promising,though standardization-dependent,source of nutraceutical,medicinal,and food-preservation agents.These results support the valorisation of Centaurium erythraea as a promising source for health promotion and green technology applications through its antioxidant,antimicrobial,and drug-like properties.
文摘Malignant diseases in both children and adults are a worldwide public health priority with a high socioeconomic burden.Ectonucleoside triphosphate diphosphohydrolase 6(ENTPD6)molecule exhibits divergent expression patterns across different cancers.Its increased expression in some tumors may allow them to escape anti-tumor immune responses,potentially by inducing an immunosuppressive tumor microenvironment and favoring a poorer prognosis.Conversely,in vivo,a mutated ENTPD6 gene may induce effective cytotoxic T cell responses,thereby reducing liver tumor size.Additionally,low expression of ENTPD6 has been related to chemotherapy resistance,whereas specific ENTPD6-derived neoepitopes may potentially enhance the efficacy of immunotherapy.This paper analyses the dual roles and clinical utility of ENTPD6 in cancer.
文摘Intradialytic hypotension(IDH)is a prevalent and critical complication of haemodialysis associated with significant morbidity,mortality,and reduced quality of life in end-stage renal disease patients.IDH results from multifactorial interactions,including excessive ultrafiltration rates(UFR),rapid osmotic shifts,impaired vascular resistance,and comorbidities such as diabetes and cardiovascular disease.It triggers hypovolemic stress,leading to myocardial stunning,cerebral ischemia,and organ dysfunction.Non-modifiable risk factors,including age and preexisting conditions,exacerbate susceptibility,while modifiable elements such as high interdialytic weight gain and improper dialysis prescriptions worsen outcomes.In this review,we aim to conduct an in-depth analysis of IDH,exploring its clinical relevance,underlying mechanisms,risk factors,and management approaches.Additionally,we advocate for a standardised definition and propose a strategic framework to guide future research efforts.Effective management requires individualised approaches,including optimised UFR,cooled dialysate,and nutritional adjustments,alongside emerging technologies like bio-impedance spectroscopy and artificial intelligence for real-time risk prediction.A multidisciplinary team approach,incorporating nephrologists,nurses,and dietitians,is essential for holistic patient care.Future research and technological advancements hold promise for mitigating IDH’s clinical and systemic impact,ultimately improving patient outcomes and survival.
文摘Essential thrombocythemia is classified as a chronic myeloproliferative disorder characterized by the overproduction of platelets stemming from a megakaryocytic clone. The diagnosis primarily relies on bone marrow biopsy findings and the detection of the JAK2 V617F mutation, after the exclusion of secondary thrombocytosis due to conditions such as inflammation, hemolysis, infection, and iron deficiency. On the other hand, Ulcerative colitis represents an inflammatory disorder of the colon. The diagnosis of ulcerative colitis is established through clinical assessment, endoscopic examination, and histological criteria, without a discernible alternative etiology. The concomitant occurrence of these two conditions is infrequent. We present the case of an 85-year-old patient with a history of essential thrombocythemia who exhibited gastrointestinal symptoms characterized by alternating episodes of diarrhea and constipation. A subsequent colonoscopy accompanied by a biopsy revealed histological features consistent with ulcerative colitis. The patient was administered cytoreductive therapy in combination with mesalazine, resulting in favorable outcomes. Current literature addressing this association is limited, indicating the need for further investigative studies to elucidate the causal relationships between these two pathologies and to achieve improved therapeutic management strategies.
文摘In light of the growing urgency to address environmental degradation and improve carbon sequestration strategies,this study rigorously investigates the potential of Cistus ladaniferus as a viable feedstock for biochar and activated carbon production.The influence of pyrolysis temperature,heating rate and particle size on biochar yield was systematically examined.The results demonstrate that increasing pyrolysis temperature and heating rate significantly reduces biochar yield,while particle size plays a crucial role in thermal degradation and biochar retention.To evaluate the structural and chemical properties of the materials,various characterization techniques were employed,including Fourier-transform infrared spectroscopy(FTIR),scanning electron microscopy(SEM),and energy-dispersive X-ray analysis(EDXA).FTIR identified key functional groups,while SEM and EDXA provided valuable insights into the morphology and elemental composition of the materials.Activated carbons exhibited enhanced porosity and carbon content compared to their biochar counterparts,achieving specific surface areas of up to 1210 m^(2) g^(-1) for acidactivated shells(AC-Sha).The Brunauer-Emmett-Teller(BET)method confirmed the mesoporous characteristics of these materials,with AC-Sa displaying a surface area of 678.74 m^(2) g^(-1) and an average pore size of 2.73 nm.Elemental analysis revealed that activated carbons possessed a higher carbon content(96.40 wt.%for AC-Sha)and lower oxygen content(2.37 wt.%),highlighting their suitability for applications in adsorption and catalysis.These findings underscore the significant impact of activation processes on the stability and adsorption capabilities of Cistus-derived biochars and activated carbons,paving the way for future research and practical applications in pollution control,carbon sequestration,and bioenergy.
文摘Objective:To evaluate the effectiveness of two doses of coenzyme Q10(CoQ10)on semen parameters,sperm DNA damage,and the partner pregnancy rate in men with idiopathic oligoasthenozoospermia.Methods:250 patients with idiopathic oligoasthenozoospermia were examined.The first group(n=125)received 100 mg/day of CoQ10 and the second group(n=125)received 200 mg/day of CoQ10 orally for 6 months.Semen parameters,DNA fragmentation index(DFI)and the partner pregnancy rate were analyzed at baseline and after 6 months of treatment.Results:Comparing with baseline data,treatment with CoQ10(100 mg/day or 200 mg/day)resulted in a significant increase in sperm concentration(both P<0.001),a significant improvement in progressive motility and total motile sperm count(P=0.05,P=0.001,respectively).The mean DFI was significantly improved after treatment with CoQ10 at 100 mg/day and at 200 mg/day,after 6 months of treatment(P<0.01).Moreover,CoQ10 significantly improved the partner pregnancy rate.A strongest correlation was found between seminal fluid parameters and DFI(P<0.001).Conclusions:CoQ10 is effective in improving semen parameters,DFI and on the partner pregnancy rate after 6 months with CoQ10 at two doses,with a greater improvement shown in men who took 200 mg/day than in those who took 100 mg/day.
基金Niraj Shenoy’s research was supported by the Albert Einstein Cancer Center Core Grant(2P30CA013330-47).
文摘Background:Primary renal myoepithelial carcinoma is an exceptionally rare malignancy with limited data on optimal treatment,particularly in metastatic settings.Case Description:In 2020,Shenoy reported a dramatic response in a case of metastatic myoepithelial carcinoma with Ewing sarcoma breakpoint region 1-POU class 5 homeobox 1(EWSR1-POU5F1)fusion arising from the left kidney using the Ewing Sarcoma vincristine,doxorubicin,cyclophosphamide/ifosfamide,etoposide(VDC/IE)chemotherapy regimen.Ten months post-treatment,the patient showed~90%reduced disease burden on imaging.Subsequent treatment included consolidation vincristine,cyclophosphamide/ifosfamide,etoposide(VC/IE)chemotherapy,surgical resection of the remnant tumor,and follow-up imaging.Conclusion:The patient has been disease-free for 44 months off treatment and 5 years post-treatment initiation.To our knowledge,this is the first report of long-term disease-free survival in metastatic primary renal myoepithelial carcinoma.We also review the literature on this rare disease.
文摘The Mekkam inlier is located 50 km southeast of the town of Taourirt,in northeastern Morocco.It offers a great opportunity for the study of Variscan magmatism in Morocco.This inlier is punctuated by small magmatic bodies which we will characterize through a petrographic and geochemical study to situate this inlier in its geotectonic context.The petrographic study revealed the existence of three trends:acidic,intermediate,and basic,which are represented by facies ranging from granites to basanites,including andesites,rhyolites,trachytes,dacites,quartz microdiorites,Aplite and microgranites.All these facies have a mineralogical assemblage dominated by quartz,plagioclase,oligoclase,potassium feldspar,pyroxene,and biotite;the most abundant accessory minerals are zircon and apatite.Green hornblende is found in microdiorites and dacites.The geochemical analysis,conducted through the examination of major elements,trace elements,and rare earth elements,has uncovered the presence of two distinct magmatic series:a calc-alkaline series of the island arc type or active continental margin,and another alkaline series of syn-collision.Based on this combined data,we propose that the Mekkam sector represents a magmatic arc developed within a compressional tectonic regime located above a subduction zone,which was later followed by an intracontinental collision phase.
文摘Juniperus oxycedrus(J.oxycedrus)is a traditional culinary spice and medicinal herb with a longstanding history of ethnopharmacological applications across diverse cultures.While prior research has explored the biological activities and phytochemical constituents of extracts derived from its leaves and seed cones,the present study systematically investigates their mineral and phenolic profiles alongside their multifunctional bioactive potential.Inductively coupled plasma-atomic emission spectroscopy(ICP-AES)analysis revealed a substantial abundance of essential macro-and microelements.Reversed-phase high-performance liquid chromatography(RP-HPLC)further identified high concentrations of phenolic acids(e.g.,p-coumaric acid)and flavonoids(e.g.,rutin and quercetin).The extracts exhibited potent radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl(DPPH),robust antioxidant capacity against hydrogen peroxide,and significant inhibition of xanthine oxidase(XO)activity.Notably,both extracts demonstrated marked antibacterial efficacy.In silico molecular docking studies suggested that the antimicrobial activity may stem from the phenolic constituents,which exhibited favorable binding affinities to the active site of bacterial target proteins.These findings underscore J.oxycedrus as a promising reservoir of bioactive natural compounds,warranting further exploration for therapeutic and nutraceutical applications.
基金supported by grants from CNRST,Morocco(Project URAC-40)Belgium(Program 3,CUD Project)
文摘Objective: To evaluate the in vitro antioxidant power of cactus pear seed oil [Opuntia ficusincida L. MILL.(CPSO)] and its protective effect against chemically induced diabetes mellitus in mice. Methods: The in vitro antioxidant effect of CPSO was evaluated using 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging assay. The preventive effect was conducted on Swiss albino mice treated with CPSO(2 m L/kg, per os), before and after a single intraperitoneal alloxan administration(100 mg/kg). Survival rate, body weight and fasting blood glucose were measured and histopathological analysis of pancreas was performed to evaluate alloxaninduced tissue injuries. Results: CPSO exhibited an antioxidant effect in DPPH scavenging assay. Moreover, the administration of CPSO(2 m L/kg) significantly attenuated alloxaninduced death and hyperglycemia(P<0.001) in treated mice. Morphometric study of pancreas revealed that CPSO significantly protected islets of langerhans against alloxan induced-tissue alterations. Conclusions: Based on theses results, CPSO can prevent alloxan-induced-diabetes by quenching free radicals produced by alloxan and inhibiting tissue injuries in pancreatic β-cells.
文摘Landsat 8 Oli,ASTER,and Sentinel 2A satellite images processing was used to map geological formations,lineaments and hydrothermal alteration minerals in the Aouli inlier,as a case study to illustrate the application of digital images processing and Geographic Information System(GIS)in geological mapping and mining prospecting.Principal Component Analysis(PCA)applied to the Landsat images allowed good lithological discrimination and contributed to the updating of available geological maps.The Automatic lineament extraction from Sentinel images revealed the main tectonic structures affecting Aouli inlier.The ratio bands(b5+b7)/b6 and the false color composite(b4/b6,b2/b1,b3/b2)allowed the hydrothermal alteration minerals mapping from Aster images.Combined with available geological data and field observations,the satellite derived data were integrated and analyzed in a GIS software to establish mining prospecting guides.The results showed that the anomaly zones are intimately linked to NNE-SSW and NW-SE oriented faults and to highly fractured areas developing argillic and Fe rich alterations.Verified via field survey,this approach was successfully applied to the Aouli inlier to rapidly target potential areas to be explored in the tactical phase.This provides a model for future prospecting efforts for similar mineral deposits in other areas.
基金supported through the Annual Funding Track by the Deanship of Scientific Research,Vice Presidency for Graduate Studies and Scientific Research,King Faisal University,Saudi Arabia[Project No.AN000675].
文摘In this paper,natural heat convection inside square and equilateral triangular cavities was studied using a meshless method based on collocation local radial basis function(RBF).The nanofluids used were Cu-water or Al_(2)O_(3)-water mixture with nanoparticle volume fractions range of 0≤φ≤0.2.A system of continuity,momentum,and energy partial differential equations was used in modeling the flow and temperature behavior of the fluids.Partial derivatives in the governing equations were approximated using the RBF method.The artificial compressibility model was implemented to overcome the pressure velocity coupling problem that occurs in such equations.Themain goal of this work was to present a simple and efficient method to deal with complex geometries for a variety of problem conditions.To assess the accuracy of the proposed method,several test cases of natural convection in square and triangular cavities were selected.For Rayleigh numbers ranging from 103 to 105,a validation test of natural convection of Cu-water in a square cavity was used.The numerical investigation was then extended to Rayleigh number 106,as well as Al_(2)O_(3)-water nanofluid with a volume fraction range of 0≤φ≤0.2.In a second investigation,the same nanofluids were used in a triangular cavitywith varying volume fractions to test the proposed meshless approach on non-rectangular geometries.The numerical results appear to be in agreement with those from earlier investigations.Furthermore,the suggested meshless method was found to be stable and accurate,demonstrating that it may be a viable alternative for solving natural heat transfer equations of nanofluids in enclosures with irregular geometries.
基金supported by the National Research Foundation of Korea(NRF)funded by the Korean Government(MSIT)(No.2022R1A2C1006743).
文摘The formation of inorganic-organic hybrids(IOH)on the metallic substrates would play a decisive role in improving their structural and functional features.In this work,the growth of organic coating(OC)consisting of coumarin-3-carboxylic acid(3-CCA)and albumin(ALB)on the inorganic layer(IC),produced by plasma electrolysis of AZ31 Mg alloy,led to enabling organically synergistic reactions on the porous inorganic surface,forming a flake-like structure sealing the structural defects of IC.Synergistic actions between OC and IC endow the flake-like structures with chemical protection and photocatalytic performance.Upon contact with a corrosive solution,the IOH layer possesses stable morphologies that delay the corrosive degradation of the whole structure.The electrochemical stability of the sample produced by immersion IC in the organic solution for 10 h(IOH2 sample)was superior to the other samples as it had the lowest corrosion current density(1.69×10^(−10)A·cm^(−2))and the highest top layer resistance(1.2×10^(7)Ω·cm^(2)).Moreover,the IOH layer can photodegrade the organic pollutants in model wastewater,where the highest photocatalytic efficiency of 99.47%was found in the IOH2 sample.Furthermore,computational calculations were performed to assess the relative activity of different parts of the ALB and 3-CCA structures,which provide helpful information into the formation mechanism of the IOH materials.
