AIM:To assess the effectiveness and safety of VISULAS®green laser selective laser trabeculoplasty(SLT)in lowering intraocular pressure(IOP)in patients with pseudoexfoliative syndrome glaucoma(PEXG)and pseudoexfol...AIM:To assess the effectiveness and safety of VISULAS®green laser selective laser trabeculoplasty(SLT)in lowering intraocular pressure(IOP)in patients with pseudoexfoliative syndrome glaucoma(PEXG)and pseudoexfoliative syndrome ocular hypertension(PEXS-OHT).METHODS:This prospective,single-center,interventional study included 20 eyes from 20 patients diagnosed with PEXG or PEXS-OHT.Patients underwent 180°SLT using the VISULAS®green laser,a diode-pumped,frequencydoubled Nd:YVO4 laser with a 532 nm wavelength.IOP was measured at baseline and post-treatment at 1,3,and 6mo.Medications regimen was stable through the study.Primary outcomes included mean IOP reduction,while secondary outcomes assessed visual and structural parameters,and safety.RESULTS:The mean age of participants was 72.2±6.6y,with 65%of the eyes being left eyes and 35%right eyes.At baseline,the mean IOP was 22.9±2.9 mm Hg.A significant reduction in IOP was observed at all follow-up intervals:18.5±3.1 mm Hg at 1mo(18.8%reduction,P=0.001),19.0±4.2 mm Hg at 3mo(16.7%reduction,P=0.002),and 18.2±4.5 mm Hg at 6mo(19.8%reduction,P=0.001).Subgroup analysis showed greater IOP reduction in patients with Shaffer grade 4 angles,phakic eyes,and those with PEXS-OHT compared to PEXG.No significant changes were detected in visual acuity,visual field index,mean deviation,or retinal nerve fiber layer thickness.At 1h post-procedure,20%of eyes showed an IOP spike>5 mm Hg that resolved without intervention except for one patient.CONCLUSION:SLT with the VISULAS®green laser is an effective and safe treatment for PEXG and PEXS-OHT,achieving significant IOP reduction without increasing medication burden or causing severe complications.These findings suggest its potential as an alternative or adjunct therapy in managing pseudoexfoliative glaucoma.展开更多
文摘AIM:To assess the effectiveness and safety of VISULAS®green laser selective laser trabeculoplasty(SLT)in lowering intraocular pressure(IOP)in patients with pseudoexfoliative syndrome glaucoma(PEXG)and pseudoexfoliative syndrome ocular hypertension(PEXS-OHT).METHODS:This prospective,single-center,interventional study included 20 eyes from 20 patients diagnosed with PEXG or PEXS-OHT.Patients underwent 180°SLT using the VISULAS®green laser,a diode-pumped,frequencydoubled Nd:YVO4 laser with a 532 nm wavelength.IOP was measured at baseline and post-treatment at 1,3,and 6mo.Medications regimen was stable through the study.Primary outcomes included mean IOP reduction,while secondary outcomes assessed visual and structural parameters,and safety.RESULTS:The mean age of participants was 72.2±6.6y,with 65%of the eyes being left eyes and 35%right eyes.At baseline,the mean IOP was 22.9±2.9 mm Hg.A significant reduction in IOP was observed at all follow-up intervals:18.5±3.1 mm Hg at 1mo(18.8%reduction,P=0.001),19.0±4.2 mm Hg at 3mo(16.7%reduction,P=0.002),and 18.2±4.5 mm Hg at 6mo(19.8%reduction,P=0.001).Subgroup analysis showed greater IOP reduction in patients with Shaffer grade 4 angles,phakic eyes,and those with PEXS-OHT compared to PEXG.No significant changes were detected in visual acuity,visual field index,mean deviation,or retinal nerve fiber layer thickness.At 1h post-procedure,20%of eyes showed an IOP spike>5 mm Hg that resolved without intervention except for one patient.CONCLUSION:SLT with the VISULAS®green laser is an effective and safe treatment for PEXG and PEXS-OHT,achieving significant IOP reduction without increasing medication burden or causing severe complications.These findings suggest its potential as an alternative or adjunct therapy in managing pseudoexfoliative glaucoma.
