Neurofibromin 2(NF2)-related schwannomatosis(NF2-SWN)is an autosomal-dominant tumor predisposition syndrome.NF2-SWN patients develop multiple benign tumors of the nervous system,such as schwannomas,particularly bilate...Neurofibromin 2(NF2)-related schwannomatosis(NF2-SWN)is an autosomal-dominant tumor predisposition syndrome.NF2-SWN patients develop multiple benign tumors of the nervous system,such as schwannomas,particularly bilateral vestibular schwannomas,without current effective treatments.1 These tumors are caused by the bi-allelic inactivation of the NF2 gene,which encodes for merlin protein,in a cell of the Schwann cell(SC)lineage.展开更多
基金funded by Chromo22the ISCIII(No.PI20/00215,PI23/00619)(Co-funded by the European Regional Development Fund“A way to make Europe”)+4 种基金AC22/00033,partner of the EJPRDThe EJPRD initiative has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No.825575funded also by FundacióLa Maratóde TV3(No.126/C/2020)the Children's Tumor Foundation(No.CTF-2019-05-005,CTF-2022-05-005)Fundación Proyecto Neurofibromatosis,and the Government of Catalonia(No.SGR-Cat 2021-00967).
文摘Neurofibromin 2(NF2)-related schwannomatosis(NF2-SWN)is an autosomal-dominant tumor predisposition syndrome.NF2-SWN patients develop multiple benign tumors of the nervous system,such as schwannomas,particularly bilateral vestibular schwannomas,without current effective treatments.1 These tumors are caused by the bi-allelic inactivation of the NF2 gene,which encodes for merlin protein,in a cell of the Schwann cell(SC)lineage.
